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The map label for this gene is nuoI

Identifier: 108758967

GI number: 108758967

Start: 3175318

End: 3176082

Strand: Reverse

Name: nuoI

Synonym: MXAN_2726

Alternate gene names: 108758967

Gene position: 3176082-3175318 (Counterclockwise)

Preceding gene: 108761566

Following gene: 108757605

Centisome position: 34.75

GC content: 67.06

Gene sequence:

>765_bases
ATGGCCTACAAGGTAAGCAAGGACCCTCGCACGGATATCCGCGAGCGGACCTATGTGCCCAACCTGCTCCGCGGCCTGGG
CATCACCGCGAAGCACTTCTTCCGCAACCTCTTCGGGACGCGTGACACCAACACGCAGGTGGTGGACCGCACCGGCGCCA
GCCTGATGACGACGGTGGCGTACCCCGAGGAGAAGCCCATCTACCCCGAGGGCTACCGCGGCCTGCACCGGCTGGTTCCG
CGCGAGGACGGCAAGCCGCGCTGCGTGGCTTGCTACATGTGCGCCACCATCTGCCCGGCGCAGTGCATCTACATCGAGGC
GGGTGAGTACGAGGACGAAGCCTCGGACTCCGAGGACCGCGTCATCGAGAAGTACCCCACCCAGTTCGTCATCGACGAGC
TGCGGTGCATCGTGTGCGGCCTCTGCGTGGATGCGTGCCCCAAGGACGCCATCCGCATGGACACCTACACGCACACCCCA
CCCGAGTACACGCGGCAGAACTTCGTCTACGACATTCCGAAGCTGCTCAAGGGCGCGCCGGTGTCCCACCCGTCGGACCC
GTGGAACAAGCGCGAGGGCTCCGAGGAGCCGCACCACGTCCACAAGGAAGCGCACACTCGCATCGGCGAGGGCCTGGTGG
AGCTGAAGCTGCCGCACGGAGAGCACGGCGGCCACGGCAAGGCGCTGCCCGCGGGGGCCCAGGCGGGCCACCAGGCGGTC
GTCACGCAGCAGGGCCCCATCCAGGTGACGAAGTTCATCAAGTGA

Upstream 100 bases:

>100_bases
CGGTGCCCATGACCTGCCGGCGCACGCCCACGGCGTGGCCCCGGCCTCCACCCACTAGGCCGCCCCTTTCGGCCCCAGCA
TCCGGGAATCGAGAACCATC

Downstream 100 bases:

>100_bases
GTCCAGATTCCCAGTGAGGCCGTAGCGGTCTCACCCGGATTCCCGGCCCGCCCTCCCGCATTGAAGCGGAAGGCGGGCCG
GCGCTTTTTCAGGGGGCTGG

Product: NADH dehydrogenase I subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAYKVSKDPRTDIRERTYVPNLLRGLGITAKHFFRNLFGTRDTNTQVVDRTGASLMTTVAYPEEKPIYPEGYRGLHRLVP
REDGKPRCVACYMCATICPAQCIYIEAGEYEDEASDSEDRVIEKYPTQFVIDELRCIVCGLCVDACPKDAIRMDTYTHTP
PEYTRQNFVYDIPKLLKGAPVSHPSDPWNKREGSEEPHHVHKEAHTRIGEGLVELKLPHGEHGGHGKALPAGAQAGHQAV
VTQQGPIQVTKFIK

Sequences:

>Translated_254_residues
MAYKVSKDPRTDIRERTYVPNLLRGLGITAKHFFRNLFGTRDTNTQVVDRTGASLMTTVAYPEEKPIYPEGYRGLHRLVP
REDGKPRCVACYMCATICPAQCIYIEAGEYEDEASDSEDRVIEKYPTQFVIDELRCIVCGLCVDACPKDAIRMDTYTHTP
PEYTRQNFVYDIPKLLKGAPVSHPSDPWNKREGSEEPHHVHKEAHTRIGEGLVELKLPHGEHGGHGKALPAGAQAGHQAV
VTQQGPIQVTKFIK
>Mature_253_residues
AYKVSKDPRTDIRERTYVPNLLRGLGITAKHFFRNLFGTRDTNTQVVDRTGASLMTTVAYPEEKPIYPEGYRGLHRLVPR
EDGKPRCVACYMCATICPAQCIYIEAGEYEDEASDSEDRVIEKYPTQFVIDELRCIVCGLCVDACPKDAIRMDTYTHTPP
EYTRQNFVYDIPKLLKGAPVSHPSDPWNKREGSEEPHHVHKEAHTRIGEGLVELKLPHGEHGGHGKALPAGAQAGHQAVV
TQQGPIQVTKFIK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=184, Percent_Identity=33.1521739130435, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788617, Length=156, Percent_Identity=35.8974358974359, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17555194, Length=160, Percent_Identity=32.5, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17864306, Length=171, Percent_Identity=34.5029239766082, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_MYXXD (Q1D8T0)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630943.1
- STRING:   Q1D8T0
- GeneID:   4101993
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2726
- TIGR:   MXAN_2726
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   YEDEASD
- PhylomeDB:   Q1D8T0
- ProtClustDB:   CLSK946257
- BioCyc:   MXAN246197:MXAN_2726-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 28498; Mature: 28366

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKVSKDPRTDIRERTYVPNLLRGLGITAKHFFRNLFGTRDTNTQVVDRTGASLMTTVA
CCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECCCCCHHEEEEE
YPEEKPIYPEGYRGLHRLVPREDGKPRCVACYMCATICPAQCIYIEAGEYEDEASDSEDR
CCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHH
VIEKYPTQFVIDELRCIVCGLCVDACPKDAIRMDTYTHTPPEYTRQNFVYDIPKLLKGAP
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
VSHPSDPWNKREGSEEPHHVHKEAHTRIGEGLVELKLPHGEHGGHGKALPAGAQAGHQAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCEEE
VTQQGPIQVTKFIK
EECCCCCHHHCCCC
>Mature Secondary Structure 
AYKVSKDPRTDIRERTYVPNLLRGLGITAKHFFRNLFGTRDTNTQVVDRTGASLMTTVA
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECCCCCHHEEEEE
YPEEKPIYPEGYRGLHRLVPREDGKPRCVACYMCATICPAQCIYIEAGEYEDEASDSEDR
CCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHH
VIEKYPTQFVIDELRCIVCGLCVDACPKDAIRMDTYTHTPPEYTRQNFVYDIPKLLKGAP
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
VSHPSDPWNKREGSEEPHHVHKEAHTRIGEGLVELKLPHGEHGGHGKALPAGAQAGHQAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCEEE
VTQQGPIQVTKFIK
EECCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA