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The map label for this gene is gloA [H]

Identifier: 108756890

GI number: 108756890

Start: 538739

End: 539125

Strand: Reverse

Name: gloA [H]

Synonym: MXAN_0480

Alternate gene names: 108756890

Gene position: 539125-538739 (Counterclockwise)

Preceding gene: 108757815

Following gene: 108759999

Centisome position: 5.9

GC content: 66.41

Gene sequence:

>387_bases
ATGCGAATCCTGCACACCATGCTCCGCGTCGGTGACCTCGAGCGCTCGCTCGACTTCTACACCCGGATCATCGGCATGAA
GTTGCTGCGCCGTCACGACTACCCCGACGGCAAGTTCACCCTGGCCTTCGTGGGCTTCGGCCCCGAGGACACCCACCCCG
CCCTGGAGCTCACGTACAACTGGGGCGTCGAGAAGTACGAGCTCGGCACGGCCTACGGCCACGTGGCCCTGGGCGTCAGT
GACATCCACGGCACCTGCGAGGCCATCCGGCAGGCCGGTGGCAAGGTGGTCCGCGAGCCCGGCCCCATGAAGCACGGCAC
CACCGTCATCGCCTTCGTCGAGGACCCGGACGGCTACAAGGTGGAACTCATCCAGAAGGACCGCTGA

Upstream 100 bases:

>100_bases
GTGCCGCCCAAGGCACAGTCCGAGGAAAAGCCCTGAGTCCATCGGACAGCGGGCAGCGGGGACGCATGACGCGACGCGAT
GATGGCGTTATGAAGCCCGC

Downstream 100 bases:

>100_bases
GCCCACCGCCGTCCCAGGCCCGCAGCGCACGCAACGCCTGCACACCCGGCCCGGGCCCGTTAGTGTGGCCCCGTGAGCTC
CGCCCCCCTCTTCGTCCCCG

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MRILHTMLRVGDLERSLDFYTRIIGMKLLRRHDYPDGKFTLAFVGFGPEDTHPALELTYNWGVEKYELGTAYGHVALGVS
DIHGTCEAIRQAGGKVVREPGPMKHGTTVIAFVEDPDGYKVELIQKDR

Sequences:

>Translated_128_residues
MRILHTMLRVGDLERSLDFYTRIIGMKLLRRHDYPDGKFTLAFVGFGPEDTHPALELTYNWGVEKYELGTAYGHVALGVS
DIHGTCEAIRQAGGKVVREPGPMKHGTTVIAFVEDPDGYKVELIQKDR
>Mature_128_residues
MRILHTMLRVGDLERSLDFYTRIIGMKLLRRHDYPDGKFTLAFVGFGPEDTHPALELTYNWGVEKYELGTAYGHVALGVS
DIHGTCEAIRQAGGKVVREPGPMKHGTTVIAFVEDPDGYKVELIQKDR

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI118402586, Length=152, Percent_Identity=34.2105263157895, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI217330598, Length=136, Percent_Identity=33.0882352941176, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787940, Length=126, Percent_Identity=68.2539682539683, Blast_Score=190, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17552228, Length=138, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323639, Length=139, Percent_Identity=36.6906474820144, Blast_Score=92, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129743, Length=147, Percent_Identity=34.0136054421769, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19920404, Length=140, Percent_Identity=29.2857142857143, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 14403; Mature: 14403

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00935 GLYOXALASE_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILHTMLRVGDLERSLDFYTRIIGMKLLRRHDYPDGKFTLAFVGFGPEDTHPALELTYN
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEC
WGVEKYELGTAYGHVALGVSDIHGTCEAIRQAGGKVVREPGPMKHGTTVIAFVEDPDGYK
CCCEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCCE
VELIQKDR
EEEEECCC
>Mature Secondary Structure
MRILHTMLRVGDLERSLDFYTRIIGMKLLRRHDYPDGKFTLAFVGFGPEDTHPALELTYN
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEC
WGVEKYELGTAYGHVALGVSDIHGTCEAIRQAGGKVVREPGPMKHGTTVIAFVEDPDGYK
CCCEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCCE
VELIQKDR
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]