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The map label for this gene is pdhB [H]

Identifier: 108758610

GI number: 108758610

Start: 3114297

End: 3115283

Strand: Direct

Name: pdhB [H]

Synonym: MXAN_2667

Alternate gene names: 108758610

Gene position: 3114297-3115283 (Clockwise)

Preceding gene: 108761872

Following gene: 108759682

Centisome position: 34.07

GC content: 66.57

Gene sequence:

>987_bases
ATGCCCGAGTTGATGTACCGCGAGGCGCTGAACCAAGCGCTCGCCGAGGAAATGGAACGCGACGCCAACGTCTATCTGAT
TGGCGAGGAAGTGGGCCGTTACAACGGCGCCTTCAAGGTGTCGCAGGGACTGCTGGACAAGTTCGGGAGCGCGCGCATCA
TCGACGCGCCCATCGCCGAGCTGGGCTTCACCGGCCTGAGCGTGGGCGCGGCCATGGTGGGCTTGCGCCCCGTGGTGGAG
ATGATGACCTGGAACTTCGCGATTCTCGCGATGGACCAGATCGTCAACAACGCGGCCAAGCTGCGGCACATGTCCGGTGG
CCAGCTGCGCTGCCCCATCGTGTTCCGCGGTCCGGGCGGCGCTGGCGGCCGGTTGTCCAGCCAGCACAGCCAGGCGCTGG
AGGCCAACTACGCGCACTTCCCGGGCTTGAAGGTGATTGCGCCCGCCACGCCCGCGGATGCCAAGGGCATGCTCAAGGCT
GCCATCCGGGACGAGAACCCGGTGCTCATGTTCGAGGGCGAGCGGCTCTACGCCATCAAGGGTGAGGTGCCGGAGGGCGA
GCACGTCGTGCCGCTCGGCAAGGCGGACGTGAAGCGCGAGGGCTCCGACGTCACCATCATCACCTGGAGCCGCATGTATT
ACTTCTGCATGCAGGCGGCTGAGGAGTTGGCGAAGGAGGGCATCAGCGTGGAGGTCCTGGACCTGCGCACGCTGCGGCCC
CTGGATGAGGAGGCCATCCTGGCGAGCGTGCGCAAGACGAACCGCGCCGTCATCGTGGAGGAGGGCTGGGCGCTCGCCGG
CGTGGGCGCGTCCGTGGTGGATATCATCCAGTCCAAGGCGTTCGACGACCTGGACGCGCCGGTGGAGCGCGTCACGGGCC
TGGACGTCAACATGTCCTATGCAGCGAACCTGGAGAACGCGACCCAGCCGGACGCACCGAAGATCATCGCCGCGGTGAAG
AAGGTGCTGTACCGCGAGGGAGCTTGA

Upstream 100 bases:

>100_bases
GCGAGCAGGCCGAGGCGGCCGACAAGAAGGCGGGCCTCATCCGCTAGGCGCGCGCTGACCTGTCTACCAACCCTTTTTCG
AGTTCGAGTCGGAGCCGACG

Downstream 100 bases:

>100_bases
ACGCGTATGGCCATTCCCATCCAGATGCCGAGCCTGTCCCCGACGATGACGGAGGGGAAGATCGTCAAGTGGCTCAAGAA
GCAAGGGGACAAGGTGTCCT

Product: pyruvate dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPELMYREALNQALAEEMERDANVYLIGEEVGRYNGAFKVSQGLLDKFGSARIIDAPIAELGFTGLSVGAAMVGLRPVVE
MMTWNFAILAMDQIVNNAAKLRHMSGGQLRCPIVFRGPGGAGGRLSSQHSQALEANYAHFPGLKVIAPATPADAKGMLKA
AIRDENPVLMFEGERLYAIKGEVPEGEHVVPLGKADVKREGSDVTIITWSRMYYFCMQAAEELAKEGISVEVLDLRTLRP
LDEEAILASVRKTNRAVIVEEGWALAGVGASVVDIIQSKAFDDLDAPVERVTGLDVNMSYAANLENATQPDAPKIIAAVK
KVLYREGA

Sequences:

>Translated_328_residues
MPELMYREALNQALAEEMERDANVYLIGEEVGRYNGAFKVSQGLLDKFGSARIIDAPIAELGFTGLSVGAAMVGLRPVVE
MMTWNFAILAMDQIVNNAAKLRHMSGGQLRCPIVFRGPGGAGGRLSSQHSQALEANYAHFPGLKVIAPATPADAKGMLKA
AIRDENPVLMFEGERLYAIKGEVPEGEHVVPLGKADVKREGSDVTIITWSRMYYFCMQAAEELAKEGISVEVLDLRTLRP
LDEEAILASVRKTNRAVIVEEGWALAGVGASVVDIIQSKAFDDLDAPVERVTGLDVNMSYAANLENATQPDAPKIIAAVK
KVLYREGA
>Mature_327_residues
PELMYREALNQALAEEMERDANVYLIGEEVGRYNGAFKVSQGLLDKFGSARIIDAPIAELGFTGLSVGAAMVGLRPVVEM
MTWNFAILAMDQIVNNAAKLRHMSGGQLRCPIVFRGPGGAGGRLSSQHSQALEANYAHFPGLKVIAPATPADAKGMLKAA
IRDENPVLMFEGERLYAIKGEVPEGEHVVPLGKADVKREGSDVTIITWSRMYYFCMQAAEELAKEGISVEVLDLRTLRPL
DEEAILASVRKTNRAVIVEEGWALAGVGASVVDIIQSKAFDDLDAPVERVTGLDVNMSYAANLENATQPDAPKIIAAVKK
VLYREGA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=50.3067484662577, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=47.239263803681, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI4557353, Length=320, Percent_Identity=36.5625, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI34101272, Length=320, Percent_Identity=36.5625, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI1786622, Length=278, Percent_Identity=23.7410071942446, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=51.0769230769231, Blast_Score=341, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17506935, Length=318, Percent_Identity=37.1069182389937, Blast_Score=211, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=52.1472392638037, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=49.3865030674847, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=49.3865030674847, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI160714828, Length=320, Percent_Identity=38.125, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI160714832, Length=320, Percent_Identity=38.125, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=56.043956043956, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=56.043956043956, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35487; Mature: 35356

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELMYREALNQALAEEMERDANVYLIGEEVGRYNGAFKVSQGLLDKFGSARIIDAPIAE
CCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEECCHHH
LGFTGLSVGAAMVGLRPVVEMMTWNFAILAMDQIVNNAAKLRHMSGGQLRCPIVFRGPGG
HCCCHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
AGGRLSSQHSQALEANYAHFPGLKVIAPATPADAKGMLKAAIRDENPVLMFEGERLYAIK
CCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEEEE
GEVPEGEHVVPLGKADVKREGSDVTIITWSRMYYFCMQAAEELAKEGISVEVLDLRTLRP
CCCCCCCEEEECCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCC
LDEEAILASVRKTNRAVIVEEGWALAGVGASVVDIIQSKAFDDLDAPVERVTGLDVNMSY
CCHHHHHHHHHHCCCEEEEECCCEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHH
AANLENATQPDAPKIIAAVKKVLYREGA
HCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PELMYREALNQALAEEMERDANVYLIGEEVGRYNGAFKVSQGLLDKFGSARIIDAPIAE
CCHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEECCHHH
LGFTGLSVGAAMVGLRPVVEMMTWNFAILAMDQIVNNAAKLRHMSGGQLRCPIVFRGPGG
HCCCHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
AGGRLSSQHSQALEANYAHFPGLKVIAPATPADAKGMLKAAIRDENPVLMFEGERLYAIK
CCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEEEE
GEVPEGEHVVPLGKADVKREGSDVTIITWSRMYYFCMQAAEELAKEGISVEVLDLRTLRP
CCCCCCCEEEECCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCC
LDEEAILASVRKTNRAVIVEEGWALAGVGASVVDIIQSKAFDDLDAPVERVTGLDVNMSY
CCHHHHHHHHHHCCCEEEEECCCEEECCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHH
AANLENATQPDAPKIIAAVKKVLYREGA
HCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]