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The map label for this gene is lysS [H]

Identifier: 108757457

GI number: 108757457

Start: 5926999

End: 5928552

Strand: Reverse

Name: lysS [H]

Synonym: MXAN_4731

Alternate gene names: 108757457

Gene position: 5928552-5926999 (Counterclockwise)

Preceding gene: 108757647

Following gene: 108758232

Centisome position: 64.87

GC content: 65.12

Gene sequence:

>1554_bases
ATGGCCGAGACCGAAAACAAGAGCGAGAAGAGTGCGGGCGAGGGCGACCTCGGGACGAAGGAACAGGAAATCTACGACCA
GCGGCTGGAGAAGGCCGCGAAGTGGCGCGAGGCCGGCTTCAATCCGTACGGCAACGGCTACCGTCCCCAGCACCAGGCCG
CCGAAATCCACGAGAAGCACGCCGCTCAGTCCGCCGAGGAAATCGAGCAGGCCGCGCCTCCGCCCTATGACGTCGCCGGC
CGCGTCGTGGCCATGCGCTCCTTCGGCAAGGCCGCCTTCATCAAGCTGCGCGACCGCTCGGGCGAAATCCAGGTCCACAT
GAAGAAGGACGCCTTGGGGGACTCCTATGAGACCTTCAAGCTCTGTGACTTGGGCGACTTCCTGGCCGCCACCGGTCCGG
TGTTCCGTTCGAAGACGGGCGAGCTCACGCTCTCCGCCACGAAGTTCACCCCGCTCACCAAGTCCCTGCGCCCCCTGCCG
GAGAAGTGGCACGGCCTGACGGACGTGGAGGTCCGCTACCGTCAGCGGTACCTGGACCTCGTGTCCAACCCGGACGTGAA
GCAGACCTTCCTCCGGCGCAACAAGCTCATCCGCTTCATCCGGAACTTCCTCGACACGCGTGACTTCGTCGAGGTCGAAA
CGCCGATGATGCACCCGCTCGTGTCCGGCGCGGCGGCGCGGCCCTTCACCACGCACCACAACGCGCTCGACATTGACCTG
TACATGCGCATCGCCCCGGAGCTGTATCTCAAGCGCCTGGTGGTGGGCGGCCTGGAGCGCGTCTACGAGGTCAACCGCAA
CTTCCGCAATGAAGGCATCAGCACCCGGCACAACCCGGAATTCACGATGCTGGAGTTCTATCAGGCGTACGCCACGTACG
AGGACCTGATGGACCTCTCCGAGGAGATGATTTCGGAGGCCGCCAAGGCCGTCACCGGCGACACGAAGGTGAAGTACGGC
GACCACGTGCTCGACTTCGGCAAGGGCTGGAAGCGCATCTCCATGACGGAGGCCATCCGCGAGGTGGTGAGCGGCCTGTC
CGACAAGGACATGGCGGACGCGGACCGGCTGCGCCACGAACTGCTCAAGACGAGCCACTCGGAGGCCGAGCGGCGGGCCA
TCGACACGATGAACCACGGTGAGCTGGTGGGCGCGCTCTTCGAGCACCACGTCGAGCACACGCTCATCCATCCCACCTTC
ATCACCCATTTCCCCACCGCCGTCTCGCCGCTGGCCCGGCGCAATGACCAGAACCCGGACGTGACGGACCGCTTCGAGCT
GTACGTGGCGGGCCGCGAAATCGCGAACGCCTTCTCCGAGCTGAACGACCCGCTGGACCAGAAGGGCCGCTTCCAGGCTC
AGCTGGACGCGAAGCAGCGGGGCCAGCAGGAGACCATGGACTACGACGAGGACTACATCCGGGCCCTCGAGCACGGCATG
CCGCCCACCGCCGGTGAAGGCATCGGGATTGATCGGCTCGCCATGCTGTTCACGGATTCGCAGAGCATCCGGGACGTCAT
CCTGTTTCCCCTCCTCAAGCCACTGGCGAAGTAG

Upstream 100 bases:

>100_bases
CCTTCCTGGTGATGGTCGCTCCCTGAGCGGCCATCCGCTGTGTTGCGTTGCTTCCCGGGGGAGGCTTGGCTACGGTGCCG
CGCCTTTGGGAAAGCGCGTC

Downstream 100 bases:

>100_bases
CCAGGAGGCCGCGTGCACTCCGCCGAACGGCAGACCGTCCATCGCTGGACCTTCATCTGGATTGGGGCGCTGGTCGCCCT
GGTGGGCTTCAGCCTGCTCG

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MAETENKSEKSAGEGDLGTKEQEIYDQRLEKAAKWREAGFNPYGNGYRPQHQAAEIHEKHAAQSAEEIEQAAPPPYDVAG
RVVAMRSFGKAAFIKLRDRSGEIQVHMKKDALGDSYETFKLCDLGDFLAATGPVFRSKTGELTLSATKFTPLTKSLRPLP
EKWHGLTDVEVRYRQRYLDLVSNPDVKQTFLRRNKLIRFIRNFLDTRDFVEVETPMMHPLVSGAAARPFTTHHNALDIDL
YMRIAPELYLKRLVVGGLERVYEVNRNFRNEGISTRHNPEFTMLEFYQAYATYEDLMDLSEEMISEAAKAVTGDTKVKYG
DHVLDFGKGWKRISMTEAIREVVSGLSDKDMADADRLRHELLKTSHSEAERRAIDTMNHGELVGALFEHHVEHTLIHPTF
ITHFPTAVSPLARRNDQNPDVTDRFELYVAGREIANAFSELNDPLDQKGRFQAQLDAKQRGQQETMDYDEDYIRALEHGM
PPTAGEGIGIDRLAMLFTDSQSIRDVILFPLLKPLAK

Sequences:

>Translated_517_residues
MAETENKSEKSAGEGDLGTKEQEIYDQRLEKAAKWREAGFNPYGNGYRPQHQAAEIHEKHAAQSAEEIEQAAPPPYDVAG
RVVAMRSFGKAAFIKLRDRSGEIQVHMKKDALGDSYETFKLCDLGDFLAATGPVFRSKTGELTLSATKFTPLTKSLRPLP
EKWHGLTDVEVRYRQRYLDLVSNPDVKQTFLRRNKLIRFIRNFLDTRDFVEVETPMMHPLVSGAAARPFTTHHNALDIDL
YMRIAPELYLKRLVVGGLERVYEVNRNFRNEGISTRHNPEFTMLEFYQAYATYEDLMDLSEEMISEAAKAVTGDTKVKYG
DHVLDFGKGWKRISMTEAIREVVSGLSDKDMADADRLRHELLKTSHSEAERRAIDTMNHGELVGALFEHHVEHTLIHPTF
ITHFPTAVSPLARRNDQNPDVTDRFELYVAGREIANAFSELNDPLDQKGRFQAQLDAKQRGQQETMDYDEDYIRALEHGM
PPTAGEGIGIDRLAMLFTDSQSIRDVILFPLLKPLAK
>Mature_516_residues
AETENKSEKSAGEGDLGTKEQEIYDQRLEKAAKWREAGFNPYGNGYRPQHQAAEIHEKHAAQSAEEIEQAAPPPYDVAGR
VVAMRSFGKAAFIKLRDRSGEIQVHMKKDALGDSYETFKLCDLGDFLAATGPVFRSKTGELTLSATKFTPLTKSLRPLPE
KWHGLTDVEVRYRQRYLDLVSNPDVKQTFLRRNKLIRFIRNFLDTRDFVEVETPMMHPLVSGAAARPFTTHHNALDIDLY
MRIAPELYLKRLVVGGLERVYEVNRNFRNEGISTRHNPEFTMLEFYQAYATYEDLMDLSEEMISEAAKAVTGDTKVKYGD
HVLDFGKGWKRISMTEAIREVVSGLSDKDMADADRLRHELLKTSHSEAERRAIDTMNHGELVGALFEHHVEHTLIHPTFI
THFPTAVSPLARRNDQNPDVTDRFELYVAGREIANAFSELNDPLDQKGRFQAQLDAKQRGQQETMDYDEDYIRALEHGMP
PTAGEGIGIDRLAMLFTDSQSIRDVILFPLLKPLAK

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=449, Percent_Identity=43.652561247216, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI194272210, Length=449, Percent_Identity=43.652561247216, Blast_Score=357, Evalue=1e-98,
Organism=Escherichia coli, GI1790571, Length=492, Percent_Identity=52.6422764227642, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=52.9411764705882, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI87082379, Length=330, Percent_Identity=30.3030303030303, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1788173, Length=271, Percent_Identity=26.9372693726937, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535927, Length=518, Percent_Identity=38.8030888030888, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17535925, Length=518, Percent_Identity=38.8030888030888, Blast_Score=354, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI71994340, Length=504, Percent_Identity=39.2857142857143, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI32566633, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320242, Length=501, Percent_Identity=43.1137724550898, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324256, Length=476, Percent_Identity=33.6134453781513, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6323011, Length=360, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325153, Length=134, Percent_Identity=31.3432835820896, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640849, Length=453, Percent_Identity=42.8256070640177, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24640851, Length=453, Percent_Identity=42.8256070640177, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI24584738, Length=224, Percent_Identity=26.3392857142857, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58801; Mature: 58670

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETENKSEKSAGEGDLGTKEQEIYDQRLEKAAKWREAGFNPYGNGYRPQHQAAEIHEKH
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AAQSAEEIEQAAPPPYDVAGRVVAMRSFGKAAFIKLRDRSGEIQVHMKKDALGDSYETFK
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCEE
LCDLGDFLAATGPVFRSKTGELTLSATKFTPLTKSLRPLPEKWHGLTDVEVRYRQRYLDL
ECCCHHHHHHCCCHHHCCCCCEEEEECCCCHHHHHHCCCCHHHCCCCHHHHHHHHHHHHH
VSNPDVKQTFLRRNKLIRFIRNFLDTRDFVEVETPMMHPLVSGAAARPFTTHHNALDIDL
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCCCCCCCCCEEEHHH
YMRIAPELYLKRLVVGGLERVYEVNRNFRNEGISTRHNPEFTMLEFYQAYATYEDLMDLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEMISEAAKAVTGDTKVKYGDHVLDFGKGWKRISMTEAIREVVSGLSDKDMADADRLRHE
HHHHHHHHHHHCCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LLKTSHSEAERRAIDTMNHGELVGALFEHHVEHTLIHPTFITHFPTAVSPLARRNDQNPD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCC
VTDRFELYVAGREIANAFSELNDPLDQKGRFQAQLDAKQRGQQETMDYDEDYIRALEHGM
CCCCCCEEECHHHHHHHHHHHCCCHHHCCCEEEECCHHHCCCHHCCCCCHHHHHHHHHCC
PPTAGEGIGIDRLAMLFTDSQSIRDVILFPLLKPLAK
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AETENKSEKSAGEGDLGTKEQEIYDQRLEKAAKWREAGFNPYGNGYRPQHQAAEIHEKH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
AAQSAEEIEQAAPPPYDVAGRVVAMRSFGKAAFIKLRDRSGEIQVHMKKDALGDSYETFK
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCCEE
LCDLGDFLAATGPVFRSKTGELTLSATKFTPLTKSLRPLPEKWHGLTDVEVRYRQRYLDL
ECCCHHHHHHCCCHHHCCCCCEEEEECCCCHHHHHHCCCCHHHCCCCHHHHHHHHHHHHH
VSNPDVKQTFLRRNKLIRFIRNFLDTRDFVEVETPMMHPLVSGAAARPFTTHHNALDIDL
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCCCCCCCCCEEEHHH
YMRIAPELYLKRLVVGGLERVYEVNRNFRNEGISTRHNPEFTMLEFYQAYATYEDLMDLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEMISEAAKAVTGDTKVKYGDHVLDFGKGWKRISMTEAIREVVSGLSDKDMADADRLRHE
HHHHHHHHHHHCCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LLKTSHSEAERRAIDTMNHGELVGALFEHHVEHTLIHPTFITHFPTAVSPLARRNDQNPD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCC
VTDRFELYVAGREIANAFSELNDPLDQKGRFQAQLDAKQRGQQETMDYDEDYIRALEHGM
CCCCCCEEECHHHHHHHHHHHCCCHHHCCCEEEECCHHHCCCHHCCCCCHHHHHHHHHCC
PPTAGEGIGIDRLAMLFTDSQSIRDVILFPLLKPLAK
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA