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The map label for this gene is yngE [H]

Identifier: 108758347

GI number: 108758347

Start: 4476390

End: 4477931

Strand: Direct

Name: yngE [H]

Synonym: MXAN_3759

Alternate gene names: 108758347

Gene position: 4476390-4477931 (Clockwise)

Preceding gene: 108762855

Following gene: 108757986

Centisome position: 48.98

GC content: 66.28

Gene sequence:

>1542_bases
GTGCCACGGGCCATGTCCCAAGACTCGAGACTGCTGGAGAAGATCGCCCAGGTGGAGAAGGGTGGCGCGCAGAAGTACCA
CGCCAAGAACGCGGAGGCGGGCAAGCTCTTCGCCCGCGAGCGCATCCGTCTGCTGGTGGATGAAGGCTCCTTCGTGGAGG
ACGCGAAGCTCGCCAACAACCTGGACCCGGACCTGCCCTCGGATGGTGTCGTCATCGGCGTGGGCAAGGTGGCCGGGCGC
ACCGTGGCCATCATGGCCAACGACTCCACGGTGAAGGCCGGGAGCTGGGGCGCCCGCACGGTGGAGAAGATCCTCCGCAT
CCAGGAGACGGCCCGAGACCTGCGCTGCCCGCTGTTCTACCTGGTGGACTCCGCCGGTGCCCGCATCACCGACCAGGTGG
AGATGTTCCCCGGGCGGCGGGGCGCCGGCCGCATCTTCTACAACGAGGTGCACATGTCCGGCTTCGTGCCGCAGGTGTGC
CTGCTCTTCGGCCCGTCCGCCGCCGGTGGCGCGTACATCCCCGCGTTCTGCGACCTGGTCATCATGGTGGAAGGCAATGC
CTCCATGTACCTGGGCAGCCCGCGCATGGCGGAGATGGTCATCGGCGAGAAGGTCACCCTGGAGGAGATGGGTGGCGCGA
AGATGCACTGCTCCATCTCCGGCGTCGGCGACGTGCTGGTGAAGACGGAGCAGGAGGCCATCGAGGCGGCGAAGAAGTAC
ATCGGCTACTTCCCGGAGAACTTCTCCCAGGCGCCGCCGCGCGCCGAGCCCAAGGCCCCCAAGGCCGGCGGCAAGAAGGT
GGAAGAGATTGTCCCTGTCGACCAGAACAAGCCCTTCAACATGCATGAGCTCATCAACGAGCTCATCGACGAGGGGAGCT
GGTTCGAGGTGAAGAAGCTCTTCGCCCAGGAGCTCGTCACGGGACTGGCTCGCATCGACGGCCGCCCGGTGGGCATCGTC
GCCAACCAGCCCAAGTACAAGGGCGGCGTGCTGTTCGTGGACAGCGCGGACAAGGCGGCCCGCTTCATCTGGCTGTGTGA
TGCCTTCAACATCCCGCTGCTCTATCTGGCGGACGTGCCGGGCTTCATGATTGGCACCAAGGTGGAGCGCGCGGGTATCA
TCCGCGCCGGCGCGAAGATGATCTCCGCGGTGTCCGAGGCCAGCGTGCCGCGCATCTGCGTGGTGGTCCGCAAGGCCTAC
GGCGCCGGCCTCTACGCCATGAGCGGCCCCGGCTTCGCCCCGGACGCCACCATCGCGCTGCCCGGAGCGATGATCGCCGT
CATGGGCCCGGAGGCGGCGGTGAACGCTGTCTACTACAACAAGATCCAGGAGCTGCCGGAGGCCGAGCGGCCCGCCTACG
TCCAGAAGCTGCGCGACGAGTACAAGCAGGACGTGGACATCTACAAGCTGGCCAGCGAGCTGGTCATCGACGACATCGTC
CCGGGTGACCGGCTGCGTCAAGAGCTCACCCAGCGCTACAGCGTCTACTCCCAGCGGCATCAGCCCCGTGCGGAAAAGAA
ACACGGTGTCTATCCGGTTTGA

Upstream 100 bases:

>100_bases
GCATCCCCTGCGGGGACCGTTCTGCGCGGTGCGTCGTCTGCCTGTCACGCCGCGCCGGTCCCTCAGCGAGAGGGCAGCCA
GCCGTAGCCCTTTCTGCTAT

Downstream 100 bases:

>100_bases
GTAGGTAGCGTTACCCCACCTCCAAGGCCCGGGCTGCGCTTGGGCCGTCTGCTATAGATCCTGCTGACACCATGGATTTT
GACCTTCCAGAAAGCCATCG

Product: carboxyl transferase domain-containing protein

Products: ADP; H+; Malonyl-CoA; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MPRAMSQDSRLLEKIAQVEKGGAQKYHAKNAEAGKLFARERIRLLVDEGSFVEDAKLANNLDPDLPSDGVVIGVGKVAGR
TVAIMANDSTVKAGSWGARTVEKILRIQETARDLRCPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNEVHMSGFVPQVC
LLFGPSAAGGAYIPAFCDLVIMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGAKMHCSISGVGDVLVKTEQEAIEAAKKY
IGYFPENFSQAPPRAEPKAPKAGGKKVEEIVPVDQNKPFNMHELINELIDEGSWFEVKKLFAQELVTGLARIDGRPVGIV
ANQPKYKGGVLFVDSADKAARFIWLCDAFNIPLLYLADVPGFMIGTKVERAGIIRAGAKMISAVSEASVPRICVVVRKAY
GAGLYAMSGPGFAPDATIALPGAMIAVMGPEAAVNAVYYNKIQELPEAERPAYVQKLRDEYKQDVDIYKLASELVIDDIV
PGDRLRQELTQRYSVYSQRHQPRAEKKHGVYPV

Sequences:

>Translated_513_residues
MPRAMSQDSRLLEKIAQVEKGGAQKYHAKNAEAGKLFARERIRLLVDEGSFVEDAKLANNLDPDLPSDGVVIGVGKVAGR
TVAIMANDSTVKAGSWGARTVEKILRIQETARDLRCPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNEVHMSGFVPQVC
LLFGPSAAGGAYIPAFCDLVIMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGAKMHCSISGVGDVLVKTEQEAIEAAKKY
IGYFPENFSQAPPRAEPKAPKAGGKKVEEIVPVDQNKPFNMHELINELIDEGSWFEVKKLFAQELVTGLARIDGRPVGIV
ANQPKYKGGVLFVDSADKAARFIWLCDAFNIPLLYLADVPGFMIGTKVERAGIIRAGAKMISAVSEASVPRICVVVRKAY
GAGLYAMSGPGFAPDATIALPGAMIAVMGPEAAVNAVYYNKIQELPEAERPAYVQKLRDEYKQDVDIYKLASELVIDDIV
PGDRLRQELTQRYSVYSQRHQPRAEKKHGVYPV
>Mature_512_residues
PRAMSQDSRLLEKIAQVEKGGAQKYHAKNAEAGKLFARERIRLLVDEGSFVEDAKLANNLDPDLPSDGVVIGVGKVAGRT
VAIMANDSTVKAGSWGARTVEKILRIQETARDLRCPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNEVHMSGFVPQVCL
LFGPSAAGGAYIPAFCDLVIMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGAKMHCSISGVGDVLVKTEQEAIEAAKKYI
GYFPENFSQAPPRAEPKAPKAGGKKVEEIVPVDQNKPFNMHELINELIDEGSWFEVKKLFAQELVTGLARIDGRPVGIVA
NQPKYKGGVLFVDSADKAARFIWLCDAFNIPLLYLADVPGFMIGTKVERAGIIRAGAKMISAVSEASVPRICVVVRKAYG
AGLYAMSGPGFAPDATIALPGAMIAVMGPEAAVNAVYYNKIQELPEAERPAYVQKLRDEYKQDVDIYKLASELVIDDIVP
GDRLRQELTQRYSVYSQRHQPRAEKKHGVYPV

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=521, Percent_Identity=35.8925143953935, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI295821216, Length=541, Percent_Identity=34.7504621072089, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI11545863, Length=437, Percent_Identity=38.4439359267735, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI310133460, Length=120, Percent_Identity=39.1666666666667, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=501, Percent_Identity=35.9281437125749, Blast_Score=310, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI25147359, Length=501, Percent_Identity=35.9281437125749, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17552936, Length=435, Percent_Identity=40.2298850574713, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24586065, Length=471, Percent_Identity=37.3673036093418, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.2 [C]

Molecular weight: Translated: 55958; Mature: 55827

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRAMSQDSRLLEKIAQVEKGGAQKYHAKNAEAGKLFARERIRLLVDEGSFVEDAKLANN
CCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHCC
LDPDLPSDGVVIGVGKVAGRTVAIMANDSTVKAGSWGARTVEKILRIQETARDLRCPLFY
CCCCCCCCCEEEEECCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEE
LVDSAGARITDQVEMFPGRRGAGRIFYNEVHMSGFVPQVCLLFGPSAAGGAYIPAFCDLV
EECCCCCCCCHHHHHCCCCCCCCEEEEEEHHHCCCHHHHHHHCCCCCCCCCCHHCCCCEE
IMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGAKMHCSISGVGDVLVKTEQEAIEAAKKY
EEEECCCEEEECCCHHHHHHHCCCEEHHHCCCCEEEEEECCCCCHHEECHHHHHHHHHHH
IGYFPENFSQAPPRAEPKAPKAGGKKVEEIVPVDQNKPFNMHELINELIDEGSWFEVKKL
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
FAQELVTGLARIDGRPVGIVANQPKYKGGVLFVDSADKAARFIWLCDAFNIPLLYLADVP
HHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFMIGTKVERAGIIRAGAKMISAVSEASVPRICVVVRKAYGAGLYAMSGPGFAPDATIAL
CCHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEC
PGAMIAVMGPEAAVNAVYYNKIQELPEAERPAYVQKLRDEYKQDVDIYKLASELVIDDIV
CCEEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
PGDRLRQELTQRYSVYSQRHQPRAEKKHGVYPV
CCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure 
PRAMSQDSRLLEKIAQVEKGGAQKYHAKNAEAGKLFARERIRLLVDEGSFVEDAKLANN
CCCCCHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHCC
LDPDLPSDGVVIGVGKVAGRTVAIMANDSTVKAGSWGARTVEKILRIQETARDLRCPLFY
CCCCCCCCCEEEEECCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEE
LVDSAGARITDQVEMFPGRRGAGRIFYNEVHMSGFVPQVCLLFGPSAAGGAYIPAFCDLV
EECCCCCCCCHHHHHCCCCCCCCEEEEEEHHHCCCHHHHHHHCCCCCCCCCCHHCCCCEE
IMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGAKMHCSISGVGDVLVKTEQEAIEAAKKY
EEEECCCEEEECCCHHHHHHHCCCEEHHHCCCCEEEEEECCCCCHHEECHHHHHHHHHHH
IGYFPENFSQAPPRAEPKAPKAGGKKVEEIVPVDQNKPFNMHELINELIDEGSWFEVKKL
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
FAQELVTGLARIDGRPVGIVANQPKYKGGVLFVDSADKAARFIWLCDAFNIPLLYLADVP
HHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFMIGTKVERAGIIRAGAKMISAVSEASVPRICVVVRKAYGAGLYAMSGPGFAPDATIAL
CCHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEC
PGAMIAVMGPEAAVNAVYYNKIQELPEAERPAYVQKLRDEYKQDVDIYKLASELVIDDIV
CCEEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
PGDRLRQELTQRYSVYSQRHQPRAEKKHGVYPV
CCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; ATP; Bicarbonate [C]

Specific reaction: Acetyl-CoA + ATP + Bicarbonate <==> ADP + H+ + Malonyl-CoA + Phosphate [C]

General reaction: Carboxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]