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The map label for this gene is kbl [C]

Identifier: 108760814

GI number: 108760814

Start: 956187

End: 957491

Strand: Reverse

Name: kbl [C]

Synonym: MXAN_0841

Alternate gene names: 108760814

Gene position: 957491-956187 (Counterclockwise)

Preceding gene: 108761030

Following gene: 108760221

Centisome position: 10.48

GC content: 67.36

Gene sequence:

>1305_bases
ATGGACCCAACCCGCAATGCCTTTCCCGAGAAGAACCGCAATCTCGCCGTGGGCTCCGCCCGGCTCCAGGAAGTCCAGAA
GGCGGTCCATTACTACGTGGACAACCATCACTGTGACGTCATTGGACGGGTGTTTCACGGGATGCCGGGCCGGGAGGCGC
GCGTCAGCTTCAGTCCGACGCGCCGGGATGTGAGGCTGAACGCGGAGGGACCTCGGGACGTCCTCCACTTCGGCTCCTAC
AACTACTCCGGGCTGAACGGGCACCCGCGCGTGGTGGCCGCGGCGGAGGCGGCGCTGCGCCGCTACGGGACGACGGTCAG
CGGCGTGCGTCTGCTCAACGGGACGTGTGAGCTGCACCTGGAGCTGGAGCGCGCGTTGGCGGAGTTCCTGGGCTTCGAGG
ACTGCGTCACCTACAGCAGCGGCTACGCGGCGAACCTGTCCGTGTTGTCCGCACTGTGTGCTGAGGGCGACGTGGTGCTG
TCGGACATGCTCAACCACCAGTCCATCATCGACGGGCTGAAGCTGTCCGGCGCGGACATCCGCACCTACCGGCACAAGAG
CCTGCGCAGCATCGAGTCCACGCTGAAGAAGCTGCCATACGAGCAGCGCAAGTTCATCATCACCGACGGCGTGTTCAGCA
TGGACGGCGACGTGGCGGACCTGCCGGGCATCGTGGCGCTGGCGGAGAGCTACAACGCCTTCATCCTCGTGGATGACGCG
CACGCCACCGCCGCCATGGGGCCCAACGGCCGCGGCACCCCGGCCTATTTCGGGCTCCAGTCGCAGGTGGACGTGCTCAC
CGGCAGCCTCAGCAAGGGCCTGCCGGGCATCGGTGGGTTCGCCGCCGGCTCCAAGGCCACCATCGACCTGCTGCGCTTCG
GCTCCAACGGCTACATCTTCTCCGCCTCGCTGCCGCCGCCCATCGCCGCGGGCCTGCTGGAGGGCATCCGCATCCTCCAG
GAGCAGCCCGAGCTCCAGGAGCGCCTGCACCACAACGAGAACTACCTGCGCGCCGGCATCCGCTCCATGGGCCTGGACTG
CATGAACAGCGAGTCCCCCATCATCCCCATCCTGATGCCCGCCTACGAGAAGACGTTCGAGCTGACGCGGCTGCTCCACC
TGGAGGGCATCTACGTCAACCCGGTGGGCTACCCCGCCGTGAGCAAGAACCGCACGCGCCTGCGCATCAACGTCAGCGCC
AACCTCACCCAGGCGGACCTGGACCGATTCCTGGACGCGCTGGACCGCTGCAGCCGCAAACTCAACCTCCAGGACGCGCC
GCCGCTCCAGCAGACCGGCACCTGA

Upstream 100 bases:

>100_bases
TTCGTACGCTCGTATCCGCGGCTTGAGTGGCGCGGAGGGTGGGACGTGTCTGTCCGGCGGACGGAAGTGCCCGCCAGACG
CGCACCAGGAAGCCACCGTC

Downstream 100 bases:

>100_bases
GCCGGCGCCCTACGCCACCCACGCCACTGGAAGACCCGCCATGGACCTCAAGGAACAGCTCCTCTACGGCCTGCCCGTGT
TCCTCGCTCCCATCCTCATC

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDPTRNAFPEKNRNLAVGSARLQEVQKAVHYYVDNHHCDVIGRVFHGMPGREARVSFSPTRRDVRLNAEGPRDVLHFGSY
NYSGLNGHPRVVAAAEAALRRYGTTVSGVRLLNGTCELHLELERALAEFLGFEDCVTYSSGYAANLSVLSALCAEGDVVL
SDMLNHQSIIDGLKLSGADIRTYRHKSLRSIESTLKKLPYEQRKFIITDGVFSMDGDVADLPGIVALAESYNAFILVDDA
HATAAMGPNGRGTPAYFGLQSQVDVLTGSLSKGLPGIGGFAAGSKATIDLLRFGSNGYIFSASLPPPIAAGLLEGIRILQ
EQPELQERLHHNENYLRAGIRSMGLDCMNSESPIIPILMPAYEKTFELTRLLHLEGIYVNPVGYPAVSKNRTRLRINVSA
NLTQADLDRFLDALDRCSRKLNLQDAPPLQQTGT

Sequences:

