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The map label for this gene is hisC [H]

Identifier: 108757852

GI number: 108757852

Start: 5186635

End: 5187672

Strand: Reverse

Name: hisC [H]

Synonym: MXAN_4228

Alternate gene names: 108757852

Gene position: 5187672-5186635 (Counterclockwise)

Preceding gene: 108759254

Following gene: 108762544

Centisome position: 56.76

GC content: 68.59

Gene sequence:

>1038_bases
ATGATTCCCAGGCGGGCTTCGTATCGGGACATTCCGCTGTACGCGCCTTCGACGCGGCCGTGCCGGGTGGACCTGAGTGA
CAACACCAACCTCTTTGGCGTTCCGCCCTCCGTGGAGCGGGTTCTTGCCACCACCGTGTCCCGCGTACCGCGTTATCCGC
GGGGTTATGCCCCGGACCTGCGCCGGGCGCTGGCTGCGTCCATTGGAGCGGCGCCCGACGAGATAACGACGGGCTGTGGC
TCGGATGATGTCATCGACTCGGCGCTGCGCGCCTTCTTGGAGCCCGGGGACACGCTGGCCTATCAGGACCCGACCTTCGT
CATGGTGCCGTTGTTCGCCAAGGTGAACGGACTCGAGGGCGTGCCGGTGCCGTTGAAGCCGGACTTCGATGTGGATGCGG
ACGCACTGCTCGGCACGGGGGCGAAGGTCATCTTCCTGTGCTCGCCCAACAACCCCACAGGCACCGCGCTGTCGCGGGCG
GCGGTGGAGCGTGTTGTCGAGGACGCACCTGGCATCGTCATCATCGATGAGGCCTATGCGGACTTCGCGCCGGGGAAGGA
CTTCCTCGACCTGGCGCGACGGCGGTCGAATGTCCTGGTGACGCGCACCTTCTCCAAGGCCTTCGGGCTGGCGGGGCTGA
GAGTCGGGTGGGGCGTCGGAGCGCCCGAACTGGTGGCGGAGCTCGAGAAGGCTCGCGGACCCTACAAGCTCACCAGTGTC
GCGGAGGCCGTGGCCGTCTCGGTGCTGAAGGGTGACGCGGACTGGGTGCGAGCCCGTGCGGAGGAAGCCGTCGCCTGTCG
CGAGCGGCTGCGCGGCGAGTTGGTGTCGTTGGGTCTGACGCCTCTGCCATCGGAAGCCAACTTCCTGATGGTGCCGCTGC
CGGGCGCGTTGGCGGTCGCGGAGCGGATGCGAGAGCGGGACGTGAATGTGCGGGCGTTCCAGGCGCTGACGGGCGTGGGC
GACGCGCTCCGAATCGGTGTGGGGCCCTGGCCCTTGATGGAGGCGGCGCTGGCGGCGCTGCGGGAGGCGCTGCGATGA

Upstream 100 bases:

>100_bases
CGCCCACGGCGGCGGCGTCTCTTGCGGAGGACGTGGGGCGGCTGGCCGACAGTGAAGGTCTCTTCGCGCACGCGGACGCC
GCGCGCGCCTGGGGGCGGCC

Downstream 100 bases:

>100_bases
GAGTCACCTTGTTCGACTACGGCGCGGGAAACCTCCACTCGCTGGCCAAGGCGCTGGCCACGGTGCCGGGCGCTGAGGTG
CGCGTCCAGGAGGACCCCTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MIPRRASYRDIPLYAPSTRPCRVDLSDNTNLFGVPPSVERVLATTVSRVPRYPRGYAPDLRRALAASIGAAPDEITTGCG
SDDVIDSALRAFLEPGDTLAYQDPTFVMVPLFAKVNGLEGVPVPLKPDFDVDADALLGTGAKVIFLCSPNNPTGTALSRA
AVERVVEDAPGIVIIDEAYADFAPGKDFLDLARRRSNVLVTRTFSKAFGLAGLRVGWGVGAPELVAELEKARGPYKLTSV
AEAVAVSVLKGDADWVRARAEEAVACRERLRGELVSLGLTPLPSEANFLMVPLPGALAVAERMRERDVNVRAFQALTGVG
DALRIGVGPWPLMEAALAALREALR

Sequences:

>Translated_345_residues
MIPRRASYRDIPLYAPSTRPCRVDLSDNTNLFGVPPSVERVLATTVSRVPRYPRGYAPDLRRALAASIGAAPDEITTGCG
SDDVIDSALRAFLEPGDTLAYQDPTFVMVPLFAKVNGLEGVPVPLKPDFDVDADALLGTGAKVIFLCSPNNPTGTALSRA
AVERVVEDAPGIVIIDEAYADFAPGKDFLDLARRRSNVLVTRTFSKAFGLAGLRVGWGVGAPELVAELEKARGPYKLTSV
AEAVAVSVLKGDADWVRARAEEAVACRERLRGELVSLGLTPLPSEANFLMVPLPGALAVAERMRERDVNVRAFQALTGVG
DALRIGVGPWPLMEAALAALREALR
>Mature_345_residues
MIPRRASYRDIPLYAPSTRPCRVDLSDNTNLFGVPPSVERVLATTVSRVPRYPRGYAPDLRRALAASIGAAPDEITTGCG
SDDVIDSALRAFLEPGDTLAYQDPTFVMVPLFAKVNGLEGVPVPLKPDFDVDADALLGTGAKVIFLCSPNNPTGTALSRA
AVERVVEDAPGIVIIDEAYADFAPGKDFLDLARRRSNVLVTRTFSKAFGLAGLRVGWGVGAPELVAELEKARGPYKLTSV
AEAVAVSVLKGDADWVRARAEEAVACRERLRGELVSLGLTPLPSEANFLMVPLPGALAVAERMRERDVNVRAFQALTGVG
DALRIGVGPWPLMEAALAALREALR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=326, Percent_Identity=29.7546012269939, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788722, Length=314, Percent_Identity=25.1592356687898, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=348, Percent_Identity=29.3103448275862, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 36843; Mature: 36843

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPRRASYRDIPLYAPSTRPCRVDLSDNTNLFGVPPSVERVLATTVSRVPRYPRGYAPDL
CCCCCCCCCCCCEECCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCHHH
RRALAASIGAAPDEITTGCGSDDVIDSALRAFLEPGDTLAYQDPTFVMVPLFAKVNGLEG
HHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEECCCCEEEEEHHHHCCCCCC
VPVPLKPDFDVDADALLGTGAKVIFLCSPNNPTGTALSRAAVERVVEDAPGIVIIDEAYA
CCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHH
DFAPGKDFLDLARRRSNVLVTRTFSKAFGLAGLRVGWGVGAPELVAELEKARGPYKLTSV
CCCCCHHHHHHHHHHCCEEEEEEHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCHHHHH
AEAVAVSVLKGDADWVRARAEEAVACRERLRGELVSLGLTPLPSEANFLMVPLPGALAVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHH
ERMRERDVNVRAFQALTGVGDALRIGVGPWPLMEAALAALREALR
HHHHHCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIPRRASYRDIPLYAPSTRPCRVDLSDNTNLFGVPPSVERVLATTVSRVPRYPRGYAPDL
CCCCCCCCCCCCEECCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCHHH
RRALAASIGAAPDEITTGCGSDDVIDSALRAFLEPGDTLAYQDPTFVMVPLFAKVNGLEG
HHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEECCCCEEEEEHHHHCCCCCC
VPVPLKPDFDVDADALLGTGAKVIFLCSPNNPTGTALSRAAVERVVEDAPGIVIIDEAYA
CCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHH
DFAPGKDFLDLARRRSNVLVTRTFSKAFGLAGLRVGWGVGAPELVAELEKARGPYKLTSV
CCCCCHHHHHHHHHHCCEEEEEEHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCHHHHH
AEAVAVSVLKGDADWVRARAEEAVACRERLRGELVSLGLTPLPSEANFLMVPLPGALAVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHH
ERMRERDVNVRAFQALTGVGDALRIGVGPWPLMEAALAALREALR
HHHHHCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA