Click here to switch to the map view.

The map label for this gene is iorA [H]

Identifier: 108762706

GI number: 108762706

Start: 6045383

End: 6045844

Strand: Reverse

Name: iorA [H]

Synonym: MXAN_4830

Alternate gene names: 108762706

Gene position: 6045844-6045383 (Counterclockwise)

Preceding gene: 108758815

Following gene: 108757464

Centisome position: 66.15

GC content: 68.83

Gene sequence:

>462_bases
GTGACGGTTCGCGTTCGCATCAACGGTGAGGAGAAGGAGCTGGACGTCGACCCGGAGATGCCGCTGCTGTGGGCGGTACG
GGACGTGCTCGGGCTCACTGGCACGAAGTACGGCTGCGGCCAGGCGCTGTGTGGCTCGTGCACCGTCCACCTCGACGGGC
AGCCGGTCCGCGCATGCGTGACACCCATCCGCCGCGCGGAGGGGCACTCGGTGACGACCATCGAAGGGCTGTCGCCCGAC
GGCAACCACCCGCTGCAGAAGGCCTGGGTGGAGCTGGGGGTGCCGCAGTGTGGCTTCTGCCAGACGGGGCAGATCATGTG
CGCGGCGGCGCTGCTGGCGAAGAAGCCGCAGCCGTCCGACAAGGAGATCGACCAGTCGCTCGCAGGCAACCTCTGCCGGT
GTGGGACGTACACGCGAATCCGCTCGGCCGTGAAGAAGGCCGCGGGCATGTCCGAGGAGTGA

Upstream 100 bases:

>100_bases
CGGGGCGTAAGCCCGCTCCGGGGACGCAGGCGCAGTTCGGCGCCATCGTCGCGGCCTGGGTGGAGACGGGCTCGGAGTGC
CCGAGCGAGGAGGCACGGCC

Downstream 100 bases:

>100_bases
CGAGGCCGCCATGACGAAGCTGCTCACGTTGATTAGCCGGCGCTCGTTCCTGGAAGGGCTGAATCTGTCCGTGGGAGGGC
TCGCCCTGGGGGTCTTCTCC

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MTVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACVTPIRRAEGHSVTTIEGLSPD
GNHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSDKEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE

Sequences:

>Translated_153_residues
MTVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACVTPIRRAEGHSVTTIEGLSPD
GNHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSDKEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE
>Mature_152_residues
TVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACVTPIRRAEGHSVTTIEGLSPDG
NHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSDKEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=155, Percent_Identity=37.4193548387097, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI71773480, Length=152, Percent_Identity=37.5, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786480, Length=165, Percent_Identity=38.1818181818182, Blast_Score=120, Evalue=4e-29,
Organism=Escherichia coli, GI1789232, Length=147, Percent_Identity=39.4557823129252, Blast_Score=91, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17539860, Length=150, Percent_Identity=40, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI32566215, Length=150, Percent_Identity=40, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=38.9261744966443, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17737937, Length=165, Percent_Identity=38.1818181818182, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24647197, Length=164, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647195, Length=164, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24647193, Length=164, Percent_Identity=33.5365853658537, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24647199, Length=158, Percent_Identity=31.6455696202532, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24647201, Length=158, Percent_Identity=31.0126582278481, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16408; Mature: 16277

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
5.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACV
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHH
TPIRRAEGHSVTTIEGLSPDGNHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSD
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCH
KEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE
HHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACV
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHH
TPIRRAEGHSVTTIEGLSPDGNHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSD
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCH
KEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE
HHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]