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The map label for this gene is mutA [H]

Identifier: 108758002

GI number: 108758002

Start: 2626145

End: 2628025

Strand: Reverse

Name: mutA [H]

Synonym: MXAN_2264

Alternate gene names: 108758002

Gene position: 2628025-2626145 (Counterclockwise)

Preceding gene: 108762273

Following gene: 108762175

Centisome position: 28.75

GC content: 73.95

Gene sequence:

>1881_bases
ATGGCTCAAGAGCCTCTCCATATCGCCTCGGAGTTCCCGGCCCCGTCGGTGGAAGACTGGCGCCGGCTCGTGGACAAGGA
CCTGAAGGGCAAGCCCTTCACCGCGCTCCAGTCGCAGTTGGAAGGCGGCCTATCGCTCCAGCCGCTCTACACGCAGCAGG
ATGCCGCCGTCGCGCCGCCCGGCGTGGCCCCCTACGTGCGCGGCACCCAGGCCCTGGGCCTCACCGAGGGTGGATGGCTG
GTGTGCCAGGAGTACAGCGAGCCAGACGTGACGCAGGCCGCCGAGGCCATCCGCACGGACCTGGACCGGGGCGGCTGGGG
CGTGTGGCTCCACCTGGGCGACACGCACGGCGTTCGCGTACCGGATGCCGAGGCGCTGCGGCGGCTGCTCGCCCATGCGC
CACTGGACACGACGCCCGTCCACCTGGAGCCCGAGTCCGACCCGCTGGCCGCCGCCCAGCGCCTGCTCCACGTCGCGGAG
CAGACGGGCGTGTCCCGCGCGGCGCTGAAGGGCAGCCTCGGCGTGGATCCGCTCGGCATCCTGGCCCGTACGGGCTCGCT
GCCCATGGGGCTGGACGCGACGCTTTCCCAGGCCGCGCCCCTGGTCACCTCGCTGCGTGAAGCCGCGCCCGGCCTCCGGG
TGCTGCTCGTGTCCACGCGCGCCTACGCGGACGCGGGCGCCACATCGGTGCACGAGCTGGCCTGGGCCATCGCCACGGGC
GTGGCGTACCTGCGCGGACTGGAGCGCGCGGGCGTCTCCCCCGACGTCGCGGCGCGCTCCGTCCAGTTCGCCATGTCCGT
GGGGGGACAGTTCTTCCCGGAGATTGCCCGGCTGCGCGCGGCGAGGCTCTTGTGGTCCAAGGCCGTGGCGGCCTGTGGCG
GCTCGCCGGAGGCCCAGGCCATGGTGCTGCACGCGCGCACCGCGAGCACCACGAAGACGCAGCGGGACCCGTGGGTGAAC
ATCCTCCGCGCCACCGCGGAGTCCTTCGCCGCCGTCGTCGGTGGCGCGGACAGCGTCAGCACCTCGCCGTTCGACGAAGC
CCTGGGCACGCCCGACGCGTCCGCCCGCCGGCTGGCGCGCAATACGCAGCTCATCCTGCGCGACGAGTCGAGCCTCAACC
GCGTCGCCGACCCCGCGGGCGGCAGCTACTACCTGGAGCAGCTCACACAGGACATCGCCCGCGCGGCGTGGACCGAGCTG
CGGCGCATCGAGGCGCTGGGCCGCATGGAGCAAGCGCTCACGAGCGGCGACGTGGCCCGCGTGCTCGCGGAGACGCGCGC
GGCGCGCGACAAGGCCGTGCGCACCCGCCGCCTGCCCATTGTCGGCGTGAGTGAGTTCCCCCACCTGGGCGAAACACCCG
TTCAGCGGAAGTCCCGCGCCGAGGCGTCCACGGCGCCAGCGACATCGGGCCCCCTGCCGCTGCGCCCGGCGCGAGTGGCC
GAGCCCTTCGAGGCGCTGCGCGACGCGAGCGACCGCCACCTCGCCGCGCACGGTGCACGCCCCAAGGCCTTCCTGGCAAG
CCTGGGCACGGTGGCCGAGCACACCACCCGCTCCACGTGGACGGCCAACGTCCTGGCCGCGGGCGGTATCGAGCCGGCGG
ACCAGCATGGCTTCGCGGACATCGCGGACGCGGTGGCCCGCTTCCAGGCATCCGGCGCGCCGCTCGCCGTCATCTCCGGG
CCGGACGCGCTGTATCCAGAATGGGTGCCCGCGTTGACGGCGGCGCTGAAGTCGAAGGGCGCGCGCGCGGTGGCCGTGGC
GGGCCGGCCCGGTGACCATGAGGCCGCCTTCCGCGCGGCCGGCGTGGACGTCTTCTTCTACGCGGGAGCGGACCTGTTCG
CGCTCCTGTCCTCACTGCACCAGCAGCTCGGAGTGGCCTGA

Upstream 100 bases:

>100_bases
ACGTCCCGTCGGAAGACTGAGGCAGCCCCTCCAAGCCCATTGCCCCGCCGGTCCATTGCGCCTATGGGTCGGTGCCACTC
CCATCCCGCGAGGACGCAGC

Downstream 100 bases:

>100_bases
TGCGCCCCCACGTACCGGACTTCTCGGGCATCGACTTCGACGCCCCCGAAACGCACTCCGCCGCGCCCATGCGCGACCAG
CAACTGCGTCAGGCCGGCGA

Product: methylmalonyl-CoA mutase subunit beta

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MAQEPLHIASEFPAPSVEDWRRLVDKDLKGKPFTALQSQLEGGLSLQPLYTQQDAAVAPPGVAPYVRGTQALGLTEGGWL
VCQEYSEPDVTQAAEAIRTDLDRGGWGVWLHLGDTHGVRVPDAEALRRLLAHAPLDTTPVHLEPESDPLAAAQRLLHVAE
QTGVSRAALKGSLGVDPLGILARTGSLPMGLDATLSQAAPLVTSLREAAPGLRVLLVSTRAYADAGATSVHELAWAIATG
VAYLRGLERAGVSPDVAARSVQFAMSVGGQFFPEIARLRAARLLWSKAVAACGGSPEAQAMVLHARTASTTKTQRDPWVN
ILRATAESFAAVVGGADSVSTSPFDEALGTPDASARRLARNTQLILRDESSLNRVADPAGGSYYLEQLTQDIARAAWTEL
RRIEALGRMEQALTSGDVARVLAETRAARDKAVRTRRLPIVGVSEFPHLGETPVQRKSRAEASTAPATSGPLPLRPARVA
EPFEALRDASDRHLAAHGARPKAFLASLGTVAEHTTRSTWTANVLAAGGIEPADQHGFADIADAVARFQASGAPLAVISG
PDALYPEWVPALTAALKSKGARAVAVAGRPGDHEAAFRAAGVDVFFYAGADLFALLSSLHQQLGVA

Sequences:

>Translated_626_residues
MAQEPLHIASEFPAPSVEDWRRLVDKDLKGKPFTALQSQLEGGLSLQPLYTQQDAAVAPPGVAPYVRGTQALGLTEGGWL
VCQEYSEPDVTQAAEAIRTDLDRGGWGVWLHLGDTHGVRVPDAEALRRLLAHAPLDTTPVHLEPESDPLAAAQRLLHVAE
QTGVSRAALKGSLGVDPLGILARTGSLPMGLDATLSQAAPLVTSLREAAPGLRVLLVSTRAYADAGATSVHELAWAIATG
VAYLRGLERAGVSPDVAARSVQFAMSVGGQFFPEIARLRAARLLWSKAVAACGGSPEAQAMVLHARTASTTKTQRDPWVN
ILRATAESFAAVVGGADSVSTSPFDEALGTPDASARRLARNTQLILRDESSLNRVADPAGGSYYLEQLTQDIARAAWTEL
RRIEALGRMEQALTSGDVARVLAETRAARDKAVRTRRLPIVGVSEFPHLGETPVQRKSRAEASTAPATSGPLPLRPARVA
EPFEALRDASDRHLAAHGARPKAFLASLGTVAEHTTRSTWTANVLAAGGIEPADQHGFADIADAVARFQASGAPLAVISG
PDALYPEWVPALTAALKSKGARAVAVAGRPGDHEAAFRAAGVDVFFYAGADLFALLSSLHQQLGVA
>Mature_625_residues
AQEPLHIASEFPAPSVEDWRRLVDKDLKGKPFTALQSQLEGGLSLQPLYTQQDAAVAPPGVAPYVRGTQALGLTEGGWLV
CQEYSEPDVTQAAEAIRTDLDRGGWGVWLHLGDTHGVRVPDAEALRRLLAHAPLDTTPVHLEPESDPLAAAQRLLHVAEQ
TGVSRAALKGSLGVDPLGILARTGSLPMGLDATLSQAAPLVTSLREAAPGLRVLLVSTRAYADAGATSVHELAWAIATGV
AYLRGLERAGVSPDVAARSVQFAMSVGGQFFPEIARLRAARLLWSKAVAACGGSPEAQAMVLHARTASTTKTQRDPWVNI
LRATAESFAAVVGGADSVSTSPFDEALGTPDASARRLARNTQLILRDESSLNRVADPAGGSYYLEQLTQDIARAAWTELR
RIEALGRMEQALTSGDVARVLAETRAARDKAVRTRRLPIVGVSEFPHLGETPVQRKSRAEASTAPATSGPLPLRPARVAE
PFEALRDASDRHLAAHGARPKAFLASLGTVAEHTTRSTWTANVLAAGGIEPADQHGFADIADAVARFQASGAPLAVISGP
DALYPEWVPALTAALKSKGARAVAVAGRPGDHEAAFRAAGVDVFFYAGADLFALLSSLHQQLGVA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=476, Percent_Identity=28.781512605042, Blast_Score=195, Evalue=9e-50,
Organism=Escherichia coli, GI1789284, Length=468, Percent_Identity=30.3418803418803, Blast_Score=205, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI25144500, Length=459, Percent_Identity=28.322440087146, Blast_Score=188, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65935; Mature: 65804

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQEPLHIASEFPAPSVEDWRRLVDKDLKGKPFTALQSQLEGGLSLQPLYTQQDAAVAPP
CCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVAPYVRGTQALGLTEGGWLVCQEYSEPDVTQAAEAIRTDLDRGGWGVWLHLGDTHGVRV
CCCCHHCCCCEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
PDAEALRRLLAHAPLDTTPVHLEPESDPLAAAQRLLHVAEQTGVSRAALKGSLGVDPLGI
CCHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHH
LARTGSLPMGLDATLSQAAPLVTSLREAAPGLRVLLVSTRAYADAGATSVHELAWAIATG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHHH
VAYLRGLERAGVSPDVAARSVQFAMSVGGQFFPEIARLRAARLLWSKAVAACGGSPEAQA
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
MVLHARTASTTKTQRDPWVNILRATAESFAAVVGGADSVSTSPFDEALGTPDASARRLAR
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHH
NTQLILRDESSLNRVADPAGGSYYLEQLTQDIARAAWTELRRIEALGRMEQALTSGDVAR
CCEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAETRAARDKAVRTRRLPIVGVSEFPHLGETPVQRKSRAEASTAPATSGPLPLRPARVA
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
EPFEALRDASDRHLAAHGARPKAFLASLGTVAEHTTRSTWTANVLAAGGIEPADQHGFAD
HHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCHHCCHHH
IADAVARFQASGAPLAVISGPDALYPEWVPALTAALKSKGARAVAVAGRPGDHEAAFRAA
HHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHC
GVDVFFYAGADLFALLSSLHQQLGVA
CCEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQEPLHIASEFPAPSVEDWRRLVDKDLKGKPFTALQSQLEGGLSLQPLYTQQDAAVAPP
CCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVAPYVRGTQALGLTEGGWLVCQEYSEPDVTQAAEAIRTDLDRGGWGVWLHLGDTHGVRV
CCCCHHCCCCEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
PDAEALRRLLAHAPLDTTPVHLEPESDPLAAAQRLLHVAEQTGVSRAALKGSLGVDPLGI
CCHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHH
LARTGSLPMGLDATLSQAAPLVTSLREAAPGLRVLLVSTRAYADAGATSVHELAWAIATG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHHH
VAYLRGLERAGVSPDVAARSVQFAMSVGGQFFPEIARLRAARLLWSKAVAACGGSPEAQA
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
MVLHARTASTTKTQRDPWVNILRATAESFAAVVGGADSVSTSPFDEALGTPDASARRLAR
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHH
NTQLILRDESSLNRVADPAGGSYYLEQLTQDIARAAWTELRRIEALGRMEQALTSGDVAR
CCEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAETRAARDKAVRTRRLPIVGVSEFPHLGETPVQRKSRAEASTAPATSGPLPLRPARVA
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
EPFEALRDASDRHLAAHGARPKAFLASLGTVAEHTTRSTWTANVLAAGGIEPADQHGFAD
HHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCHHCCHHH
IADAVARFQASGAPLAVISGPDALYPEWVPALTAALKSKGARAVAVAGRPGDHEAAFRAA
HHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHC
GVDVFFYAGADLFALLSSLHQQLGVA
CCEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]