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The map label for this gene is htrA [H]

Identifier: 108759219

GI number: 108759219

Start: 348818

End: 349735

Strand: Reverse

Name: htrA [H]

Synonym: MXAN_0295

Alternate gene names: 108759219

Gene position: 349735-348818 (Counterclockwise)

Preceding gene: 108761766

Following gene: 108756840

Centisome position: 3.83

GC content: 69.5

Gene sequence:

>918_bases
GTGAAACTGCTGCAACACTTCTCGGATGATTTGGAGTCGCTGGTGGCGCGTGCCTCGCCCGCCGTCGTGGGCGTGGAGCA
CGCACGCGGCCACGGCACCGGCCTCTTCCTCACACCGGACGGCTACGTCCTCACCAACCGCCACGTGGTGGTGCGCGGCT
CACGCAAGCTCACCGTCCAGCTCTCCAACGGAGAGGAACTGCGTGGCACCCTGGTGGGCAGCGACGCCCCCACCGACCTG
GCCGTGGTCCGCGCGGAGGGCGGTGACTTCCCCACCCTGCCGCTCGCCGAGCCCGAGTCGGTGCGCGTGGGCCAGCTCGT
CATGGCCATTGGCAACCCGTTCCACCTGGAACAGTCCGTGTCGCTGGGCGTGGTGAGCGCCATCAACCGCAGCATCAGCC
TGCCCGACGGCGTCATGCTGGAGGGCATGCTCCAGACGGATGCCGCCATCAATCCGGGCAACTCCGGGGGGCCGCTGCTC
AACATGCGAGGACAGGTGGTGGGCCTCAACACGCTGGTGTTGCCCTACGCGCAAGGTATCGGCTTCGCGGTGAGCGCCAC
CACGGCGGCGTGGATTGCCAGCCTGCTCATCCAACGCGGCAAGGTGGACCGGCGCTTCCTGGGCATCGCCGCGACGGCGG
TGAGCCTGGACGCACGACTCACCCGGGAGAACGGCCAGTCCCGCGCGGTGAAGGTGCTCCGCGTGCAGGACGGGACACCT
GCCCACGAGGCCGGACTCCAGGTGGATGACTTACTGCTGGCCATCAACCAGCGGCCGGTGAACAGCGTGGACGACCTCCA
GCGGCTCATGGCGCTGGCCACGGAGGACGAGGTGACGCTGGACCTGCTGCGCAAGGGCGGTGGCCGCAAGACGGCCCAGG
CACGGACGCGACCGCGCATGGAGCCCGTGGCCGCCTGA

Upstream 100 bases:

>100_bases
CGAGAAGGTGGGCACCACCCTCCAGGTCCGCGTGCTGCGCGCCGGAGAGGTTCGCGAAGTGCCCATCACCGTGGGCAAGC
GCTCGTGAAGGGAGGCCACC

Downstream 100 bases:

>100_bases
CTCAGGCCACGCCGCCCGGCGTCCGCCCCTGCGCGTCCGGCATCTTCCCCTGGAGCAGCAGGTTGTCGCCCCGGCAGAGG
CTCTTGTAGGACCACACGCA

Product: S1C family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKLLQHFSDDLESLVARASPAVVGVEHARGHGTGLFLTPDGYVLTNRHVVVRGSRKLTVQLSNGEELRGTLVGSDAPTDL
AVVRAEGGDFPTLPLAEPESVRVGQLVMAIGNPFHLEQSVSLGVVSAINRSISLPDGVMLEGMLQTDAAINPGNSGGPLL
NMRGQVVGLNTLVLPYAQGIGFAVSATTAAWIASLLIQRGKVDRRFLGIAATAVSLDARLTRENGQSRAVKVLRVQDGTP
AHEAGLQVDDLLLAINQRPVNSVDDLQRLMALATEDEVTLDLLRKGGGRKTAQARTRPRMEPVAA

Sequences:

>Translated_305_residues
MKLLQHFSDDLESLVARASPAVVGVEHARGHGTGLFLTPDGYVLTNRHVVVRGSRKLTVQLSNGEELRGTLVGSDAPTDL
AVVRAEGGDFPTLPLAEPESVRVGQLVMAIGNPFHLEQSVSLGVVSAINRSISLPDGVMLEGMLQTDAAINPGNSGGPLL
NMRGQVVGLNTLVLPYAQGIGFAVSATTAAWIASLLIQRGKVDRRFLGIAATAVSLDARLTRENGQSRAVKVLRVQDGTP
AHEAGLQVDDLLLAINQRPVNSVDDLQRLMALATEDEVTLDLLRKGGGRKTAQARTRPRMEPVAA
>Mature_305_residues
MKLLQHFSDDLESLVARASPAVVGVEHARGHGTGLFLTPDGYVLTNRHVVVRGSRKLTVQLSNGEELRGTLVGSDAPTDL
AVVRAEGGDFPTLPLAEPESVRVGQLVMAIGNPFHLEQSVSLGVVSAINRSISLPDGVMLEGMLQTDAAINPGNSGGPLL
NMRGQVVGLNTLVLPYAQGIGFAVSATTAAWIASLLIQRGKVDRRFLGIAATAVSLDARLTRENGQSRAVKVLRVQDGTP
AHEAGLQVDDLLLAINQRPVNSVDDLQRLMALATEDEVTLDLLRKGGGRKTAQARTRPRMEPVAA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=302, Percent_Identity=31.7880794701987, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4506141, Length=313, Percent_Identity=30.3514376996805, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24308541, Length=270, Percent_Identity=30.7407407407407, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI7019477, Length=312, Percent_Identity=30.7692307692308, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1789629, Length=291, Percent_Identity=35.7388316151203, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1789630, Length=286, Percent_Identity=36.013986013986, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786356, Length=262, Percent_Identity=35.1145038167939, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=29.0441176470588, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32303; Mature: 32303

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLQHFSDDLESLVARASPAVVGVEHARGHGTGLFLTPDGYVLTNRHVVVRGSRKLTVQ
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCEEEECCEEEEECCEEEEEE
LSNGEELRGTLVGSDAPTDLAVVRAEGGDFPTLPLAEPESVRVGQLVMAIGNPFHLEQSV
ECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHEEEEECCCCEEECCCC
SLGVVSAINRSISLPDGVMLEGMLQTDAAINPGNSGGPLLNMRGQVVGLNTLVLPYAQGI
CHHHHHHHCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEEHHCCC
GFAVSATTAAWIASLLIQRGKVDRRFLGIAATAVSLDARLTRENGQSRAVKVLRVQDGTP
CEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEHHHEEECCCCCCEEEEEEEECCCCC
AHEAGLQVDDLLLAINQRPVNSVDDLQRLMALATEDEVTLDLLRKGGGRKTAQARTRPRM
HHHHCCCHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCC
EPVAA
CCCCC
>Mature Secondary Structure
MKLLQHFSDDLESLVARASPAVVGVEHARGHGTGLFLTPDGYVLTNRHVVVRGSRKLTVQ
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCEEEECCEEEEECCEEEEEE
LSNGEELRGTLVGSDAPTDLAVVRAEGGDFPTLPLAEPESVRVGQLVMAIGNPFHLEQSV
ECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHEEEEECCCCEEECCCC
SLGVVSAINRSISLPDGVMLEGMLQTDAAINPGNSGGPLLNMRGQVVGLNTLVLPYAQGI
CHHHHHHHCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEEHHCCC
GFAVSATTAAWIASLLIQRGKVDRRFLGIAATAVSLDARLTRENGQSRAVKVLRVQDGTP
CEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEHHHEEECCCCCCEEEEEEEECCCCC
AHEAGLQVDDLLLAINQRPVNSVDDLQRLMALATEDEVTLDLLRKGGGRKTAQARTRPRM
HHHHCCCHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCC
EPVAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]