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The map label for this gene is ahpF [H]

Identifier: 108760020

GI number: 108760020

Start: 506898

End: 507947

Strand: Direct

Name: ahpF [H]

Synonym: MXAN_0444

Alternate gene names: 108760020

Gene position: 506898-507947 (Clockwise)

Preceding gene: 108758525

Following gene: 108759123

Centisome position: 5.55

GC content: 70.38

Gene sequence:

>1050_bases
ATGACGAATCGGGCGGCGTGGACGCGCCGTGAGGCCCTGGCCCTCGCCGGGCTGGGACTGGCCGGTGCCGCGCTGCCCCT
GGGCTGCAGACACGCAATGGACGCGACGAGGACGGATGACATGGAGCGCAAGGACGTGAAGGACGTGGTGGTGGTGGGTG
GTGGCCCAGGCGGTTTGAGCGCGGCGCTGGCGCTGGGGCGTGGCCGCAAGAAGGTCCTGGTGTGCGACGGGGGGACGCCT
CGGAACGCAGCAGCAGAGGAGGTGCACACCTACCTCACGCGGGATGGCATCCCACCCCGGGAGTTCCGGCGTGTCGCCTG
GGAGCAGATGCGCCCCTATGACGTGGAGCTGCGCGAGGCGCGGGTGCTGGACGTCGAGCGTGCGGGGACGGTGTTCCGCG
TGGCGCTCGAAGGGGGCGACGTGGTGGAGGCCCGCCGGGTGCTGCTGGCCACGGGGATGGTGGACGTGATGCGCGAGCTG
CCCGGTTACAGCGACTTGTGGGGCAAGGCCATCTTCCAGTGCCCGTTCTGCCATGGTTGGGAAATCCAGGACCGGGCCTG
GGGCGTGCTGGCCACGAACGCGGTGTCGCTCGACTTCGCCGTGATGTTGACGGGGTGGACCCGCGACCTGGTGGTGTTCG
CCATGGACGGTTTCGAGGTGCCCTCCGACAAGCGTGCGCTGCTGGAGAAGGCGGGGGTTCGGCTCGAGACGCGGCGTATT
CGCGGCCTCATCGCGGCAGGGGAGAAGCTGGATGCGGTGGAGCTGGAGGACGGTACCCGGGTGCCCCGGGAGATTCTCTT
CGACCGTCCACCCCAGCGGCAGTCGTCGCTCGTGCAGCGGCTGGGGCTCGAGCTGAACGAGGAGGGCTTCGTGAAGCTGA
AGGGCCCGGGCGAGACGTCGGTGCCGGGCATCTACGCGGCGGGGGACCTCGGCACCCGGGCGCAGGCGGCCATCGTGGCC
GCGTCCGCGGGGATGCTGGCGGCGGGCATGTTGAACCATGACCTGAACCTGGAACGGGCGGGCGCCGCGCATGGACCTGC
TCAGGGTTGA

Upstream 100 bases:

>100_bases
GGCGCCGCCCGAGGGAGTGCCGCAACGAACGCGCGAATCCGCCGATTCGGCGTGAAGCCGCGCCCTCCCGGGGCCGGGGG
CCGCCGGTTAGCACTTCTCC

Downstream 100 bases:

>100_bases
GCCCGGCGGCTTCGCTCGCTACGAAGGGGCGATGCCGTCCGAGCCACAACCGCCGTCCTGGGGGCCTGATTCGTCGTCGC
GCCTGGACTTCGAAAAAGGG

Product: pyridine nucleotide-disulphide oxidoreductase domain-containing protein

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTNRAAWTRREALALAGLGLAGAALPLGCRHAMDATRTDDMERKDVKDVVVVGGGPGGLSAALALGRGRKKVLVCDGGTP
RNAAAEEVHTYLTRDGIPPREFRRVAWEQMRPYDVELREARVLDVERAGTVFRVALEGGDVVEARRVLLATGMVDVMREL
PGYSDLWGKAIFQCPFCHGWEIQDRAWGVLATNAVSLDFAVMLTGWTRDLVVFAMDGFEVPSDKRALLEKAGVRLETRRI
RGLIAAGEKLDAVELEDGTRVPREILFDRPPQRQSSLVQRLGLELNEEGFVKLKGPGETSVPGIYAAGDLGTRAQAAIVA
ASAGMLAAGMLNHDLNLERAGAAHGPAQG

Sequences:

>Translated_349_residues
MTNRAAWTRREALALAGLGLAGAALPLGCRHAMDATRTDDMERKDVKDVVVVGGGPGGLSAALALGRGRKKVLVCDGGTP
RNAAAEEVHTYLTRDGIPPREFRRVAWEQMRPYDVELREARVLDVERAGTVFRVALEGGDVVEARRVLLATGMVDVMREL
PGYSDLWGKAIFQCPFCHGWEIQDRAWGVLATNAVSLDFAVMLTGWTRDLVVFAMDGFEVPSDKRALLEKAGVRLETRRI
RGLIAAGEKLDAVELEDGTRVPREILFDRPPQRQSSLVQRLGLELNEEGFVKLKGPGETSVPGIYAAGDLGTRAQAAIVA
ASAGMLAAGMLNHDLNLERAGAAHGPAQG
>Mature_348_residues
TNRAAWTRREALALAGLGLAGAALPLGCRHAMDATRTDDMERKDVKDVVVVGGGPGGLSAALALGRGRKKVLVCDGGTPR
NAAAEEVHTYLTRDGIPPREFRRVAWEQMRPYDVELREARVLDVERAGTVFRVALEGGDVVEARRVLLATGMVDVMRELP
GYSDLWGKAIFQCPFCHGWEIQDRAWGVLATNAVSLDFAVMLTGWTRDLVVFAMDGFEVPSDKRALLEKAGVRLETRRIR
GLIAAGEKLDAVELEDGTRVPREILFDRPPQRQSSLVQRLGLELNEEGFVKLKGPGETSVPGIYAAGDLGTRAQAAIVAA
SAGMLAAGMLNHDLNLERAGAAHGPAQG

Specific function: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein [H]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012081
- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 37626; Mature: 37494

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRAAWTRREALALAGLGLAGAALPLGCRHAMDATRTDDMERKDVKDVVVVGGGPGGLS
CCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHH
AALALGRGRKKVLVCDGGTPRNAAAEEVHTYLTRDGIPPREFRRVAWEQMRPYDVELREA
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEHHH
RVLDVERAGTVFRVALEGGDVVEARRVLLATGMVDVMRELPGYSDLWGKAIFQCPFCHGW
EEEEHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
EIQDRAWGVLATNAVSLDFAVMLTGWTRDLVVFAMDGFEVPSDKRALLEKAGVRLETRRI
EECCCCCEEEEECEEEEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCEEEHHHH
RGLIAAGEKLDAVELEDGTRVPREILFDRPPQRQSSLVQRLGLELNEEGFVKLKGPGETS
HHHHHCCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCC
VPGIYAAGDLGTRAQAAIVAASAGMLAAGMLNHDLNLERAGAAHGPAQG
CCCEEEECCCCCCHHHHEEEHHCCHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNRAAWTRREALALAGLGLAGAALPLGCRHAMDATRTDDMERKDVKDVVVVGGGPGGLS
CCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHH
AALALGRGRKKVLVCDGGTPRNAAAEEVHTYLTRDGIPPREFRRVAWEQMRPYDVELREA
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEHHH
RVLDVERAGTVFRVALEGGDVVEARRVLLATGMVDVMRELPGYSDLWGKAIFQCPFCHGW
EEEEHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
EIQDRAWGVLATNAVSLDFAVMLTGWTRDLVVFAMDGFEVPSDKRALLEKAGVRLETRRI
EECCCCCEEEEECEEEEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCEEEHHHH
RGLIAAGEKLDAVELEDGTRVPREILFDRPPQRQSSLVQRLGLELNEEGFVKLKGPGETS
HHHHHCCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCC
VPGIYAAGDLGTRAQAAIVAASAGMLAAGMLNHDLNLERAGAAHGPAQG
CCCEEEECCCCCCHHHHEEEHHCCHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA