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The map label for this gene is hemD [H]

Identifier: 108760536

GI number: 108760536

Start: 3099288

End: 3100058

Strand: Direct

Name: hemD [H]

Synonym: MXAN_2657

Alternate gene names: 108760536

Gene position: 3099288-3100058 (Clockwise)

Preceding gene: 108761567

Following gene: 108756772

Centisome position: 33.91

GC content: 71.47

Gene sequence:

>771_bases
GTGGAACGGCGACTTGAAGGCAAGAGAGTCTTGGTGACGCGCCCGCGTGAGCGGGCCGAGGAGTTGTGCTTCCTCCTGGA
GGATGAGGGCGCCGAAGTGCTGAGCGTGCCCCTTCTGGAACTGCATCCTCCGGAGGACCCACGTCCGCTGGCGTCTGCGG
CCGAGCACATCCAGCGCTACACCTGGGTGGTGTTCGCGAGCCCGACCGGCGTGGATGCGCTGATGGAGGCCCTGCGCGAG
GCGGGCACCCAGGACCGGATACAGCGGGTGAAGGTGGCCACCGTGGGGCCGCGCACGACGCGCGCCGCGGAGGGCTACGG
CCTGGTCGTGGTGGCCGAACCTTCCGAGGGCACGGGCGCGGCCCTGCTCAACCTCATCAAGGATGCGCTGCAACCGGGTG
ACGAAGTCCTGCTTCCCGCCGCCGAGGAAGGCCGGCGTGAGCTGGAAGACGGGCTGAGAGAGTACGGCCTCCTGGTGACG
CGGGTGACGGCGTATCGCGCCACGCCCGCGCCCCTGCCACCGGAGTCGCTGGCCTTACTGGATGCCTCACCGCCGGACGT
CGTGCTCTTCGCTTCGCCGCGCACGGCCGAGGCCTTCGTGGAAGAGGCCGGACGCGAGCGCCTGGCCACCGCTCGGGTGG
TGGCAATCGGTCCGACGACGGCGTCCGCCCTGGAGCGGCTGGGCGTGCCCGCGGCGGCCGTCGCGGAGCGGCCGACGCCA
GAGTCCCTGGTGGATGCCGCCGTGCTCGCGGTGACGAGCACCGTGCACTGA

Upstream 100 bases:

>100_bases
TGAATCCCTGGCGGATGACCTGCTTTCGCGTGGGGCGGCGGACATCTTGCGTGATTTCGCGCGCCGCTTCGAGGCGCGGG
AGTCCTAGACTGCTGCTCGC

Downstream 100 bases:

>100_bases
CGGTGGCGCGGCGCCGTGCCCGCACGGCCGCACGACGTGCCTGACAGCGGCTCCATGCCTGGCTGGTGGAGCGGGGGGCG
CAGGGGTGTTTTCCGCTCGG

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTWVVFASPTGVDALMEALRE
AGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGAALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVT
RVTAYRATPAPLPPESLALLDASPPDVVLFASPRTAEAFVEEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTP
ESLVDAAVLAVTSTVH

Sequences:

>Translated_256_residues
MERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTWVVFASPTGVDALMEALRE
AGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGAALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVT
RVTAYRATPAPLPPESLALLDASPPDVVLFASPRTAEAFVEEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTP
ESLVDAAVLAVTSTVH
>Mature_256_residues
MERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTWVVFASPTGVDALMEALRE
AGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGAALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVT
RVTAYRATPAPLPPESLALLDASPPDVVLFASPRTAEAFVEEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTP
ESLVDAAVLAVTSTVH

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27382; Mature: 27382

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRY
CCCCCCCCEEEEECCHHHHHHHEEEECCCCCCEEEECCEECCCCCCCCHHHHHHHHHHHE
TWVVFASPTGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGA
EEEEEECCCCHHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCCCCEEEEEECCCCCCHH
ALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVTRVTAYRATPAPLPPESLALL
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
DASPPDVVLFASPRTAEAFVEEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTP
ECCCCCEEEEECCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCCHHHHHCCCCH
ESLVDAAVLAVTSTVH
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRY
CCCCCCCCEEEEECCHHHHHHHEEEECCCCCCEEEECCEECCCCCCCCHHHHHHHHHHHE
TWVVFASPTGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGA
EEEEEECCCCHHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCCCCEEEEEECCCCCCHH
ALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVTRVTAYRATPAPLPPESLALL
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
DASPPDVVLFASPRTAEAFVEEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTP
ECCCCCEEEEECCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCCHHHHHCCCCH
ESLVDAAVLAVTSTVH
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]