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The map label for this gene is hemC

Identifier: 108761567

GI number: 108761567

Start: 3098331

End: 3099275

Strand: Direct

Name: hemC

Synonym: MXAN_2656

Alternate gene names: 108761567

Gene position: 3098331-3099275 (Clockwise)

Preceding gene: 108763498

Following gene: 108760536

Centisome position: 33.9

GC content: 71.22

Gene sequence:

>945_bases
GTGATGACGCACGTGCGTATCGCCACCCGGCAGAGTCCCCTGGCGCTCTGGCAGGCGCGTCACGTGGGCGCGCTGCTGAC
CTCGCGGCATCCCGGTTTGGAAGTGACCCTGGTGGAGATGACCACCGAGGGAGACCGCTTCCTGTCCGCGCCGTTGTCCG
CGGTGGGCGGCAAGGGCTTGTTCGTGAAGGAAATCGAACAGGCGCTGCTCGACGGCCGTGCGGACATCGCCGTGCATAGC
CTCAAGGACATGACGTCCGTGTTCCCGGAAGGGCTGATACTCGCGGCGGTGCCGGAGCGGGAGGATCCGCGCGACGTCTT
CTGTGGCCTGGGCGGGCTGACGTTGGACACGCTTCCGCAGGGCGCGCGCGTGGGCACGTCGTCGCTGCGCCGGAGCTGCA
TCTTGCGCTCGCGCCGGCCGGACGTGGACATCGTCAGCGTGCGCGGCAACGTGCAGACGCGCCTGGCGAGGACGCGGGAG
CAGGGGCTCGCGGGTGCGCTGCTGGCCTACGCCGGACTCAAGCGCCTGGGCCTGGAGGACGTCATCACCCAGGTGCTGCC
GCCCGAGGTGAGCCTGCCCGCGGTGGGGCAGGGCGTGTTGGCCATCCAGTGCCGCACGGACGATGCGCGCGTGCGCGCGC
TGCTGGTGCCGCTGGAGCACGCCACCACTCGCATCGCCGTCACCGCCGAGCGCGCGCTGCTGGCGAAGCTGGAGGGGGGC
TGCACCGTGCCCCTGGCCGGGTATGCCACCGTGTCGGGCGACACCGTCTTCCTGCGCGGACTCGTGGGCCGTCCGGATGG
CACACACGTGGTGCGGGGCGAGGTGCGCGGCCCCGTGTCGCAGGCCCATGCACTGGGTGAATCCCTGGCGGATGACCTGC
TTTCGCGTGGGGCGGCGGACATCTTGCGTGATTTCGCGCGCCGCTTCGAGGCGCGGGAGTCCTAG

Upstream 100 bases:

>100_bases
CCGCCGCCGAGCTGTTCGGTCTCCTGGAGGAGGAGGTCGGCACCGCCGCCGCCGCGCCCTCCGTCATGGCCGCGCCAGTC
CAGGTCGCCACGGGGGGCAA

Downstream 100 bases:

>100_bases
ACTGCTGCTCGCGTGGAACGGCGACTTGAAGGCAAGAGAGTCTTGGTGACGCGCCCGCGTGAGCGGGCCGAGGAGTTGTG
CTTCCTCCTGGAGGATGAGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MMTHVRIATRQSPLALWQARHVGALLTSRHPGLEVTLVEMTTEGDRFLSAPLSAVGGKGLFVKEIEQALLDGRADIAVHS
LKDMTSVFPEGLILAAVPEREDPRDVFCGLGGLTLDTLPQGARVGTSSLRRSCILRSRRPDVDIVSVRGNVQTRLARTRE
QGLAGALLAYAGLKRLGLEDVITQVLPPEVSLPAVGQGVLAIQCRTDDARVRALLVPLEHATTRIAVTAERALLAKLEGG
CTVPLAGYATVSGDTVFLRGLVGRPDGTHVVRGEVRGPVSQAHALGESLADDLLSRGAADILRDFARRFEARES

Sequences:

>Translated_314_residues
MMTHVRIATRQSPLALWQARHVGALLTSRHPGLEVTLVEMTTEGDRFLSAPLSAVGGKGLFVKEIEQALLDGRADIAVHS
LKDMTSVFPEGLILAAVPEREDPRDVFCGLGGLTLDTLPQGARVGTSSLRRSCILRSRRPDVDIVSVRGNVQTRLARTRE
QGLAGALLAYAGLKRLGLEDVITQVLPPEVSLPAVGQGVLAIQCRTDDARVRALLVPLEHATTRIAVTAERALLAKLEGG
CTVPLAGYATVSGDTVFLRGLVGRPDGTHVVRGEVRGPVSQAHALGESLADDLLSRGAADILRDFARRFEARES
>Mature_314_residues
MMTHVRIATRQSPLALWQARHVGALLTSRHPGLEVTLVEMTTEGDRFLSAPLSAVGGKGLFVKEIEQALLDGRADIAVHS
LKDMTSVFPEGLILAAVPEREDPRDVFCGLGGLTLDTLPQGARVGTSSLRRSCILRSRRPDVDIVSVRGNVQTRLARTRE
QGLAGALLAYAGLKRLGLEDVITQVLPPEVSLPAVGQGVLAIQCRTDDARVRALLVPLEHATTRIAVTAERALLAKLEGG
CTVPLAGYATVSGDTVFLRGLVGRPDGTHVVRGEVRGPVSQAHALGESLADDLLSRGAADILRDFARRFEARES

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI66933009, Length=342, Percent_Identity=39.1812865497076, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI20149500, Length=339, Percent_Identity=39.2330383480826, Blast_Score=208, Evalue=5e-54,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=56.7656765676568, Blast_Score=323, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=35.4430379746835, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20130425, Length=311, Percent_Identity=38.2636655948553, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_MYXXD (Q1D8Z8)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630875.1
- ProteinModelPortal:   Q1D8Z8
- SMR:   Q1D8Z8
- STRING:   Q1D8Z8
- GeneID:   4101117
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2656
- TIGR:   MXAN_2656
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   Q1D8Z8
- BioCyc:   MXAN246197:MXAN_2656-MONOMER
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 33545; Mature: 33545

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTHVRIATRQSPLALWQARHVGALLTSRHPGLEVTLVEMTTEGDRFLSAPLSAVGGKGL
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHCCHHHHCCCCC
FVKEIEQALLDGRADIAVHSLKDMTSVFPEGLILAAVPEREDPRDVFCGLGGLTLDTLPQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCCCHHCCCC
GARVGTSSLRRSCILRSRRPDVDIVSVRGNVQTRLARTREQGLAGALLAYAGLKRLGLED
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHH
VITQVLPPEVSLPAVGQGVLAIQCRTDDARVRALLVPLEHATTRIAVTAERALLAKLEGG
HHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEHHHCCEEEEEEHHHHHHHHHCCC
CTVPLAGYATVSGDTVFLRGLVGRPDGTHVVRGEVRGPVSQAHALGESLADDLLSRGAAD
CCEEECCEEEECCCEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHH
ILRDFARRFEARES
HHHHHHHHHHCCCC
>Mature Secondary Structure
MMTHVRIATRQSPLALWQARHVGALLTSRHPGLEVTLVEMTTEGDRFLSAPLSAVGGKGL
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHCCHHHHCCCCC
FVKEIEQALLDGRADIAVHSLKDMTSVFPEGLILAAVPEREDPRDVFCGLGGLTLDTLPQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCCCCCHHCCCC
GARVGTSSLRRSCILRSRRPDVDIVSVRGNVQTRLARTREQGLAGALLAYAGLKRLGLED
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHH
VITQVLPPEVSLPAVGQGVLAIQCRTDDARVRALLVPLEHATTRIAVTAERALLAKLEGG
HHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEHHHCCEEEEEEHHHHHHHHHCCC
CTVPLAGYATVSGDTVFLRGLVGRPDGTHVVRGEVRGPVSQAHALGESLADDLLSRGAAD
CCEEECCEEEECCCEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHH
ILRDFARRFEARES
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA