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The map label for this gene is mccB [H]

Identifier: 108757174

GI number: 108757174

Start: 1119498

End: 1120598

Strand: Reverse

Name: mccB [H]

Synonym: MXAN_0970

Alternate gene names: 108757174

Gene position: 1120598-1119498 (Counterclockwise)

Preceding gene: 108762994

Following gene: 108763912

Centisome position: 12.26

GC content: 70.21

Gene sequence:

>1101_bases
ATGAAACTCGCCACCGCTCTCGTCCACGCCGGCGTGCGCCGCGACCCCACCACCGGCGCGGTCGCCGTCCCCATCTACCA
ATCCGCCACCTTCCAGCACCCCGCGCTCGGGCAATCCACCGGCTACGACTACTCGCGCACGCGAAACCCCACCCGCTCCG
CGCTGGAGGATGCGCTGGCGCAACTGGAGGGTGGCAGCCGGGGCCTGGCCTTCAGCTCCGGCATGGCGGCGCTGCACTGT
GCCCTCCAGCTCTTCGGCCCGGAGGACCACATCCTCCTCACCGAGGACCTCTACGGCGGCACCTACCGGCTGGTGGACCG
CATCCTCCACGTCCCCTGCACCTTCGTGGACACCTCACACCCCAGCGCCGTGCGGGACGCGCTGCGCCCCAACACCCGCG
CCATCGTCGTGGAGACGCCCACCAACCCGATGATGCGCACCGCCGACCTCTCCGAACTGGCGGCCATTGCCCGCAAGGCC
GGGGTGCTGCTCATCGTCGACAACACCTTCCTCACGCCGTGGTTGCAACGCCCGCTGGAGCTGGGCGCGGACATCGTCGT
GCACAGCGCGACGAAGTACCTGGCCGGACACAACGACGTCGTCGCGGGCGCGCTGGTGGTCAAGGACGCCGCGCTGGGCG
AGCGGCTGGCGTACCTCCAGAACGGCATCGGCGCGATTCTCGGTCCGCAGGACGCGTACCTGGTGATTCGCGGCCTGAAG
ACGCTGGCCCTGCGCATGGAGCGGCACCAGGCCAACGCGCGGGAAGTGGCCGCGTGGCTGCGCGCCCACCCGGGCGTGGA
GCGCGTCTTCTATCCCGGCGTGGGCGGAATGCTGTCCTTCACCGTCGCCCACGCGGCCCTGGTGCCCCAGGTGCTCGCGT
CCGTGCAGTTGTGTCTCTTCGCCGAGTCGCTCGGCGGCGTTGAAACGCTCATCACCTACCCCACCACGCAGACCCACGCT
GACATCCCCGCCGAGCGCCGGGAGGCGCTGGGCATCTCCGACCGGCTGCTCCGGCTCTCCGTAGGAATCGAGGACTCCCA
TGACATCATCGCCGACCTGGCCCAGGCGCTTCGCGACCCGTCTGCTGCACACGGGGCATGA

Upstream 100 bases:

>100_bases
CGCGGGCGGCGCCGTCACCGCGTCCGGCGTGCTGGCGGACATCCTCCGCATCTCCCAGACGCTGCGCGGTCGCTGAGCGC
GCCACCGAAAGGGTCCTCTC

Downstream 100 bases:

>100_bases
GCAGGACCCCACCACGGGCGCCGCCGCTGTCCCCATCTACCAGGTGTCCATGTTCGACCAGCCGGGCCTGGAGACGCCCG
GCGAGTTCGACTACGCGCGC

Product: Cys/Met metabolism PLP-dependent enzyme

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKLATALVHAGVRRDPTTGAVAVPIYQSATFQHPALGQSTGYDYSRTRNPTRSALEDALAQLEGGSRGLAFSSGMAALHC
ALQLFGPEDHILLTEDLYGGTYRLVDRILHVPCTFVDTSHPSAVRDALRPNTRAIVVETPTNPMMRTADLSELAAIARKA
GVLLIVDNTFLTPWLQRPLELGADIVVHSATKYLAGHNDVVAGALVVKDAALGERLAYLQNGIGAILGPQDAYLVIRGLK
TLALRMERHQANAREVAAWLRAHPGVERVFYPGVGGMLSFTVAHAALVPQVLASVQLCLFAESLGGVETLITYPTTQTHA
DIPAERREALGISDRLLRLSVGIEDSHDIIADLAQALRDPSAAHGA

Sequences:

>Translated_366_residues
MKLATALVHAGVRRDPTTGAVAVPIYQSATFQHPALGQSTGYDYSRTRNPTRSALEDALAQLEGGSRGLAFSSGMAALHC
ALQLFGPEDHILLTEDLYGGTYRLVDRILHVPCTFVDTSHPSAVRDALRPNTRAIVVETPTNPMMRTADLSELAAIARKA
GVLLIVDNTFLTPWLQRPLELGADIVVHSATKYLAGHNDVVAGALVVKDAALGERLAYLQNGIGAILGPQDAYLVIRGLK
TLALRMERHQANAREVAAWLRAHPGVERVFYPGVGGMLSFTVAHAALVPQVLASVQLCLFAESLGGVETLITYPTTQTHA
DIPAERREALGISDRLLRLSVGIEDSHDIIADLAQALRDPSAAHGA
>Mature_366_residues
MKLATALVHAGVRRDPTTGAVAVPIYQSATFQHPALGQSTGYDYSRTRNPTRSALEDALAQLEGGSRGLAFSSGMAALHC
ALQLFGPEDHILLTEDLYGGTYRLVDRILHVPCTFVDTSHPSAVRDALRPNTRAIVVETPTNPMMRTADLSELAAIARKA
GVLLIVDNTFLTPWLQRPLELGADIVVHSATKYLAGHNDVVAGALVVKDAALGERLAYLQNGIGAILGPQDAYLVIRGLK
TLALRMERHQANAREVAAWLRAHPGVERVFYPGVGGMLSFTVAHAALVPQVLASVQLCLFAESLGGVETLITYPTTQTHA
DIPAERREALGISDRLLRLSVGIEDSHDIIADLAQALRDPSAAHGA

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=392, Percent_Identity=43.1122448979592, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI299473759, Length=389, Percent_Identity=40.6169665809769, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI25453487, Length=391, Percent_Identity=38.3631713554987, Blast_Score=218, Evalue=5e-57,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=41.5343915343915, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=30.0771208226221, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17538055, Length=383, Percent_Identity=39.9477806788512, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17560056, Length=382, Percent_Identity=39.2670157068063, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71980708, Length=368, Percent_Identity=36.1413043478261, Blast_Score=224, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6319307, Length=386, Percent_Identity=42.7461139896373, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=32.0099255583127, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=28.3887468030691, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321170, Length=277, Percent_Identity=32.129963898917, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922554, Length=387, Percent_Identity=41.8604651162791, Blast_Score=305, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 39158; Mature: 39158

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLATALVHAGVRRDPTTGAVAVPIYQSATFQHPALGQSTGYDYSRTRNPTRSALEDALA
CCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHH
QLEGGSRGLAFSSGMAALHCALQLFGPEDHILLTEDLYGGTYRLVDRILHVPCTFVDTSH
HHCCCCCCCEECCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEECCC
PSAVRDALRPNTRAIVVETPTNPMMRTADLSELAAIARKAGVLLIVDNTFLTPWLQRPLE
CHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHH
LGADIVVHSATKYLAGHNDVVAGALVVKDAALGERLAYLQNGIGAILGPQDAYLVIRGLK
CCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
TLALRMERHQANAREVAAWLRAHPGVERVFYPGVGGMLSFTVAHAALVPQVLASVQLCLF
HHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AESLGGVETLITYPTTQTHADIPAERREALGISDRLLRLSVGIEDSHDIIADLAQALRDP
HHHHCCEEEEEECCCCCCCCCCCHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHHHCCC
SAAHGA
CCCCCC
>Mature Secondary Structure
MKLATALVHAGVRRDPTTGAVAVPIYQSATFQHPALGQSTGYDYSRTRNPTRSALEDALA
CCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHH
QLEGGSRGLAFSSGMAALHCALQLFGPEDHILLTEDLYGGTYRLVDRILHVPCTFVDTSH
HHCCCCCCCEECCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEECCC
PSAVRDALRPNTRAIVVETPTNPMMRTADLSELAAIARKAGVLLIVDNTFLTPWLQRPLE
CHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHH
LGADIVVHSATKYLAGHNDVVAGALVVKDAALGERLAYLQNGIGAILGPQDAYLVIRGLK
CCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
TLALRMERHQANAREVAAWLRAHPGVERVFYPGVGGMLSFTVAHAALVPQVLASVQLCLF
HHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AESLGGVETLITYPTTQTHADIPAERREALGISDRLLRLSVGIEDSHDIIADLAQALRDP
HHHHCCEEEEEECCCCCCCCCCCHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHHHCCC
SAAHGA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]