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The map label for this gene is lpxA

Identifier: 108760565

GI number: 108760565

Start: 5918397

End: 5919173

Strand: Reverse

Name: lpxA

Synonym: MXAN_4724

Alternate gene names: 108760565

Gene position: 5919173-5918397 (Counterclockwise)

Preceding gene: 108762744

Following gene: 108763981

Centisome position: 64.76

GC content: 67.05

Gene sequence:

>777_bases
ATGGCTCAGGTTCATCCCACCGCGGTGGTTCATCCCGACGCCCGCCTTCACGAAACCGTCGAGGTCGGCCCCTATTCCAT
CATCGGTCCCCAGGTAACGATTGGTGCAGGCTCCCGCGTGGGGCCCCACGTCGTCATCGAAGGCCGCACGACGCTGGGCG
AGCGCAATCGCATCTTCCAGTTCGCCTCCGTTGGCGCCGACCCGCAAGACCTCAAGTACGCGGGCGAGGACACGGAGCTG
GTGCTCGGCGACGACAACCAGATTCGCGAGTTCGTGTCGCTGCACAAGGGCACCGCCGGTGGTGGCGGCGCGACCCGCGT
TGGCAGTGGCAACCTCTTCATGGCCAACTGTCACGTCGCGCATGACTGCGTGGTGGGCAATGGCTGCCGCATCGGCAATG
GCTCCGCGCTCGCGGGCCACGTGACGATGGAGGACCACGTCATCATCAGCGGCCTTGCGGCGGTGCATCAGTTCACCCGC
CTGGGCAAGCACGCCTTCATCTCCGGCGGCGCCATGGTGACCATGGACATCCCGCCGTACGCCACCGCCCAGGGAGACCG
GGCGGAGCTGGTGGGCCTCAACACGGTGGGCCTGGAGCGCAGCGGTTTCTCCAAGGAGCAGATCGAGCGGGTGAAGGAAG
CGCACCGCATCCTGTTCCGCTCGAAGCTGACGCTCCAGGAGGCCATGGTGCGGCTGCGCGCGGAGCTGGCGGGCCACTCC
GAGGTGGACCACCTCATCCAGTTCATCCAGCAGAGCAAGCGCGGCCTCACGCGCTGA

Upstream 100 bases:

>100_bases
TCGCCGAAGGCGAGTTCCTGGCAACCGTCGTGGACAAGGACGCCGACGCGGCTGAGAGCGCGGCATCCTGATTCGCGCCC
CGCGAGCACGAGGAGACTTC

Downstream 100 bases:

>100_bases
CGCCGTGAGCGACGGAGGGGAATCGGCGGTGGATCGGATTGGCCTCATCGCGGGCAATGGTCGGCTGCCTTTTCTCTTCG
CGCGCGCCGCGAGGAAGAAG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MAQVHPTAVVHPDARLHETVEVGPYSIIGPQVTIGAGSRVGPHVVIEGRTTLGERNRIFQFASVGADPQDLKYAGEDTEL
VLGDDNQIREFVSLHKGTAGGGGATRVGSGNLFMANCHVAHDCVVGNGCRIGNGSALAGHVTMEDHVIISGLAAVHQFTR
LGKHAFISGGAMVTMDIPPYATAQGDRAELVGLNTVGLERSGFSKEQIERVKEAHRILFRSKLTLQEAMVRLRAELAGHS
EVDHLIQFIQQSKRGLTR

Sequences:

>Translated_258_residues
MAQVHPTAVVHPDARLHETVEVGPYSIIGPQVTIGAGSRVGPHVVIEGRTTLGERNRIFQFASVGADPQDLKYAGEDTEL
VLGDDNQIREFVSLHKGTAGGGGATRVGSGNLFMANCHVAHDCVVGNGCRIGNGSALAGHVTMEDHVIISGLAAVHQFTR
LGKHAFISGGAMVTMDIPPYATAQGDRAELVGLNTVGLERSGFSKEQIERVKEAHRILFRSKLTLQEAMVRLRAELAGHS
EVDHLIQFIQQSKRGLTR
>Mature_257_residues
AQVHPTAVVHPDARLHETVEVGPYSIIGPQVTIGAGSRVGPHVVIEGRTTLGERNRIFQFASVGADPQDLKYAGEDTELV
LGDDNQIREFVSLHKGTAGGGGATRVGSGNLFMANCHVAHDCVVGNGCRIGNGSALAGHVTMEDHVIISGLAAVHQFTRL
GKHAFISGGAMVTMDIPPYATAQGDRAELVGLNTVGLERSGFSKEQIERVKEAHRILFRSKLTLQEAMVRLRAELAGHSE
VDHLIQFIQQSKRGLTR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=48.062015503876, Blast_Score=247, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_MYXXD (Q1D387)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632886.1
- ProteinModelPortal:   Q1D387
- SMR:   Q1D387
- STRING:   Q1D387
- GeneID:   4102153
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4724
- TIGR:   MXAN_4724
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   Q1D387
- ProtClustDB:   PRK05289
- BioCyc:   MXAN246197:MXAN_4724-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 27622; Mature: 27491

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVHPTAVVHPDARLHETVEVGPYSIIGPQVTIGAGSRVGPHVVIEGRTTLGERNRIFQ
CCCCCCCEEECCCHHHHHEEECCCEEEECCEEEECCCCCCCCEEEEECCCCCCCCHHEEE
FASVGADPQDLKYAGEDTELVLGDDNQIREFVSLHKGTAGGGGATRVGSGNLFMANCHVA
EECCCCCHHHCEECCCCCEEEECCCHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCEE
HDCVVGNGCRIGNGSALAGHVTMEDHVIISGLAAVHQFTRLGKHAFISGGAMVTMDIPPY
EEEEECCCEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCC
ATAQGDRAELVGLNTVGLERSGFSKEQIERVKEAHRILFRSKLTLQEAMVRLRAELAGHS
CCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVDHLIQFIQQSKRGLTR
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQVHPTAVVHPDARLHETVEVGPYSIIGPQVTIGAGSRVGPHVVIEGRTTLGERNRIFQ
CCCCCCEEECCCHHHHHEEECCCEEEECCEEEECCCCCCCCEEEEECCCCCCCCHHEEE
FASVGADPQDLKYAGEDTELVLGDDNQIREFVSLHKGTAGGGGATRVGSGNLFMANCHVA
EECCCCCHHHCEECCCCCEEEECCCHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCEE
HDCVVGNGCRIGNGSALAGHVTMEDHVIISGLAAVHQFTRLGKHAFISGGAMVTMDIPPY
EEEEECCCEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCC
ATAQGDRAELVGLNTVGLERSGFSKEQIERVKEAHRILFRSKLTLQEAMVRLRAELAGHS
CCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVDHLIQFIQQSKRGLTR
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA