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The map label for this gene is metR [H]

Identifier: 108757711

GI number: 108757711

Start: 2030610

End: 2031524

Strand: Reverse

Name: metR [H]

Synonym: MXAN_1711

Alternate gene names: 108757711

Gene position: 2031524-2030610 (Counterclockwise)

Preceding gene: 108761808

Following gene: 108763079

Centisome position: 22.23

GC content: 70.93

Gene sequence:

>915_bases
ATGCTCGAGCTCCGTCACTTCAAGCTGATTGCCGCGGTCGCCGACACGGGAAGCCTGGCCGCTGCGAGCCGGCAGCTTCA
CCTCACGTCCTCGGCACTGAGTCACCAACTCCGCGATGCCGAGGAGCGCCTGGGCGTGCAGCTCTTCCAGCGTCGCCAGC
GCCGCCTGCTCCTGACCGGCGCAGGCGAGAAGCTGCTCCTCTCCGCACGGCGGGTCCTGAGCGAGGTGGCCCAGGCCGAG
GCGGTCTGCCGTGCGCACCCGCAGGACGACCTGCTCCGGCTCAGCACGGGCTGCTACACGGTGTATGGCTGGCTGCCGCC
CATCCTGGGGCGGTGGCAGGCCGAGCACCCACGCGTCGAGCTGCGCATCGTCCTGGAGGCCACGCGCCAGCCTCTTGGGG
CGCTGCTGAATGGCGAGCTGGATCTCGCCTTGACCACCGACGTCCCGCCGCAGGCCCGCCTGGCACAGACTGCACTCTTC
GAGGACGAGCTCATGCTGGTGGTCCCCGAGGACCACGCGCTGGCGCGGCGGGGACATGTCACGGCGGAGGACCTGGTGCG
GGAGCACCTGCTCACCTATGCCGCGCCTCGGGAGCAGCTCGATGTCTTCACGCGCGTGCTCTGGCCGGCGGGCATCGAGC
CGCACCGGGTCTCCCCCGTCCCCCTCACCGAGGCGCTGATCGAGCTGGTGCGTGGCGGTATCGGCGTGACGGCGCTGCCC
CAATGGATGCTGCCGAGCCAGCACCCTGGACTGCAGACGGTCCGGCTGACGCCGCAGGGAATCCGACGCCGCTGGAGCGC
CGTCACCCGCGCATCCCGCCAGCGCCCCGCTCCACTGACCTACTTCATCCAACTGCTCCGCGAGCGCTTCTCCCGCCACG
GCAAAGCAGGGCCACGGGCTGCCTCACGGCGATGA

Upstream 100 bases:

>100_bases
TCCTGGCTCTGGGGCACCAACGTTAAGGAGACCCATTCCATAAGCGCAGCGAAACGATTTCACGATGATGCTGAATTCAG
TTCATGTGAAGCTGACCGGC

Downstream 100 bases:

>100_bases
GTGCCGCCCAAACGCTCTCGCTGCATCATGGGTGAGAGCGCAGAGGCGTGCGCTGTCCTTCCGGTCGCATCTTTGCGCTT
CTTCTCCGCCTTGACCTTGT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLELRHFKLIAAVADTGSLAAASRQLHLTSSALSHQLRDAEERLGVQLFQRRQRRLLLTGAGEKLLLSARRVLSEVAQAE
AVCRAHPQDDLLRLSTGCYTVYGWLPPILGRWQAEHPRVELRIVLEATRQPLGALLNGELDLALTTDVPPQARLAQTALF
EDELMLVVPEDHALARRGHVTAEDLVREHLLTYAAPREQLDVFTRVLWPAGIEPHRVSPVPLTEALIELVRGGIGVTALP
QWMLPSQHPGLQTVRLTPQGIRRRWSAVTRASRQRPAPLTYFIQLLRERFSRHGKAGPRAASRR

Sequences:

>Translated_304_residues
MLELRHFKLIAAVADTGSLAAASRQLHLTSSALSHQLRDAEERLGVQLFQRRQRRLLLTGAGEKLLLSARRVLSEVAQAE
AVCRAHPQDDLLRLSTGCYTVYGWLPPILGRWQAEHPRVELRIVLEATRQPLGALLNGELDLALTTDVPPQARLAQTALF
EDELMLVVPEDHALARRGHVTAEDLVREHLLTYAAPREQLDVFTRVLWPAGIEPHRVSPVPLTEALIELVRGGIGVTALP
QWMLPSQHPGLQTVRLTPQGIRRRWSAVTRASRQRPAPLTYFIQLLRERFSRHGKAGPRAASRR
>Mature_304_residues
MLELRHFKLIAAVADTGSLAAASRQLHLTSSALSHQLRDAEERLGVQLFQRRQRRLLLTGAGEKLLLSARRVLSEVAQAE
AVCRAHPQDDLLRLSTGCYTVYGWLPPILGRWQAEHPRVELRIVLEATRQPLGALLNGELDLALTTDVPPQARLAQTALF
EDELMLVVPEDHALARRGHVTAEDLVREHLLTYAAPREQLDVFTRVLWPAGIEPHRVSPVPLTEALIELVRGGIGVTALP
QWMLPSQHPGLQTVRLTPQGIRRRWSAVTRASRQRPAPLTYFIQLLRERFSRHGKAGPRAASRR

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=294, Percent_Identity=38.7755102040816, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI157672245, Length=303, Percent_Identity=29.7029702970297, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787879, Length=298, Percent_Identity=26.510067114094, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787806, Length=289, Percent_Identity=25.6055363321799, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=24.4897959183673, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788887, Length=252, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790399, Length=248, Percent_Identity=27.8225806451613, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787530, Length=310, Percent_Identity=26.7741935483871, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367136, Length=252, Percent_Identity=24.6031746031746, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790208, Length=297, Percent_Identity=24.5791245791246, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786401, Length=308, Percent_Identity=25, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081904, Length=232, Percent_Identity=27.1551724137931, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=30.4054054054054, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786448, Length=120, Percent_Identity=39.1666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788481, Length=252, Percent_Identity=25.7936507936508, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788296, Length=198, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788706, Length=156, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789173, Length=204, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789204, Length=308, Percent_Identity=27.5974025974026, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082132, Length=253, Percent_Identity=25.6916996047431, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=283, Percent_Identity=23.6749116607774, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34052; Mature: 34052

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELRHFKLIAAVADTGSLAAASRQLHLTSSALSHQLRDAEERLGVQLFQRRQRRLLLTG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
AGEKLLLSARRVLSEVAQAEAVCRAHPQDDLLRLSTGCYTVYGWLPPILGRWQAEHPRVE
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEHHHHHHHHHCCCCCCCCCEE
LRIVLEATRQPLGALLNGELDLALTTDVPPQARLAQTALFEDELMLVVPEDHALARRGHV
EEEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHHHHCCCC
TAEDLVREHLLTYAAPREQLDVFTRVLWPAGIEPHRVSPVPLTEALIELVRGGIGVTALP
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCC
QWMLPSQHPGLQTVRLTPQGIRRRWSAVTRASRQRPAPLTYFIQLLRERFSRHGKAGPRA
HHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
ASRR
CCCC
>Mature Secondary Structure
MLELRHFKLIAAVADTGSLAAASRQLHLTSSALSHQLRDAEERLGVQLFQRRQRRLLLTG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
AGEKLLLSARRVLSEVAQAEAVCRAHPQDDLLRLSTGCYTVYGWLPPILGRWQAEHPRVE
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEHHHHHHHHHCCCCCCCCCEE
LRIVLEATRQPLGALLNGELDLALTTDVPPQARLAQTALFEDELMLVVPEDHALARRGHV
EEEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCHHHHHCCCC
TAEDLVREHLLTYAAPREQLDVFTRVLWPAGIEPHRVSPVPLTEALIELVRGGIGVTALP
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCC
QWMLPSQHPGLQTVRLTPQGIRRRWSAVTRASRQRPAPLTYFIQLLRERFSRHGKAGPRA
HHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
ASRR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]