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The map label for this gene is wecC [H]

Identifier: 108757761

GI number: 108757761

Start: 3139093

End: 3140412

Strand: Direct

Name: wecC [H]

Synonym: MXAN_2689

Alternate gene names: 108757761

Gene position: 3139093-3140412 (Clockwise)

Preceding gene: 108762209

Following gene: 108764072

Centisome position: 34.35

GC content: 63.33

Gene sequence:

>1320_bases
ATGGTGAGCAGCCCGCTTCTGGATCGCATCAAGAAGCGGGACGCGAGGGTGGGTGTGGTCGGGCTTGGCTATGTCGGTCT
TCCGCTAGGGATGGCGTTCGCGGAGGCGGGCTTCCCCGTCATGGGGCTCGACGTCGACAAGCGGAAGATCGACAAAATCG
AGAAGGGGGAGAGCTACATCAAGCACATCCCCGGCGCTCCGCTGGCGGAGCTGAGCAAGTCGGGCAAGCTGAAGGCCACC
ACGGACTTCGCCAAGGCGAAGGATATGGACTGCGTCATCATCTGCGTGCCCACGCCGCTCACGGCGTCGCGTGAGCCGGA
CATGAGCTACATCATCCAGACGGGTGAGGCGCTCGCGCCGCACGTGCGTCCTGGACAGCTCTTCATCCTGGAGTCCACCA
CGTACCCGGGGACGACAGAGGAGGTGCTCAAACCGCTGCTGGAGAAGAACGGCCTCAAGGCCGGCAAGGACTTCTACCTG
GCCTTCAGCCCCGAGCGCGAGGACCCGGGCAACAAGAGCTTCAACACCAAGACGATTCCGAAGATTGTCGGTGGCTACTC
ACCCGAATGCTCCGAGATGGCCGCGGCCCTCTACGGCAGCGCGCTGAAGGAAGTGGTGCCGGTGTCCTCCACCCGCGTGG
CGGAGCTGACCAAGCTGCTGGAGAACATCTTCCGCTGCGTCAACATCGCCATGGTCAACGAGATGAAGATGCTCTGCGAC
CGCATGGGCGTGGACGTGTGGGAGGCCATCCAGGCCGCGAGCACCAAGCCCTTCGGCTACATGCCCTTCTACCCAGGCCC
GGGCCTCGGTGGGCATTGCATCCCCATCGACCCGTTCTACCTGACGTGGAAGGCGCGCGAGTACGAGTTCCACACCAAGT
TCATCGAGCTGGCCGGCGAGGTGAACTGGCAGATGCCGTACTACGTGGTGCAGCGCACGATGGAGGCGCTGAACAAGAAC
AAGCAGACGCTCAACGGCGCGAAGGTCCTCTGCCTGGGGGCGGCGTACAAAAAGGACATCGACGACATGCGTGAGAGTCC
ATCGCTGCGCGTCATGACGCTGCTGGCGGAGAAGGGCGCCGAGCTGTCGTACCACGACCCGTACGTCCCCGAGCTGCACA
AGGGCCACGGCTTCAACTTGGAGATGAAGTCCGTGCCGCTGAAGCCGGAGACGCTGGGCCAGTACGACGCGGTCCTCATC
CTCACGGACCACTCGGACATCGACTACGCCATGTTGGTGGACCGCGCGAAGGTCGTCGTCGACACGCGCAACGCCACCAA
GGGTGTCAGCAAGGGTCGTGAGAAAGTGACGAAGGCCTGA

Upstream 100 bases:

>100_bases
GCGTGGTTGAGGTGGGGGGTCGTTTTCCGCTGAGTGTCGGGTCGGGGCGTGACCGTCTTAACGGCACGTCGCATCAGGAG
AGGTGAGGACGATGAGGGTG

Downstream 100 bases:

>100_bases
CAGTCATTCGCCGCCCGCCCGGAAACCGACCCTCCGAGCGGGGGGCCCCTCGTTCACGGATTCCGCCTTCGCGGCATCCG
TGAGCGTGGAGCTGCTCGTA

Product: lipopolysaccharide biosynthesis protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MVSSPLLDRIKKRDARVGVVGLGYVGLPLGMAFAEAGFPVMGLDVDKRKIDKIEKGESYIKHIPGAPLAELSKSGKLKAT
TDFAKAKDMDCVIICVPTPLTASREPDMSYIIQTGEALAPHVRPGQLFILESTTYPGTTEEVLKPLLEKNGLKAGKDFYL
AFSPEREDPGNKSFNTKTIPKIVGGYSPECSEMAAALYGSALKEVVPVSSTRVAELTKLLENIFRCVNIAMVNEMKMLCD
RMGVDVWEAIQAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYEFHTKFIELAGEVNWQMPYYVVQRTMEALNKN
KQTLNGAKVLCLGAAYKKDIDDMRESPSLRVMTLLAEKGAELSYHDPYVPELHKGHGFNLEMKSVPLKPETLGQYDAVLI
LTDHSDIDYAMLVDRAKVVVDTRNATKGVSKGREKVTKA

Sequences:

>Translated_439_residues
MVSSPLLDRIKKRDARVGVVGLGYVGLPLGMAFAEAGFPVMGLDVDKRKIDKIEKGESYIKHIPGAPLAELSKSGKLKAT
TDFAKAKDMDCVIICVPTPLTASREPDMSYIIQTGEALAPHVRPGQLFILESTTYPGTTEEVLKPLLEKNGLKAGKDFYL
AFSPEREDPGNKSFNTKTIPKIVGGYSPECSEMAAALYGSALKEVVPVSSTRVAELTKLLENIFRCVNIAMVNEMKMLCD
RMGVDVWEAIQAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYEFHTKFIELAGEVNWQMPYYVVQRTMEALNKN
KQTLNGAKVLCLGAAYKKDIDDMRESPSLRVMTLLAEKGAELSYHDPYVPELHKGHGFNLEMKSVPLKPETLGQYDAVLI
LTDHSDIDYAMLVDRAKVVVDTRNATKGVSKGREKVTKA
>Mature_439_residues
MVSSPLLDRIKKRDARVGVVGLGYVGLPLGMAFAEAGFPVMGLDVDKRKIDKIEKGESYIKHIPGAPLAELSKSGKLKAT
TDFAKAKDMDCVIICVPTPLTASREPDMSYIIQTGEALAPHVRPGQLFILESTTYPGTTEEVLKPLLEKNGLKAGKDFYL
AFSPEREDPGNKSFNTKTIPKIVGGYSPECSEMAAALYGSALKEVVPVSSTRVAELTKLLENIFRCVNIAMVNEMKMLCD
RMGVDVWEAIQAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYEFHTKFIELAGEVNWQMPYYVVQRTMEALNKN
KQTLNGAKVLCLGAAYKKDIDDMRESPSLRVMTLLAEKGAELSYHDPYVPELHKGHGFNLEMKSVPLKPETLGQYDAVLI
LTDHSDIDYAMLVDRAKVVVDTRNATKGVSKGREKVTKA

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=375, Percent_Identity=25.3333333333333, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI296040438, Length=279, Percent_Identity=25.8064516129032, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI296040443, Length=171, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI48994968, Length=407, Percent_Identity=34.1523341523341, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788340, Length=367, Percent_Identity=23.9782016348774, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=384, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136908, Length=377, Percent_Identity=25.7294429708223, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48466; Mature: 48466

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00720 RASGEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSPLLDRIKKRDARVGVVGLGYVGLPLGMAFAEAGFPVMGLDVDKRKIDKIEKGESYI
CCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCHHH
KHIPGAPLAELSKSGKLKATTDFAKAKDMDCVIICVPTPLTASREPDMSYIIQTGEALAP
HHCCCCCHHHHHCCCCCEEECCHHHHCCCCEEEEEECCCCCCCCCCCHHHEEECCCHHCC
HVRPGQLFILESTTYPGTTEEVLKPLLEKNGLKAGKDFYLAFSPEREDPGNKSFNTKTIP
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHH
KIVGGYSPECSEMAAALYGSALKEVVPVSSTRVAELTKLLENIFRCVNIAMVNEMKMLCD
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMGVDVWEAIQAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYEFHTKFIELAGE
HHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCHHHHHHHHHHHCC
VNWQMPYYVVQRTMEALNKNKQTLNGAKVLCLGAAYKKDIDDMRESPSLRVMTLLAEKGA
CCCCCHHHHHHHHHHHHHCCCHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEEEEHHCCC
ELSYHDPYVPELHKGHGFNLEMKSVPLKPETLGQYDAVLILTDHSDIDYAMLVDRAKVVV
CCCCCCCCCCCCCCCCCCCEEECCCCCCCHHCCCCCEEEEEECCCCCCHHHHCCCEEEEE
DTRNATKGVSKGREKVTKA
ECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSSPLLDRIKKRDARVGVVGLGYVGLPLGMAFAEAGFPVMGLDVDKRKIDKIEKGESYI
CCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCHHH
KHIPGAPLAELSKSGKLKATTDFAKAKDMDCVIICVPTPLTASREPDMSYIIQTGEALAP
HHCCCCCHHHHHCCCCCEEECCHHHHCCCCEEEEEECCCCCCCCCCCHHHEEECCCHHCC
HVRPGQLFILESTTYPGTTEEVLKPLLEKNGLKAGKDFYLAFSPEREDPGNKSFNTKTIP
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCHHH
KIVGGYSPECSEMAAALYGSALKEVVPVSSTRVAELTKLLENIFRCVNIAMVNEMKMLCD
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMGVDVWEAIQAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYEFHTKFIELAGE
HHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEECCHHHHHHHHHHHCC
VNWQMPYYVVQRTMEALNKNKQTLNGAKVLCLGAAYKKDIDDMRESPSLRVMTLLAEKGA
CCCCCHHHHHHHHHHHHHCCCHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEEEEHHCCC
ELSYHDPYVPELHKGHGFNLEMKSVPLKPETLGQYDAVLILTDHSDIDYAMLVDRAKVVV
CCCCCCCCCCCCCCCCCCCEEECCCCCCCHHCCCCCEEEEEECCCCCCHHHHCCCEEEEE
DTRNATKGVSKGREKVTKA
ECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA