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The map label for this gene is hmgA

Identifier: 108760263

GI number: 108760263

Start: 3243500

End: 3244813

Strand: Direct

Name: hmgA

Synonym: MXAN_2787

Alternate gene names: 108760263

Gene position: 3243500-3244813 (Clockwise)

Preceding gene: 108760279

Following gene: 108759498

Centisome position: 35.49

GC content: 69.86

Gene sequence:

>1314_bases
GTGTCGCCGGGGAGCGTCCTCAAGACGGCTCCCGGCGCCTATCTGTCTGGCTTTGGCAACGAGTTCGCCACCGAGGCGGT
GCCCGGCGCACTGCCCGAGGGACAGAACTCACCCCAGCGGGCGCCGTTCGGCCTCTATGCCGAGCAGTTGTCGGGCTCGG
CCTTCACGGCCCCGCGCCGGGAGAACCGGCGCTCGTGGCTGTACCGCCTGCGGCCCAGCGCCAACCACCCTGCGTTCCAG
CCGCTGGCGCAGGGACTCTTGCGCAGCGGGCCCTTCGACGAGGTGCCCGCCTCGCCCAACCGGCTGCGGTGGAGTCCCCA
GCCCCCGCCGGCCCAGCCCACTGATTTCGTGGACGGGCTCGTCACCTACGCGGGCAACGGGGACGCGGCGTCAGGGGCGG
GCATCAGCATCCACCTGTACGCGGCCAACCGCTCCATGGTGGACCGGGTGTTCTTCGACGCGGACGGTGAGCTGCTCATC
GTCCCGCAGGCGGGGCGGCTGCGGCTGGTGACGGAGCTGGGCGTGCTGGACGTGGCGCCGGGCGAAATCGCGGTGGTGCC
GCGCGGGGTTCGCTTCCGCGCGGAGCTGCCGGAGGGCCAGGCCGCCGGCTACGTCTGTGAGAACCACGGTGCGTTCTTCC
GGCTGCCGGACCTGGGGCCCATTGGGGCCAATGGACTGGCCAACCCGCGCGACTTCCTGACGCCGGTGGCGGCCTTCGAG
GACGTGGACCGGCCCACGGAGGTGGTGCAGAAGTTCCTGGGGCGGCTGTGGTCGGCGCGGTATTCGTACTCACCGCTGGA
CGTGGTGGCGTGGCACGGGAACCTGGTGCCGTACAAGTACGACCTGGCCCGCTTCAACACCATCAACACGGTGAGCTTCG
ACCATCCGGACCCGTCCATCTTCACGGTCCTCACGTCGCCCAGCGAGGTGCCGGGCACGGCCAACTGCGACTTCGTCATC
TTCCCGCCGCGGTGGATGGTGGCCGAGCACACCTTCCGGCCGCCCTGGTTCCACCGCAACGTGATGAGCGAGTTCATGGG
GCTGGTGCACGGCGTCTACGACGCGAAGGCGGGCGGCTTCGCCCCGGGCGGCGGCTCGCTGCACAACTGCATGAGCGGCC
ATGGCCCGGACCGGACCAGCTACGAGCAGGCCATCCAGGCGGACCTGAAGCCTCACAAAATCAAGGACACGCTGGCCTTC
ATGTTCGAGTCGCGCTGGGTCATCCGTCCCACGCGCTTCGCCATGGAGACGCCCGCGCTCCAGCAGGACTACGACGCGTG
CTGGGCGGGCTTCCAGAAGGCGAAGTTGCCTTGA

Upstream 100 bases:

>100_bases
CATCGAACTGGACCAGATTCGCCGCGGCGTCATCAAGGTCGACTAGTCCGCTCGCCGCGCTTGCGAGGAGAATCCGGTGA
CCACCCAGCCTTCCTCCGAG

Downstream 100 bases:

>100_bases
GGGCCGCGTGAGCACGGGGGGGGAGACGGCGGGGCGCAAGCGCGTCTGGTCGACGCCGGCCAACGTGAAGCTGCTCCCGG
TGAGCGCCCTGGAGGACCCC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRRENRRSWLYRLRPSANHPAFQ
PLAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGLVTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLI
VPQAGRLRLVTELGVLDVAPGEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFE
DVDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSIFTVLTSPSEVPGTANCDFVI
FPPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGFAPGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAF
MFESRWVIRPTRFAMETPALQQDYDACWAGFQKAKLP

Sequences:

>Translated_437_residues
MSPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRRENRRSWLYRLRPSANHPAFQ
PLAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGLVTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLI
VPQAGRLRLVTELGVLDVAPGEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFE
DVDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSIFTVLTSPSEVPGTANCDFVI
FPPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGFAPGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAF
MFESRWVIRPTRFAMETPALQQDYDACWAGFQKAKLP
>Mature_436_residues
SPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRRENRRSWLYRLRPSANHPAFQP
LAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGLVTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLIV
PQAGRLRLVTELGVLDVAPGEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFED
VDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSIFTVLTSPSEVPGTANCDFVIF
PPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGFAPGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAFM
FESRWVIRPTRFAMETPALQQDYDACWAGFQKAKLP

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family

Homologues:

Organism=Homo sapiens, GI115527117, Length=424, Percent_Identity=53.3018867924528, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17507969, Length=425, Percent_Identity=53.8823529411765, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24583650, Length=428, Percent_Identity=53.9719626168224, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HGD_MYXXD (Q1D8L9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631004.1
- STRING:   Q1D8L9
- GeneID:   4103449
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2787
- TIGR:   MXAN_2787
- eggNOG:   COG3508
- HOGENOM:   HBG293508
- OMA:   RNCMSEF
- ProtClustDB:   PRK05341
- BioCyc:   MXAN246197:MXAN_2787-MONOMER
- HAMAP:   MF_00334
- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- PANTHER:   PTHR11056
- TIGRFAMs:   TIGR01015

Pfam domain/function: PF04209 HgmA; SSF51182 RmlC_like_cupin

EC number: =1.13.11.5

Molecular weight: Translated: 47825; Mature: 47694

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRR
CCCCCCEECCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCH
ENRRSWLYRLRPSANHPAFQPLAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGL
HCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHH
VTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLIVPQAGRLRLVTELGVLDVAP
EEECCCCCCCCCCCEEEEEEECCCHHHHHHEECCCCCEEEEECCCCEEEEEECCEEEECC
GEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFE
CCEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
DVDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSI
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEHHHHCCEEEEEEECCCCCCE
FTVLTSPSEVPGTANCDFVIFPPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGF
EEEEECCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
APGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAFMFESRWVIRPTRFAMETPAL
CCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCHHHHHCCCCH
QQDYDACWAGFQKAKLP
HHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
SPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRR
CCCCCEECCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCH
ENRRSWLYRLRPSANHPAFQPLAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGL
HCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHH
VTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLIVPQAGRLRLVTELGVLDVAP
EEECCCCCCCCCCCEEEEEEECCCHHHHHHEECCCCCEEEEECCCCEEEEEECCEEEECC
GEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFE
CCEEEECCCEEEEEECCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
DVDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSI
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEHHHHCCEEEEEEECCCCCCE
FTVLTSPSEVPGTANCDFVIFPPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGF
EEEEECCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
APGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAFMFESRWVIRPTRFAMETPAL
CCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCHHHHHCCCCH
QQDYDACWAGFQKAKLP
HHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA