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The map label for this gene is hppD [H]

Identifier: 108760279

GI number: 108760279

Start: 3242381

End: 3243445

Strand: Direct

Name: hppD [H]

Synonym: MXAN_2786

Alternate gene names: 108760279

Gene position: 3242381-3243445 (Clockwise)

Preceding gene: 108757576

Following gene: 108760263

Centisome position: 35.48

GC content: 64.98

Gene sequence:

>1065_bases
ATGGCGGATACGGCAGAGAACCCTCTTGGGCTGAATGGCTTCGAGTTCGTGGAGTTCACCAGCCCCCAGCCCGAGGTGAT
GGAGCACCTCTTCGAGCGGCTGGGGTTCACCGCGTACTCCAAGCACCCGTCCAAGGAGCTGGTCCGCTACAAGCAGGGCG
GCATCAACCTGCTCATCAACCGCGAGGCTTCCGGGCAGGCCGCTGAGTTCCGCGCGGAGCACGGCCCGTCCGCCAGCGGC
ATGGCCTTCCGCGTGGCGAACGCGCGCACCGCCTACGAGATGGCCCTGGAGCGTGGCGCCAAGGCGGCGGACCCGGAGCG
GGGCTCGCTGGGCGAGGGCTCCTATGTCCTGGAGGGAATCGGTGGCAGCCTGCTGTATCTGGTGGACCGCCACGGGGAGA
AGGGGACGCTCTATGACTCCTGGCAGGAGATTCCTGGCGCCGAGGCGGCCGAGGCGAAGAACAGCGTGGGCCTGGAGACG
CTGGACCACCTGACCCACAACGTGCGCCGCGGGCAGATGCGCACCTGGTCGTCCTTCTACAACCGCATCTTCGGCTTCAC
CGAGCAGAAGTACTTCGACATCAAGGGCCAGGCCACGGGCCTGTTCAGCCAGGCGATGATCGCCCCGGACAAGGCCATCC
GGATTCCGCTCAACGAGAGCCAGGACGACAAGTCGCAGATTGAAGAGTTCATCCGCCAGTACAAGGGCGAGGGCATCCAG
CACCTGGCGCTCACCACGCCGGACATCTACGACACCGTGGAGCGGCTGCGCGCGCGCGGCGTGGTGCTGCAGGACACGCT
GGAAACCTACTACGACCTGGTCGACAAGCGCGTCCCCAAGCACGGCGAGGACCTGGCGCGGATGCGCAAGAACCGCATCC
TCATCGACGGCAGCGAGGAAGAGGGCCTGCTGCTCCAGATCTTTACCGAGAATCTCTTCGGGCCCATCTTCTTCGAAATC
ATCCAGCGCAAGGGCAACGAGGGTTTCGGGAACGGCAACTTCCAGGCGCTCTTCGAGTCCATCGAACTGGACCAGATTCG
CCGCGGCGTCATCAAGGTCGACTAG

Upstream 100 bases:

>100_bases
CCCTACGTTCGCGAGAGGAAGCGCTCCCGACCAGGGGGCGCTTCGGCGACTCGCGCGGGCCGTGAAGGCCCGCGCCCCAG
CAACGCACGGAGGCGGCGTC

Downstream 100 bases:

>100_bases
TCCGCTCGCCGCGCTTGCGAGGAGAATCCGGTGACCACCCAGCCTTCCTCCGAGGTGTCGCCGGGGAGCGTCCTCAAGAC
GGCTCCCGGCGCCTATCTGT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MADTAENPLGLNGFEFVEFTSPQPEVMEHLFERLGFTAYSKHPSKELVRYKQGGINLLINREASGQAAEFRAEHGPSASG
MAFRVANARTAYEMALERGAKAADPERGSLGEGSYVLEGIGGSLLYLVDRHGEKGTLYDSWQEIPGAEAAEAKNSVGLET
LDHLTHNVRRGQMRTWSSFYNRIFGFTEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYKGEGIQ
HLALTTPDIYDTVERLRARGVVLQDTLETYYDLVDKRVPKHGEDLARMRKNRILIDGSEEEGLLLQIFTENLFGPIFFEI
IQRKGNEGFGNGNFQALFESIELDQIRRGVIKVD

Sequences:

>Translated_354_residues
MADTAENPLGLNGFEFVEFTSPQPEVMEHLFERLGFTAYSKHPSKELVRYKQGGINLLINREASGQAAEFRAEHGPSASG
MAFRVANARTAYEMALERGAKAADPERGSLGEGSYVLEGIGGSLLYLVDRHGEKGTLYDSWQEIPGAEAAEAKNSVGLET
LDHLTHNVRRGQMRTWSSFYNRIFGFTEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYKGEGIQ
HLALTTPDIYDTVERLRARGVVLQDTLETYYDLVDKRVPKHGEDLARMRKNRILIDGSEEEGLLLQIFTENLFGPIFFEI
IQRKGNEGFGNGNFQALFESIELDQIRRGVIKVD
>Mature_353_residues
ADTAENPLGLNGFEFVEFTSPQPEVMEHLFERLGFTAYSKHPSKELVRYKQGGINLLINREASGQAAEFRAEHGPSASGM
AFRVANARTAYEMALERGAKAADPERGSLGEGSYVLEGIGGSLLYLVDRHGEKGTLYDSWQEIPGAEAAEAKNSVGLETL
DHLTHNVRRGQMRTWSSFYNRIFGFTEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYKGEGIQH
LALTTPDIYDTVERLRARGVVLQDTLETYYDLVDKRVPKHGEDLARMRKNRILIDGSEEEGLLLQIFTENLFGPIFFEII
QRKGNEGFGNGNFQALFESIELDQIRRGVIKVD

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=333, Percent_Identity=30.03003003003, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI285002264, Length=333, Percent_Identity=30.03003003003, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI14249394, Length=298, Percent_Identity=27.5167785234899, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17555220, Length=301, Percent_Identity=33.8870431893688, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17550752, Length=297, Percent_Identity=30.6397306397306, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21356105, Length=291, Percent_Identity=32.3024054982818, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24667510, Length=291, Percent_Identity=32.3024054982818, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39807; Mature: 39676

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTAENPLGLNGFEFVEFTSPQPEVMEHLFERLGFTAYSKHPSKELVRYKQGGINLLIN
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCEEEEEE
REASGQAAEFRAEHGPSASGMAFRVANARTAYEMALERGAKAADPERGSLGEGSYVLEGI
CCCCCCHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECC
GGSLLYLVDRHGEKGTLYDSWQEIPGAEAAEAKNSVGLETLDHLTHNVRRGQMRTWSSFY
CCEEEEEEECCCCCCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHH
NRIFGFTEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYKGEGIQ
HHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEE
HLALTTPDIYDTVERLRARGVVLQDTLETYYDLVDKRVPKHGEDLARMRKNRILIDGSEE
EEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEEEEECCCC
EGLLLQIFTENLFGPIFFEIIQRKGNEGFGNGNFQALFESIELDQIRRGVIKVD
CCEEEEEHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHCCCEECC
>Mature Secondary Structure 
ADTAENPLGLNGFEFVEFTSPQPEVMEHLFERLGFTAYSKHPSKELVRYKQGGINLLIN
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHCCCCHHHHHHHHCCCEEEEEE
REASGQAAEFRAEHGPSASGMAFRVANARTAYEMALERGAKAADPERGSLGEGSYVLEGI
CCCCCCHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECC
GGSLLYLVDRHGEKGTLYDSWQEIPGAEAAEAKNSVGLETLDHLTHNVRRGQMRTWSSFY
CCEEEEEEECCCCCCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHH
NRIFGFTEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYKGEGIQ
HHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEE
HLALTTPDIYDTVERLRARGVVLQDTLETYYDLVDKRVPKHGEDLARMRKNRILIDGSEE
EEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCEEEEECCCC
EGLLLQIFTENLFGPIFFEIIQRKGNEGFGNGNFQALFESIELDQIRRGVIKVD
CCEEEEEHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA