Click here to switch to the map view.

The map label for this gene is pcoS [H]

Identifier: 108760500

GI number: 108760500

Start: 6504442

End: 6505914

Strand: Reverse

Name: pcoS [H]

Synonym: MXAN_5211

Alternate gene names: 108760500

Gene position: 6505914-6504442 (Counterclockwise)

Preceding gene: 108762500

Following gene: 108761348

Centisome position: 71.18

GC content: 68.09

Gene sequence:

>1473_bases
ATGAAGCGTCTCACGGACTCCCTGGCGCCGCGCCTGATCGCGGCCGTCCTCGCAACGCAGCTCATCGTCATCACCGGGCT
GATGCTGTTCTGGATGGTGTTCTCCCACTCCGTCTCGCACGACGATCTGTCCGCCGCGACCTCCCAACGTCGCGTCGCCG
AGTCGATCACGCTGGACCCGGCAGGCGCCCCTCGCATCGAGCCCTCGAGCGCTCTGCGCGCCTATCAGGCACGACGTCCG
CAGCTGGCCTACGCCGTGTACCTGGACGGCCGCCTGGTGTCCGGATCATCGCAGCAGCTTGCCCACGCGATCTCTCCACG
CGGCTGGGCCGCACCTGGCGCGAACCTCGAACCGGCGCCCACCCTCGCCGACCTGTACCGGCACTTCCCCGACCTGCAGT
GTGTGCAGCTGCTTGCTGAGTGCGGAGATCCGGTGATCGCCCTCGGAGAGGGCCAGCGCGCGAACGTCTCGATGTTCCCG
ATCCACGGCATCGGGACCGCGGTCGTCGTGACGAGCGGCAATCGCCTCGGACTGGATGACCTGCCAACCGCGCTGCTGAC
GCTGATTCCGCGCGTGATGAAGCTGTTTGGTTCGGCCGTCCTCGCCACCGTCCTCGTGCTGCCACTGATGCTGCGTCGCG
CGCTACAACCCCTCACGAGGGCCGCCAACGCCGCATCCGGCATCGGCCTCGAGACGCTGGACCAGCGGCTGTCGCCCGAT
GGCGTGCCCAAGGAGATCCAGCCCTTCGTCACGGCCATCAATCAGCTGCTGGAAAGGCTCGAGCGCGGCGTCTCCCGCCA
GCAACTGTTCGTCGCCAATGCCGCGCACGAGTTGCGCACCCCTGTGGCGATTCTCTGCGCCCGGCTCGACTCCCTGGGCG
ACAGCCCCGCCACGCGCGACCTGCGGCGCGATGCGACGCGGCTGGGGCTGATGGTCGACCAGCTGCTCGCGGCTTTCCGC
ATGCAGGGACAGACCCCGGCGGATTGGAGAGCGCTGGATCTGGTCCAGCAGCTGCGTGATCTGATCAGCGACATGGCGCC
GCTGGCGCTGCGGAGCGGACGAGCCATCGCCCTGGAAGCCGCATCGCCCTCCGAGATGGTGCTGGGACAGGCCGATGGCC
TTCGGTCGGCGTTGGCCAACCTGCTCGACAATGCGCTGCGCGCCGAGCCCGCTGGCGGGACGGTGATCGTCAGGATGGAA
GCCAGCACGTCCAGCGTCACGGTCGACGTCGTCGATCACGGCCCCGGCGTCGAGGAGTCCGACCGAGAGAACATCTTCGA
GCCCTTTTGGCGCCGGGAAGGTCAGTGGAGTGGAACCGGGTTGGGTCTGGCCATCGCCCGCCGCATCTCGGAAGGCCACG
GCGGTAGCCTGCAGCACCTGCCCACAGAAGGCGGCGGCGCGACATTCCGGATGCGGGTGGGAAGATCTCCCGCAGGAAGA
AGCATCGACCCGTCAGCGTGTTGCAAGGATTGA

Upstream 100 bases:

>100_bases
TGGAAGCACACATCTCCAGGCTGCGGCGGCGGCTCGAGGATTGTGGCGCGGGTGTGGTGCTGCACCCGGTCCGGGGCGTC
GGCTATCTTATCGACGAGCC

Downstream 100 bases:

>100_bases
GGCGCGTACTGGCTGGAGTTGCCCCCCGTCAAATCGGACAGCTCAGGGGTGAGAGTTCGCAGTGCGGAACTCGCGGGGTG
ACTTCACCTTGAGCCCGCGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDPAGAPRIEPSSALRAYQARRP
QLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAPTLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFP
IHGIGTAVVVTSGNRLGLDDLPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPD
GVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRDLRRDATRLGLMVDQLLAAFR
MQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEAASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRME
ASTSSVTVDVVDHGPGVEESDRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGR
SIDPSACCKD

Sequences:

>Translated_490_residues
MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDPAGAPRIEPSSALRAYQARRP
QLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAPTLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFP
IHGIGTAVVVTSGNRLGLDDLPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPD
GVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRDLRRDATRLGLMVDQLLAAFR
MQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEAASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRME
ASTSSVTVDVVDHGPGVEESDRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGR
SIDPSACCKD
>Mature_490_residues
MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDPAGAPRIEPSSALRAYQARRP
QLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAPTLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFP
IHGIGTAVVVTSGNRLGLDDLPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPD
GVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRDLRRDATRLGLMVDQLLAAFR
MQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEAASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRME
ASTSSVTVDVVDHGPGVEESDRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGR
SIDPSACCKD

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May activate pcoR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=280, Percent_Identity=29.6428571428571, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=29.3436293436293, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790551, Length=247, Percent_Identity=29.9595141700405, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789403, Length=273, Percent_Identity=31.5018315018315, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=29.0780141843972, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=28.125, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=29.6137339055794, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788279, Length=269, Percent_Identity=23.0483271375465, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=27.1653543307087, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=276, Percent_Identity=25.7246376811594, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=28.2442748091603, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=288, Percent_Identity=24.6527777777778, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790861, Length=248, Percent_Identity=27.0161290322581, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=27.7580071174377, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=29.3859649122807, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=249, Percent_Identity=25.3012048192771, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=107, Percent_Identity=35.5140186915888, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=23.0434782608696, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52416; Mature: 52416

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCEECC
AGAPRIEPSSALRAYQARRPQLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAP
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCEEECCCHHHHHHHCCCCCCCCCCCCCCCCC
TLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFPIHGIGTAVVVTSGNRLGLDD
CHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCHH
LPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
GVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRD
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHH
LRRDATRLGLMVDQLLAAFRMQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
ASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRMEASTSSVTVDVVDHGPGVEES
CCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCC
DRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGR
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
SIDPSACCKD
CCCHHHCCCC
>Mature Secondary Structure
MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCEECC
AGAPRIEPSSALRAYQARRPQLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAP
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCEEECCCHHHHHHHCCCCCCCCCCCCCCCCC
TLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFPIHGIGTAVVVTSGNRLGLDD
CHHHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCHH
LPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
GVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRD
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHH
LRRDATRLGLMVDQLLAAFRMQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
ASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRMEASTSSVTVDVVDHGPGVEES
CCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCC
DRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGR
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
SIDPSACCKD
CCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]