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The map label for this gene is hisN [H]

Identifier: 108759195

GI number: 108759195

Start: 5183262

End: 5184041

Strand: Reverse

Name: hisN [H]

Synonym: MXAN_4223

Alternate gene names: 108759195

Gene position: 5184041-5183262 (Counterclockwise)

Preceding gene: 108762116

Following gene: 108763389

Centisome position: 56.72

GC content: 71.41

Gene sequence:

>780_bases
ATGACGGACTCGGGTAATCTGATGCAGGCCGCCGCCGAGGTGGCGCGGATAGCGGGTGACGCGGCGTTGGGGTTCTTCCG
CGGTGGCATCGCGGTGGACACGAAGTCGGACGGCTCTCCGGTGACGGTGGCGGACCGCACGGCGGAGTCCCGTGCGCGCG
AGTGGCTGGAAGCGCGCTTCCCCCAGGACGGCATCCTGGGCGAGGAGTTCGGCGAGACACGTCCGGGCGCGAAGCGCCGG
TGGATTCTGGATCCCATTGACGGGACGAAGACGTTCATCCGCGGTGTCCCACTGTGGGGCACGTTGGTGGCGCTGGCGGA
GGGCGAGCGCATCCTCGTGGGGGCCGCGTACTTCCCCGCGGTGAGTGAGTTGCTGGTGGCCGCGCCGGGGCGGGGCTGCT
TCTGGAACGACCAGCGCGCGGCGGTGTCCACGCAGGCGGAGCTGTCCCAGGCCGTGGTGCTGTCCACGGATGAGCGCTTC
CCGGTGTACCCGGAGCGCGGGGCCGCCTGGCGCTCGCTCGCGCGGGATGCGGCCGTGGACCGCACCTGGGGGGATTGCTA
CGGCTACCTGTTGGTCGCCACCGGGCGCGCGGAGGTCATGGTGGATGAGCTGCTGTCCCCCTGGGATGGAGCGGCCTTGC
AGCCCATCATCGAGGAGGCCGGCGGTGTGTTCACCGACTGGACGGGGCGGCGGACCGCGTTCGGCGGAAATGGAATCGCC
ACCAACGCGGCCATGGCGCGCGTGGTGCGGGAGCGGCTCGGCGCCGTGGAGACACGCTGA

Upstream 100 bases:

>100_bases
ATGCGGCATTGGTCGCGGGCATCCTTCACGACGGCGTCACTACCGTGGGCGCCATCAAGGCGCTGCTCCGCGAGAGCGGC
CTTCACATTCGGAGCCTGAC

Downstream 100 bases:

>100_bases
TGCTCGACCTGGACGCGCTCGACTTCGCGAAGGGCAACGGACTGGTGACGGTCGTCACGCAGGACGCGAGCACCGGTGAC
GTGTTGATGGTGGCGCATGC

Product: putative histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTDSGNLMQAAAEVARIAGDAALGFFRGGIAVDTKSDGSPVTVADRTAESRAREWLEARFPQDGILGEEFGETRPGAKRR
WILDPIDGTKTFIRGVPLWGTLVALAEGERILVGAAYFPAVSELLVAAPGRGCFWNDQRAAVSTQAELSQAVVLSTDERF
PVYPERGAAWRSLARDAAVDRTWGDCYGYLLVATGRAEVMVDELLSPWDGAALQPIIEEAGGVFTDWTGRRTAFGGNGIA
TNAAMARVVRERLGAVETR

Sequences:

>Translated_259_residues
MTDSGNLMQAAAEVARIAGDAALGFFRGGIAVDTKSDGSPVTVADRTAESRAREWLEARFPQDGILGEEFGETRPGAKRR
WILDPIDGTKTFIRGVPLWGTLVALAEGERILVGAAYFPAVSELLVAAPGRGCFWNDQRAAVSTQAELSQAVVLSTDERF
PVYPERGAAWRSLARDAAVDRTWGDCYGYLLVATGRAEVMVDELLSPWDGAALQPIIEEAGGVFTDWTGRRTAFGGNGIA
TNAAMARVVRERLGAVETR
>Mature_258_residues
TDSGNLMQAAAEVARIAGDAALGFFRGGIAVDTKSDGSPVTVADRTAESRAREWLEARFPQDGILGEEFGETRPGAKRRW
ILDPIDGTKTFIRGVPLWGTLVALAEGERILVGAAYFPAVSELLVAAPGRGCFWNDQRAAVSTQAELSQAVVLSTDERFP
VYPERGAAWRSLARDAAVDRTWGDCYGYLLVATGRAEVMVDELLSPWDGAALQPIIEEAGGVFTDWTGRRTAFGGNGIAT
NAAMARVVRERLGAVETR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=247, Percent_Identity=29.5546558704453, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI221625487, Length=247, Percent_Identity=29.5546558704453, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI7657236, Length=239, Percent_Identity=30.1255230125523, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788882, Length=257, Percent_Identity=30.3501945525292, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790659, Length=130, Percent_Identity=32.3076923076923, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193202572, Length=211, Percent_Identity=32.7014218009479, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202570, Length=218, Percent_Identity=32.5688073394495, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320493, Length=220, Percent_Identity=31.8181818181818, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664926, Length=238, Percent_Identity=31.9327731092437, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664922, Length=206, Percent_Identity=33.0097087378641, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24664918, Length=233, Percent_Identity=31.3304721030043, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357329, Length=210, Percent_Identity=30.4761904761905, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357957, Length=208, Percent_Identity=29.3269230769231, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357303, Length=242, Percent_Identity=28.099173553719, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27805; Mature: 27673

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSGNLMQAAAEVARIAGDAALGFFRGGIAVDTKSDGSPVTVADRTAESRAREWLEARF
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHC
PQDGILGEEFGETRPGAKRRWILDPIDGTKTFIRGVPLWGTLVALAEGERILVGAAYFPA
CCCCCCCHHHCCCCCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHCCCCEEEEECHHHHH
VSELLVAAPGRGCFWNDQRAAVSTQAELSQAVVLSTDERFPVYPERGAAWRSLARDAAVD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
RTWGDCYGYLLVATGRAEVMVDELLSPWDGAALQPIIEEAGGVFTDWTGRRTAFGGNGIA
CCHHHHEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCCCCEEECCCCCCH
TNAAMARVVRERLGAVETR
HHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDSGNLMQAAAEVARIAGDAALGFFRGGIAVDTKSDGSPVTVADRTAESRAREWLEARF
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCHHHHHHHHHHHHHC
PQDGILGEEFGETRPGAKRRWILDPIDGTKTFIRGVPLWGTLVALAEGERILVGAAYFPA
CCCCCCCHHHCCCCCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHCCCCEEEEECHHHHH
VSELLVAAPGRGCFWNDQRAAVSTQAELSQAVVLSTDERFPVYPERGAAWRSLARDAAVD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
RTWGDCYGYLLVATGRAEVMVDELLSPWDGAALQPIIEEAGGVFTDWTGRRTAFGGNGIA
CCHHHHEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEECCCCCEEECCCCCCH
TNAAMARVVRERLGAVETR
HHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]