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The map label for this gene is degS [H]

Identifier: 108759452

GI number: 108759452

Start: 4987823

End: 4989106

Strand: Direct

Name: degS [H]

Synonym: MXAN_4071

Alternate gene names: 108759452

Gene position: 4987823-4989106 (Clockwise)

Preceding gene: 108761086

Following gene: 108757533

Centisome position: 54.57

GC content: 67.76

Gene sequence:

>1284_bases
ATGGATTCCCAACTCGCATTGAGCGAGGAAACGCCTGCCAACGACCTGCGCGCCCGGGTGCGGAAGGTCCTGGAGCGCCG
CAAGCTGACGGACAGCGTGTCGGCGGAGCAGGCCGCCGCCTCGTGGGAGCAGGACCGCTTCGTGGCACGGGCCCGCGCGC
TCTTCTACGCGCGGATGATGTTCCTCACGCTGGGCCTGCTCATCCTCGCGGTGCCGGCCTGGAGCGGCTACTTCGGCCTC
ACCGGGCCCTTCTCCTTCGTGGGCTACTTCGCGATGCTGCTCTACAGCGTCGCCAACCTCCTGGTCATCGACCACCCCAA
GGCCGGCCGCTGGGTGACGTACATCACCCTCTGCCTGGACGTGACCATCAGCGTGGTGCTCATCGCCAAGCCGCACGTCG
GCGGCGGTCTCCAGAGCCCGCTGCTGGCCACGCAGCTGCTCTTCACCACGCTCTTCGCCATCCTCTTTCCCAAGCCGCTG
GCGATCCTGCCGCCGCTGCTGGCGCTGCCCATCACCACCCGGCTGGACCTGCTCCTCAACCGCTCCGTGACGGCGGTGGA
GCTGCTGACCCTGCTCTGGTACCTGGCGCTCAACTTCATCATCGTCTACGTGCTCGTGTACCTGAACGAGCGCGAGGCCG
CCGCGCACCGCGAGGTCGTGTCGCTCCAGGGAGACCTCAAGGAGCTCGCGGTGGTGGAGGAGCGCAACCGGATGGCCCGG
GAGATCCACGACGGCCTGGGCGCGTCCCTGTCGTCGATGATCATCCAGTCCGAATACATCCTGAACCTCGCGCGCGAGGA
GGGCCTGCGCGAGGAGATCCGCGAACTGAAGCTCACCGCGGAGGAGTCCATCGAGGAGCTGCGGCGCAGCCTGCGGATGA
TGCGCGAGGACTTCGAGCTGGCGCAGGGCCTGGAGGACTACGCGAAGACGTTCCGCGAGCGCACGGGCCTGGACATCCGC
TTCGAGCGCACCGGGCTCCAGCGCAAGCTGGACCCGGACGTGCAACTGGCGCTGTTCCGCATCCTCCAGGAGTCGCTGTC
CAACGCGGTGAAGCACGCGGAGGCCAAGGGCGTCCAGGTGCGGCTCGACTTCAGCGAGGACCGTGTCAACCTCGTCGTAC
GCGACGACGGCAAGGGCTTCGACCCTTCCCGGACGCCGCGCGGCCACTATGGCCTGTTGAACATGCGCGAGCGCGCCATG
AAGCTCGGTGGCCAGCTCATCGTGGACTCGTCACCCGGCGCTGGCGCCCAGGTGGCATTCTCCCTTCCCTGTCGCCCGTC
ATGA

Upstream 100 bases:

>100_bases
TCCGCCCGGCGTGGGGCCTGCCCCCTCGCCCCCCAGAAAACGGGGCGGGCCACCTCCGGGATTCCCGGCCCCCCGGTTGC
TCCCGTAGACTGCCGGACGA

Downstream 100 bases:

>100_bases
CCGGAGCTCCCGTGGACGCCCCGCAGCCTCCTGATTCGCCGCCCATTCGCGTCTTCGTGGTCGAGGATCAAACGAAGATC
CTCAAGAACCAGCTCCGCCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MDSQLALSEETPANDLRARVRKVLERRKLTDSVSAEQAAASWEQDRFVARARALFYARMMFLTLGLLILAVPAWSGYFGL
TGPFSFVGYFAMLLYSVANLLVIDHPKAGRWVTYITLCLDVTISVVLIAKPHVGGGLQSPLLATQLLFTTLFAILFPKPL
AILPPLLALPITTRLDLLLNRSVTAVELLTLLWYLALNFIIVYVLVYLNEREAAAHREVVSLQGDLKELAVVEERNRMAR
EIHDGLGASLSSMIIQSEYILNLAREEGLREEIRELKLTAEESIEELRRSLRMMREDFELAQGLEDYAKTFRERTGLDIR
FERTGLQRKLDPDVQLALFRILQESLSNAVKHAEAKGVQVRLDFSEDRVNLVVRDDGKGFDPSRTPRGHYGLLNMRERAM
KLGGQLIVDSSPGAGAQVAFSLPCRPS

Sequences:

>Translated_427_residues
MDSQLALSEETPANDLRARVRKVLERRKLTDSVSAEQAAASWEQDRFVARARALFYARMMFLTLGLLILAVPAWSGYFGL
TGPFSFVGYFAMLLYSVANLLVIDHPKAGRWVTYITLCLDVTISVVLIAKPHVGGGLQSPLLATQLLFTTLFAILFPKPL
AILPPLLALPITTRLDLLLNRSVTAVELLTLLWYLALNFIIVYVLVYLNEREAAAHREVVSLQGDLKELAVVEERNRMAR
EIHDGLGASLSSMIIQSEYILNLAREEGLREEIRELKLTAEESIEELRRSLRMMREDFELAQGLEDYAKTFRERTGLDIR
FERTGLQRKLDPDVQLALFRILQESLSNAVKHAEAKGVQVRLDFSEDRVNLVVRDDGKGFDPSRTPRGHYGLLNMRERAM
KLGGQLIVDSSPGAGAQVAFSLPCRPS
>Mature_427_residues
MDSQLALSEETPANDLRARVRKVLERRKLTDSVSAEQAAASWEQDRFVARARALFYARMMFLTLGLLILAVPAWSGYFGL
TGPFSFVGYFAMLLYSVANLLVIDHPKAGRWVTYITLCLDVTISVVLIAKPHVGGGLQSPLLATQLLFTTLFAILFPKPL
AILPPLLALPITTRLDLLLNRSVTAVELLTLLWYLALNFIIVYVLVYLNEREAAAHREVVSLQGDLKELAVVEERNRMAR
EIHDGLGASLSSMIIQSEYILNLAREEGLREEIRELKLTAEESIEELRRSLRMMREDFELAQGLEDYAKTFRERTGLDIR
FERTGLQRKLDPDVQLALFRILQESLSNAVKHAEAKGVQVRLDFSEDRVNLVVRDDGKGFDPSRTPRGHYGLLNMRERAM
KLGGQLIVDSSPGAGAQVAFSLPCRPS

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=30.0970873786408, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082311, Length=226, Percent_Identity=30.5309734513274, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787474, Length=204, Percent_Identity=30.8823529411765, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47952; Mature: 47952

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSQLALSEETPANDLRARVRKVLERRKLTDSVSAEQAAASWEQDRFVARARALFYARMM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTLGLLILAVPAWSGYFGLTGPFSFVGYFAMLLYSVANLLVIDHPKAGRWVTYITLCLD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
VTISVVLIAKPHVGGGLQSPLLATQLLFTTLFAILFPKPLAILPPLLALPITTRLDLLLN
HHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHC
RSVTAVELLTLLWYLALNFIIVYVLVYLNEREAAAHREVVSLQGDLKELAVVEERNRMAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIHDGLGASLSSMIIQSEYILNLAREEGLREEIRELKLTAEESIEELRRSLRMMREDFEL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGLEDYAKTFRERTGLDIRFERTGLQRKLDPDVQLALFRILQESLSNAVKHAEAKGVQV
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
RLDFSEDRVNLVVRDDGKGFDPSRTPRGHYGLLNMRERAMKLGGQLIVDSSPGAGAQVAF
EEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEE
SLPCRPS
ECCCCCC
>Mature Secondary Structure
MDSQLALSEETPANDLRARVRKVLERRKLTDSVSAEQAAASWEQDRFVARARALFYARMM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTLGLLILAVPAWSGYFGLTGPFSFVGYFAMLLYSVANLLVIDHPKAGRWVTYITLCLD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
VTISVVLIAKPHVGGGLQSPLLATQLLFTTLFAILFPKPLAILPPLLALPITTRLDLLLN
HHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHC
RSVTAVELLTLLWYLALNFIIVYVLVYLNEREAAAHREVVSLQGDLKELAVVEERNRMAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIHDGLGASLSSMIIQSEYILNLAREEGLREEIRELKLTAEESIEELRRSLRMMREDFEL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGLEDYAKTFRERTGLDIRFERTGLQRKLDPDVQLALFRILQESLSNAVKHAEAKGVQV
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
RLDFSEDRVNLVVRDDGKGFDPSRTPRGHYGLLNMRERAMKLGGQLIVDSSPGAGAQVAF
EEECCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEE
SLPCRPS
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]