>Translated_434_residues
MDPTRNAFPEKNRNLAVGSARLQEVQKAVHYYVDNHHCDVIGRVFHGMPGREARVSFSPTRRDVRLNAEGPRDVLHFGSY
NYSGLNGHPRVVAAAEAALRRYGTTVSGVRLLNGTCELHLELERALAEFLGFEDCVTYSSGYAANLSVLSALCAEGDVVL
SDMLNHQSIIDGLKLSGADIRTYRHKSLRSIESTLKKLPYEQRKFIITDGVFSMDGDVADLPGIVALAESYNAFILVDDA
HATAAMGPNGRGTPAYFGLQSQVDVLTGSLSKGLPGIGGFAAGSKATIDLLRFGSNGYIFSASLPPPIAAGLLEGIRILQ
EQPELQERLHHNENYLRAGIRSMGLDCMNSESPIIPILMPAYEKTFELTRLLHLEGIYVNPVGYPAVSKNRTRLRINVSA
NLTQADLDRFLDALDRCSRKLNLQDAPPLQQTGT
>Mature_434_residues
MDPTRNAFPEKNRNLAVGSARLQEVQKAVHYYVDNHHCDVIGRVFHGMPGREARVSFSPTRRDVRLNAEGPRDVLHFGSY
NYSGLNGHPRVVAAAEAALRRYGTTVSGVRLLNGTCELHLELERALAEFLGFEDCVTYSSGYAANLSVLSALCAEGDVVL
SDMLNHQSIIDGLKLSGADIRTYRHKSLRSIESTLKKLPYEQRKFIITDGVFSMDGDVADLPGIVALAESYNAFILVDDA
HATAAMGPNGRGTPAYFGLQSQVDVLTGSLSKGLPGIGGFAAGSKATIDLLRFGSNGYIFSASLPPPIAAGLLEGIRILQ
EQPELQERLHHNENYLRAGIRSMGLDCMNSESPIIPILMPAYEKTFELTRLLHLEGIYVNPVGYPAVSKNRTRLRINVSA
NLTQADLDRFLDALDRCSRKLNLQDAPPLQQTGT

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=347, Percent_Identity=34.5821325648415, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=34.5821325648415, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI119220554, Length=378, Percent_Identity=33.5978835978836, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=31.6091954022989, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=31.6091954022989, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=31.6091954022989, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4502025, Length=400, Percent_Identity=29.75, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI40316939, Length=400, Percent_Identity=29.75, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI5454084, Length=263, Percent_Identity=34.2205323193916, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1790046, Length=376, Percent_Identity=36.7021276595745, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=30.5475504322767, Blast_Score=168, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=367, Percent_Identity=37.0572207084469, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32566772, Length=400, Percent_Identity=31, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=31.4917127071823, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=31.4917127071823, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71982625, Length=386, Percent_Identity=27.2020725388601, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=386, Percent_Identity=27.2020725388601, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=406, Percent_Identity=30.7881773399015, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320438, Length=372, Percent_Identity=29.5698924731183, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323954, Length=257, Percent_Identity=30.7392996108949, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24662918, Length=353, Percent_Identity=36.8271954674221, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=32.3450134770889, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17137420, Length=358, Percent_Identity=29.3296089385475, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24653280, Length=386, Percent_Identity=26.9430051813472, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653276, Length=386, Percent_Identity=26.9430051813472, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653278, Length=386, Percent_Identity=26.9430051813472, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47437; Mature: 47437

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPTRNAFPEKNRNLAVGSARLQEVQKAVHYYVDNHHCDVIGRVFHGMPGREARVSFSPT
CCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCC
RRDVRLNAEGPRDVLHFGSYNYSGLNGHPRVVAAAEAALRRYGTTVSGVRLLNGTCELHL
CCEEEECCCCCHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHCCCHHCEEEECCEEEEEE
ELERALAEFLGFEDCVTYSSGYAANLSVLSALCAEGDVVLSDMLNHQSIIDGLKLSGADI
HHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHH
RTYRHKSLRSIESTLKKLPYEQRKFIITDGVFSMDGDVADLPGIVALAESYNAFILVDDA
HHHHHHHHHHHHHHHHHCCHHHCEEEEECCEEECCCCCCCCCHHHHHHCCCCEEEEEECC
HATAAMGPNGRGTPAYFGLQSQVDVLTGSLSKGLPGIGGFAAGSKATIDLLRFGSNGYIF
CCEEECCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCEEE
SASLPPPIAAGLLEGIRILQEQPELQERLHHNENYLRAGIRSMGLDCMNSESPIIPILMP
ECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCHHCCCCCCEEEEEEC
AYEKTFELTRLLHLEGIYVNPVGYPAVSKNRTRLRINVSANLTQADLDRFLDALDRCSRK
CHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
LNLQDAPPLQQTGT
CCCCCCCCCCCCCC
>Mature Secondary Structure
MDPTRNAFPEKNRNLAVGSARLQEVQKAVHYYVDNHHCDVIGRVFHGMPGREARVSFSPT
CCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCC
RRDVRLNAEGPRDVLHFGSYNYSGLNGHPRVVAAAEAALRRYGTTVSGVRLLNGTCELHL
CCEEEECCCCCHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHCCCHHCEEEECCEEEEEE
ELERALAEFLGFEDCVTYSSGYAANLSVLSALCAEGDVVLSDMLNHQSIIDGLKLSGADI
HHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHH
RTYRHKSLRSIESTLKKLPYEQRKFIITDGVFSMDGDVADLPGIVALAESYNAFILVDDA
HHHHHHHHHHHHHHHHHCCHHHCEEEEECCEEECCCCCCCCCHHHHHHCCCCEEEEEECC
HATAAMGPNGRGTPAYFGLQSQVDVLTGSLSKGLPGIGGFAAGSKATIDLLRFGSNGYIF
CCEEECCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCEEE
SASLPPPIAAGLLEGIRILQEQPELQERLHHNENYLRAGIRSMGLDCMNSESPIIPILMP
ECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCHHCCCCCCEEEEEEC
AYEKTFELTRLLHLEGIYVNPVGYPAVSKNRTRLRINVSANLTQADLDRFLDALDRCSRK
CHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH
LNLQDAPPLQQTGT
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA