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The map label for this gene is fadA [H]

Identifier: 108762905

GI number: 108762905

Start: 6415098

End: 6416297

Strand: Reverse

Name: fadA [H]

Synonym: MXAN_5135

Alternate gene names: 108762905

Gene position: 6416297-6415098 (Counterclockwise)

Preceding gene: 108761054

Following gene: 108762174

Centisome position: 70.2

GC content: 69.33

Gene sequence:

>1200_bases
GTGCCCCCCGGGCAAGGAGACATCAAAATGGCTGGTCGAGTCGTGATTGCCAGCGCGGTCCGCACGCCCTTCACCCGCGC
GCACAAGGGAGAGTTCAAGGACACCCGGCCGGATACCCTGGCCGCTGTCGCCATCAAGGAGGCCGTTGCCCAGGTCCCGG
GCCTGAAGCCGGAGGACATCGGTGACGTCGTCCTGGGCTGTGCCATGCCGGAGGCCGAGCAGGGCATGAACGTGGCCCGC
GTGGCCACGCTGCTGGCGGGCCTGCCCGTCACGGTGCCCGCGATGACCATCAACCGGTTCTGTTCCTCCGGTTCGCAGGC
CATCGCCCAGGTGGCCCAGGCCATCCAGGCGGGGATGTACGACGTGGGCATCGGTGGTGGCACCGAGTCCATGACGATGG
TCCCCATGGGCGGCAACAAGGCGAGCGCCAACCCCGAGGCCATGGAGCGCCTGCCGGAGATCTACACCTCCATGGGCGCC
ACGGCGGAGAACATCGCGTCGCGCTACGGCGTGTCGCGTGAGGACTCGGACAAGTTCGCCGCCGAGAGCCAGCGCCGTGC
CGCCACCGCGCGCGAGCAGGGCAAGTTCAAGGAGGAGATCGTCCCCGTCACCACGACGTACTACGACGACGACGGCGTGG
CGCAGAACGTCACCGTCACGGTGGACACCATCCTCCGCCCGGAGACCACGCAGGAGGGCCTGGCCAAGCTGCGCCCGGCC
TTCAACCCCAAGGGCGTGGTGACGGCTGGTAACGCGTCGCCGCTGACGGACGGCGCCGCCGCCGCGGTGGTGATGAGTGA
GGCCAAGGCGAAGGAGCTGGGCGTCAAGCCGCTGGGCTACTTCATCGACGCCGCGGTGGCGGGCGTGCCCCCGGAAATCA
TGGGCATCGGCCCGGTTCCCGCGGTCCGCAAGCTGCTGGAGAAGAACAAGCTCAAGGTCGAGGACATCGACGTCTTCGAG
CTGAACGAGGCCTTCGGGGCGCAGGCGCTGTACTGCGTGCGCGAGCTGGGCATCCCCGCCGACAAGGTGAACCCCAACGG
CGGCGCCATCGCCCTGGGTCACCCGCTGGGCGTCTCTGGCGCGCGCATGGTGGCCACCATCCTGCGCGAGCTGAAGCGCC
GCAACGGCCGCTACGGCGTCGTCTCCATGTGCATCGGCGGCGGCATGGGCTTCGCCGCCCTCATCGAGGCGCCCAAGTAG

Upstream 100 bases:

>100_bases
GACCGCCTGCAGCACATGATCGAGAAGGGCAAGCCGCTGCGGAACTGACGGCCGGCCAGTATCCATAGGCTACTGAACCT
GAGATTCGCTGAATGCCCGG

Downstream 100 bases:

>100_bases
TCACCGCTTCGACGCAAGTCACTGATTCAAGCGCGGGCCTCGGGGGAAACCCCGGGGCCCGTGTCGTTTCGGGCCTGCGT
TTCGGGCTCAGCGCGCCGCC

Product: acetyl-CoA acetyltransferase family protein

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MPPGQGDIKMAGRVVIASAVRTPFTRAHKGEFKDTRPDTLAAVAIKEAVAQVPGLKPEDIGDVVLGCAMPEAEQGMNVAR
VATLLAGLPVTVPAMTINRFCSSGSQAIAQVAQAIQAGMYDVGIGGGTESMTMVPMGGNKASANPEAMERLPEIYTSMGA
TAENIASRYGVSREDSDKFAAESQRRAATAREQGKFKEEIVPVTTTYYDDDGVAQNVTVTVDTILRPETTQEGLAKLRPA
FNPKGVVTAGNASPLTDGAAAAVVMSEAKAKELGVKPLGYFIDAAVAGVPPEIMGIGPVPAVRKLLEKNKLKVEDIDVFE
LNEAFGAQALYCVRELGIPADKVNPNGGAIALGHPLGVSGARMVATILRELKRRNGRYGVVSMCIGGGMGFAALIEAPK

Sequences:

>Translated_399_residues
MPPGQGDIKMAGRVVIASAVRTPFTRAHKGEFKDTRPDTLAAVAIKEAVAQVPGLKPEDIGDVVLGCAMPEAEQGMNVAR
VATLLAGLPVTVPAMTINRFCSSGSQAIAQVAQAIQAGMYDVGIGGGTESMTMVPMGGNKASANPEAMERLPEIYTSMGA
TAENIASRYGVSREDSDKFAAESQRRAATAREQGKFKEEIVPVTTTYYDDDGVAQNVTVTVDTILRPETTQEGLAKLRPA
FNPKGVVTAGNASPLTDGAAAAVVMSEAKAKELGVKPLGYFIDAAVAGVPPEIMGIGPVPAVRKLLEKNKLKVEDIDVFE
LNEAFGAQALYCVRELGIPADKVNPNGGAIALGHPLGVSGARMVATILRELKRRNGRYGVVSMCIGGGMGFAALIEAPK
>Mature_398_residues
PPGQGDIKMAGRVVIASAVRTPFTRAHKGEFKDTRPDTLAAVAIKEAVAQVPGLKPEDIGDVVLGCAMPEAEQGMNVARV
ATLLAGLPVTVPAMTINRFCSSGSQAIAQVAQAIQAGMYDVGIGGGTESMTMVPMGGNKASANPEAMERLPEIYTSMGAT
AENIASRYGVSREDSDKFAAESQRRAATAREQGKFKEEIVPVTTTYYDDDGVAQNVTVTVDTILRPETTQEGLAKLRPAF
NPKGVVTAGNASPLTDGAAAAVVMSEAKAKELGVKPLGYFIDAAVAGVPPEIMGIGPVPAVRKLLEKNKLKVEDIDVFEL
NEAFGAQALYCVRELGIPADKVNPNGGAIALGHPLGVSGARMVATILRELKRRNGRYGVVSMCIGGGMGFAALIEAPK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=51.150895140665, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=39.6464646464646, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=38.6363636363636, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=38.8174807197943, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=37.8172588832487, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=34.2592592592593, Blast_Score=195, Evalue=7e-50,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=47.0149253731343, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI48994986, Length=388, Percent_Identity=45.360824742268, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI87082165, Length=395, Percent_Identity=40, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=41.2060301507538, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1788683, Length=429, Percent_Identity=34.4988344988345, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=42.25, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=38.5390428211587, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=384, Percent_Identity=35.4166666666667, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=34.338747099768, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535917, Length=378, Percent_Identity=30.6878306878307, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=43.0379746835443, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=37.468982630273, Blast_Score=202, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24655093, Length=399, Percent_Identity=42.3558897243108, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI17648125, Length=357, Percent_Identity=42.296918767507, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24640423, Length=395, Percent_Identity=35.4430379746835, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=34.2528735632184, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41636; Mature: 41505

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPGQGDIKMAGRVVIASAVRTPFTRAHKGEFKDTRPDTLAAVAIKEAVAQVPGLKPEDI
CCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCH
GDVVLGCAMPEAEQGMNVARVATLLAGLPVTVPAMTINRFCSSGSQAIAQVAQAIQAGMY
HHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCE
DVGIGGGTESMTMVPMGGNKASANPEAMERLPEIYTSMGATAENIASRYGVSREDSDKFA
EEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHH
AESQRRAATAREQGKFKEEIVPVTTTYYDDDGVAQNVTVTVDTILRPETTQEGLAKLRPA
HHHHHHHHHHHHHCCHHHHCEEEEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHCCC
FNPKGVVTAGNASPLTDGAAAAVVMSEAKAKELGVKPLGYFIDAAVAGVPPEIMGIGPVP
CCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCCHH
AVRKLLEKNKLKVEDIDVFELNEAFGAQALYCVRELGIPADKVNPNGGAIALGHPLGVSG
HHHHHHHHCCCEEECCCEEECHHHHCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCH
ARMVATILRELKRRNGRYGVVSMCIGGGMGFAALIEAPK
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCC
>Mature Secondary Structure 
PPGQGDIKMAGRVVIASAVRTPFTRAHKGEFKDTRPDTLAAVAIKEAVAQVPGLKPEDI
CCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCH
GDVVLGCAMPEAEQGMNVARVATLLAGLPVTVPAMTINRFCSSGSQAIAQVAQAIQAGMY
HHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCE
DVGIGGGTESMTMVPMGGNKASANPEAMERLPEIYTSMGATAENIASRYGVSREDSDKFA
EEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHH
AESQRRAATAREQGKFKEEIVPVTTTYYDDDGVAQNVTVTVDTILRPETTQEGLAKLRPA
HHHHHHHHHHHHHCCHHHHCEEEEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHCCC
FNPKGVVTAGNASPLTDGAAAAVVMSEAKAKELGVKPLGYFIDAAVAGVPPEIMGIGPVP
CCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHCCCCCHH
AVRKLLEKNKLKVEDIDVFELNEAFGAQALYCVRELGIPADKVNPNGGAIALGHPLGVSG
HHHHHHHHCCCEEECCCEEECHHHHCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCH
ARMVATILRELKRRNGRYGVVSMCIGGGMGFAALIEAPK
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]