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The map label for this gene is basR [H]

Identifier: 108762500

GI number: 108762500

Start: 6505911

End: 6506585

Strand: Reverse

Name: basR [H]

Synonym: MXAN_5212

Alternate gene names: 108762500

Gene position: 6506585-6505911 (Counterclockwise)

Preceding gene: 108763760

Following gene: 108760500

Centisome position: 71.19

GC content: 68.74

Gene sequence:

>675_bases
ATGCGTGCGCTCCTTGTCGAGGATGAGCCGGAACTCGCGCGGCTGGTGGCAAATGAAGCGACGTCCCAGGGCTTCTCGGT
CGACGCCGTGGCTTCGGTCACCGAGGCCCGTAGCGCGATCCATCTGGGCGCCTACGCGATCGTGCTTCTGGACCGCCGCC
TGCCCGATGGCGACGGCCTGTGCCTGATTCCCGAGCTCCGTGCCATGCAGCCGGAGGCGGGCGTGCTGGTGATCAGCGCG
ATGGGAGATGTCCCGGAGAGAGTCGCAGGCCTGGATGCGGGTGCGGATGACTACATGGGAAAGCCTTTCCATGCAGACGA
GCTGCGGGCGCGCATCCGCTCGGTGCTGCGACGGCCTGCACAGGCGCGACAGCTGCAGCCGGTGCGCTGCGGCGCCATCG
AGTACGACCTCGGCTCCAGGCAGATGACGGTGCAGGGAAGGCCGCTGCTGCTTCGCCGGCGCGAGGCCTCGCTGCTGGCC
GCCCTGATGCGCCGCGCGCGGCGGGTCGTCCAGCGCGACACCCTCATCAAGGAGGTCTACGGGTTCGACGAGGAGCCCAG
TGCCAACACCCTGGAAGCACACATCTCCAGGCTGCGGCGGCGGCTCGAGGATTGTGGCGCGGGTGTGGTGCTGCACCCGG
TCCGGGGCGTCGGCTATCTTATCGACGAGCCATGA

Upstream 100 bases:

>100_bases
TCTCTTCTGGCAGCGCAGGCTTGCACGAGCCTGACAGTCGCTGATTGTCGCGGCGCCTTCGCCCCGGGAGGAGTAGCGTC
CGCCGACACGGAGGGGACTC

Downstream 100 bases:

>100_bases
AGCGTCTCACGGACTCCCTGGCGCCGCGCCTGATCGCGGCCGTCCTCGCAACGCAGCTCATCGTCATCACCGGGCTGATG
CTGTTCTGGATGGTGTTCTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRALLVEDEPELARLVANEATSQGFSVDAVASVTEARSAIHLGAYAIVLLDRRLPDGDGLCLIPELRAMQPEAGVLVISA
MGDVPERVAGLDAGADDYMGKPFHADELRARIRSVLRRPAQARQLQPVRCGAIEYDLGSRQMTVQGRPLLLRRREASLLA
ALMRRARRVVQRDTLIKEVYGFDEEPSANTLEAHISRLRRRLEDCGAGVVLHPVRGVGYLIDEP

Sequences:

>Translated_224_residues
MRALLVEDEPELARLVANEATSQGFSVDAVASVTEARSAIHLGAYAIVLLDRRLPDGDGLCLIPELRAMQPEAGVLVISA
MGDVPERVAGLDAGADDYMGKPFHADELRARIRSVLRRPAQARQLQPVRCGAIEYDLGSRQMTVQGRPLLLRRREASLLA
ALMRRARRVVQRDTLIKEVYGFDEEPSANTLEAHISRLRRRLEDCGAGVVLHPVRGVGYLIDEP
>Mature_224_residues
MRALLVEDEPELARLVANEATSQGFSVDAVASVTEARSAIHLGAYAIVLLDRRLPDGDGLCLIPELRAMQPEAGVLVISA
MGDVPERVAGLDAGADDYMGKPFHADELRARIRSVLRRPAQARQLQPVRCGAIEYDLGSRQMTVQGRPLLLRRREASLLA
ALMRRARRVVQRDTLIKEVYGFDEEPSANTLEAHISRLRRRLEDCGAGVVLHPVRGVGYLIDEP

Specific function: Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.6515837104072, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=35.4260089686099, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=31.25, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.5991189427313, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=30.6306306306306, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=32.2727272727273, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=30.6306306306306, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=31.3636363636364, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=32.1266968325792, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.0649350649351, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.3333333333333, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1786911, Length=201, Percent_Identity=31.8407960199005, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=25.3333333333333, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=30.7086614173228, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=173, Percent_Identity=29.4797687861272, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24666; Mature: 24666

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALLVEDEPELARLVANEATSQGFSVDAVASVTEARSAIHLGAYAIVLLDRRLPDGDGL
CCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCE
CLIPELRAMQPEAGVLVISAMGDVPERVAGLDAGADDYMGKPFHADELRARIRSVLRRPA
EECCHHHCCCCCCCEEEEEECCCCHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCH
QARQLQPVRCGAIEYDLGSRQMTVQGRPLLLRRREASLLAALMRRARRVVQRDTLIKEVY
HHHCCCCCCCCEEEECCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFDEEPSANTLEAHISRLRRRLEDCGAGVVLHPVRGVGYLIDEP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCC
>Mature Secondary Structure
MRALLVEDEPELARLVANEATSQGFSVDAVASVTEARSAIHLGAYAIVLLDRRLPDGDGL
CCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCE
CLIPELRAMQPEAGVLVISAMGDVPERVAGLDAGADDYMGKPFHADELRARIRSVLRRPA
EECCHHHCCCCCCCEEEEEECCCCHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCH
QARQLQPVRCGAIEYDLGSRQMTVQGRPLLLRRREASLLAALMRRARRVVQRDTLIKEVY
HHHCCCCCCCCEEEECCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFDEEPSANTLEAHISRLRRRLEDCGAGVVLHPVRGVGYLIDEP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8282725; 7610040; 9278503 [H]