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The map label for this gene is leuS [H]

Identifier: 108759560

GI number: 108759560

Start: 4963930

End: 4966416

Strand: Reverse

Name: leuS [H]

Synonym: MXAN_4051

Alternate gene names: 108759560

Gene position: 4966416-4963930 (Counterclockwise)

Preceding gene: 108758926

Following gene: 108762189

Centisome position: 54.34

GC content: 66.51

Gene sequence:

>2487_bases
ATGTCCACAGAACGGCCGAAGTACGACCCGGCGAACATCGAACCCCTCTGGCAGGCCCGTTGGGAAGAGCAGCGCATCTT
CGAGGCGCGCAGACACCCCGGCAAACCGAAGGCGTACATCCTCGACATGTTCCCTTACCCCTCGGGAGCCGGGCTGCACG
TCGGGCACCCGGAGGGCTACACGGCCACGGACATCGTCTCGCGGTACTTGCGGATGCGGGGATATGATGTCCTTCATCCC
ATGGGATGGGACGCGTTCGGCCTGCCCGCGGAGCAGCACGCGCTCGAAACGGGAACCCACCCGGCGGATACCACCGCGAA
GAACGTCGCGACGTTCAAGCGGCAGCTCAAGTCTCTTGGGTTCTCGTACGACTGGTCTCGCGAGCTCTCCACGACCGACC
CGGAGTACGTGCGTTGGACCCAGTGGCTCTTCCTCAAGCTCTTCGATCGCGGGCTGGCCTATCAGGCCGAGCTCCCGGTG
AACTGGTGCGCGGCGCTCGGCACGGTGCTCGCCAACGAGGAGGTCATTGACGGGAAAAGCGAGCGGGGCAGTCACCCGGT
CGTGCGGCTGCCGCTGCGGCAGTGGACGCTTCGCATCACGGCGTACGCCGATCGGCTCGCCGAGGACCTTTCGGGGCTGG
ATTGGCCCGAGACGCGGGAGAAGCAGCTCCACTGGATTGGGCGCAGTGAGGGCGCTGAGGTCGATTTCGCCATCGAGGGC
AGCGCGGACCGCCTCCGCATCTTCACCACCCGTCCGGACACGCTCTTCGGCGCGACGTACATGGTCGTCGCACCCGAGCA
CCCGCTGCTGGAGCGGTTCGCCACGGCGGAGCGGCGCGCCGAGGTTCTGGCCTACCGAGAAGCGACCGCAAGCCGAAGCG
AGTTGGACCGCACCGCGCTCACGAAAGCCAAGACCGGCGTGTTCACCGGCTCCTATGCGCTGCACCCGCTCACGGGAGCG
CGCCTCCCCATCTGGGTCGCGGACTTCGTGCTCGGCTCTTATGGGACGGGCGCCATCATGAGCGTGCCCGGCCATGACGC
GCGTGATTTCGAGTTCGCGCGTGCCTTCGGCTTGCCCGTCGTCGAGGTGGTTTCGGTCGACGGCGCCCTGAACGAGACTG
GCACGTGGACGGAGGCATTCGTGGGGGACGGCGTCGCGGTGCGCTCGCGCTTCCTCGATGGGCTGCGGACGCCCGAGGCC
AAGGCGGCCATGCTCGCCCACCTCGAGCGCGAGGGATTGGGCGCACGGCGCGTCCAGTACCGCTTGCGGGATTGGGTGTT
CTCGCGCCAGCGCTATTGGGGGGAGCCGATCCCCATCTATTTCCCGGTCGAGCTCGCGGAGGGCTCATCGGACCCGCGTA
TTCATCCCCACACCATTCGCTACGACCAGCCTCTGCCCGTGTCCGAGGACGAGCTGCCGGTGCGGCTCCCCGAGCTCGAG
GACTTCAAGCCCAGCGAGGACCCGGCGGGCCCGCTGGCCCGCGCCTTGGATTGGCGATTCTTCCAGCGCGACGGAAAGTG
GTACGCGCGAGAGACCAACACCATGCCTCAATGGGCGGGCTCGTGCTGGTACTACCTGCGCTTCATTGACCCGAAGAACA
CCCAGGCCATCTTCTCGCAGCAGGCGTACGACGCCTGGATGCCGGTGGACCTGTATGTCGGCGGTTCGGAGCACGCGGTG
CTGCACCTGCTCTACGCCCGGTTCTGGCACAAGGTGCTGTTCGATTGCGGCCTCGTCACGCACGCCGAGCCGTTCAAGAA
GCTCGTCCACCAGGGAATGATCCTCGGTGAGAACAACGAGAAGATGTCCAAGTCGCGTGGCAACGTGGTGAACCCGGACG
ACATTGTCCGGCAGTTCGGTGCGGACGCCCTGCGCATGTACGAGATGTTCATGGGGCCGCTGGAGGCGGTGAAGCCGTGG
CAGACCAACGGCGTCATCGGCGTGCGGCGTTTCCTTGACCGCGTGTGGAACATGCTCGCGTTCGTGACGGAGGACGCGGG
TGGTGCACCGGCGGAGCTGACCGAGGACGCGCGGCGGCTGCTGCACAAGACGGTGAAGAAGGTGGGGGAGGACATCGAAG
CGCTGCGCTTCAACACGGCCGTGAGCGCGATGATGATTCTCGCCAACGCGCTGGCCGAGCTCCCGCGCGTGCCGCTCGAG
GCGGCCAGGGTCTTTGCGCGGATTCTCTCCCCATTCGCGCCTCACCTCTCGGAGGAACTCTGGCACCGCTGGGGCGCAAG
CGAGTCCATTTCCCTCCAGCCGTGGCCTGAATACGACCCCGCGTTGACCGTGGACGAGCTCGTCGAAATGGCCATCCAGG
TCAACGGCAAGGTCCGAGGGAAGCTGCGCCTGAAGCGAGACGCCACGGAGGCGGAGGCGCGCGAGGCCGTCCACCGAGAG
CCGGAGCTCATCCCGCATCTCGCTGGAAAGACCGAGCGCCGATTCGTCTACGTGCCAGGGCGAATCATCAACATCGTCGT
TGGCTGA

Upstream 100 bases:

>100_bases
GGATGGCGGGCTTGAGAACGATCATCATCGCGGAGCAGACCACCCGAAGAGCCGCTCTGCCGCCTGCTGACTGGGCATGC
CCGTTGTGGTAACTGGCGCC

Downstream 100 bases:

>100_bases
GGCGCTGCGGCGAACGCAGTCACTTGCGCGGGAAGTGCGGATACACGTCCTCCTGGAGCACCTGACGCAGCTTCGGGAAG
TTCAACGCCCACTTCACGCC

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 828; Mature: 827

Protein sequence:

>828_residues
MSTERPKYDPANIEPLWQARWEEQRIFEARRHPGKPKAYILDMFPYPSGAGLHVGHPEGYTATDIVSRYLRMRGYDVLHP
MGWDAFGLPAEQHALETGTHPADTTAKNVATFKRQLKSLGFSYDWSRELSTTDPEYVRWTQWLFLKLFDRGLAYQAELPV
NWCAALGTVLANEEVIDGKSERGSHPVVRLPLRQWTLRITAYADRLAEDLSGLDWPETREKQLHWIGRSEGAEVDFAIEG
SADRLRIFTTRPDTLFGATYMVVAPEHPLLERFATAERRAEVLAYREATASRSELDRTALTKAKTGVFTGSYALHPLTGA
RLPIWVADFVLGSYGTGAIMSVPGHDARDFEFARAFGLPVVEVVSVDGALNETGTWTEAFVGDGVAVRSRFLDGLRTPEA
KAAMLAHLEREGLGARRVQYRLRDWVFSRQRYWGEPIPIYFPVELAEGSSDPRIHPHTIRYDQPLPVSEDELPVRLPELE
DFKPSEDPAGPLARALDWRFFQRDGKWYARETNTMPQWAGSCWYYLRFIDPKNTQAIFSQQAYDAWMPVDLYVGGSEHAV
LHLLYARFWHKVLFDCGLVTHAEPFKKLVHQGMILGENNEKMSKSRGNVVNPDDIVRQFGADALRMYEMFMGPLEAVKPW
QTNGVIGVRRFLDRVWNMLAFVTEDAGGAPAELTEDARRLLHKTVKKVGEDIEALRFNTAVSAMMILANALAELPRVPLE
AARVFARILSPFAPHLSEELWHRWGASESISLQPWPEYDPALTVDELVEMAIQVNGKVRGKLRLKRDATEAEAREAVHRE
PELIPHLAGKTERRFVYVPGRIINIVVG

Sequences:

>Translated_828_residues
MSTERPKYDPANIEPLWQARWEEQRIFEARRHPGKPKAYILDMFPYPSGAGLHVGHPEGYTATDIVSRYLRMRGYDVLHP
MGWDAFGLPAEQHALETGTHPADTTAKNVATFKRQLKSLGFSYDWSRELSTTDPEYVRWTQWLFLKLFDRGLAYQAELPV
NWCAALGTVLANEEVIDGKSERGSHPVVRLPLRQWTLRITAYADRLAEDLSGLDWPETREKQLHWIGRSEGAEVDFAIEG
SADRLRIFTTRPDTLFGATYMVVAPEHPLLERFATAERRAEVLAYREATASRSELDRTALTKAKTGVFTGSYALHPLTGA
RLPIWVADFVLGSYGTGAIMSVPGHDARDFEFARAFGLPVVEVVSVDGALNETGTWTEAFVGDGVAVRSRFLDGLRTPEA
KAAMLAHLEREGLGARRVQYRLRDWVFSRQRYWGEPIPIYFPVELAEGSSDPRIHPHTIRYDQPLPVSEDELPVRLPELE
DFKPSEDPAGPLARALDWRFFQRDGKWYARETNTMPQWAGSCWYYLRFIDPKNTQAIFSQQAYDAWMPVDLYVGGSEHAV
LHLLYARFWHKVLFDCGLVTHAEPFKKLVHQGMILGENNEKMSKSRGNVVNPDDIVRQFGADALRMYEMFMGPLEAVKPW
QTNGVIGVRRFLDRVWNMLAFVTEDAGGAPAELTEDARRLLHKTVKKVGEDIEALRFNTAVSAMMILANALAELPRVPLE
AARVFARILSPFAPHLSEELWHRWGASESISLQPWPEYDPALTVDELVEMAIQVNGKVRGKLRLKRDATEAEAREAVHRE
PELIPHLAGKTERRFVYVPGRIINIVVG
>Mature_827_residues
STERPKYDPANIEPLWQARWEEQRIFEARRHPGKPKAYILDMFPYPSGAGLHVGHPEGYTATDIVSRYLRMRGYDVLHPM
GWDAFGLPAEQHALETGTHPADTTAKNVATFKRQLKSLGFSYDWSRELSTTDPEYVRWTQWLFLKLFDRGLAYQAELPVN
WCAALGTVLANEEVIDGKSERGSHPVVRLPLRQWTLRITAYADRLAEDLSGLDWPETREKQLHWIGRSEGAEVDFAIEGS
ADRLRIFTTRPDTLFGATYMVVAPEHPLLERFATAERRAEVLAYREATASRSELDRTALTKAKTGVFTGSYALHPLTGAR
LPIWVADFVLGSYGTGAIMSVPGHDARDFEFARAFGLPVVEVVSVDGALNETGTWTEAFVGDGVAVRSRFLDGLRTPEAK
AAMLAHLEREGLGARRVQYRLRDWVFSRQRYWGEPIPIYFPVELAEGSSDPRIHPHTIRYDQPLPVSEDELPVRLPELED
FKPSEDPAGPLARALDWRFFQRDGKWYARETNTMPQWAGSCWYYLRFIDPKNTQAIFSQQAYDAWMPVDLYVGGSEHAVL
HLLYARFWHKVLFDCGLVTHAEPFKKLVHQGMILGENNEKMSKSRGNVVNPDDIVRQFGADALRMYEMFMGPLEAVKPWQ
TNGVIGVRRFLDRVWNMLAFVTEDAGGAPAELTEDARRLLHKTVKKVGEDIEALRFNTAVSAMMILANALAELPRVPLEA
ARVFARILSPFAPHLSEELWHRWGASESISLQPWPEYDPALTVDELVEMAIQVNGKVRGKLRLKRDATEAEAREAVHREP
ELIPHLAGKTERRFVYVPGRIINIVVG

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=904, Percent_Identity=32.853982300885, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI94721239, Length=683, Percent_Identity=23.5724743777452, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI94721241, Length=683, Percent_Identity=23.5724743777452, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI5454158, Length=434, Percent_Identity=24.1935483870968, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1786861, Length=888, Percent_Identity=41.2162162162162, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1790708, Length=385, Percent_Identity=25.4545454545455, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71997517, Length=840, Percent_Identity=27.7380952380952, Blast_Score=294, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71997510, Length=814, Percent_Identity=28.2555282555283, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI212645227, Length=338, Percent_Identity=28.698224852071, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17510661, Length=430, Percent_Identity=23.7209302325581, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17554638, Length=277, Percent_Identity=24.187725631769, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323414, Length=870, Percent_Identity=34.0229885057471, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321531, Length=390, Percent_Identity=26.4102564102564, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21355409, Length=894, Percent_Identity=31.3199105145414, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI17864482, Length=414, Percent_Identity=24.8792270531401, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653289, Length=414, Percent_Identity=24.8792270531401, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574730, Length=774, Percent_Identity=23.7726098191214, Blast_Score=104, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24668547, Length=774, Percent_Identity=23.7726098191214, Blast_Score=104, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24668543, Length=774, Percent_Identity=23.7726098191214, Blast_Score=104, Evalue=3e-22,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93938; Mature: 93807

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTERPKYDPANIEPLWQARWEEQRIFEARRHPGKPKAYILDMFPYPSGAGLHVGHPEGY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEECCCCCCC
TATDIVSRYLRMRGYDVLHPMGWDAFGLPAEQHALETGTHPADTTAKNVATFKRQLKSLG
CHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
FSYDWSRELSTTDPEYVRWTQWLFLKLFDRGLAYQAELPVNWCAALGTVLANEEVIDGKS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCHHCCCCC
ERGSHPVVRLPLRQWTLRITAYADRLAEDLSGLDWPETREKQLHWIGRSEGAEVDFAIEG
CCCCCCEEEECHHHHEEHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCCCCEEEEEEEC
SADRLRIFTTRPDTLFGATYMVVAPEHPLLERFATAERRAEVLAYREATASRSELDRTAL
CCCEEEEEEECCCCHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TKAKTGVFTGSYALHPLTGARLPIWVADFVLGSYGTGAIMSVPGHDARDFEFARAFGLPV
HHHHCCEEECCCEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHCCCE
VEVVSVDGALNETGTWTEAFVGDGVAVRSRFLDGLRTPEAKAAMLAHLEREGLGARRVQY
EEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHH
RLRDWVFSRQRYWGEPIPIYFPVELAEGSSDPRIHPHTIRYDQPLPVSEDELPVRLPELE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCEECCCCC
DFKPSEDPAGPLARALDWRFFQRDGKWYARETNTMPQWAGSCWYYLRFIDPKNTQAIFSQ
CCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHH
QAYDAWMPVDLYVGGSEHAVLHLLYARFWHKVLFDCGLVTHAEPFKKLVHQGMILGENNE
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCCH
KMSKSRGNVVNPDDIVRQFGADALRMYEMFMGPLEAVKPWQTNGVIGVRRFLDRVWNMLA
HHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHH
FVTEDAGGAPAELTEDARRLLHKTVKKVGEDIEALRFNTAVSAMMILANALAELPRVPLE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AARVFARILSPFAPHLSEELWHRWGASESISLQPWPEYDPALTVDELVEMAIQVNGKVRG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
KLRLKRDATEAEAREAVHREPELIPHLAGKTERRFVYVPGRIINIVVG
EEEECCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCEEEEEEEC
>Mature Secondary Structure 
STERPKYDPANIEPLWQARWEEQRIFEARRHPGKPKAYILDMFPYPSGAGLHVGHPEGY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEECCCCCCC
TATDIVSRYLRMRGYDVLHPMGWDAFGLPAEQHALETGTHPADTTAKNVATFKRQLKSLG
CHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
FSYDWSRELSTTDPEYVRWTQWLFLKLFDRGLAYQAELPVNWCAALGTVLANEEVIDGKS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCHHCCCCC
ERGSHPVVRLPLRQWTLRITAYADRLAEDLSGLDWPETREKQLHWIGRSEGAEVDFAIEG
CCCCCCEEEECHHHHEEHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCCCCEEEEEEEC
SADRLRIFTTRPDTLFGATYMVVAPEHPLLERFATAERRAEVLAYREATASRSELDRTAL
CCCEEEEEEECCCCHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TKAKTGVFTGSYALHPLTGARLPIWVADFVLGSYGTGAIMSVPGHDARDFEFARAFGLPV
HHHHCCEEECCCEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHCCCE
VEVVSVDGALNETGTWTEAFVGDGVAVRSRFLDGLRTPEAKAAMLAHLEREGLGARRVQY
EEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHH
RLRDWVFSRQRYWGEPIPIYFPVELAEGSSDPRIHPHTIRYDQPLPVSEDELPVRLPELE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCCEECCCCC
DFKPSEDPAGPLARALDWRFFQRDGKWYARETNTMPQWAGSCWYYLRFIDPKNTQAIFSQ
CCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHH
QAYDAWMPVDLYVGGSEHAVLHLLYARFWHKVLFDCGLVTHAEPFKKLVHQGMILGENNE
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCCH
KMSKSRGNVVNPDDIVRQFGADALRMYEMFMGPLEAVKPWQTNGVIGVRRFLDRVWNMLA
HHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHHHH
FVTEDAGGAPAELTEDARRLLHKTVKKVGEDIEALRFNTAVSAMMILANALAELPRVPLE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
AARVFARILSPFAPHLSEELWHRWGASESISLQPWPEYDPALTVDELVEMAIQVNGKVRG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
KLRLKRDATEAEAREAVHREPELIPHLAGKTERRFVYVPGRIINIVVG
EEEECCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA