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The map label for this gene is erg3 [H]

Identifier: 108760221

GI number: 108760221

Start: 954866

End: 956146

Strand: Reverse

Name: erg3 [H]

Synonym: MXAN_0840

Alternate gene names: 108760221

Gene position: 956146-954866 (Counterclockwise)

Preceding gene: 108760814

Following gene: 108759893

Centisome position: 10.46

GC content: 67.84

Gene sequence:

>1281_bases
ATGGACCTCAAGGAACAGCTCCTCTACGGCCTGCCCGTGTTCCTCGCTCCCATCCTCATCGAGCTGGTGGTGGGGCTCTT
GCGGCGCAAGCCGGCCTACCGGCTCAATGACCTGCTCACCAACGTGACGATGAGCCTGCTCACCGTCCTGGGCAGCGTGG
TCATCGCGGGCGCCACCTTCGTCTTCTACGGCTACGTCTACAAGCACCACGCCCTCTTCAGCCTGGCGAAGGACTCCGCG
TGGACGTGGGTGGTGGCCTTCTTCGCCTACGACTTCTTCTATTACTGGGCGCACCGGATGCACCACACCATGGCGTGGAT
GTGGGGCGTCCACGTCGCCCACCACTCCGGCGAGGACATGAACTTCGGCCTCGCGGTGCGGCAGAGCGCGCTGGGTGAGC
TGACCACGTGGCCCTTCTTCGTGCCCATGGCGCTGCTGGGCATCGCGCCGGAGGTGTTCCTGGGCATCACCGGCATCCAG
CTCATCTTCCAGTACGCCATCCACAACACCTACGTGCCGCCGCTGGGCTGGCTGGAGTACGTGCTCGTCACGCCCTCCCA
GCACCGCGTCCACCACAGCCGCAACACGCCATACATCGACAAGAACTACGGCAACATCCTCGTCGTCTGGGACCTGCTGT
TCCGCACCTACCAGCCGGAGCTGAAGGACCAGCCTCCCGTCTACGGCCTGCGCAGCAGCCTGCGCTCGTGGAACCCCTTC
ACCGCGCACTTCCACTACTTCGTGGAGCTGTTCCAGAAGTCCGCCGCCTGCGCGCGGCTGGCCGACAAGGTGCTGTGCTT
CATCAAGGGGCCGGACTGGAACCCGCCGTCGCTGCGCCAGGAGCGCTTCACCGGCCCCCCGGATGGCGGCCCGTCCGCCA
CCTTCCAGAAGTACGACCCGCGCCTGCCCTTGCCCGTCACCGCCTACTGCGTGACACAGTTCTTCAGCCTGGCGGCCAGC
ATCCTGCTGCTCGCGTGGTACCTGGACACGCTCAGCCCCGGGGCCCGCGCCGTAACGCTGGGGCTGGTCCTCTTCGGTAC
CTGGAGCCTGGGCGCGCTGATGGACTCGCGCGCCTTCGCGTGGCGGCAGGAGTTCGCGCGGCTGGCGGGTATCGCGCTGC
TGGGTCCCGCCCTGGCGCTGATGGAGGGCGTTCCGCTGGTCAGCGCGCTCCCCATCCTGCTCCACCCCGCCCTCAGCGCC
GCGTGGCTGCTGCGCTTCCGCGCCGCGTTCCACGAAGGCGCTGACACCTCCACGCGAGGCTCCAGCGCCCTGGCCGCCTG
A

Upstream 100 bases:

>100_bases
CGCTGCAGCCGCAAACTCAACCTCCAGGACGCGCCGCCGCTCCAGCAGACCGGCACCTGAGCCGGCGCCCTACGCCACCC
ACGCCACTGGAAGACCCGCC

Downstream 100 bases:

>100_bases
AAGCCCCGTCCCCTGTTTCGACGTCCCCAACCCACCCGAAAGACATGACCGCGTCCGCACCCGTCACCGGAAGCGCTCCC
GCCTTCCACACCTTCCCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MDLKEQLLYGLPVFLAPILIELVVGLLRRKPAYRLNDLLTNVTMSLLTVLGSVVIAGATFVFYGYVYKHHALFSLAKDSA
WTWVVAFFAYDFFYYWAHRMHHTMAWMWGVHVAHHSGEDMNFGLAVRQSALGELTTWPFFVPMALLGIAPEVFLGITGIQ
LIFQYAIHNTYVPPLGWLEYVLVTPSQHRVHHSRNTPYIDKNYGNILVVWDLLFRTYQPELKDQPPVYGLRSSLRSWNPF
TAHFHYFVELFQKSAACARLADKVLCFIKGPDWNPPSLRQERFTGPPDGGPSATFQKYDPRLPLPVTAYCVTQFFSLAAS
ILLLAWYLDTLSPGARAVTLGLVLFGTWSLGALMDSRAFAWRQEFARLAGIALLGPALALMEGVPLVSALPILLHPALSA
AWLLRFRAAFHEGADTSTRGSSALAA

Sequences:

>Translated_426_residues
MDLKEQLLYGLPVFLAPILIELVVGLLRRKPAYRLNDLLTNVTMSLLTVLGSVVIAGATFVFYGYVYKHHALFSLAKDSA
WTWVVAFFAYDFFYYWAHRMHHTMAWMWGVHVAHHSGEDMNFGLAVRQSALGELTTWPFFVPMALLGIAPEVFLGITGIQ
LIFQYAIHNTYVPPLGWLEYVLVTPSQHRVHHSRNTPYIDKNYGNILVVWDLLFRTYQPELKDQPPVYGLRSSLRSWNPF
TAHFHYFVELFQKSAACARLADKVLCFIKGPDWNPPSLRQERFTGPPDGGPSATFQKYDPRLPLPVTAYCVTQFFSLAAS
ILLLAWYLDTLSPGARAVTLGLVLFGTWSLGALMDSRAFAWRQEFARLAGIALLGPALALMEGVPLVSALPILLHPALSA
AWLLRFRAAFHEGADTSTRGSSALAA
>Mature_426_residues
MDLKEQLLYGLPVFLAPILIELVVGLLRRKPAYRLNDLLTNVTMSLLTVLGSVVIAGATFVFYGYVYKHHALFSLAKDSA
WTWVVAFFAYDFFYYWAHRMHHTMAWMWGVHVAHHSGEDMNFGLAVRQSALGELTTWPFFVPMALLGIAPEVFLGITGIQ
LIFQYAIHNTYVPPLGWLEYVLVTPSQHRVHHSRNTPYIDKNYGNILVVWDLLFRTYQPELKDQPPVYGLRSSLRSWNPF
TAHFHYFVELFQKSAACARLADKVLCFIKGPDWNPPSLRQERFTGPPDGGPSATFQKYDPRLPLPVTAYCVTQFFSLAAS
ILLLAWYLDTLSPGARAVTLGLVLFGTWSLGALMDSRAFAWRQEFARLAGIALLGPALALMEGVPLVSALPILLHPALSA
AWLLRFRAAFHEGADTSTRGSSALAA

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=401, Percent_Identity=34.1645885286783, Blast_Score=209, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI25144659, Length=361, Percent_Identity=29.3628808864266, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 47792; Mature: 47792

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure
MDLKEQLLYGLPVFLAPILIELVVGLLRRKPAYRLNDLLTNVTMSLLTVLGSVVIAGATF
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFYGYVYKHHALFSLAKDSAWTWVVAFFAYDFFYYWAHRMHHTMAWMWGVHVAHHSGEDM
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFGLAVRQSALGELTTWPFFVPMALLGIAPEVFLGITGIQLIFQYAIHNTYVPPLGWLEY
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHE
VLVTPSQHRVHHSRNTPYIDKNYGNILVVWDLLFRTYQPELKDQPPVYGLRSSLRSWNPF
EEECCCHHHHHCCCCCCCEECCCCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCH
TAHFHYFVELFQKSAACARLADKVLCFIKGPDWNPPSLRQERFTGPPDGGPSATFQKYDP
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCC
RLPLPVTAYCVTQFFSLAASILLLAWYLDTLSPGARAVTLGLVLFGTWSLGALMDSRAFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WRQEFARLAGIALLGPALALMEGVPLVSALPILLHPALSAAWLLRFRAAFHEGADTSTRG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSALAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]