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The map label for this gene is lysN [H]

Identifier: 108759824

GI number: 108759824

Start: 258998

End: 260218

Strand: Reverse

Name: lysN [H]

Synonym: MXAN_0212

Alternate gene names: 108759824

Gene position: 260218-258998 (Counterclockwise)

Preceding gene: 108760405

Following gene: 108763921

Centisome position: 2.85

GC content: 71.09

Gene sequence:

>1221_bases
ATGAGCGCCGACGCGATGAGCGCCCCCCTTCCCCCGCCGCCCGTATGGCGGTTGGCCCAGCGGATGTCCCGCATCAAGAC
GTCCGCGGTGCGCGAAATCCTGAAGGTCGCCGAGCGGCCCGACATCCTCTCCTTCGCGGGAGGCCTGCCAGCCCCGGAGC
TCTTCCCGCTGGAGGCCATCGCCGAGGCGCACGCCGAGGCCCTGGCGACCGAGGGCCGCGCCGCGCTCCAGTACAGCACC
ACCGAGGGCTTCGGCCCGCTGCGTGAGTGGATTTGCGGCCACCTCCAGAAGCGCGGCCGCCAGTCCAACGCGGACCAGGT
GCTCATCACCAACGGCTCGCAGCAGGGCATCGACCTGGTGGCCAAGGTGATGCTGGACCCCGGTGACCTCGTCATCGTGG
AGAACCCCAGCTACCTGGCGGCGCTGCAGACGTTCGGCGCCTATGAGGCGCGCTTCGCCACGGTGGGCAGCGACGACCAG
GGCATGCGCACCGACGACCTGGAGCGCCTGCTGGCCACGCACAAGCCCAAGCTGGTGTACGTGGTCGCCAACTTCCAGAA
CCCCAAGGGCACCACCCTGTCGCTGGAGCGGCGGCGCGAACTGGTCCGCCTGGCCCAGCAGTACCGCTTCCTCATCCTGG
AGGACGACCCGTACGGCGAGCTGCGCTTCCGCGGCGAGCACGTGCCGTCCCTGTCCGCCTTCGACGACGAGGGCGTCGTC
GTGTCGCTGGGCACCTTCTCCAAGACGCTGGCCCCGGGCATGCGCCTGGGCTGGGTGGTGGGCCCGCGCGACTTCGTGCG
CAGCCTGGCCATCGCCAAGCAGTCCACCGACCTGCACACGGCCACGCTGGCTCAGCGCGCGGTGGTGAAGCTGCTGGCGC
GCTTCGATTACGCGGCCCACCTGGAGTCGCTGCGCCCCGTCTACGGCGAGCGCGCCCAGGCCATGCTGGACGCCCTCCAG
GCGCACATGCCCGCGGGCACCCAGTGGACGCACCCCGAAGGCGGCATGTTCCTGTGGGTGGAGCTGCCCGGCGGGCTGGA
CGCCCAGGCGCTGCTGCCCAAGGCGGTGGAGCAGAAGGTGGCCTTCGTGCCGGGCGCGCCCTTCTACGCCAACAACCCGC
GCCCGGAGTTCATGCGCCTCAACTACTCCAACCGCCCGCCGGACCTGATTGCCGAGGGCATGCGCCGCCTGGGCGCCGTG
ATTGCCGCCGAGCTGGGTTGA

Upstream 100 bases:

>100_bases
CGCGGGAGTCACCCGCACGCAGACCACCATCGTCCTGACGTCCATGAAGGAGGACACGCATGTCCGCGTGCCTCCAGACA
CCCCAAAAGGAGCGTGACGT

Downstream 100 bases:

>100_bases
GCCCCTGACGGAGCCTCTTTGCCGCGCCGCGTCGGAAACGACGCGGCGCTTTTCATTTCAAGAAGTTGAAGATTGATTCA
GGTTTCAACTCGCTCGCCGC

Product: class I/II family aminotransferase

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSADAMSAPLPPPPVWRLAQRMSRIKTSAVREILKVAERPDILSFAGGLPAPELFPLEAIAEAHAEALATEGRAALQYST
TEGFGPLREWICGHLQKRGRQSNADQVLITNGSQQGIDLVAKVMLDPGDLVIVENPSYLAALQTFGAYEARFATVGSDDQ
GMRTDDLERLLATHKPKLVYVVANFQNPKGTTLSLERRRELVRLAQQYRFLILEDDPYGELRFRGEHVPSLSAFDDEGVV
VSLGTFSKTLAPGMRLGWVVGPRDFVRSLAIAKQSTDLHTATLAQRAVVKLLARFDYAAHLESLRPVYGERAQAMLDALQ
AHMPAGTQWTHPEGGMFLWVELPGGLDAQALLPKAVEQKVAFVPGAPFYANNPRPEFMRLNYSNRPPDLIAEGMRRLGAV
IAAELG

Sequences:

>Translated_406_residues
MSADAMSAPLPPPPVWRLAQRMSRIKTSAVREILKVAERPDILSFAGGLPAPELFPLEAIAEAHAEALATEGRAALQYST
TEGFGPLREWICGHLQKRGRQSNADQVLITNGSQQGIDLVAKVMLDPGDLVIVENPSYLAALQTFGAYEARFATVGSDDQ
GMRTDDLERLLATHKPKLVYVVANFQNPKGTTLSLERRRELVRLAQQYRFLILEDDPYGELRFRGEHVPSLSAFDDEGVV
VSLGTFSKTLAPGMRLGWVVGPRDFVRSLAIAKQSTDLHTATLAQRAVVKLLARFDYAAHLESLRPVYGERAQAMLDALQ
AHMPAGTQWTHPEGGMFLWVELPGGLDAQALLPKAVEQKVAFVPGAPFYANNPRPEFMRLNYSNRPPDLIAEGMRRLGAV
IAAELG
>Mature_405_residues
SADAMSAPLPPPPVWRLAQRMSRIKTSAVREILKVAERPDILSFAGGLPAPELFPLEAIAEAHAEALATEGRAALQYSTT
EGFGPLREWICGHLQKRGRQSNADQVLITNGSQQGIDLVAKVMLDPGDLVIVENPSYLAALQTFGAYEARFATVGSDDQG
MRTDDLERLLATHKPKLVYVVANFQNPKGTTLSLERRRELVRLAQQYRFLILEDDPYGELRFRGEHVPSLSAFDDEGVVV
SLGTFSKTLAPGMRLGWVVGPRDFVRSLAIAKQSTDLHTATLAQRAVVKLLARFDYAAHLESLRPVYGERAQAMLDALQA
HMPAGTQWTHPEGGMFLWVELPGGLDAQALLPKAVEQKVAFVPGAPFYANNPRPEFMRLNYSNRPPDLIAEGMRRLGAVI
AAELG

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=411, Percent_Identity=30.4136253041363, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI33469970, Length=411, Percent_Identity=30.4136253041363, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4507369, Length=385, Percent_Identity=24.6753246753247, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787710, Length=380, Percent_Identity=30.7894736842105, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1790797, Length=393, Percent_Identity=25.6997455470738, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788722, Length=357, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788627, Length=384, Percent_Identity=23.6979166666667, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=374, Percent_Identity=21.6577540106952, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321236, Length=477, Percent_Identity=25.1572327044025, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321000, Length=432, Percent_Identity=26.1574074074074, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321929, Length=464, Percent_Identity=23.0603448275862, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356535, Length=394, Percent_Identity=28.1725888324873, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 44556; Mature: 44424

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADAMSAPLPPPPVWRLAQRMSRIKTSAVREILKVAERPDILSFAGGLPAPELFPLEAI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHH
AEAHAEALATEGRAALQYSTTEGFGPLREWICGHLQKRGRQSNADQVLITNGSQQGIDLV
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHH
AKVMLDPGDLVIVENPSYLAALQTFGAYEARFATVGSDDQGMRTDDLERLLATHKPKLVY
HHHHCCCCCEEEEECCHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
VVANFQNPKGTTLSLERRRELVRLAQQYRFLILEDDPYGELRFRGEHVPSLSAFDDEGVV
EEEECCCCCCCEEEHHHHHHHHHHHHHCEEEEEECCCCCCEEECCCCCCCCCCCCCCCEE
VSLGTFSKTLAPGMRLGWVVGPRDFVRSLAIAKQSTDLHTATLAQRAVVKLLARFDYAAH
EEECCCHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LESLRPVYGERAQAMLDALQAHMPAGTQWTHPEGGMFLWVELPGGLDAQALLPKAVEQKV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHE
AFVPGAPFYANNPRPEFMRLNYSNRPPDLIAEGMRRLGAVIAAELG
EECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SADAMSAPLPPPPVWRLAQRMSRIKTSAVREILKVAERPDILSFAGGLPAPELFPLEAI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHH
AEAHAEALATEGRAALQYSTTEGFGPLREWICGHLQKRGRQSNADQVLITNGSQQGIDLV
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHH
AKVMLDPGDLVIVENPSYLAALQTFGAYEARFATVGSDDQGMRTDDLERLLATHKPKLVY
HHHHCCCCCEEEEECCHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHHCCCCEEE
VVANFQNPKGTTLSLERRRELVRLAQQYRFLILEDDPYGELRFRGEHVPSLSAFDDEGVV
EEEECCCCCCCEEEHHHHHHHHHHHHHCEEEEEECCCCCCEEECCCCCCCCCCCCCCCEE
VSLGTFSKTLAPGMRLGWVVGPRDFVRSLAIAKQSTDLHTATLAQRAVVKLLARFDYAAH
EEECCCHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LESLRPVYGERAQAMLDALQAHMPAGTQWTHPEGGMFLWVELPGGLDAQALLPKAVEQKV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHE
AFVPGAPFYANNPRPEFMRLNYSNRPPDLIAEGMRRLGAVIAAELG
EECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA