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The map label for this gene is myrA [H]

Identifier: 108757061

GI number: 108757061

Start: 6299445

End: 6300338

Strand: Direct

Name: myrA [H]

Synonym: MXAN_5038

Alternate gene names: 108757061

Gene position: 6299445-6300338 (Clockwise)

Preceding gene: 108762976

Following gene: 108761291

Centisome position: 68.92

GC content: 69.8

Gene sequence:

>894_bases
ATGTCAGCGCCCGCTTCGCCCCGCTTTCCGCCGCCCCTTCTTCCACTGCTCTGCTGCCCCATCTGCCAGTCACCGCTTCG
CCAGGAAGCAACGGCGCTGCGCTGTGTGGCGCGCCATGGCTTCGACGTCGCCAGACAGGGCTATGTCAACCTCCTGCCGG
GCCACCGGGCCCCGGGCAATGCCGACACCCAGTCGATGGTCGCCGCGCGAGAGACATTCCTCGCGCGAGGCCACTACGAA
CCGTTGGCCGCGCTATTGGCGGAGCATGCCGCGCGGCTCACCGGCGCCGATGCCACAGAGGGCTGCGTGCTCGATGTGGG
AGCGGGTACCGGGCACTACCTGGCCCGTGTCCTCGACCGGTGCCCGGCGCTGACGGGGCTCGCCATCGACATCTCCCGCT
TCGCTGCCCGCCGGGCCGCTAGGGCCCACGCCCGCGCGGGAGCCCTCATCGCGGACGGCGAGCGGACGTTGCCCATCCGA
AATCACAGCGTTGCACTGGCGCTCAGCGTCTTCGCTCCTCGCAACGTCACAGAGCTCCACCGCATCCTGAATCGCCGAGG
CGCACTGCTCATCGTGACACCCACGGACCAGCACCTGACACAGCTCATCCAACCCATGGGGCTGCTGAGCGTCGACGCGC
GAAAGGAGGAGCGGCTCCACACACGGCTGCGGGCCACGTTCAAGCCAGGCGTCCGGGAAGCGCTGGAGCTGACCTTGCGG
CTGACGCGCGACGACGCGTTCCACATCGCGGCCATGGGGCCCAGCGCGTTCCATGCATCCACGGAGGAGCTGCGGCGGCG
CGCGGACGTGTTGCCCGAGCTCCTCACCGTCAGCGCGTCCTTCACCGTGGCCAGCTACCACCGCGTGGAGAGGAACGGCT
CCGCGCCCGCCTGA

Upstream 100 bases:

>100_bases
CGGGCGCTCATGCCAGGGTCCTGACACACCCCGCGCCTGAGGGCCTCCCGCGACTCGTTCCCGGCCATGCGCCGCCACGA
GCCTCTGGAGCCCTTTCCGC

Downstream 100 bases:

>100_bases
GCAGCGCTCGCGCGAGGAGCCCAGACCGCGATGCGCCGCGCGGTCTGGGCCCCTGCCCCGCGCAGGGCATGGGGTTGAAG
GCCAGGGAGAAACCCGGCGT

Product: putative ribosomal RNA large subunit methyltransferase A

Products: S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSAPASPRFPPPLLPLLCCPICQSPLRQEATALRCVARHGFDVARQGYVNLLPGHRAPGNADTQSMVAARETFLARGHYE
PLAALLAEHAARLTGADATEGCVLDVGAGTGHYLARVLDRCPALTGLAIDISRFAARRAARAHARAGALIADGERTLPIR
NHSVALALSVFAPRNVTELHRILNRRGALLIVTPTDQHLTQLIQPMGLLSVDARKEERLHTRLRATFKPGVREALELTLR
LTRDDAFHIAAMGPSAFHASTEELRRRADVLPELLTVSASFTVASYHRVERNGSAPA

Sequences:

>Translated_297_residues
MSAPASPRFPPPLLPLLCCPICQSPLRQEATALRCVARHGFDVARQGYVNLLPGHRAPGNADTQSMVAARETFLARGHYE
PLAALLAEHAARLTGADATEGCVLDVGAGTGHYLARVLDRCPALTGLAIDISRFAARRAARAHARAGALIADGERTLPIR
NHSVALALSVFAPRNVTELHRILNRRGALLIVTPTDQHLTQLIQPMGLLSVDARKEERLHTRLRATFKPGVREALELTLR
LTRDDAFHIAAMGPSAFHASTEELRRRADVLPELLTVSASFTVASYHRVERNGSAPA
>Mature_296_residues
SAPASPRFPPPLLPLLCCPICQSPLRQEATALRCVARHGFDVARQGYVNLLPGHRAPGNADTQSMVAARETFLARGHYEP
LAALLAEHAARLTGADATEGCVLDVGAGTGHYLARVLDRCPALTGLAIDISRFAARRAARAHARAGALIADGERTLPIRN
HSVALALSVFAPRNVTELHRILNRRGALLIVTPTDQHLTQLIQPMGLLSVDARKEERLHTRLRATFKPGVREALELTLRL
TRDDAFHIAAMGPSAFHASTEELRRRADVLPELLTVSASFTVASYHRVERNGSAPA

Specific function: Confers strong resistance to mycinamicin (MM) and tylosin (TY). May function as methyltransferase [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=275, Percent_Identity=31.6363636363636, Blast_Score=124, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.51 [C]

Molecular weight: Translated: 32139; Mature: 32008

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPASPRFPPPLLPLLCCPICQSPLRQEATALRCVARHGFDVARQGYVNLLPGHRAPGN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCEEECCCCCCCCC
ADTQSMVAARETFLARGHYEPLAALLAEHAARLTGADATEGCVLDVGAGTGHYLARVLDR
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHH
CPALTGLAIDISRFAARRAARAHARAGALIADGERTLPIRNHSVALALSVFAPRNVTELH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHH
RILNRRGALLIVTPTDQHLTQLIQPMGLLSVDARKEERLHTRLRATFKPGVREALELTLR
HHHHCCCCEEEEECCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
LTRDDAFHIAAMGPSAFHASTEELRRRADVLPELLTVSASFTVASYHRVERNGSAPA
EECCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAPASPRFPPPLLPLLCCPICQSPLRQEATALRCVARHGFDVARQGYVNLLPGHRAPGN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCEEECCCCCCCCC
ADTQSMVAARETFLARGHYEPLAALLAEHAARLTGADATEGCVLDVGAGTGHYLARVLDR
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHH
CPALTGLAIDISRFAARRAARAHARAGALIADGERTLPIRNHSVALALSVFAPRNVTELH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHH
RILNRRGALLIVTPTDQHLTQLIQPMGLLSVDARKEERLHTRLRATFKPGVREALELTLR
HHHHCCCCEEEEECCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
LTRDDAFHIAAMGPSAFHASTEELRRRADVLPELLTVSASFTVASYHRVERNGSAPA
EECCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Unidentified protein factor B [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; rRNA [C]

Specific reaction: S-Adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

General reaction: Methyl group transfer [C]

Inhibitor: Mg2+; Unidentified protein factor A1 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8163173 [H]