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The map label for this gene is blh [H]

Identifier: 108758319

GI number: 108758319

Start: 216504

End: 217208

Strand: Reverse

Name: blh [H]

Synonym: MXAN_0179

Alternate gene names: 108758319

Gene position: 217208-216504 (Counterclockwise)

Preceding gene: 108759840

Following gene: 108757850

Centisome position: 2.38

GC content: 70.07

Gene sequence:

>705_bases
ATGCTCTTCCGCCAGCTCTTCGACGCGGACACCTCGACGTATACGTACCTCCTGGCCGACGAGGCCACGGGCGCCGCCGC
GCTCATCGACCCGGTGCTGGAACAGACGGAGCGCGACCTGAAGCTCCTCCGGGAGCTGGGCCTCACGTTGTCCGTGGTGC
TGGAGACGCACGTCCACGCCGACCACGTCACCGGCGCGGGTGTACTCCGCGAGCGGACAGGCGCCACCGTGGTGGCCTCC
AGCCGCGGCGCGCCCTGCGTGGACCGGACGGTGAACCATGGAGACATCGTGCGCGTGGGCGGCCTCGAAGTCCGTGTCCT
CGAGACGCCCGGCCACACCGACGACAGCCTGAGCTTCCTCTGTGAGCGCCGCCTCTTCACCGGGGACGCGCTGCTCATCC
GCGGCACCGGAAGGACGGACTTCCAGAACGGCGACCCGGGCCAACTCTACGACGCCATCACCCGCGTCCTCTTCACCCTT
CCCGACGACACGGCGGTCTACCCCGGCCACGACTACGCCGGGCACGCCATGTCCACGGTGGGCGAGGAGAAGCAGCACAA
CCCCCGGCTGGCTGGACGCACGCGCGCGGACTTCATCGTCTTGATGAACGCGCTCCAGCTCCCACCTCCCCGGAAGCTGG
ACGTGGCCGTCCCCGCCAACCGGGCCTGCGGACACACGCCGCCCTCACCTTCCCTCCAGGCCTGA

Upstream 100 bases:

>100_bases
CCGTGTCCCCTCGACCCGAGTCCCGCCACCTCCATCACCCCGCCTGTTGGCACGTCACTGGCAATGACGGCCTCGCACCC
GATTCCGACGGAGGCGAACG

Downstream 100 bases:

>100_bases
AGTCACGCGGAGCCCCCATGCATCCTCTCTGCGACAACGCCGCGCCCCATCCCGCGGGCTACCGCGACGTGGAGGTGGGA
CAGCTCGCGGCGTTCCTGCC

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MLFRQLFDADTSTYTYLLADEATGAAALIDPVLEQTERDLKLLRELGLTLSVVLETHVHADHVTGAGVLRERTGATVVAS
SRGAPCVDRTVNHGDIVRVGGLEVRVLETPGHTDDSLSFLCERRLFTGDALLIRGTGRTDFQNGDPGQLYDAITRVLFTL
PDDTAVYPGHDYAGHAMSTVGEEKQHNPRLAGRTRADFIVLMNALQLPPPRKLDVAVPANRACGHTPPSPSLQA

Sequences:

>Translated_234_residues
MLFRQLFDADTSTYTYLLADEATGAAALIDPVLEQTERDLKLLRELGLTLSVVLETHVHADHVTGAGVLRERTGATVVAS
SRGAPCVDRTVNHGDIVRVGGLEVRVLETPGHTDDSLSFLCERRLFTGDALLIRGTGRTDFQNGDPGQLYDAITRVLFTL
PDDTAVYPGHDYAGHAMSTVGEEKQHNPRLAGRTRADFIVLMNALQLPPPRKLDVAVPANRACGHTPPSPSLQA
>Mature_234_residues
MLFRQLFDADTSTYTYLLADEATGAAALIDPVLEQTERDLKLLRELGLTLSVVLETHVHADHVTGAGVLRERTGATVVAS
SRGAPCVDRTVNHGDIVRVGGLEVRVLETPGHTDDSLSFLCERRLFTGDALLIRGTGRTDFQNGDPGQLYDAITRVLFTL
PDDTAVYPGHDYAGHAMSTVGEEKQHNPRLAGRTRADFIVLMNALQLPPPRKLDVAVPANRACGHTPPSPSLQA

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=232, Percent_Identity=44.8275862068966, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI94538320, Length=176, Percent_Identity=32.3863636363636, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI94538322, Length=176, Percent_Identity=32.3863636363636, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI21703352, Length=241, Percent_Identity=30.7053941908714, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI116642887, Length=241, Percent_Identity=30.7053941908714, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI14150041, Length=168, Percent_Identity=35.7142857142857, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI46361987, Length=168, Percent_Identity=35.7142857142857, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1787158, Length=202, Percent_Identity=34.1584158415842, Blast_Score=94, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17538952, Length=227, Percent_Identity=45.8149779735683, Blast_Score=206, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17536925, Length=174, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324614, Length=186, Percent_Identity=29.5698924731183, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320478, Length=186, Percent_Identity=30.1075268817204, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI221330176, Length=227, Percent_Identity=48.4581497797357, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24667711, Length=183, Percent_Identity=34.9726775956284, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667703, Length=183, Percent_Identity=34.9726775956284, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356335, Length=174, Percent_Identity=36.2068965517241, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 25315; Mature: 25315

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFRQLFDADTSTYTYLLADEATGAAALIDPVLEQTERDLKLLRELGLTLSVVLETHVHA
CCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCC
DHVTGAGVLRERTGATVVASSRGAPCVDRTVNHGDIVRVGGLEVRVLETPGHTDDSLSFL
CCCCCCHHHHHCCCCEEEECCCCCCHHHCCCCCCCEEEECCEEEEEEECCCCCCHHHHHH
CERRLFTGDALLIRGTGRTDFQNGDPGQLYDAITRVLFTLPDDTAVYPGHDYAGHAMSTV
HHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHEECCCCCEECCCCCCCCHHHHHH
GEEKQHNPRLAGRTRADFIVLMNALQLPPPRKLDVAVPANRACGHTPPSPSLQA
CCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLFRQLFDADTSTYTYLLADEATGAAALIDPVLEQTERDLKLLRELGLTLSVVLETHVHA
CCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHCC
DHVTGAGVLRERTGATVVASSRGAPCVDRTVNHGDIVRVGGLEVRVLETPGHTDDSLSFL
CCCCCCHHHHHCCCCEEEECCCCCCHHHCCCCCCCEEEECCEEEEEEECCCCCCHHHHHH
CERRLFTGDALLIRGTGRTDFQNGDPGQLYDAITRVLFTLPDDTAVYPGHDYAGHAMSTV
HHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHEECCCCCEECCCCCCCCHHHHHH
GEEKQHNPRLAGRTRADFIVLMNALQLPPPRKLDVAVPANRACGHTPPSPSLQA
CCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]