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The map label for this gene is atoC [H]

Identifier: 108759840

GI number: 108759840

Start: 217450

End: 218832

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_0180

Alternate gene names: 108759840

Gene position: 218832-217450 (Counterclockwise)

Preceding gene: 108760109

Following gene: 108758319

Centisome position: 2.39

GC content: 72.6

Gene sequence:

>1383_bases
GTGGCTGCTGAAGAAGTACGGCCTGCCACGCCTCTACTGGGCATTCATGATGCGGGGCCTTGCGTAAGACGCCGGGAGCC
GGGCTATGCACCGGCGATGCCCACCTCCCACCTCGCGCTCCCCGCTCTGGATGCCCTCGCGGGCCCCGTGCTCCTCGTGG
ACGACGCGCGGAAGGTGACCGCGCTCACGCCCGCGCTCGAAGCCCTGCTGGGCGGCACGCTGCGCGCTGGGACACCGCTG
GCGCAGGTCCTGGGGCGCGCTGACGGCACGGAGCCGCTGGACGCCGTCCTGAAGAACGGGTGTGAGGCCTCTGTCCGCTT
GCGCGTGGGTGGGCGCTCGAAGCCCGTGCGGGTGCGCGCCGTCCCCCTGGCGCGAGGGCCTCGGGCATCCGGGTGGGCCC
TGCTCGTCTCGCCTGACGCGGTGGAAGAGACGAACGGTCGCGCGGAGCTGTTCCACGGCCTGTGGACCCAGGCGCCCGAG
TTGCAGCGCGTCTTCCGCATCGTCGAGAAGGTGGCCCGCACCGAGTCCAGCGTGCTCGTTCGCGGGGAGTCGGGCACCGG
CAAGGAGCACATCGCTCACGCGCTGCATGCGCTGTCGGCACGGGCGCGAGGGCCGTTTCGCGCCATCAACTGCGCGGCGC
TGCCGCCCAACCTGCTGGAGAGCGAGCTGTTCGGCCATGTGCGCGGCGCCTTCACGGGCGCGGTGCGCGACAGCCCAGGA
CATTTCCGGCTCGCGGACAAGGGCTCGCTGTTCCTGGACGAGGTGGCGGAGATGCCCCTGGACCTCCAGGCGAAGATGCT
GCGCGTGCTGGAGACGCGCACCGTCATCCCCGTGGGAGGCCGCCAGCCCGTGCCCGTGGACGTGCGCATCATCGCCGCCA
CGCACCGGCCGCTTCGGCGCGAAGTGGAGACGGGGCGCTTCCGCGCGGACTTGATGTACCGCCTGCGCGTGGTGCCGCTC
TTCCTCCCCACGCTGCGGGAGCGACGAGGCGACATCCTCCCACTGGCCCTGCGGTTCCTGGAGGAACTGCACCAGCGAGG
CGCCCGCCGCGTGGAGCGCTTCTCTCCTGGCGCCCGCCGCTTGCTGGAGGAGCACCCCTGGCCCGGCAACGTGCGCGAAC
TGCGCAACGTGATGGAGTACGCCTACGTCATTGGCGAAGGCCCGGTGGTTCGAGAGGCGGACCTGCCACCGGAGTTCTCC
GAGCAGCGGCAGGCCGCTCCCGCGAAGCTGCCGCCTCCGGATGCCTCGCTGGAGCCGGAACGGATCCGCGCCGCGCTCGC
CCAGGCGGGCGGCAACCGCTCCGAGGCCGCGCGCCTGCTCGGCGTCAGCCGCGTGACGCTGTGGCGGCGCCTGCGCGACC
TGGGTGCGACGGCGGAGCGCTGA

Upstream 100 bases:

>100_bases
CCACCGGCTACGGGCGCCTGCTGCTCGCCGAGTTCGACTACGACGGCAAGCCCGCGCCCACCATCCCCTTCATCGACACC
ATGCAGGAGCGGCGCGACAT

Downstream 100 bases:

>100_bases
GCGACGGGCGGACGTCGGCCACGAAACACCACGAGCATGGCCCTCAAACGACGTTTCACGCCTGTTTCAGGTGCGTTTCA
CGCCTGCGCGCTTGAAGCAT

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAAEEVRPATPLLGIHDAGPCVRRREPGYAPAMPTSHLALPALDALAGPVLLVDDARKVTALTPALEALLGGTLRAGTPL
AQVLGRADGTEPLDAVLKNGCEASVRLRVGGRSKPVRVRAVPLARGPRASGWALLVSPDAVEETNGRAELFHGLWTQAPE
LQRVFRIVEKVARTESSVLVRGESGTGKEHIAHALHALSARARGPFRAINCAALPPNLLESELFGHVRGAFTGAVRDSPG
HFRLADKGSLFLDEVAEMPLDLQAKMLRVLETRTVIPVGGRQPVPVDVRIIAATHRPLRREVETGRFRADLMYRLRVVPL
FLPTLRERRGDILPLALRFLEELHQRGARRVERFSPGARRLLEEHPWPGNVRELRNVMEYAYVIGEGPVVREADLPPEFS
EQRQAAPAKLPPPDASLEPERIRAALAQAGGNRSEAARLLGVSRVTLWRRLRDLGATAER

Sequences:

>Translated_460_residues
MAAEEVRPATPLLGIHDAGPCVRRREPGYAPAMPTSHLALPALDALAGPVLLVDDARKVTALTPALEALLGGTLRAGTPL
AQVLGRADGTEPLDAVLKNGCEASVRLRVGGRSKPVRVRAVPLARGPRASGWALLVSPDAVEETNGRAELFHGLWTQAPE
LQRVFRIVEKVARTESSVLVRGESGTGKEHIAHALHALSARARGPFRAINCAALPPNLLESELFGHVRGAFTGAVRDSPG
HFRLADKGSLFLDEVAEMPLDLQAKMLRVLETRTVIPVGGRQPVPVDVRIIAATHRPLRREVETGRFRADLMYRLRVVPL
FLPTLRERRGDILPLALRFLEELHQRGARRVERFSPGARRLLEEHPWPGNVRELRNVMEYAYVIGEGPVVREADLPPEFS
EQRQAAPAKLPPPDASLEPERIRAALAQAGGNRSEAARLLGVSRVTLWRRLRDLGATAER
>Mature_459_residues
AAEEVRPATPLLGIHDAGPCVRRREPGYAPAMPTSHLALPALDALAGPVLLVDDARKVTALTPALEALLGGTLRAGTPLA
QVLGRADGTEPLDAVLKNGCEASVRLRVGGRSKPVRVRAVPLARGPRASGWALLVSPDAVEETNGRAELFHGLWTQAPEL
QRVFRIVEKVARTESSVLVRGESGTGKEHIAHALHALSARARGPFRAINCAALPPNLLESELFGHVRGAFTGAVRDSPGH
FRLADKGSLFLDEVAEMPLDLQAKMLRVLETRTVIPVGGRQPVPVDVRIIAATHRPLRREVETGRFRADLMYRLRVVPLF
LPTLRERRGDILPLALRFLEELHQRGARRVERFSPGARRLLEEHPWPGNVRELRNVMEYAYVIGEGPVVREADLPPEFSE
QRQAAPAKLPPPDASLEPERIRAALAQAGGNRSEAARLLGVSRVTLWRRLRDLGATAER

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=311, Percent_Identity=45.9807073954984, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1790437, Length=300, Percent_Identity=46.3333333333333, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1790299, Length=325, Percent_Identity=44.6153846153846, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1789233, Length=309, Percent_Identity=44.0129449838188, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI87082117, Length=318, Percent_Identity=43.3962264150943, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788905, Length=299, Percent_Identity=43.1438127090301, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786524, Length=314, Percent_Identity=43.6305732484076, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI87082152, Length=314, Percent_Identity=43.312101910828, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1789087, Length=325, Percent_Identity=42.1538461538462, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=40.8805031446541, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787583, Length=319, Percent_Identity=34.1692789968652, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=32.4590163934426, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=37.9310344827586, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50236; Mature: 50105

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAEEVRPATPLLGIHDAGPCVRRREPGYAPAMPTSHLALPALDALAGPVLLVDDARKVT
CCCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCHHH
ALTPALEALLGGTLRAGTPLAQVLGRADGTEPLDAVLKNGCEASVRLRVGGRSKPVRVRA
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEEE
VPLARGPRASGWALLVSPDAVEETNGRAELFHGLWTQAPELQRVFRIVEKVARTESSVLV
ECCCCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEE
RGESGTGKEHIAHALHALSARARGPFRAINCAALPPNLLESELFGHVRGAFTGAVRDSPG
ECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
HFRLADKGSLFLDEVAEMPLDLQAKMLRVLETRTVIPVGGRQPVPVDVRIIAATHRPLRR
CEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHCCEEECCCCCCCCEEEEEEEECCCHHHH
EVETGRFRADLMYRLRVVPLFLPTLRERRGDILPLALRFLEELHQRGARRVERFSPGARR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLEEHPWPGNVRELRNVMEYAYVIGEGPVVREADLPPEFSEQRQAAPAKLPPPDASLEPE
HHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHH
RIRAALAQAGGNRSEAARLLGVSRVTLWRRLRDLGATAER
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AAEEVRPATPLLGIHDAGPCVRRREPGYAPAMPTSHLALPALDALAGPVLLVDDARKVT
CCCCCCCCCCEEECCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCHHH
ALTPALEALLGGTLRAGTPLAQVLGRADGTEPLDAVLKNGCEASVRLRVGGRSKPVRVRA
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEEE
VPLARGPRASGWALLVSPDAVEETNGRAELFHGLWTQAPELQRVFRIVEKVARTESSVLV
ECCCCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEE
RGESGTGKEHIAHALHALSARARGPFRAINCAALPPNLLESELFGHVRGAFTGAVRDSPG
ECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
HFRLADKGSLFLDEVAEMPLDLQAKMLRVLETRTVIPVGGRQPVPVDVRIIAATHRPLRR
CEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHCCEEECCCCCCCCEEEEEEEECCCHHHH
EVETGRFRADLMYRLRVVPLFLPTLRERRGDILPLALRFLEELHQRGARRVERFSPGARR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LLEEHPWPGNVRELRNVMEYAYVIGEGPVVREADLPPEFSEQRQAAPAKLPPPDASLEPE
HHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHH
RIRAALAQAGGNRSEAARLLGVSRVTLWRRLRDLGATAER
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]