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The map label for this gene is zraS [H]

Identifier: 108757728

GI number: 108757728

Start: 5204210

End: 5205316

Strand: Reverse

Name: zraS [H]

Synonym: MXAN_4244

Alternate gene names: 108757728

Gene position: 5205316-5204210 (Counterclockwise)

Preceding gene: 108763091

Following gene: 108757595

Centisome position: 56.95

GC content: 70.55

Gene sequence:

>1107_bases
ATGAGCGAGCCCACCTCTCCGTCCCGTCCGTCCGTCCTGGTGGTGGATGACAACGCGGCCTTTCTGGACAACTTGGAGGA
GTTGCTCGGGGACGCGGGCTACGCGGTCCGCGGCGCGTCCAGTTGCAAGGCGGCACGCGAGCGGGTCCGGGAGGGCTTCG
ACGTGGCGCTGGTGGATCTGCGCCTGCCAGACGGAGACGGGACGGCGCTGGCCGCCGAGCTGAAGGCCGCGTCGCCGGAC
TCGGAGGTGGTGCTGCTCACGGGCTTCGCCACGTTGGAGACGGCGGTGGCCGCGGTGCGGGCGGGCGCGTGTGCGTACCT
GATGAAGCCTTGCGCGCCGCAGGAGCTGCTGCTGACGCTGGAGCAAGCGATGCGGCAGGTGCGCCTGCACGCGGAGAAGC
GCGAGCTGGCGCGGCGCGCCCAGGTGACGGAGAAGCTGGCGGCGGTGGGGACGATGACGGCGGGCCTGTCCCACGAAATC
CGCAATCCACTGAACGCGGCGGCGCTCCAGCTCTCCGTCCTCGAGCGGCGTCTACGGCGTCTTCCGGATGGACAGCAGGC
GCCCTTGCTGGAGCCGCTGCTGTTGGTGCGCGATGAGATTCGCCGCCTGGATCACATCCTGGAGGACTTCCTCCAGTTCG
CGAGGCCACGCGAGTTCCGTCCCGCCTCCGTGGACGTGAACGAGATGCTGCGGCGGGTGGTGGATCTGCTGAGCGGGCAG
GCCGCGTCCCGCAAGGTGTCGCTGGAAGTCACGCCACGCGAGGCGCCGGTGCCGTCGGTGGCGGGCGAGGAGGAGCGGCT
GCGTCAGGTGCTCATCAACCTGTGCCTCAACGCGCTGGAGGCCACGCCAGCGGGAGGCACCGTGACGCTGTCTGCGGGGC
ACGAGGGCGGGCGCGTGTGGCTCACCGTGGACGACAGCGGCCCGGGTGTTCCCCAGGAGGCCCGGGACCGCATCTTCGAG
CCCTTCTTCACCACGAAGGCTCAGGGCTCGGGGCTGGGGCTGTCCATCGTCCATGCCATCGTCACGCAGCATGGTGGTTC
GCTGGAGGTGGACACCGCGCCCGGTGGGGGCGCTCGTTTCATCCTCCGGATGCCGCTGGCGGGGTAG

Upstream 100 bases:

>100_bases
CGCTTGACGGGACCACGGGCGTCTTCTCCAAACCCTTCGACCCAGGCGCGCTGATGGAGGTGCTGGAAACGGCGCACGCG
GCACGTCCCACCCACGCCTT

Downstream 100 bases:

>100_bases
GGCCCGTCAGCGGAATGTAGGATGCGCTACCGGCGCGCCGTCGGGCTGTGGAACTCGAAGGTGTCGCAGTCGTCGCACGT
CCCTGGGGCCGCGGCGCCCA

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSEPTSPSRPSVLVVDDNAAFLDNLEELLGDAGYAVRGASSCKAARERVREGFDVALVDLRLPDGDGTALAAELKAASPD
SEVVLLTGFATLETAVAAVRAGACAYLMKPCAPQELLLTLEQAMRQVRLHAEKRELARRAQVTEKLAAVGTMTAGLSHEI
RNPLNAAALQLSVLERRLRRLPDGQQAPLLEPLLLVRDEIRRLDHILEDFLQFARPREFRPASVDVNEMLRRVVDLLSGQ
AASRKVSLEVTPREAPVPSVAGEEERLRQVLINLCLNALEATPAGGTVTLSAGHEGGRVWLTVDDSGPGVPQEARDRIFE
PFFTTKAQGSGLGLSIVHAIVTQHGGSLEVDTAPGGGARFILRMPLAG

Sequences:

>Translated_368_residues
MSEPTSPSRPSVLVVDDNAAFLDNLEELLGDAGYAVRGASSCKAARERVREGFDVALVDLRLPDGDGTALAAELKAASPD
SEVVLLTGFATLETAVAAVRAGACAYLMKPCAPQELLLTLEQAMRQVRLHAEKRELARRAQVTEKLAAVGTMTAGLSHEI
RNPLNAAALQLSVLERRLRRLPDGQQAPLLEPLLLVRDEIRRLDHILEDFLQFARPREFRPASVDVNEMLRRVVDLLSGQ
AASRKVSLEVTPREAPVPSVAGEEERLRQVLINLCLNALEATPAGGTVTLSAGHEGGRVWLTVDDSGPGVPQEARDRIFE
PFFTTKAQGSGLGLSIVHAIVTQHGGSLEVDTAPGGGARFILRMPLAG
>Mature_367_residues
SEPTSPSRPSVLVVDDNAAFLDNLEELLGDAGYAVRGASSCKAARERVREGFDVALVDLRLPDGDGTALAAELKAASPDS
EVVLLTGFATLETAVAAVRAGACAYLMKPCAPQELLLTLEQAMRQVRLHAEKRELARRAQVTEKLAAVGTMTAGLSHEIR
NPLNAAALQLSVLERRLRRLPDGQQAPLLEPLLLVRDEIRRLDHILEDFLQFARPREFRPASVDVNEMLRRVVDLLSGQA
ASRKVSLEVTPREAPVPSVAGEEERLRQVLINLCLNALEATPAGGTVTLSAGHEGGRVWLTVDDSGPGVPQEARDRIFEP
FFTTKAQGSGLGLSIVHAIVTQHGGSLEVDTAPGGGARFILRMPLAG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=37.219730941704, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=31.063829787234, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=30.3571428571429, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI145693157, Length=249, Percent_Identity=29.718875502008, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=29.3478260869565, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=33.7962962962963, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=211, Percent_Identity=29.3838862559242, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=42.1052631578947, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790300, Length=249, Percent_Identity=29.718875502008, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=227, Percent_Identity=27.7533039647577, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=27.7566539923954, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=34.1666666666667, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=30, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788550, Length=168, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=262, Percent_Identity=23.2824427480916, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=220, Percent_Identity=26.8181818181818, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786912, Length=259, Percent_Identity=27.7992277992278, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=116, Percent_Identity=33.6206896551724, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790567, Length=119, Percent_Identity=32.7731092436975, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=219, Percent_Identity=28.7671232876712, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788279, Length=238, Percent_Identity=23.9495798319328, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39484; Mature: 39352

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPTSPSRPSVLVVDDNAAFLDNLEELLGDAGYAVRGASSCKAARERVREGFDVALVDL
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHCCCCEEEEEE
RLPDGDGTALAAELKAASPDSEVVLLTGFATLETAVAAVRAGACAYLMKPCAPQELLLTL
ECCCCCCCEEEEEHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EQAMRQVRLHAEKRELARRAQVTEKLAAVGTMTAGLSHEIRNPLNAAALQLSVLERRLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LPDGQQAPLLEPLLLVRDEIRRLDHILEDFLQFARPREFRPASVDVNEMLRRVVDLLSGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
AASRKVSLEVTPREAPVPSVAGEEERLRQVLINLCLNALEATPAGGTVTLSAGHEGGRVW
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEE
LTVDDSGPGVPQEARDRIFEPFFTTKAQGSGLGLSIVHAIVTQHGGSLEVDTAPGGGARF
EEECCCCCCCCHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEE
ILRMPLAG
EEECCCCC
>Mature Secondary Structure 
SEPTSPSRPSVLVVDDNAAFLDNLEELLGDAGYAVRGASSCKAARERVREGFDVALVDL
CCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHCCCCEEEEEE
RLPDGDGTALAAELKAASPDSEVVLLTGFATLETAVAAVRAGACAYLMKPCAPQELLLTL
ECCCCCCCEEEEEHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EQAMRQVRLHAEKRELARRAQVTEKLAAVGTMTAGLSHEIRNPLNAAALQLSVLERRLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LPDGQQAPLLEPLLLVRDEIRRLDHILEDFLQFARPREFRPASVDVNEMLRRVVDLLSGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
AASRKVSLEVTPREAPVPSVAGEEERLRQVLINLCLNALEATPAGGTVTLSAGHEGGRVW
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEE
LTVDDSGPGVPQEARDRIFEPFFTTKAQGSGLGLSIVHAIVTQHGGSLEVDTAPGGGARF
EEECCCCCCCCHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEE
ILRMPLAG
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]