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The map label for this gene is mdeA [H]

Identifier: 108758343

GI number: 108758343

Start: 2292868

End: 2294052

Strand: Direct

Name: mdeA [H]

Synonym: MXAN_1955

Alternate gene names: 108758343

Gene position: 2292868-2294052 (Clockwise)

Preceding gene: 108760871

Following gene: 108757331

Centisome position: 25.09

GC content: 71.05

Gene sequence:

>1185_bases
ATGAGCTCGAAGCAGAAGACGGTGGCGGTGCACGCCGGGACGCGGCTGGCTGGAAGCAAGGCAGTGCCGGTGTCGCCGCC
CATCTACCCGGCGGCGGTGAACTGGTTCGACAGCAGCGATGACCTGGACAGCGCCCTGGACGGGAAGGACTACGCCTACG
CCCGAATCAGCGCGCCCAACACCACGTTGCTGGAGGAGGCGGTGGCCGCGCTGGAAGGCGCCGAGGACTGTGTGGCCTAT
GCCAGCGGCATGGCCGCGCTGCGCTCCGTCTTCGAGGCCCAGGGCTTCCGGGCCGGTGACAAGCTGGTGATGCCGGCGGA
TGGCTACGGCGTCACGCGCGCGCTGTACAAGAGTCTGTGCGCCACGCTGGGCGTGGAGCTGCATGCGTTCCTGATGACGG
ACCCCGAGGTGCCCGAGCGCATCCGAGCGCTGAAGCCGCGCATGGTGCTGGCGGAGAGTATCTCCAATCCGCTGCTGCGC
GTGCCCGACCTGCGCGTGCTGGCGCGGGCCTGCCAGGACGTGGGCGCGACGTTCGTGGTGGATGGCACCTTCCCGTCGCC
CGTGGGACAGCGCGCGTTGGCGCTGGGCGCGGACTACGCGGTGCAGTCCACCAGCAAGTGGCTCAACGGGCACAGCGACG
CGCTGGGCGGCACGGTGAGCGCCTCGCGTGAGCGGATGGCGCCACTGCGCGCCGCGCGGGTGCTGGCGGGGGACGTGCTG
GGGCCCTTCGAGGCGTGGCTCACCCTGCGCGGCCTGCGCACGCTGCCGGTGCGCATGAAGGCGCATGTCGAGCACGCGGC
GCATGTGGCGCGGCGCCTCATGGAGTCGCCCCTGTTGGAGCGGGTCATCTACCCGGGGCTGACTTCGCACCCGGACCACG
CCACCGCGCAGGAGCTACTGCTGGGCGGCGGCCCCATGGTGGCCTTTGAAATCAAGGGCGCGGGGCGGCCGGAGAGCATG
CGCTTCCTGGAGGCGTTGAAGGTGGGGCGGCCCGGTCCTTCACTGGGGGATGTGTGCACGTTGGTGATGCACGCGGCCAG
CGCCAGCGCGCGCCGGTTCACACCGGAGGAGCGGGAGGCCGCGGGCATCCGGGAGAATCTCATCCGCGTCTCCGTGGGGT
TGGAGGACCCAGACGACATCGTGGATGACCTGCTCGCCGCGGTGGCCCAGGGGGTGCGCCGATGA

Upstream 100 bases:

>100_bases
GCGAGTAGTCCACCCGCTCGCGCGGCTCCGCTGAGCATTCCCAGGCCGGCCCCTTCCCGGGGCCGGCCTTTCCATTCCCG
CGAAGGACGCAGCAATCCCC

Downstream 100 bases:

>100_bases
AGATGGTGGACGTGGGGGAGAAGCCGAAGACGGGCCGCGTGGCCGTGGCCACCGCGCTGCTGCGGATGTTGCCCGACACG
CGCGAGCGCATCCTGGCGGG

Product: Cys/Met metabolism PLP-dependent enzyme

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSSKQKTVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPNTTLLEEAVAALEGAEDCVAY
ASGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLCATLGVELHAFLMTDPEVPERIRALKPRMVLAESISNPLLR
VPDLRVLARACQDVGATFVVDGTFPSPVGQRALALGADYAVQSTSKWLNGHSDALGGTVSASRERMAPLRAARVLAGDVL
GPFEAWLTLRGLRTLPVRMKAHVEHAAHVARRLMESPLLERVIYPGLTSHPDHATAQELLLGGGPMVAFEIKGAGRPESM
RFLEALKVGRPGPSLGDVCTLVMHAASASARRFTPEEREAAGIRENLIRVSVGLEDPDDIVDDLLAAVAQGVRR

Sequences:

>Translated_394_residues
MSSKQKTVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPNTTLLEEAVAALEGAEDCVAY
ASGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLCATLGVELHAFLMTDPEVPERIRALKPRMVLAESISNPLLR
VPDLRVLARACQDVGATFVVDGTFPSPVGQRALALGADYAVQSTSKWLNGHSDALGGTVSASRERMAPLRAARVLAGDVL
GPFEAWLTLRGLRTLPVRMKAHVEHAAHVARRLMESPLLERVIYPGLTSHPDHATAQELLLGGGPMVAFEIKGAGRPESM
RFLEALKVGRPGPSLGDVCTLVMHAASASARRFTPEEREAAGIRENLIRVSVGLEDPDDIVDDLLAAVAQGVRR
>Mature_393_residues
SSKQKTVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPNTTLLEEAVAALEGAEDCVAYA
SGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLCATLGVELHAFLMTDPEVPERIRALKPRMVLAESISNPLLRV
PDLRVLARACQDVGATFVVDGTFPSPVGQRALALGADYAVQSTSKWLNGHSDALGGTVSASRERMAPLRAARVLAGDVLG
PFEAWLTLRGLRTLPVRMKAHVEHAAHVARRLMESPLLERVIYPGLTSHPDHATAQELLLGGGPMVAFEIKGAGRPESMR
FLEALKVGRPGPSLGDVCTLVMHAASASARRFTPEEREAAGIRENLIRVSVGLEDPDDIVDDLLAAVAQGVRR

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=36, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI299473759, Length=325, Percent_Identity=32.3076923076923, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI25453487, Length=324, Percent_Identity=31.7901234567901, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1790375, Length=391, Percent_Identity=36.3171355498721, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789383, Length=347, Percent_Identity=29.1066282420749, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17560056, Length=381, Percent_Identity=37.007874015748, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=36.0526315789474, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71980708, Length=400, Percent_Identity=30, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319307, Length=362, Percent_Identity=34.8066298342541, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323333, Length=442, Percent_Identity=28.9592760180996, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321254, Length=409, Percent_Identity=27.3838630806846, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=28.3208020050125, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321170, Length=317, Percent_Identity=29.3375394321767, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922554, Length=393, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 41975; Mature: 41843

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKQKTVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPN
CCCCCCEEEEECCCEECCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCCCCEEEEECCCC
TTLLEEAVAALEGAEDCVAYASGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLC
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHH
ATLGVELHAFLMTDPEVPERIRALKPRMVLAESISNPLLRVPDLRVLARACQDVGATFVV
HHHCHHHEEEEECCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEE
DGTFPSPVGQRALALGADYAVQSTSKWLNGHSDALGGTVSASRERMAPLRAARVLAGDVL
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GPFEAWLTLRGLRTLPVRMKAHVEHAAHVARRLMESPLLERVIYPGLTSHPDHATAQELL
HHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LGGGPMVAFEIKGAGRPESMRFLEALKVGRPGPSLGDVCTLVMHAASASARRFTPEEREA
HCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHH
AGIRENLIRVSVGLEDPDDIVDDLLAAVAQGVRR
HHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKQKTVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPN
CCCCCEEEEECCCEECCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCCCCEEEEECCCC
TTLLEEAVAALEGAEDCVAYASGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLC
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHH
ATLGVELHAFLMTDPEVPERIRALKPRMVLAESISNPLLRVPDLRVLARACQDVGATFVV
HHHCHHHEEEEECCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEE
DGTFPSPVGQRALALGADYAVQSTSKWLNGHSDALGGTVSASRERMAPLRAARVLAGDVL
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GPFEAWLTLRGLRTLPVRMKAHVEHAAHVARRLMESPLLERVIYPGLTSHPDHATAQELL
HHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LGGGPMVAFEIKGAGRPESMRFLEALKVGRPGPSLGDVCTLVMHAASASARRFTPEEREA
HCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHCCCCHHHHH
AGIRENLIRVSVGLEDPDDIVDDLLAAVAQGVRR
HHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]