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The map label for this gene is guaA [H]

Identifier: 108758106

GI number: 108758106

Start: 6996698

End: 6997453

Strand: Direct

Name: guaA [H]

Synonym: MXAN_5631

Alternate gene names: 108758106

Gene position: 6996698-6997453 (Clockwise)

Preceding gene: 108761814

Following gene: 108758740

Centisome position: 76.55

GC content: 70.5

Gene sequence:

>756_bases
ATGCGGCAACCTACGGCGGTGAAGAACGTCCTCTTGCTGAAAGCCGGTGAGGCGGCCGAGGCCGTGCGCGTCTCCGTCGG
CGATTACGACCGGTGGTTTCTGCAAGCCATCGGACTGTCCGGCTACCGCTTCGACATCGTGCTGGCACACCGGGACGCCC
CCTTGCCCACGCGCGCGGATGGCTACGACGCGGTGATGATGACGGGCTCGCCGCTGTCGGTGACGGCGCTCGAGCCGTGG
ATGAAGCGCGCCGCGGACTTCATGGTGGAGGCCGGTGAGCGGGGCACGCCCGTGCTGGGCGTGTGCTTCGGCCAGCAACT
CCTGGCGCATGCGTATGGCGGCCGCGTCTCGCGCAATCCCCAGGGGCGGGAGACGGGCAGCGTCGAGGTGACGCTCACCG
AGGCCGGCAAGCAGGACCCACTCTTCGACGGCGTGCCGGAGCGCTTCATCGCGCAGGCGACGCACGAGGACATCGTCTCG
CACCTCCCCGACGGCGCGCAGGTTCTGGCGGGCAACGCGAACACGGCCGCGCAGGCGCTGGCCTTCCGCCCCACCGTGCG
CGGCGTGCAGTTCTATCCAGAGGCCAGCGTGGACACCCTCCGCGCCGTCATCGAGGCCCGCTGGGAGGGCCTCGAGCGGG
ACTCCGTGGCGCGAGGCGCCGCGCCCGGCGAATACGTCCGTCAGCTCCTGGCGGGCCTCACACCCTCTCCCGCGGGCCGC
AGAATCCTGCTGAACTTCCTCGAGCGATTCACCTGA

Upstream 100 bases:

>100_bases
GGCGCCGGTCATGTGGGTACCTCGAAGCACACGGGCGCGTTCCACTGCGACTGGCCAGGAACGGACACGCGGGGCACGAC
ACGGTAGGAATGGGGACGCA

Downstream 100 bases:

>100_bases
CCTGACAGAGGCCCTCCGTGTCCCGTCTTGCCCTGCCGACCCTGCTCCTCGCCCTGCTCACCACCGCGTGCTCGGAAGAC
CTGTGCACCCAGGCGCCCCG

Product: class I glutamine amidotransferase family protein

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MRQPTAVKNVLLLKAGEAAEAVRVSVGDYDRWFLQAIGLSGYRFDIVLAHRDAPLPTRADGYDAVMMTGSPLSVTALEPW
MKRAADFMVEAGERGTPVLGVCFGQQLLAHAYGGRVSRNPQGRETGSVEVTLTEAGKQDPLFDGVPERFIAQATHEDIVS
HLPDGAQVLAGNANTAAQALAFRPTVRGVQFYPEASVDTLRAVIEARWEGLERDSVARGAAPGEYVRQLLAGLTPSPAGR
RILLNFLERFT

Sequences:

>Translated_251_residues
MRQPTAVKNVLLLKAGEAAEAVRVSVGDYDRWFLQAIGLSGYRFDIVLAHRDAPLPTRADGYDAVMMTGSPLSVTALEPW
MKRAADFMVEAGERGTPVLGVCFGQQLLAHAYGGRVSRNPQGRETGSVEVTLTEAGKQDPLFDGVPERFIAQATHEDIVS
HLPDGAQVLAGNANTAAQALAFRPTVRGVQFYPEASVDTLRAVIEARWEGLERDSVARGAAPGEYVRQLLAGLTPSPAGR
RILLNFLERFT
>Mature_251_residues
MRQPTAVKNVLLLKAGEAAEAVRVSVGDYDRWFLQAIGLSGYRFDIVLAHRDAPLPTRADGYDAVMMTGSPLSVTALEPW
MKRAADFMVEAGERGTPVLGVCFGQQLLAHAYGGRVSRNPQGRETGSVEVTLTEAGKQDPLFDGVPERFIAQATHEDIVS
HLPDGAQVLAGNANTAAQALAFRPTVRGVQFYPEASVDTLRAVIEARWEGLERDSVARGAAPGEYVRQLLAGLTPSPAGR
RILLNFLERFT

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=139, Percent_Identity=30.9352517985612, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 27143; Mature: 27143

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQPTAVKNVLLLKAGEAAEAVRVSVGDYDRWFLQAIGLSGYRFDIVLAHRDAPLPTRAD
CCCCHHHHHEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
GYDAVMMTGSPLSVTALEPWMKRAADFMVEAGERGTPVLGVCFGQQLLAHAYGGRVSRNP
CCCEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCC
QGRETGSVEVTLTEAGKQDPLFDGVPERFIAQATHEDIVSHLPDGAQVLAGNANTAAQAL
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
AFRPTVRGVQFYPEASVDTLRAVIEARWEGLERDSVARGAAPGEYVRQLLAGLTPSPAGR
HHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCH
RILLNFLERFT
HHHHHHHHHCC
>Mature Secondary Structure
MRQPTAVKNVLLLKAGEAAEAVRVSVGDYDRWFLQAIGLSGYRFDIVLAHRDAPLPTRAD
CCCCHHHHHEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
GYDAVMMTGSPLSVTALEPWMKRAADFMVEAGERGTPVLGVCFGQQLLAHAYGGRVSRNP
CCCEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCC
QGRETGSVEVTLTEAGKQDPLFDGVPERFIAQATHEDIVSHLPDGAQVLAGNANTAAQAL
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
AFRPTVRGVQFYPEASVDTLRAVIEARWEGLERDSVARGAAPGEYVRQLLAGLTPSPAGR
HHCCCCCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCH
RILLNFLERFT
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA