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The map label for this gene is pdhC [H]

Identifier: 108759682

GI number: 108759682

Start: 3115290

End: 3116873

Strand: Direct

Name: pdhC [H]

Synonym: MXAN_2668

Alternate gene names: 108759682

Gene position: 3115290-3116873 (Clockwise)

Preceding gene: 108758610

Following gene: 108763030

Centisome position: 34.09

GC content: 68.94

Gene sequence:

>1584_bases
ATGGCCATTCCCATCCAGATGCCGAGCCTGTCCCCGACGATGACGGAGGGGAAGATCGTCAAGTGGCTCAAGAAGCAAGG
GGACAAGGTGTCCTCCGGCGATGCCGTGGCCGAGGTGGAGACGGACAAGTCCAACCTCGAAATCGAGGCCTACGACGACG
GGTACCTGCTGCAGGTGCTCGTCGGCGAGGGCGAGATGGCCAAGGTGGGCGCGCCCATCGCCTATATCGGTGCGAAGGGT
GAGAAGGTGGGGGCCGGCAAGCAGGTCGCGCCCGCCGCCGCGCCTCCTGAGCAGAAGCCCCAGCCGGCACCCGCGGCCCC
CGCGCCGCAGGCCGCCGCGAAGCCCGCATCGTCGGGCGGCGGCGACAACCGCATCGCCATCCAGATGCCGAGCCTGTCCC
CGACGATGACGGAGGGGAAGATCGTCAAGTGGCTCAAGAAGCAGGGGGACAAGGTGTCCTCCGGCGATGCCGTGGCCGAG
GTGGAGACAGACAAGTCCAACCTCGAAATCGAGGCCTACGACAACGGCACCCTGGCGGAGATCGTCGTCGGAGAGAACCA
GATGGCGAAGGTAGGGGCACCCATCGCGTACCTCACCGCGAAGGGCGCCAAGGCGGCCCCGGCCGCTCCGGCGGCGCAGC
CCAAGCCGCCTGCTCCGGCTCCCGAGAAGCCGGCGGCAGCGAAGCCCGCGGCGGCTCCGGCCCAGGCGGGTGGCCGGCGT
CTCCGCGCCAGCCCCGTGGCGAAGAGAATCGCGCGCGAGAAGGGTCTGGACCTCACCCAGGTGAGTGGCTCCGGTCCGTC
TGGCCGCGTGGTGAAGCGCGACATCGAGGAGGCGCTCGCGCGTGGACCGGCGGCGGTTCCTGCCGCGAAGAAGGCCCCGG
CCGCGCAGCCCGCTCCGGGCGTGCGTCCCGAGCCGACCGTGCTCCCCCTCTCGTCCATGCGCAAGGTCATCGCGCAGCGG
ATGACGGAGGTGAAGCCCGGCGTGCCTCACTTCTACCTCACCATCGAGGTGGACATGGAGGCGGCGTCGAAGGTGCGCGA
AGAGGCGAAGGCGATGGACCTCAAGGTCTCCGTCAACGACCTCATCGTGAAGGCCGTGGCCATGGCGGTGCGCCGTTACC
CGAAGATCAACGTCTCGCTGCAGGGCGACAAGGTCGTCCAGTTCCACAGTGTGGATGTGGGCATCGCGGTGGCGCTGGAG
GAAGGCCTCATCACGCCCATCCTCCGGGATGCGGACCAGAAGGGCCTGCAGGCCATCGCGTCGGGCGTGCGTGAGCTGGC
GGAGCGCGCTCGCAAGCGTGCCCTCAAGCCGGAGGAGTACACCGGCGGCTCCATCACCGTCAGCAACCTGGGCATGTACG
GCATCGACCAGTTCGTCGCCGTCATCAACCCGCCGCAGGCCTCCATCCTCGCGGTGGGTGCCGTCTCCGAGAAGGCGGTG
GTGCGCGATGGTCAGCTGGCGGTCCGGAAGATGATGACGGCGACGCTGTCGTGCGATCACCGCGTCATCGACGGTGCCAT
TGGCGCCGAGTTCCTGCGCGAGCTGCGCGGGCTGCTTGAGCACCCCACGCGGCTGCTGTTCTAG

Upstream 100 bases:

>100_bases
GTCCTATGCAGCGAACCTGGAGAACGCGACCCAGCCGGACGCACCGAAGATCATCGCCGCGGTGAAGAAGGTGCTGTACC
GCGAGGGAGCTTGAACGCGT

Downstream 100 bases:

>100_bases
GCCGTCCGGTTGCCCCGCTCCGTGTGCCCGTCCTGGGGCGCGCGCGGGCGGGGCAGCGCCCGGATGGACCCTTGTTACTT
GCGCGTCGGCTCTTTGCGGC

Product: pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MAIPIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDDGYLLQVLVGEGEMAKVGAPIAYIGAKG
EKVGAGKQVAPAAAPPEQKPQPAPAAPAPQAAAKPASSGGGDNRIAIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAE
VETDKSNLEIEAYDNGTLAEIVVGENQMAKVGAPIAYLTAKGAKAAPAAPAAQPKPPAPAPEKPAAAKPAAAPAQAGGRR
LRASPVAKRIAREKGLDLTQVSGSGPSGRVVKRDIEEALARGPAAVPAAKKAPAAQPAPGVRPEPTVLPLSSMRKVIAQR
MTEVKPGVPHFYLTIEVDMEAASKVREEAKAMDLKVSVNDLIVKAVAMAVRRYPKINVSLQGDKVVQFHSVDVGIAVALE
EGLITPILRDADQKGLQAIASGVRELAERARKRALKPEEYTGGSITVSNLGMYGIDQFVAVINPPQASILAVGAVSEKAV
VRDGQLAVRKMMTATLSCDHRVIDGAIGAEFLRELRGLLEHPTRLLF

Sequences:

>Translated_527_residues
MAIPIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDDGYLLQVLVGEGEMAKVGAPIAYIGAKG
EKVGAGKQVAPAAAPPEQKPQPAPAAPAPQAAAKPASSGGGDNRIAIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAE
VETDKSNLEIEAYDNGTLAEIVVGENQMAKVGAPIAYLTAKGAKAAPAAPAAQPKPPAPAPEKPAAAKPAAAPAQAGGRR
LRASPVAKRIAREKGLDLTQVSGSGPSGRVVKRDIEEALARGPAAVPAAKKAPAAQPAPGVRPEPTVLPLSSMRKVIAQR
MTEVKPGVPHFYLTIEVDMEAASKVREEAKAMDLKVSVNDLIVKAVAMAVRRYPKINVSLQGDKVVQFHSVDVGIAVALE
EGLITPILRDADQKGLQAIASGVRELAERARKRALKPEEYTGGSITVSNLGMYGIDQFVAVINPPQASILAVGAVSEKAV
VRDGQLAVRKMMTATLSCDHRVIDGAIGAEFLRELRGLLEHPTRLLF
>Mature_526_residues
AIPIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDDGYLLQVLVGEGEMAKVGAPIAYIGAKGE
KVGAGKQVAPAAAPPEQKPQPAPAAPAPQAAAKPASSGGGDNRIAIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEV
ETDKSNLEIEAYDNGTLAEIVVGENQMAKVGAPIAYLTAKGAKAAPAAPAAQPKPPAPAPEKPAAAKPAAAPAQAGGRRL
RASPVAKRIAREKGLDLTQVSGSGPSGRVVKRDIEEALARGPAAVPAAKKAPAAQPAPGVRPEPTVLPLSSMRKVIAQRM
TEVKPGVPHFYLTIEVDMEAASKVREEAKAMDLKVSVNDLIVKAVAMAVRRYPKINVSLQGDKVVQFHSVDVGIAVALEE
GLITPILRDADQKGLQAIASGVRELAERARKRALKPEEYTGGSITVSNLGMYGIDQFVAVINPPQASILAVGAVSEKAVV
RDGQLAVRKMMTATLSCDHRVIDGAIGAEFLRELRGLLEHPTRLLF

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=570, Percent_Identity=39.8245614035088, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI203098816, Length=485, Percent_Identity=37.319587628866, Blast_Score=292, Evalue=6e-79,
Organism=Homo sapiens, GI203098753, Length=446, Percent_Identity=38.3408071748879, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI110671329, Length=428, Percent_Identity=26.8691588785047, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI260898739, Length=193, Percent_Identity=40.9326424870466, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI19923748, Length=244, Percent_Identity=33.6065573770492, Blast_Score=127, Evalue=4e-29,
Organism=Escherichia coli, GI1786946, Length=408, Percent_Identity=31.3725490196078, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786305, Length=416, Percent_Identity=30.2884615384615, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17560088, Length=443, Percent_Identity=41.0835214446953, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17538894, Length=302, Percent_Identity=34.4370860927152, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17537937, Length=418, Percent_Identity=26.555023923445, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI25146366, Length=421, Percent_Identity=30.8788598574822, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324258, Length=450, Percent_Identity=37.7777777777778, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6320352, Length=418, Percent_Identity=28.2296650717703, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321632, Length=152, Percent_Identity=36.8421052631579, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129315, Length=439, Percent_Identity=38.0410022779043, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24582497, Length=427, Percent_Identity=37.7049180327869, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI18859875, Length=428, Percent_Identity=27.1028037383178, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645909, Length=228, Percent_Identity=31.5789473684211, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR006257
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 55096; Mature: 54965

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDDGYLLQVL
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCEEEEEE
VGEGEMAKVGAPIAYIGAKGEKVGAGKQVAPAAAPPEQKPQPAPAAPAPQAAAKPASSGG
ECCCCCHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
GDNRIAIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDNGTLAE
CCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEE
IVVGENQMAKVGAPIAYLTAKGAKAAPAAPAAQPKPPAPAPEKPAAAKPAAAPAQAGGRR
EEECCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
LRASPVAKRIAREKGLDLTQVSGSGPSGRVVKRDIEEALARGPAAVPAAKKAPAAQPAPG
CCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VRPEPTVLPLSSMRKVIAQRMTEVKPGVPHFYLTIEVDMEAASKVREEAKAMDLKVSVND
CCCCCCEECHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHEEEEECHHH
LIVKAVAMAVRRYPKINVSLQGDKVVQFHSVDVGIAVALEEGLITPILRDADQKGLQAIA
HHHHHHHHHHHHCCCEEEEECCCEEEEEEECCEEEEEEECCCCCCHHHHCCCHHHHHHHH
SGVRELAERARKRALKPEEYTGGSITVSNLGMYGIDQFVAVINPPQASILAVGAVSEKAV
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHEEECCCCCEEEEEECCCCCHH
VRDGQLAVRKMMTATLSCDHRVIDGAIGAEFLRELRGLLEHPTRLLF
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCC
>Mature Secondary Structure 
AIPIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDDGYLLQVL
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCEEEEEE
VGEGEMAKVGAPIAYIGAKGEKVGAGKQVAPAAAPPEQKPQPAPAAPAPQAAAKPASSGG
ECCCCCHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCC
GDNRIAIQMPSLSPTMTEGKIVKWLKKQGDKVSSGDAVAEVETDKSNLEIEAYDNGTLAE
CCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEE
IVVGENQMAKVGAPIAYLTAKGAKAAPAAPAAQPKPPAPAPEKPAAAKPAAAPAQAGGRR
EEECCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
LRASPVAKRIAREKGLDLTQVSGSGPSGRVVKRDIEEALARGPAAVPAAKKAPAAQPAPG
CCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
VRPEPTVLPLSSMRKVIAQRMTEVKPGVPHFYLTIEVDMEAASKVREEAKAMDLKVSVND
CCCCCCEECHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHEEEEECHHH
LIVKAVAMAVRRYPKINVSLQGDKVVQFHSVDVGIAVALEEGLITPILRDADQKGLQAIA
HHHHHHHHHHHHCCCEEEEECCCEEEEEEECCEEEEEEECCCCCCHHHHCCCHHHHHHHH
SGVRELAERARKRALKPEEYTGGSITVSNLGMYGIDQFVAVINPPQASILAVGAVSEKAV
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHEEECCCCCEEEEEECCCCCHH
VRDGQLAVRKMMTATLSCDHRVIDGAIGAEFLRELRGLLEHPTRLLF
HCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]