| Definition | Myxococcus xanthus DK 1622 chromosome, complete genome. |
|---|---|
| Accession | NC_008095 |
| Length | 9,139,763 |
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The map label for this gene is thrA [H]
Identifier: 108759004
GI number: 108759004
Start: 2644911
End: 2647370
Strand: Reverse
Name: thrA [H]
Synonym: MXAN_2278
Alternate gene names: 108759004
Gene position: 2647370-2644911 (Counterclockwise)
Preceding gene: 108757768
Following gene: 108757335
Centisome position: 28.97
GC content: 71.71
Gene sequence:
>2460_bases ATGAGGGTGATGAAATTCGGGGGGACGAGCGTGGGCAACGCCGAGCGGATGCGCGGCGTGGCGGACCTGGCCGCGGCGGC GCGCAAGCAGACGCGGGTGATGATGGTCGCCTCGGCCGTGTCCGGCATCACCAACCTCCTGTTGGAAGCGGCCCGCGCGG CCCAGGAAGGTCAGCCGGTGGAGTCGCTCCACGGCCGCTTCGAGGACGTCCACCGCGGCATCATCCGCGAGCTGGCGCCG GAGCTGGGGGAGGCGCGGCAGCGCTCGCTGGAAGAGGGACTTTCCACGCTGGCCTCGGAGCTGCGCGGGCTGCTGCAGGG CGTGGGGCTGCTGCGGGAATGTTCGCCCTCCGTGCTCGCGCACCTGTCCGGACTGGGCGAGCGCGCCGCGTGCCTGATTC TGGGCGCGCTGATGCACGCACGCGGACTGGAGCCGCACGCAGTGGAGCCACGGGACGTCATCCTCTGCGCGGGGGACCCG CTCCAGGCCACGCCGCTCCAGGAGGAGACCCGGGCGCGCTTCACGCCGCTGCGCGAGGCCGGCGGTCCCGGGTTGATGCT GATGCCGGGCTTCTTCGGCGGTGACACCCGGGGCAAGACGATGTGCCTGGGCCGGGGTGGCTCGGATTATTCGGCGGCGC TGGCGGCGGCGGCGCTGGACGCGGAGCTGCTGGAGATCTGGACGGACGTGGACGGCATCTTCAGCGCCGACCCGCGGCTG GTGCCAGAAGCCTTCCCGCTGCCCGAGGTGAGCTTCGAGGAAGCCATGGAGCTGGCCTACTTCGGCGCCAAGGTGCTCCA CCCCAAGACGATTGCGCCCGCGCGCGAGCGCGGCATCCCCGTGCGCGTCTGCAACAGCTTCCGCCCCGACCACCCGGGCA CCCGCGTCACCGACGACGCCGCGCCGCCCGAGCACCCGGTGCGCGGCCTCTCCTTCCTTCCCGGCATCGCCCTGGTGAAC CTGGGCGGCGCGGGGCTCAAGGGCGTTCCGGGCACCGCCGCCCGCGTCTTCGAGTCCATGGCCCTCGCCAACATCTCCGT GGTGCTCATCACCCAGGGCTCCAGCGAATGCTCCATCAGCTTCTGCGTCCAGCAGGCGGACGCGGAGCGCGCCGTGCAGG CCCTGGAAGTCGCGTTCGAGATGGAGCGCGCGGCGGGCAAGGTGGACACCATCGAGCAGCAGCGCGGGCTCGCCGTGCTC AGCATCGTCGGTGATGGCATGCGCCACCGCGTGGGCGTGGCGGGCACCTTCTTCAGCGCGCTGGCGGACGTGGGTTGCAG CATCGCCGCCATCGCGCAGGGCTCCAGCGAGCGCAGCATCTCCGCGGTCATCGCGGAGACGGACGGTCCCCGCGCCCTGG CCCATGTCCACGGTCGGTGCTTCGGCACCACGGAAGTCGTGGAGCTGCTGCTGGCCGGCGTGGGCAGCGTGGGCGGCGAG CTGCTCAAGCAGGTCCACCAGCAGGCGCCCAAGCTGCGCGCCCACGGCGTGGACCTGCGCGTCTGCGTCATCGCCAACAG CAAGCGCGTCGCGACGGCGAGCGAGGGAATTCCCCTGGAGGACTGGAAGCAGCGGCTGGCGGCCAGCAGCGACGGCGCGC CCCTGGACGCCTTCCGCGACTGGGCCCGCGCGAAGCGGCCGGGCCGGCCCGTCTTCGTGGACTGCACCAGCAGCGAGGAC ATCGCGCTCGCCTACCCGTCGCTGATGGAGGCGGGGCTCCACGTCGTCACCGCCAACAAGAAGGCCAACGCCGGCCAGTG GAGCCACTACCGCAAGCTGCGCGAGACGGCCTCCCGTCACCAACGCCGCTTCCTCTACGAGACGAACGTGGGCGCGGCGC TGCCCGTCATCGACACGCTGAAGAACATGCTTCGCACGGGAGACCGGGTGCTGCGCGTGGAAGGCATTCTCTCCGGCTCG CTGTCATTCATCCTGGGCCTGACGGAGGAAGGCGTCCCCTTGTCGCAGGCGGTGGGCACCGCCATGGAGAAGCGCTTCAC CGAACCCGACCCGCGCGACGACCTCCACGGCACCGACGTGGCGCGCAAGGTGCTCATCCTCGCCCGCGAGCTGGGCCGCC AGGTGGAGTTGGAGCAGGTGACGCTGGACTCCCTGCTGCCGTCGGACTTCGACGCCACCGGGCCGCTGGATGACTTCCTC GCCCGGCTCCCCCAGGTGGACGCCGCCTTCCAGCGCCGCGTGGAGACACTCCGCGCGGAGGGCAAGGTGCTACGCTACGT GGGCAGCGTCACGGAGGACGGTTGCTTTGTCGGGCTCGTGCCGGTGCCCCTGACGCACCCGCTGGCGGCGGTGAAGGGCG GAGAGAACGCGCTCAGCTTCACCTCGGAGCGCTACAGCCCCACACCGCTGGTGATTCGCGGCTATGGCGCGGGCGCCGCG GTGACAGCGGCTGGCGTGCTGGCGGACGTGCTCCGCCTGGTCGACGGGCCACTCCCCTGA
Upstream 100 bases:
>100_bases TTTTCACATGCCGCAGGAGCCCCGACATGCAGCCCTCCTCGCAGTCGACACCGACAAACCCGCCGTCCCGCCTCGCCGCC TTCCACGCGGAGGTGCGCTC
Downstream 100 bases:
>100_bases GTTGACGCCCGGTCCGACAGGTCCGCGGCCGATGTACGTTTGAAGTTGGCTGCGGACTTGTCGACAATGCCCCGCCTGCC CTCGAATGCGCGAGAGGCAA
Product: aspartate kinase/homoserine dehydrogenase
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPVESLHGRFEDVHRGIIRELAP ELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLAHLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDP LQATPLQEETRARFTPLREAGGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDAAPPEHPVRGLSFLPGIALVN LGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSISFCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVL SIVGDGMRHRVGVAGTFFSALADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRDWARAKRPGRPVFVDCTSSED IALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRHQRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGS LSFILGLTEEGVPLSQAVGTAMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSFTSERYSPTPLVIRGYGAGAA VTAAGVLADVLRLVDGPLP
Sequences:
>Translated_819_residues MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPVESLHGRFEDVHRGIIRELAP ELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLAHLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDP LQATPLQEETRARFTPLREAGGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDAAPPEHPVRGLSFLPGIALVN LGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSISFCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVL SIVGDGMRHRVGVAGTFFSALADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRDWARAKRPGRPVFVDCTSSED IALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRHQRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGS LSFILGLTEEGVPLSQAVGTAMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSFTSERYSPTPLVIRGYGAGAA VTAAGVLADVLRLVDGPLP >Mature_819_residues MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPVESLHGRFEDVHRGIIRELAP ELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLAHLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDP LQATPLQEETRARFTPLREAGGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDAAPPEHPVRGLSFLPGIALVN LGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSISFCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVL SIVGDGMRHRVGVAGTFFSALADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRDWARAKRPGRPVFVDCTSSED IALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRHQRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGS LSFILGLTEEGVPLSQAVGTAMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSFTSERYSPTPLVIRGYGAGAA VTAAGVLADVLRLVDGPLP
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0460
COG function: function code E; Homoserine dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=826, Percent_Identity=45.0363196125908, Blast_Score=654, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=822, Percent_Identity=28.4671532846715, Blast_Score=288, Evalue=1e-78, Organism=Escherichia coli, GI1790455, Length=470, Percent_Identity=31.7021276595745, Blast_Score=162, Evalue=8e-41, Organism=Saccharomyces cerevisiae, GI6320893, Length=499, Percent_Identity=31.2625250501002, Blast_Score=186, Evalue=1e-47, Organism=Saccharomyces cerevisiae, GI6322599, Length=364, Percent_Identity=36.8131868131868, Blast_Score=176, Evalue=1e-44,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 86964; Mature: 86964
Theoretical pI: Translated: 6.25; Mature: 6.25
Prosite motif: PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPV CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH ESLHGRFEDVHRGIIRELAPELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH HLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDPLQATPLQEETRARFTPLREA HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCHHHC GGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL CCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDA CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCCC APPEHPVRGLSFLPGIALVNLGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSIS CCCCCCCCCHHHCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCCHH FCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVLSIVGDGMRHRVGVAGTFFSA HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHH LADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE HHHCCCCEEEHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHCHHHHH LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRD HHHHHHHHCCCHHHCCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHH WARAKRPGRPVFVDCTSSEDIALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRH HHHHCCCCCCEEEECCCCCCEEEECHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHH QRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGSLSFILGLTEEGVPLSQAVGT HHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCEEEECCCCCCCHHHHHHH AMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHH ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSF HHCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCHHHC TSERYSPTPLVIRGYGAGAAVTAAGVLADVLRLVDGPLP CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCC >Mature Secondary Structure MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPV CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH ESLHGRFEDVHRGIIRELAPELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH HLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDPLQATPLQEETRARFTPLREA HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCHHHC GGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL CCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDA CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCCC APPEHPVRGLSFLPGIALVNLGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSIS CCCCCCCCCHHHCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCCHH FCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVLSIVGDGMRHRVGVAGTFFSA HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHH LADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE HHHCCCCEEEHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHCHHHHH LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRD HHHHHHHHCCCHHHCCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHH WARAKRPGRPVFVDCTSSEDIALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRH HHHHCCCCCCEEEECCCCCCEEEECHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHH QRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGSLSFILGLTEEGVPLSQAVGT HHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCEEEECCCCCCCHHHHHHH AMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHH ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSF HHCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCHHHC TSERYSPTPLVIRGYGAGAAVTAAGVLADVLRLVDGPLP CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]