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The map label for this gene is cynR [H]

Identifier: 108759716

GI number: 108759716

Start: 3310200

End: 3311084

Strand: Reverse

Name: cynR [H]

Synonym: MXAN_2842

Alternate gene names: 108759716

Gene position: 3311084-3310200 (Counterclockwise)

Preceding gene: 108759880

Following gene: 108762820

Centisome position: 36.23

GC content: 74.01

Gene sequence:

>885_bases
ATGGAACTGCGCCACCTCCGCTACTTCTCCGCCGTCGCGGACACCCTGCACTTCGGGCGGGCCGCCAGGCGCGTCCACGT
CTCACAGCCCACGCTGTCGCAGCAGATTCGCCAGCTCGAGGAGGAGCTCGGCGCGCCCCTCTTCGAGCGCGCCCGGAGCG
GCGTGCGCCTGACGCAGGCGGGCGAGCTGTTCCGCACCTACGCATCACGAGCGCTGGAGGACGTGGACGCGGGCAGGGTC
GCCGTGGGCGCGCTGCGAGGCCTCACCACCGGCGCCCTGCGCGTGGGCTACCCGCCCAGCATGCGAGGCGTCGTGCTGCC
CGCGCTCGCCGCCGTGCTGCGAAGGCACTCGGGCTTGGTGCTGAGCGCGGAGGAAGCCGTGGTGCGGCGGGTGGAGCGGC
GGCTGGCGGATGGCCGTCTGGACGTGGGGTTGGGCTACGCCCCCGCGCGCTCACCGGACCTGGAGGCGGAGCCCGTCTTC
GACAGCAAGCTGGCGCTGGTGGTCGCCAAGGGACATCCCCTGGCGAAGCTGGAGACCGTGGGCGCGAAGCCCCTGGCCCA
GGAGCCCTTCGCGCTGCTCTCCCGAGGGTTGCGCGTGCGAGCCCGCGTGGATGCCTGGTTCGCCGCCATCCGGATTGCGC
CGCATGTCGCGTTGGAGTCGAACGCCGTGGCCACGGTGCTGGCCACCGTTCGCGCGGGGCTCGCGGTGACGGTGCTCCCG
GAGCCTCAACTCGCGGACGCCGCGGGGCTGGCGGTGAAGCGGCTCTCCCCTGCGCCCCGGGCCGAACTTGCGGCGCTCCT
GTGGCGAAAAGGCGCGCCGCGCACGCCCGCCGCGGAACTGTTCGCGGCCGAGGTGCGCGGCGCCAGACGCCCGAGCAGAC
GATGA

Upstream 100 bases:

>100_bases
TCCTTCACGACCTCGCGATGGGAGAACACTTACGCGCGGGCCATGATTGGTACATTCGTTTGTTCCCATGGCTTCGATAG
GCAATGCCTATGATGACGCC

Downstream 100 bases:

>100_bases
GCCCGCTTCAGCGCGTGTCGGGGAGCTGCGTGTAGTCGTGGAAGTTGCCGTGCAGCCGCTCGCCGGGTTCGCCCTCGGTG
ACGGCCTGGACCAGGTACTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MELRHLRYFSAVADTLHFGRAARRVHVSQPTLSQQIRQLEEELGAPLFERARSGVRLTQAGELFRTYASRALEDVDAGRV
AVGALRGLTTGALRVGYPPSMRGVVLPALAAVLRRHSGLVLSAEEAVVRRVERRLADGRLDVGLGYAPARSPDLEAEPVF
DSKLALVVAKGHPLAKLETVGAKPLAQEPFALLSRGLRVRARVDAWFAAIRIAPHVALESNAVATVLATVRAGLAVTVLP
EPQLADAAGLAVKRLSPAPRAELAALLWRKGAPRTPAAELFAAEVRGARRPSRR

Sequences:

>Translated_294_residues
MELRHLRYFSAVADTLHFGRAARRVHVSQPTLSQQIRQLEEELGAPLFERARSGVRLTQAGELFRTYASRALEDVDAGRV
AVGALRGLTTGALRVGYPPSMRGVVLPALAAVLRRHSGLVLSAEEAVVRRVERRLADGRLDVGLGYAPARSPDLEAEPVF
DSKLALVVAKGHPLAKLETVGAKPLAQEPFALLSRGLRVRARVDAWFAAIRIAPHVALESNAVATVLATVRAGLAVTVLP
EPQLADAAGLAVKRLSPAPRAELAALLWRKGAPRTPAAELFAAEVRGARRPSRR
>Mature_294_residues
MELRHLRYFSAVADTLHFGRAARRVHVSQPTLSQQIRQLEEELGAPLFERARSGVRLTQAGELFRTYASRALEDVDAGRV
AVGALRGLTTGALRVGYPPSMRGVVLPALAAVLRRHSGLVLSAEEAVVRRVERRLADGRLDVGLGYAPARSPDLEAEPVF
DSKLALVVAKGHPLAKLETVGAKPLAQEPFALLSRGLRVRARVDAWFAAIRIAPHVALESNAVATVLATVRAGLAVTVLP
EPQLADAAGLAVKRLSPAPRAELAALLWRKGAPRTPAAELFAAEVRGARRPSRR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=279, Percent_Identity=41.2186379928315, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=34.1216216216216, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787879, Length=300, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790399, Length=291, Percent_Identity=29.8969072164948, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788297, Length=243, Percent_Identity=28.8065843621399, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=32.6923076923077, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=28.6852589641434, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787806, Length=283, Percent_Identity=27.9151943462898, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787530, Length=245, Percent_Identity=27.7551020408163, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789204, Length=261, Percent_Identity=28.3524904214559, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367136, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI145693105, Length=296, Percent_Identity=23.6486486486486, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788748, Length=287, Percent_Identity=25.7839721254355, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787601, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788481, Length=273, Percent_Identity=27.8388278388278, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=146, Percent_Identity=32.1917808219178, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=297, Percent_Identity=26.5993265993266, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789506, Length=246, Percent_Identity=24.7967479674797, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31605; Mature: 31605

Theoretical pI: Translated: 11.75; Mature: 11.75

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFSAVADTLHFGRAARRVHVSQPTLSQQIRQLEEELGAPLFERARSGVRLTQA
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCEEHHH
GELFRTYASRALEDVDAGRVAVGALRGLTTGALRVGYPPSMRGVVLPALAAVLRRHSGLV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCE
LSAEEAVVRRVERRLADGRLDVGLGYAPARSPDLEAEPVFDSKLALVVAKGHPLAKLETV
EEHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHC
GAKPLAQEPFALLSRGLRVRARVDAWFAAIRIAPHVALESNAVATVLATVRAGLAVTVLP
CCCCCCCCCHHHHHCCCEEEHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCEEEECC
EPQLADAAGLAVKRLSPAPRAELAALLWRKGAPRTPAAELFAAEVRGARRPSRR
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MELRHLRYFSAVADTLHFGRAARRVHVSQPTLSQQIRQLEEELGAPLFERARSGVRLTQA
CCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCEEHHH
GELFRTYASRALEDVDAGRVAVGALRGLTTGALRVGYPPSMRGVVLPALAAVLRRHSGLV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCE
LSAEEAVVRRVERRLADGRLDVGLGYAPARSPDLEAEPVFDSKLALVVAKGHPLAKLETV
EEHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHC
GAKPLAQEPFALLSRGLRVRARVDAWFAAIRIAPHVALESNAVATVLATVRAGLAVTVLP
CCCCCCCCCHHHHHCCCEEEHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHCCCEEEECC
EPQLADAAGLAVKRLSPAPRAELAALLWRKGAPRTPAAELFAAEVRGARRPSRR
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]