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The map label for this gene is mutB [H]

Identifier: 108762175

GI number: 108762175

Start: 2623953

End: 2626145

Strand: Reverse

Name: mutB [H]

Synonym: MXAN_2263

Alternate gene names: 108762175

Gene position: 2626145-2623953 (Counterclockwise)

Preceding gene: 108758002

Following gene: 108761298

Centisome position: 28.73

GC content: 69.04

Gene sequence:

>2193_bases
ATGCGCCCCCACGTACCGGACTTCTCGGGCATCGACTTCGACGCCCCCGAAACGCACTCCGCCGCGCCCATGCGCGACCA
GCAACTGCGTCAGGCCGGCGAGGCCACGCGCAACGCCGAGCGCTGGGACACGCCCGAGGGCATCCCCGTCAAGCCGGTGT
ACACGCGAGAGGACATGGAGGGCGTGGAGCACCTGGGCTCGCTGCCGGGCCTGCCGCCCTTCGTGCGCGGCCCCTACTCC
ACCATGTACGTGCAGCAGCCGTGGACGGTGCGGCAGTACGCCGGCTTCTCCACGGCCGAGGCCTCCAACGCCTTCTACCG
CCGAAACCTCGCGGCGGGACAGAAGGGCCTGTCCATCGCCTTCGACCTCGCGACGCACCGGGGCTACGACAGCGACCATC
CCCGCGTGGCGGGTGACGTGGGCATGGCGGGCGTGGCCATCGACTCCATCAAGGACATGCGCATCCTGTTCGACCGGATT
CCGCTCGACCAGATGAGCGTGTCCATGACGATGAACGGGGCCGTGCTCCCGGTGCTGGCGCTCTACGTGGTCGCCGCCGA
GGAGCAAGGCGTGCGCCCCGAGCAGCTCAGCGGGACCATCCAGAACGACATCCTCAAGGAGTTCATGGTCCGCAACACGT
ACATCTACCCGCCCGCTCCGTCGATGCGCATCATCGGCGACATCTTCCGCTTCACGGCGGAGAAGATGCCGCGCTTCAAC
AGCATCAGCATCAGCGGCTACCACATGCAGGAAGCCGGGGCGACGCAGGACCTGGAGCTGGGCTACACGCTGGCGGATGG
CGTGGAGTACGTGCGCGCCGGGCTCGCGGCGGGACTGAGCGTGGACGCCTTCGCGCCGCGCCTGTCCTTCTTCTGGGCCA
TTGGCATGAACTTCTTCATGGAAGTGGCCAAGATGCGCGCCGCCCGCCTGCTCTGGGCGAAGCTCATCAAGGGCTTCTCC
CCGAAGACGGACAAGAGCCTGGCGCTGCGCACCCACAGCCAGACGTCGGGATGGAGCCTCACCGCGCAGGACGTCTTCAA
CAATGTCGTGCGCACCTGCGTGGAGGCCATGGCCGCCACCCAGGGCCACACGCAGAGCCTGCACACCAACTCGCTGGACG
AGGCCATCGCGCTGCCCACCGACTTCAGCGCGCGCATCGCCCGCAACACCCAGCTCTATCTCCAGTTGGAGAGCGGCACC
ACGCGCGTCATCGACCCGTGGGGTGGCAGCTACTACGTGGAGCGCCTCACGCACGAACTGGCGCACAAGGCGTGGGCCCA
CATCCAGGAGGTCGAGGCGCTGGGCGGCATGACGAAGGCCATCGAGGCCGGCCTGCCCAAGCTGCGCATCGAGGAGGCGG
CGGCGCGCACCCAGGCGCGCATCGACTCCGGCCGCCAGGCCATCATCGGCGTGAACAAGTACCCGCCCGAGCGCGAGGAC
TCCATCGAGATTCTCAAAGTGGACAACTCGGCGGTGCGCGAGGCGCAGATTGCCCGGCTGCGCGAGCTGCGCGCCGAGCG
CAACGCGGAGGACGTCCGCCGCAAGCTGGACGCGCTCACCGAGGCGGGACGGCGCGGCGAGGGCAACCTGCTGGCACTGG
CCATCGACGCGGCCCGCGCCAAGGCGACGGTGGGCGAAATCAGCGACGCGCTCGAGAAGGTGTTCGGGCGCTACGAGGCC
ACGGTGCGCAGCGTGACGGGTGTGTATTCCAGCGAAGCGGGCAAGGACGCTCAGGGAATCATCGACGCGCGCGAGAAGGC
GGACGCGTTCCTCGCGCGCTTCGGCCGCCGGCCGCGCATCCTCATCGCGAAGATGGGGCAGGACGGACATGACCGCGGCC
AGAAGGTCATCGCCACCGCGTTCGCGGACCTGGGCTTCGACGTGGACATCGGTCCCCTGTTCCAGACGCCCGAGGAGTCC
GCGCGGCAGGCGGTGGAGAACGACGTGCACGTCGTGGGCGCCAGCTCGCTCGCCGCCGGCCACCTGACGCTGGTGCCGCA
ACTCAAGCAGGCCCTCAAGGCGCTGGGCCGTGAGGACATCATGGTCGTCGTGGGCGGCGTCATCCCCGCGCAGGACTACG
ACGCGCTTCGCGCCGCGGGCGCCGCGGCCATCTTCGGCCCTGGCACGGTCATCTCCAAGGCGGCCATCGAACTGCTCGAC
AAGCTGGCCGCGTCGCTGGAGGAAGAGGCGTGA

Upstream 100 bases:

>100_bases
AGGCCGCCTTCCGCGCGGCCGGCGTGGACGTCTTCTTCTACGCGGGAGCGGACCTGTTCGCGCTCCTGTCCTCACTGCAC
CAGCAGCTCGGAGTGGCCTG

Downstream 100 bases:

>100_bases
AGCTGCTGTCCGCGGACGCGTATGTAGACGGTGTGCGCGCGGGTGACCGCGCCATGCTCGCGCGCACCATCACCCTGGTG
GAGAGCGAGCTGCCGCGCCA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 730; Mature: 730

Protein sequence:

>730_residues
MRPHVPDFSGIDFDAPETHSAAPMRDQQLRQAGEATRNAERWDTPEGIPVKPVYTREDMEGVEHLGSLPGLPPFVRGPYS
TMYVQQPWTVRQYAGFSTAEASNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIKDMRILFDRI
PLDQMSVSMTMNGAVLPVLALYVVAAEEQGVRPEQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIGDIFRFTAEKMPRFN
SISISGYHMQEAGATQDLELGYTLADGVEYVRAGLAAGLSVDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLIKGFS
PKTDKSLALRTHSQTSGWSLTAQDVFNNVVRTCVEAMAATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLYLQLESGT
TRVIDPWGGSYYVERLTHELAHKAWAHIQEVEALGGMTKAIEAGLPKLRIEEAAARTQARIDSGRQAIIGVNKYPPERED
SIEILKVDNSAVREAQIARLRELRAERNAEDVRRKLDALTEAGRRGEGNLLALAIDAARAKATVGEISDALEKVFGRYEA
TVRSVTGVYSSEAGKDAQGIIDAREKADAFLARFGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPEES
ARQAVENDVHVVGASSLAAGHLTLVPQLKQALKALGREDIMVVVGGVIPAQDYDALRAAGAAAIFGPGTVISKAAIELLD
KLAASLEEEA

Sequences:

>Translated_730_residues
MRPHVPDFSGIDFDAPETHSAAPMRDQQLRQAGEATRNAERWDTPEGIPVKPVYTREDMEGVEHLGSLPGLPPFVRGPYS
TMYVQQPWTVRQYAGFSTAEASNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIKDMRILFDRI
PLDQMSVSMTMNGAVLPVLALYVVAAEEQGVRPEQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIGDIFRFTAEKMPRFN
SISISGYHMQEAGATQDLELGYTLADGVEYVRAGLAAGLSVDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLIKGFS
PKTDKSLALRTHSQTSGWSLTAQDVFNNVVRTCVEAMAATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLYLQLESGT
TRVIDPWGGSYYVERLTHELAHKAWAHIQEVEALGGMTKAIEAGLPKLRIEEAAARTQARIDSGRQAIIGVNKYPPERED
SIEILKVDNSAVREAQIARLRELRAERNAEDVRRKLDALTEAGRRGEGNLLALAIDAARAKATVGEISDALEKVFGRYEA
TVRSVTGVYSSEAGKDAQGIIDAREKADAFLARFGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPEES
ARQAVENDVHVVGASSLAAGHLTLVPQLKQALKALGREDIMVVVGGVIPAQDYDALRAAGAAAIFGPGTVISKAAIELLD
KLAASLEEEA
>Mature_730_residues
MRPHVPDFSGIDFDAPETHSAAPMRDQQLRQAGEATRNAERWDTPEGIPVKPVYTREDMEGVEHLGSLPGLPPFVRGPYS
TMYVQQPWTVRQYAGFSTAEASNAFYRRNLAAGQKGLSIAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIKDMRILFDRI
PLDQMSVSMTMNGAVLPVLALYVVAAEEQGVRPEQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIGDIFRFTAEKMPRFN
SISISGYHMQEAGATQDLELGYTLADGVEYVRAGLAAGLSVDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLIKGFS
PKTDKSLALRTHSQTSGWSLTAQDVFNNVVRTCVEAMAATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLYLQLESGT
TRVIDPWGGSYYVERLTHELAHKAWAHIQEVEALGGMTKAIEAGLPKLRIEEAAARTQARIDSGRQAIIGVNKYPPERED
SIEILKVDNSAVREAQIARLRELRAERNAEDVRRKLDALTEAGRRGEGNLLALAIDAARAKATVGEISDALEKVFGRYEA
TVRSVTGVYSSEAGKDAQGIIDAREKADAFLARFGRRPRILIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPEES
ARQAVENDVHVVGASSLAAGHLTLVPQLKQALKALGREDIMVVVGGVIPAQDYDALRAAGAAAIFGPGTVISKAAIELLD
KLAASLEEEA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=689, Percent_Identity=64.0058055152395, Blast_Score=924, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=693, Percent_Identity=62.3376623376623, Blast_Score=872, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=689, Percent_Identity=66.1828737300435, Blast_Score=947, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 79617; Mature: 79617

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPHVPDFSGIDFDAPETHSAAPMRDQQLRQAGEATRNAERWDTPEGIPVKPVYTREDME
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
GVEHLGSLPGLPPFVRGPYSTMYVQQPWTVRQYAGFSTAEASNAFYRRNLAAGQKGLSIA
HHHHHHCCCCCCCHHCCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEE
FDLATHRGYDSDHPRVAGDVGMAGVAIDSIKDMRILFDRIPLDQMSVSMTMNGAVLPVLA
EEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHH
LYVVAAEEQGVRPEQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIGDIFRFTAEKMPRFN
HHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCC
SISISGYHMQEAGATQDLELGYTLADGVEYVRAGLAAGLSVDAFAPRLSFFWAIGMNFFM
EEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EVAKMRAARLLWAKLIKGFSPKTDKSLALRTHSQTSGWSLTAQDVFNNVVRTCVEAMAAT
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHC
QGHTQSLHTNSLDEAIALPTDFSARIARNTQLYLQLESGTTRVIDPWGGSYYVERLTHEL
CCCCCCCCCCCCHHHHCCCCCCHHHHCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
AHKAWAHIQEVEALGGMTKAIEAGLPKLRIEEAAARTQARIDSGRQAIIGVNKYPPERED
HHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
SIEILKVDNSAVREAQIARLRELRAERNAEDVRRKLDALTEAGRRGEGNLLALAIDAARA
CEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHH
KATVGEISDALEKVFGRYEATVRSVTGVYSSEAGKDAQGIIDAREKADAFLARFGRRPRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
LIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPEESARQAVENDVHVVGASSLAAG
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCHHCCC
HLTLVPQLKQALKALGREDIMVVVGGVIPAQDYDALRAAGAAAIFGPGTVISKAAIELLD
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHH
KLAASLEEEA
HHHHHHHCCC
>Mature Secondary Structure
MRPHVPDFSGIDFDAPETHSAAPMRDQQLRQAGEATRNAERWDTPEGIPVKPVYTREDME
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
GVEHLGSLPGLPPFVRGPYSTMYVQQPWTVRQYAGFSTAEASNAFYRRNLAAGQKGLSIA
HHHHHHCCCCCCCHHCCCCCEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEE
FDLATHRGYDSDHPRVAGDVGMAGVAIDSIKDMRILFDRIPLDQMSVSMTMNGAVLPVLA
EEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHH
LYVVAAEEQGVRPEQLSGTIQNDILKEFMVRNTYIYPPAPSMRIIGDIFRFTAEKMPRFN
HHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCC
SISISGYHMQEAGATQDLELGYTLADGVEYVRAGLAAGLSVDAFAPRLSFFWAIGMNFFM
EEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EVAKMRAARLLWAKLIKGFSPKTDKSLALRTHSQTSGWSLTAQDVFNNVVRTCVEAMAAT
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHC
QGHTQSLHTNSLDEAIALPTDFSARIARNTQLYLQLESGTTRVIDPWGGSYYVERLTHEL
CCCCCCCCCCCCHHHHCCCCCCHHHHCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
AHKAWAHIQEVEALGGMTKAIEAGLPKLRIEEAAARTQARIDSGRQAIIGVNKYPPERED
HHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
SIEILKVDNSAVREAQIARLRELRAERNAEDVRRKLDALTEAGRRGEGNLLALAIDAARA
CEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHH
KATVGEISDALEKVFGRYEATVRSVTGVYSSEAGKDAQGIIDAREKADAFLARFGRRPRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
LIAKMGQDGHDRGQKVIATAFADLGFDVDIGPLFQTPEESARQAVENDVHVVGASSLAAG
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCHHCCC
HLTLVPQLKQALKALGREDIMVVVGGVIPAQDYDALRAAGAAAIFGPGTVISKAAIELLD
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHH
KLAASLEEEA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]