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The map label for this gene is thrA [H]

Identifier: 108762994

GI number: 108762994

Start: 1120623

End: 1123097

Strand: Reverse

Name: thrA [H]

Synonym: MXAN_0971

Alternate gene names: 108762994

Gene position: 1123097-1120623 (Counterclockwise)

Preceding gene: 108757161

Following gene: 108757174

Centisome position: 12.29

GC content: 72.65

Gene sequence:

>2475_bases
GTGATGAAGTTCGGTGGCACGTCCGTGGGCTCACCCACGCGGCTCCGCCAGGTAGTGGAGCTGATTGGCAAGCACGCGCG
GCAAGGCCCGCTGGCAGTGGTCGTCTCCGCGATGGGCGACACCACGGACTGGCTGCTGGACGCGGCCCACCTCGCCACCG
AGGGTGACCTGGAAGGCGCGCTCGCGGTGGCCACGCGCATCGCCGACCTCGCGAAGGCCAACGCCGCGGCGCTGGCGCCC
GGACAAGCCACCGCGCTGGCCGAGCGTGTCGACGGGCTCCTCGCGCCGCTGCGTCAGTTGCTCCATGGCGTCTCACTCAC
GCGAGAGTGCTCCGCCCCCACGAGAGACCGGGTGCTGTCGTTCGGTGAGTTGGTGTCCGCCACGCTGCTGGCGGAGCTGC
TCACGGCCCATCGCACGCCCGCCACCTTCCGTGACGCGCGGCAGCTCCTGGTGACGGATGACCGCTTTGGCGCGGCGCGG
GTGGACCTGGTTCGGACGCGGGAGCGACTCCAAGCCGCCCGGGAGACGTGGGGCGTCGAGGTGCCCGTGCTCCCCGGCTT
CATCGCCGCGACGCCGGATGGACGCACCACCACGCTGGGCCGCAACGGCTCCGACTACACCGCGGCGCTGGTGGCCCAGG
GCCTGGGCGCGTCGGAAGTCACGGTGTGGACGGACGTGCTCGGCCTGCACACCGCCGACCCGGAGCTGGTCACGGACGCC
TACCCCGTGGCGCACCTCACCCATGGCGAGGGCCTGGAGCTGGCGGCGGTGGGTGCCCGCATGCTGCACCCGCGCACGAT
GATTCCGCTCATCGAGTCCGGAATCTCCCTGCGCATCCGCAACACCATGGAGCCGGAGCACCCGGGCACGCTCATCGACG
CCATCGGTTCGCGCGACGGCCAGCGTCCCGCCTGCATCGCGACGCGCGAGGACCTGGCGCTGCTCGGCATCGAGGTGCGC
AAGCTGTCCGACCAGTTCCAACTGGGGGAGCGCGTGCTGGCCGCGCTGCGAGAAGCGCGCGTCACGGTGTGGATGACCGC
GCAGTCCGCCAATGGCCAGTCACTGGCCGTCGTCGTGCCTCGCCCCGACGCGGAGCACGCGCGGTCCGTGCTCGTCACCG
AGCTGGCGCAGGAGCTGTCACGCCGCGAAGTGGAACCGCTGGAGGTCCGCCAGCCGGTGACGCTGCTGACGCTGGTGGCG
GAGACCATGGGCCACGGCGTCAACGTGGCCGGGCGCTTCTTCAGCGCGCTGGGCGCGGTGGGCGTCAACGTGCGCGCCAG
CGCCCAGGGTGCCAGCTCCCGCTCCCTTTCGTGTGTCGTCGACGCGGCGGACACCGCCGTCGCCGCGCGCACCACGCACG
CGGCCTTCAACCTGGCCCATCAGCAGGTGAGCCTCTTCGTCCTCGGCCGAGGCACGGTGGGCGGACAACTGCTGGCCCAG
CTGCGCGCCCAGCAAGCGCTGCTCCGGGACAGGCACGGCATCGCGCTGCGCGTCGTGGGGCTGGCGGACAGCAAGCGCGC
GCTCTTCGACGCGGCGGGGCTCACGCTCGATGGCGTGGAGGCGCGGCTCGAAGGCGTGACGCCCGAGGCGCCCCAGGCGC
GCACCCTGGTCCCCTTGTTGGACGCGCTCCGGCGGCTGCCCGTCCCCATCCTGGTCGACTGCACCGCCGCGGGCGGGTTG
GAGGCGCTCTACACGGAGGCCTTCCAGCGCGGCATCCACGTGGTGGCGGCCAACAAGAAGCCGCTGGCGCTGCCGTGGGA
GGCCCGCGAAGCGCTGGTGGACACGGCGCGCCGCAACCACGTCGCGTACCACTACGAGACGACGGTGGCGTCCAGCCTGC
CCGTCATCGACACGCTGGCGAACCTGGTGCGCACCGGTGACACCGTTCGCCTCATCACCGCGTCCCTGTCCGGCAGCCTG
GGCTTCATCTGCAACGAACTGACGGCCGGCGTGCCCCTGTCCCGGGCCGTCCGCACCGCCCGGGAGCGCGGCTTCACGGA
GCCGGACCCTCGCGAGGACCTGAGCGGCACGGACGTCGCGCGCAAGGCGCTCATCCTCGCTCGGGAGCTGGGCCTGCCGC
TCTCCCTGTCGGACGTGGCGCTGGAGCCCTTCGTCGCCACGGACGAATGCGCCAGCGTGGACTCGTTCTTCCAGGTGCTC
GCCACGCAGGATGCGGCCTACGCGGAGCGCGTGGCCCGCTGCCGCCACGCCGGCACCGTGCTGCGCTACCTGGCACGCAT
CGACCCATCGAAGGCGGGCACAGGCAGTCCCGTCATCCGTGTGGGCCCCGTAGGCGTTGAAGCGGGCCACCCCGCGGCGG
ACCTCCGCGGCTCCGAGTCCTTCGTCTCCTTCACCACCACCCGCCACAGCGACTTCCCGCTCACCGTTCGAGGCGCGGGC
GCGGGCGGCGCCGTCACCGCGTCCGGCGTGCTGGCGGACATCCTCCGCATCTCCCAGACGCTGCGCGGTCGCTGA

Upstream 100 bases:

>100_bases
CGGCGTGTGTCCGGCACAGGGCGCCGCGTCTGCCCTTCCCTTTCGAATCAGGGCCCGCCGGCCCCCTTGAGGTTCTTCAA
TGAGCAGCACGTCCCTGCAG

Downstream 100 bases:

>100_bases
GCGCGCCACCGAAAGGGTCCTCTCATGAAACTCGCCACCGCTCTCGTCCACGCCGGCGTGCGCCGCGACCCCACCACCGG
CGCGGTCGCCGTCCCCATCT

Product: aspartate kinase/homoserine dehydrogenase

Products: NA

Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 824; Mature: 824

Protein sequence:

>824_residues
MMKFGGTSVGSPTRLRQVVELIGKHARQGPLAVVVSAMGDTTDWLLDAAHLATEGDLEGALAVATRIADLAKANAAALAP
GQATALAERVDGLLAPLRQLLHGVSLTRECSAPTRDRVLSFGELVSATLLAELLTAHRTPATFRDARQLLVTDDRFGAAR
VDLVRTRERLQAARETWGVEVPVLPGFIAATPDGRTTTLGRNGSDYTAALVAQGLGASEVTVWTDVLGLHTADPELVTDA
YPVAHLTHGEGLELAAVGARMLHPRTMIPLIESGISLRIRNTMEPEHPGTLIDAIGSRDGQRPACIATREDLALLGIEVR
KLSDQFQLGERVLAALREARVTVWMTAQSANGQSLAVVVPRPDAEHARSVLVTELAQELSRREVEPLEVRQPVTLLTLVA
ETMGHGVNVAGRFFSALGAVGVNVRASAQGASSRSLSCVVDAADTAVAARTTHAAFNLAHQQVSLFVLGRGTVGGQLLAQ
LRAQQALLRDRHGIALRVVGLADSKRALFDAAGLTLDGVEARLEGVTPEAPQARTLVPLLDALRRLPVPILVDCTAAGGL
EALYTEAFQRGIHVVAANKKPLALPWEAREALVDTARRNHVAYHYETTVASSLPVIDTLANLVRTGDTVRLITASLSGSL
GFICNELTAGVPLSRAVRTARERGFTEPDPREDLSGTDVARKALILARELGLPLSLSDVALEPFVATDECASVDSFFQVL
ATQDAAYAERVARCRHAGTVLRYLARIDPSKAGTGSPVIRVGPVGVEAGHPAADLRGSESFVSFTTTRHSDFPLTVRGAG
AGGAVTASGVLADILRISQTLRGR

Sequences:

>Translated_824_residues
MMKFGGTSVGSPTRLRQVVELIGKHARQGPLAVVVSAMGDTTDWLLDAAHLATEGDLEGALAVATRIADLAKANAAALAP
GQATALAERVDGLLAPLRQLLHGVSLTRECSAPTRDRVLSFGELVSATLLAELLTAHRTPATFRDARQLLVTDDRFGAAR
VDLVRTRERLQAARETWGVEVPVLPGFIAATPDGRTTTLGRNGSDYTAALVAQGLGASEVTVWTDVLGLHTADPELVTDA
YPVAHLTHGEGLELAAVGARMLHPRTMIPLIESGISLRIRNTMEPEHPGTLIDAIGSRDGQRPACIATREDLALLGIEVR
KLSDQFQLGERVLAALREARVTVWMTAQSANGQSLAVVVPRPDAEHARSVLVTELAQELSRREVEPLEVRQPVTLLTLVA
ETMGHGVNVAGRFFSALGAVGVNVRASAQGASSRSLSCVVDAADTAVAARTTHAAFNLAHQQVSLFVLGRGTVGGQLLAQ
LRAQQALLRDRHGIALRVVGLADSKRALFDAAGLTLDGVEARLEGVTPEAPQARTLVPLLDALRRLPVPILVDCTAAGGL
EALYTEAFQRGIHVVAANKKPLALPWEAREALVDTARRNHVAYHYETTVASSLPVIDTLANLVRTGDTVRLITASLSGSL
GFICNELTAGVPLSRAVRTARERGFTEPDPREDLSGTDVARKALILARELGLPLSLSDVALEPFVATDECASVDSFFQVL
ATQDAAYAERVARCRHAGTVLRYLARIDPSKAGTGSPVIRVGPVGVEAGHPAADLRGSESFVSFTTTRHSDFPLTVRGAG
AGGAVTASGVLADILRISQTLRGR
>Mature_824_residues
MMKFGGTSVGSPTRLRQVVELIGKHARQGPLAVVVSAMGDTTDWLLDAAHLATEGDLEGALAVATRIADLAKANAAALAP
GQATALAERVDGLLAPLRQLLHGVSLTRECSAPTRDRVLSFGELVSATLLAELLTAHRTPATFRDARQLLVTDDRFGAAR
VDLVRTRERLQAARETWGVEVPVLPGFIAATPDGRTTTLGRNGSDYTAALVAQGLGASEVTVWTDVLGLHTADPELVTDA
YPVAHLTHGEGLELAAVGARMLHPRTMIPLIESGISLRIRNTMEPEHPGTLIDAIGSRDGQRPACIATREDLALLGIEVR
KLSDQFQLGERVLAALREARVTVWMTAQSANGQSLAVVVPRPDAEHARSVLVTELAQELSRREVEPLEVRQPVTLLTLVA
ETMGHGVNVAGRFFSALGAVGVNVRASAQGASSRSLSCVVDAADTAVAARTTHAAFNLAHQQVSLFVLGRGTVGGQLLAQ
LRAQQALLRDRHGIALRVVGLADSKRALFDAAGLTLDGVEARLEGVTPEAPQARTLVPLLDALRRLPVPILVDCTAAGGL
EALYTEAFQRGIHVVAANKKPLALPWEAREALVDTARRNHVAYHYETTVASSLPVIDTLANLVRTGDTVRLITASLSGSL
GFICNELTAGVPLSRAVRTARERGFTEPDPREDLSGTDVARKALILARELGLPLSLSDVALEPFVATDECASVDSFFQVL
ATQDAAYAERVARCRHAGTVLRYLARIDPSKAGTGSPVIRVGPVGVEAGHPAADLRGSESFVSFTTTRHSDFPLTVRGAG
AGGAVTASGVLADILRISQTLRGR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=822, Percent_Identity=35.1581508515815, Blast_Score=437, Evalue=1e-123,
Organism=Escherichia coli, GI1790376, Length=831, Percent_Identity=29.8435619735259, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1790455, Length=452, Percent_Identity=28.5398230088496, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320893, Length=495, Percent_Identity=27.8787878787879, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322599, Length=377, Percent_Identity=32.8912466843501, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 87153; Mature: 87153

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFGGTSVGSPTRLRQVVELIGKHARQGPLAVVVSAMGDTTDWLLDAAHLATEGDLEGA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHH
LAVATRIADLAKANAAALAPGQATALAERVDGLLAPLRQLLHGVSLTRECSAPTRDRVLS
HHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHH
FGELVSATLLAELLTAHRTPATFRDARQLLVTDDRFGAARVDLVRTRERLQAARETWGVE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
VPVLPGFIAATPDGRTTTLGRNGSDYTAALVAQGLGASEVTVWTDVLGLHTADPELVTDA
CCCCCCEEEECCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHCC
YPVAHLTHGEGLELAAVGARMLHPRTMIPLIESGISLRIRNTMEPEHPGTLIDAIGSRDG
CCCEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCC
QRPACIATREDLALLGIEVRKLSDQFQLGERVLAALREARVTVWMTAQSANGQSLAVVVP
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCEEEEEEC
RPDAEHARSVLVTELAQELSRREVEPLEVRQPVTLLTLVAETMGHGVNVAGRFFSALGAV
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GVNVRASAQGASSRSLSCVVDAADTAVAARTTHAAFNLAHQQVSLFVLGRGTVGGQLLAQ
CCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHH
LRAQQALLRDRHGIALRVVGLADSKRALFDAAGLTLDGVEARLEGVTPEAPQARTLVPLL
HHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEECCHHHHHCCCCCCCCCCHHHHHHH
DALRRLPVPILVDCTAAGGLEALYTEAFQRGIHVVAANKKPLALPWEAREALVDTARRNH
HHHHHCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
VAYHYETTVASSLPVIDTLANLVRTGDTVRLITASLSGSLGFICNELTAGVPLSRAVRTA
EEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
RERGFTEPDPREDLSGTDVARKALILARELGLPLSLSDVALEPFVATDECASVDSFFQVL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHH
ATQDAAYAERVARCRHAGTVLRYLARIDPSKAGTGSPVIRVGPVGVEAGHPAADLRGSES
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHCCCCCC
FVSFTTTRHSDFPLTVRGAGAGGAVTASGVLADILRISQTLRGR
EEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMKFGGTSVGSPTRLRQVVELIGKHARQGPLAVVVSAMGDTTDWLLDAAHLATEGDLEGA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHH
LAVATRIADLAKANAAALAPGQATALAERVDGLLAPLRQLLHGVSLTRECSAPTRDRVLS
HHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHH
FGELVSATLLAELLTAHRTPATFRDARQLLVTDDRFGAARVDLVRTRERLQAARETWGVE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
VPVLPGFIAATPDGRTTTLGRNGSDYTAALVAQGLGASEVTVWTDVLGLHTADPELVTDA
CCCCCCEEEECCCCCEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHCC
YPVAHLTHGEGLELAAVGARMLHPRTMIPLIESGISLRIRNTMEPEHPGTLIDAIGSRDG
CCCEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCC
QRPACIATREDLALLGIEVRKLSDQFQLGERVLAALREARVTVWMTAQSANGQSLAVVVP
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCEEEEEEC
RPDAEHARSVLVTELAQELSRREVEPLEVRQPVTLLTLVAETMGHGVNVAGRFFSALGAV
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GVNVRASAQGASSRSLSCVVDAADTAVAARTTHAAFNLAHQQVSLFVLGRGTVGGQLLAQ
CCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHH
LRAQQALLRDRHGIALRVVGLADSKRALFDAAGLTLDGVEARLEGVTPEAPQARTLVPLL
HHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCEECCHHHHHCCCCCCCCCCHHHHHHH
DALRRLPVPILVDCTAAGGLEALYTEAFQRGIHVVAANKKPLALPWEAREALVDTARRNH
HHHHHCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
VAYHYETTVASSLPVIDTLANLVRTGDTVRLITASLSGSLGFICNELTAGVPLSRAVRTA
EEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
RERGFTEPDPREDLSGTDVARKALILARELGLPLSLSDVALEPFVATDECASVDSFFQVL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHHHH
ATQDAAYAERVARCRHAGTVLRYLARIDPSKAGTGSPVIRVGPVGVEAGHPAADLRGSES
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHCCCCCC
FVSFTTTRHSDFPLTVRGAGAGGAVTASGVLADILRISQTLRGR
EEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]