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The map label for this gene is iorB [H]

Identifier: 108757464

GI number: 108757464

Start: 6043111

End: 6045372

Strand: Reverse

Name: iorB [H]

Synonym: MXAN_4829

Alternate gene names: 108757464

Gene position: 6045372-6043111 (Counterclockwise)

Preceding gene: 108762706

Following gene: 108757967

Centisome position: 66.14

GC content: 70.11

Gene sequence:

>2262_bases
ATGACGAAGCTGCTCACGTTGATTAGCCGGCGCTCGTTCCTGGAAGGGCTGAATCTGTCCGTGGGAGGGCTCGCCCTGGG
GGTCTTCTCCGGAGGCCTGGCCGCGGCGGCCAGTGACGCCTCCACGGCGAAGGGCGCTCCGGGGTTGAACCCGAACGTGT
TCGTCCACGTGGCTCCGGACGGAGCGGTCACCATCGTCTGTGCCCGCTCGGAGATGGGGCAGGGCGTGCGCAGCTCGCTG
CCGGTGCTCGTCGCCGATGAGCTGGGCGCGGACATGGCGCGGGTGACGGTGGCCCAGGCCGACGGTGACAAGGTCTACGG
CGACCAGAACACGGACGGCTCCAGCAGCGTGCGGGGCGTGTACGACGACATCCGCCGCATGGGGGCCACCGCTCGGGTGA
TGCTGGTGGCCGCCGCCGCCCGCCGCTGGAAGGTGAAGCCGGAGGCGTGCGAGGCCCGCGACCACGCGGTGTTCCTCCGC
GATGGCAAGCGCTCGCTGGGCTTTGGCGAACTGGTGGCCGATGCGTCGAGGCTGCCCATCCCGAAGGCGAAGGACGTCAA
GCTGCGGCCGAAGAGTGAGCTGCGGATGGCCGGCCGGCCCATGCCGCTGCTGGATGGCCCGGCCTATGTGACGGGAACCG
CGGTGTTCGGCGCCGACATCCGTCTGCCGGGCATGCTCATCGCGGTGGTGGCGCGCCCGCCTGTCGTGGGCGGCAAGGTC
GTTCGCTTTGACGCCACCCGCGCGCTCGCGGTGCCCGGGGTGAAGAAGGTTCTCGAACTGCCCGCGCCGAAGCCGCCCTA
CACGTTCCAGTTCTGGGGCGGCGTCGCGGTGCTCGCGGAGAACACCTGGGCGGCGATGCGCGGGCGCGATGCCCTGGACA
TCACCTGGGAGGACGGGCCGAACGCCTCCTATGACTCGACGACGTACCGGGAGCAGTTGACGGCGTCGATTCGCGAGCCG
GGAACGGTGGCGCGCAACGTCGGTGACATCGACGCGGCGCTCGCTTCCGCCGCCCGCATCATCCAGGCCGAGTACCACAT
CCCCCACCAGTCCCACGTGCCCATGGAGCCTCCCGTGGCCCTGGCGCGGGTGGAGAACGGGACGTGTGAGGTCTGGGCGC
CCACGCAGCATCCGCAGGCTGCGCGCGGCGTGGCGGCGGCGACGGCGGAGCTGCCAGAGGAGAAGGTCCAGGTCCACGTC
ACGTTCCTGGGCGGAGGTTTCGGCCGCAAGTCCAAGGCGGACTTCATCGCCGAGGTGGTGTGGCTGGCGAAGGAAGCGGG
CGTTCCGGTGCGCGTGCAATGGACGCGCGAGGACGACGTCCGGCACGACTACTACCACCCCGTCAGCGCGCAGCAGCTCA
CCGCTGGGCTGGATGCATCCGGCAAGGTCATCGCGTGGCGGCACCGCACCGCGTTCCCGCCCATCGCGTCCACCTTCGGG
CAGGCCACGCGGCCCAGCCCGTCGGACCTCCAGCAGGGTGTGCTCGACCTGGCGCTCTCCGTGCCCAACGTCCGGGCGGA
GACCTGCGAGGCGCCTCCGCACGTGCGCATCGGCTGGCTCCGGTCCGTCTACAACATCTTCCACGCCTTCTCCGTGAACG
CGTTCGTGGACGAGCTGGCGCACCTTCGCGGCACGGATTCGCGCGACATGCTCCTGGAGGTGCTGGGGCCGCCGCGCAAG
GCGTCGCTCCAGGAACTGGGCATCACCGCGCTGCGGAACTATGGCGCGTCGGTGGAGGACCACCCCGTGGACGCGGGGCG
CTTGCGCGGCGTCATCGAGCGCGTGACGGCGATGTCCGGCTGGGACGCGCGCAAGGCGAATGGCCGGGCGCTGGGGCTCG
CCGCGCACCGCAGCTTCCTCAGCTACGTGGCCGTGGTGGCTTCTGTGGTCAAGGATGACCAGGGGCGTATCCGCGTCGAC
GAGGCGTGGGTGTCGGTGGATGCCGGAACGATTCTCAATCCGGAGCGCGTGCGCTCACAGATGGAGGGCTCGATCATCTT
CGGCATGAGCATCGCGTTGCATGGCGCCGTCACCATGAAGCGCGGCGTGACGGAGCAGTCGAACTTCCGCGACCTCAAGC
TGGTGCGCATCGGCGAGGCGCCGCGGAAGATTCATGTCGACATCGTTCCCAGTGAGCTGCCGTCCGGGGGCATTGGCGAG
CCCGGCGTGCCTCCGGTGGCGCCCGCCATCATCAACGCCATCTTCGCGCTCACGGGCACGCGCATCCGCGAGTTGCCGGT
GTCCCGCACGCTGGCAGTCTGA

Upstream 100 bases:

>100_bases
CAGTCGCTCGCAGGCAACCTCTGCCGGTGTGGGACGTACACGCGAATCCGCTCGGCCGTGAAGAAGGCCGCGGGCATGTC
CGAGGAGTGACGAGGCCGCC

Downstream 100 bases:

>100_bases
GTGTCACGTCCGGTGCCTGGGGTGTGTCGCCAGGCACCGGGACGTCGCGCCTCGGATTTCGGGCGCGCGCTGCGTCAGGT
GCTTCACCGCAGGCACTCAG

Product: isoquinoline 1-oxidoreductase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MTKLLTLISRRSFLEGLNLSVGGLALGVFSGGLAAAASDASTAKGAPGLNPNVFVHVAPDGAVTIVCARSEMGQGVRSSL
PVLVADELGADMARVTVAQADGDKVYGDQNTDGSSSVRGVYDDIRRMGATARVMLVAAAARRWKVKPEACEARDHAVFLR
DGKRSLGFGELVADASRLPIPKAKDVKLRPKSELRMAGRPMPLLDGPAYVTGTAVFGADIRLPGMLIAVVARPPVVGGKV
VRFDATRALAVPGVKKVLELPAPKPPYTFQFWGGVAVLAENTWAAMRGRDALDITWEDGPNASYDSTTYREQLTASIREP
GTVARNVGDIDAALASAARIIQAEYHIPHQSHVPMEPPVALARVENGTCEVWAPTQHPQAARGVAAATAELPEEKVQVHV
TFLGGGFGRKSKADFIAEVVWLAKEAGVPVRVQWTREDDVRHDYYHPVSAQQLTAGLDASGKVIAWRHRTAFPPIASTFG
QATRPSPSDLQQGVLDLALSVPNVRAETCEAPPHVRIGWLRSVYNIFHAFSVNAFVDELAHLRGTDSRDMLLEVLGPPRK
ASLQELGITALRNYGASVEDHPVDAGRLRGVIERVTAMSGWDARKANGRALGLAAHRSFLSYVAVVASVVKDDQGRIRVD
EAWVSVDAGTILNPERVRSQMEGSIIFGMSIALHGAVTMKRGVTEQSNFRDLKLVRIGEAPRKIHVDIVPSELPSGGIGE
PGVPPVAPAIINAIFALTGTRIRELPVSRTLAV

Sequences:

>Translated_753_residues
MTKLLTLISRRSFLEGLNLSVGGLALGVFSGGLAAAASDASTAKGAPGLNPNVFVHVAPDGAVTIVCARSEMGQGVRSSL
PVLVADELGADMARVTVAQADGDKVYGDQNTDGSSSVRGVYDDIRRMGATARVMLVAAAARRWKVKPEACEARDHAVFLR
DGKRSLGFGELVADASRLPIPKAKDVKLRPKSELRMAGRPMPLLDGPAYVTGTAVFGADIRLPGMLIAVVARPPVVGGKV
VRFDATRALAVPGVKKVLELPAPKPPYTFQFWGGVAVLAENTWAAMRGRDALDITWEDGPNASYDSTTYREQLTASIREP
GTVARNVGDIDAALASAARIIQAEYHIPHQSHVPMEPPVALARVENGTCEVWAPTQHPQAARGVAAATAELPEEKVQVHV
TFLGGGFGRKSKADFIAEVVWLAKEAGVPVRVQWTREDDVRHDYYHPVSAQQLTAGLDASGKVIAWRHRTAFPPIASTFG
QATRPSPSDLQQGVLDLALSVPNVRAETCEAPPHVRIGWLRSVYNIFHAFSVNAFVDELAHLRGTDSRDMLLEVLGPPRK
ASLQELGITALRNYGASVEDHPVDAGRLRGVIERVTAMSGWDARKANGRALGLAAHRSFLSYVAVVASVVKDDQGRIRVD
EAWVSVDAGTILNPERVRSQMEGSIIFGMSIALHGAVTMKRGVTEQSNFRDLKLVRIGEAPRKIHVDIVPSELPSGGIGE
PGVPPVAPAIINAIFALTGTRIRELPVSRTLAV
>Mature_752_residues
TKLLTLISRRSFLEGLNLSVGGLALGVFSGGLAAAASDASTAKGAPGLNPNVFVHVAPDGAVTIVCARSEMGQGVRSSLP
VLVADELGADMARVTVAQADGDKVYGDQNTDGSSSVRGVYDDIRRMGATARVMLVAAAARRWKVKPEACEARDHAVFLRD
GKRSLGFGELVADASRLPIPKAKDVKLRPKSELRMAGRPMPLLDGPAYVTGTAVFGADIRLPGMLIAVVARPPVVGGKVV
RFDATRALAVPGVKKVLELPAPKPPYTFQFWGGVAVLAENTWAAMRGRDALDITWEDGPNASYDSTTYREQLTASIREPG
TVARNVGDIDAALASAARIIQAEYHIPHQSHVPMEPPVALARVENGTCEVWAPTQHPQAARGVAAATAELPEEKVQVHVT
FLGGGFGRKSKADFIAEVVWLAKEAGVPVRVQWTREDDVRHDYYHPVSAQQLTAGLDASGKVIAWRHRTAFPPIASTFGQ
ATRPSPSDLQQGVLDLALSVPNVRAETCEAPPHVRIGWLRSVYNIFHAFSVNAFVDELAHLRGTDSRDMLLEVLGPPRKA
SLQELGITALRNYGASVEDHPVDAGRLRGVIERVTAMSGWDARKANGRALGLAAHRSFLSYVAVVASVVKDDQGRIRVDE
AWVSVDAGTILNPERVRSQMEGSIIFGMSIALHGAVTMKRGVTEQSNFRDLKLVRIGEAPRKIHVDIVPSELPSGGIGEP
GVPPVAPAIINAIFALTGTRIRELPVSRTLAV

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=348, Percent_Identity=25.5747126436782, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786478, Length=305, Percent_Identity=24.5901639344262, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 80485; Mature: 80354

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLLTLISRRSFLEGLNLSVGGLALGVFSGGLAAAASDASTAKGAPGLNPNVFVHVAPD
CHHHHHHHHHHHHHHCCCCCCCCEEEEHHCCCHHHHCCCCCCCCCCCCCCCCEEEEECCC
GAVTIVCARSEMGQGVRSSLPVLVADELGADMARVTVAQADGDKVYGDQNTDGSSSVRGV
CCEEEEEECHHHCCCHHHCCCEEEEHHCCCCEEEEEEEECCCCEECCCCCCCCCCHHHHH
YDDIRRMGATARVMLVAAAARRWKVKPEACEARDHAVFLRDGKRSLGFGELVADASRLPI
HHHHHHCCCHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHCHHHCCC
PKAKDVKLRPKSELRMAGRPMPLLDGPAYVTGTAVFGADIRLPGMLIAVVARPPVVGGKV
CCCCCCEECCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCCCEE
VRFDATRALAVPGVKKVLELPAPKPPYTFQFWGGVAVLAENTWAAMRGRDALDITWEDGP
EEEECCCEEECCCHHHHHHCCCCCCCEEEEECCCEEEEECCCCHHHCCCCEEEEEECCCC
NASYDSTTYREQLTASIREPGTVARNVGDIDAALASAARIIQAEYHIPHQSHVPMEPPVA
CCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
LARVENGTCEVWAPTQHPQAARGVAAATAELPEEKVQVHVTFLGGGFGRKSKADFIAEVV
EEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHH
WLAKEAGVPVRVQWTREDDVRHDYYHPVSAQQLTAGLDASGKVIAWRHRTAFPPIASTFG
HHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCHHHHCC
QATRPSPSDLQQGVLDLALSVPNVRAETCEAPPHVRIGWLRSVYNIFHAFSVNAFVDELA
CCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
HLRGTDSRDMLLEVLGPPRKASLQELGITALRNYGASVEDHPVDAGRLRGVIERVTAMSG
HHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
WDARKANGRALGLAAHRSFLSYVAVVASVVKDDQGRIRVDEAWVSVDAGTILNPERVRSQ
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHH
MEGSIIFGMSIALHGAVTMKRGVTEQSNFRDLKLVRIGEAPRKIHVDIVPSELPSGGIGE
HCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCC
PGVPPVAPAIINAIFALTGTRIRELPVSRTLAV
CCCCCHHHHHHHHHHHHCCCHHHHCCCCHHCCC
>Mature Secondary Structure 
TKLLTLISRRSFLEGLNLSVGGLALGVFSGGLAAAASDASTAKGAPGLNPNVFVHVAPD
HHHHHHHHHHHHHHCCCCCCCCEEEEHHCCCHHHHCCCCCCCCCCCCCCCCEEEEECCC
GAVTIVCARSEMGQGVRSSLPVLVADELGADMARVTVAQADGDKVYGDQNTDGSSSVRGV
CCEEEEEECHHHCCCHHHCCCEEEEHHCCCCEEEEEEEECCCCEECCCCCCCCCCHHHHH
YDDIRRMGATARVMLVAAAARRWKVKPEACEARDHAVFLRDGKRSLGFGELVADASRLPI
HHHHHHCCCHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHCHHHCCC
PKAKDVKLRPKSELRMAGRPMPLLDGPAYVTGTAVFGADIRLPGMLIAVVARPPVVGGKV
CCCCCCEECCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCCCEE
VRFDATRALAVPGVKKVLELPAPKPPYTFQFWGGVAVLAENTWAAMRGRDALDITWEDGP
EEEECCCEEECCCHHHHHHCCCCCCCEEEEECCCEEEEECCCCHHHCCCCEEEEEECCCC
NASYDSTTYREQLTASIREPGTVARNVGDIDAALASAARIIQAEYHIPHQSHVPMEPPVA
CCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
LARVENGTCEVWAPTQHPQAARGVAAATAELPEEKVQVHVTFLGGGFGRKSKADFIAEVV
EEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHH
WLAKEAGVPVRVQWTREDDVRHDYYHPVSAQQLTAGLDASGKVIAWRHRTAFPPIASTFG
HHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCHHHHCC
QATRPSPSDLQQGVLDLALSVPNVRAETCEAPPHVRIGWLRSVYNIFHAFSVNAFVDELA
CCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
HLRGTDSRDMLLEVLGPPRKASLQELGITALRNYGASVEDHPVDAGRLRGVIERVTAMSG
HHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
WDARKANGRALGLAAHRSFLSYVAVVASVVKDDQGRIRVDEAWVSVDAGTILNPERVRSQ
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHH
MEGSIIFGMSIALHGAVTMKRGVTEQSNFRDLKLVRIGEAPRKIHVDIVPSELPSGGIGE
HCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCC
PGVPPVAPAIINAIFALTGTRIRELPVSRTLAV
CCCCCHHHHHHHHHHHHCCCHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]