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The map label for this gene is folD

Identifier: 108760590

GI number: 108760590

Start: 2567508

End: 2568386

Strand: Reverse

Name: folD

Synonym: MXAN_2226

Alternate gene names: 108760590

Gene position: 2568386-2567508 (Counterclockwise)

Preceding gene: 108758295

Following gene: 108761415

Centisome position: 28.1

GC content: 69.97

Gene sequence:

>879_bases
ATGGCGCGGACCCTCGATGGAACCGAAATCAGCCGGGTGATGCGGGCGGAGATGGCCCAGGACGTCGCGGCGCTCCAGGC
CGCCGGCGTGACCCCCGGGCTCTCCGTGGTGCTGGTGGGCAACAATCCGGCGAGCCAGGCGTACGTCGCGAGCAAGACAC
GAGCGTGCGAGTCCCTGGGGATGCGCGGCCAGACGCTGACGTTGCCCGAGGACGTGTCGAAGGAGGCGCTGTTCGCCGTC
ATCGACCGGCTGAACGCCGACCCGTCCGTGCACGGCATCCTGGTGCAACTGCCGCTGCCGGCCCACCTGCCCTACAAGGC
CGTCCTGGAGCACATCCACCCGGCGAAGGACGTGGATGGCTTTCACCCGGTGAACGCCGGGCTCGCCTTCGTCGGAGACC
CCCGGGCCTTCGTGCCCTGCACCCCCGCCGGCATCATGGAGATGCTCCGGCGCGAGGACATCCCCACCCGGGGCAAACAC
GTGGTCATCGTGGGCCGCAGCCTCATCGTCAGCAAGCCGCTGGCGTCGCTGCTGATGGCGCCGGGCCCCGACGCCACCGT
CACCATCACCCACCGCCACACGCCGGACCTCGCGTCATTCACGCGGCAGGCGGACATCCTCATCGTCGCGGTGGGCAAGC
AGAACCTCATCACCGCGGACATGGTGAAGCCGGGCGTCGTCGTCATCGACGTGGGGCAGAACCGCGTGTCCGACGCGAGC
TCACCGCGCGGCTACCGCATGGTGGGGGACGTGGATTTCGATGCCATCCAGCCCATTGCCAGCGCCATCACCCCGGTGCC
CGGCGGCGTGGGGCCGATGACCATCACCATGCTGCTGGCGAACACGCTCCAGGCCGCGCGGCAGACCCAGGCCCGGTGA

Upstream 100 bases:

>100_bases
CGCGGGGTACGACGGGGAGCGTGTCCCAGGACACCGTCTGGGGTGGACATCAAGAAGAAGCGCTGCGCCAACCTGGAGAA
TCTGGCGTAAGAAGCCGCGC

Downstream 100 bases:

>100_bases
GCCCGTCAGCGGCCCGGGCCTGGACGTACGCCGCCAGGCCCAGAGGCGGACTCGCACGGCCACGAAACAATCGCTCGACG
CCCGCGGGGACGTTCACCAC

Product: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MARTLDGTEISRVMRAEMAQDVAALQAAGVTPGLSVVLVGNNPASQAYVASKTRACESLGMRGQTLTLPEDVSKEALFAV
IDRLNADPSVHGILVQLPLPAHLPYKAVLEHIHPAKDVDGFHPVNAGLAFVGDPRAFVPCTPAGIMEMLRREDIPTRGKH
VVIVGRSLIVSKPLASLLMAPGPDATVTITHRHTPDLASFTRQADILIVAVGKQNLITADMVKPGVVVIDVGQNRVSDAS
SPRGYRMVGDVDFDAIQPIASAITPVPGGVGPMTITMLLANTLQAARQTQAR

Sequences:

>Translated_292_residues
MARTLDGTEISRVMRAEMAQDVAALQAAGVTPGLSVVLVGNNPASQAYVASKTRACESLGMRGQTLTLPEDVSKEALFAV
IDRLNADPSVHGILVQLPLPAHLPYKAVLEHIHPAKDVDGFHPVNAGLAFVGDPRAFVPCTPAGIMEMLRREDIPTRGKH
VVIVGRSLIVSKPLASLLMAPGPDATVTITHRHTPDLASFTRQADILIVAVGKQNLITADMVKPGVVVIDVGQNRVSDAS
SPRGYRMVGDVDFDAIQPIASAITPVPGGVGPMTITMLLANTLQAARQTQAR
>Mature_291_residues
ARTLDGTEISRVMRAEMAQDVAALQAAGVTPGLSVVLVGNNPASQAYVASKTRACESLGMRGQTLTLPEDVSKEALFAVI
DRLNADPSVHGILVQLPLPAHLPYKAVLEHIHPAKDVDGFHPVNAGLAFVGDPRAFVPCTPAGIMEMLRREDIPTRGKHV
VIVGRSLIVSKPLASLLMAPGPDATVTITHRHTPDLASFTRQADILIVAVGKQNLITADMVKPGVVVIDVGQNRVSDASS
PRGYRMVGDVDFDAIQPIASAITPVPGGVGPMTITMLLANTLQAARQTQAR

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=293, Percent_Identity=47.7815699658703, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI94721354, Length=296, Percent_Identity=46.9594594594595, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI222136639, Length=292, Percent_Identity=41.0958904109589, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI36796743, Length=216, Percent_Identity=26.8518518518519, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786741, Length=286, Percent_Identity=50.6993006993007, Blast_Score=260, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17568735, Length=296, Percent_Identity=37.1621621621622, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321643, Length=298, Percent_Identity=40.9395973154362, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=42.1602787456446, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322933, Length=334, Percent_Identity=24.5508982035928, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136816, Length=297, Percent_Identity=48.4848484848485, Blast_Score=267, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17136818, Length=297, Percent_Identity=48.4848484848485, Blast_Score=267, Evalue=8e-72,
Organism=Drosophila melanogaster, GI62472483, Length=295, Percent_Identity=40.6779661016949, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI45551871, Length=295, Percent_Identity=40.6779661016949, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24645718, Length=295, Percent_Identity=40.6779661016949, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17137370, Length=295, Percent_Identity=40.6779661016949, Blast_Score=228, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD1_MYXXD (Q1DA76)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630447.1
- ProteinModelPortal:   Q1DA76
- SMR:   Q1DA76
- STRING:   Q1DA76
- GeneID:   4104285
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2226
- TIGR:   MXAN_2226
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   TYVRNKQ
- PhylomeDB:   Q1DA76
- BioCyc:   MXAN246197:MXAN_2226-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30827; Mature: 30696

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTLDGTEISRVMRAEMAQDVAALQAAGVTPGLSVVLVGNNPASQAYVASKTRACESLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
MRGQTLTLPEDVSKEALFAVIDRLNADPSVHGILVQLPLPAHLPYKAVLEHIHPAKDVDG
CCCCEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCC
FHPVNAGLAFVGDPRAFVPCTPAGIMEMLRREDIPTRGKHVVIVGRSLIVSKPLASLLMA
CCCCCCCEEEECCCCEECCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCC
PGPDATVTITHRHTPDLASFTRQADILIVAVGKQNLITADMVKPGVVVIDVGQNRVSDAS
CCCCCEEEEEECCCCCHHHHHCCCCEEEEEECCCCCEEHHCCCCCEEEEECCCCCCCCCC
SPRGYRMVGDVDFDAIQPIASAITPVPGGVGPMTITMLLANTLQAARQTQAR
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARTLDGTEISRVMRAEMAQDVAALQAAGVTPGLSVVLVGNNPASQAYVASKTRACESLG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
MRGQTLTLPEDVSKEALFAVIDRLNADPSVHGILVQLPLPAHLPYKAVLEHIHPAKDVDG
CCCCEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCC
FHPVNAGLAFVGDPRAFVPCTPAGIMEMLRREDIPTRGKHVVIVGRSLIVSKPLASLLMA
CCCCCCCEEEECCCCEECCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCC
PGPDATVTITHRHTPDLASFTRQADILIVAVGKQNLITADMVKPGVVVIDVGQNRVSDAS
CCCCCEEEEEECCCCCHHHHHCCCCEEEEEECCCCCEEHHCCCCCEEEEECCCCCCCCCC
SPRGYRMVGDVDFDAIQPIASAITPVPGGVGPMTITMLLANTLQAARQTQAR
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA