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The map label for this gene is panB

Identifier: 108756848

GI number: 108756848

Start: 2386895

End: 2387812

Strand: Direct

Name: panB

Synonym: MXAN_2055

Alternate gene names: 108756848

Gene position: 2386895-2387812 (Clockwise)

Preceding gene: 108757889

Following gene: 108761160

Centisome position: 26.12

GC content: 69.17

Gene sequence:

>918_bases
GTGAAGGACAAGGTCACCATCCACACACTGAAGCGCTTCAAGCAGATCGGTCAGAAGATCTGCATGGTCACCGCTTACGA
CGCCACGTTCGCCCACATCCTCGAAGAGGCAGGCGCGGATGTGCTGCTGATAGGCGACTCGCTGGGCATGGTCATCCAGG
GGCATGACTCCACGCTGCCGGTGACGATGGACCAGATGGTCTACCACACGGCCGCGGTGGCCCGTGGCGCGCGCCGGGCG
CACGTCGTGGCCGACCTGCCGTTCATGAGCTACCAGGTGTCGAACCAGGAGGCGGTCCGCAACGCGGGCCGGCTGGTGGC
GGAAGGCGGCGCGGGCAGCATCAAGCTGGAGGGCGGCGCTGAGTTCGCGGACACGGTGCGGGCCATCGTCCGCGCGAGCA
TCCCCGTCATGGGACACCTGGGGCTGACGCCGCAGTCCGTCCACAAGATGGGCGGCTACGTCGTCCAGGGCCGCGGCGAG
GACCAGGCGCGGCAGATTCTGGACGACGCGCTGGCGCTGGAGCAGGCCGGGGCCTACGCGCTGGTGCTGGAAGGCGTGCC
CATGGACCTGGCGCGCACGGTGACGCAGCGCCTGTCCATCCCCACCATCGGCATTGGCGCCGGCGTGGACTGTGATGGCC
AGGTGCTCGTCTGCTACGACCTGCTGGGCATGAACCCGGACTTCAAGCCGAAGTTCGTGAAGCGCTACGCCAACCTCCAC
GGCTCGATTACCGAGGCCGCGGGCGCGTACTTCGCGGAGGTCCGCAAGGGCGCGTTCCCGGACGAGGAGCACTCCTTCAA
GGCGACCAAGAACATCCGGCTGGCGCCGGGGGCTCCGGCTCCGGCGGCCCGGGTGGAGCCGTCCGCGCCCGCCGAGGCTG
GCGAGAAGCTGGGCCCCGTCTACGGGAGACCCGCCTAG

Upstream 100 bases:

>100_bases
TGCGGTGGCGGGCCCAGGGCTCCCGGCGATCCCCGGTGGGGACGGCGAGGCGCGAATGGGCCCGTCAGGCCGTTCAACCC
GTAGCCATAGGAGGTGAACC

Downstream 100 bases:

>100_bases
TCATGGCTCCCGCCGTCCTGAAAACCGTTGCGGACGTGAAGGACTGGACGGCGGGGCTGCGCCGGGAGGGGCACCGGCTC
GCGCTGGTGCCCACCATGGG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKDKVTIHTLKRFKQIGQKICMVTAYDATFAHILEEAGADVLLIGDSLGMVIQGHDSTLPVTMDQMVYHTAAVARGARRA
HVVADLPFMSYQVSNQEAVRNAGRLVAEGGAGSIKLEGGAEFADTVRAIVRASIPVMGHLGLTPQSVHKMGGYVVQGRGE
DQARQILDDALALEQAGAYALVLEGVPMDLARTVTQRLSIPTIGIGAGVDCDGQVLVCYDLLGMNPDFKPKFVKRYANLH
GSITEAAGAYFAEVRKGAFPDEEHSFKATKNIRLAPGAPAPAARVEPSAPAEAGEKLGPVYGRPA

Sequences:

>Translated_305_residues
MKDKVTIHTLKRFKQIGQKICMVTAYDATFAHILEEAGADVLLIGDSLGMVIQGHDSTLPVTMDQMVYHTAAVARGARRA
HVVADLPFMSYQVSNQEAVRNAGRLVAEGGAGSIKLEGGAEFADTVRAIVRASIPVMGHLGLTPQSVHKMGGYVVQGRGE
DQARQILDDALALEQAGAYALVLEGVPMDLARTVTQRLSIPTIGIGAGVDCDGQVLVCYDLLGMNPDFKPKFVKRYANLH
GSITEAAGAYFAEVRKGAFPDEEHSFKATKNIRLAPGAPAPAARVEPSAPAEAGEKLGPVYGRPA
>Mature_305_residues
MKDKVTIHTLKRFKQIGQKICMVTAYDATFAHILEEAGADVLLIGDSLGMVIQGHDSTLPVTMDQMVYHTAAVARGARRA
HVVADLPFMSYQVSNQEAVRNAGRLVAEGGAGSIKLEGGAEFADTVRAIVRASIPVMGHLGLTPQSVHKMGGYVVQGRGE
DQARQILDDALALEQAGAYALVLEGVPMDLARTVTQRLSIPTIGIGAGVDCDGQVLVCYDLLGMNPDFKPKFVKRYANLH
GSITEAAGAYFAEVRKGAFPDEEHSFKATKNIRLAPGAPAPAARVEPSAPAEAGEKLGPVYGRPA

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=261, Percent_Identity=50.9578544061303, Blast_Score=258, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6319653, Length=275, Percent_Identity=37.0909090909091, Blast_Score=191, Evalue=9e-50,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_MYXXD (Q1DAN9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630284.1
- ProteinModelPortal:   Q1DAN9
- SMR:   Q1DAN9
- STRING:   Q1DAN9
- GeneID:   4105344
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2055
- TIGR:   MXAN_2055
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   YATPEQT
- PhylomeDB:   Q1DAN9
- ProtClustDB:   PRK00311
- BioCyc:   MXAN246197:MXAN_2055-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 32374; Mature: 32374

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: ACT_SITE 184-184 BINDING 85-85 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKVTIHTLKRFKQIGQKICMVTAYDATFAHILEEAGADVLLIGDSLGMVIQGHDSTLP
CCCCCHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCC
VTMDQMVYHTAAVARGARRAHVVADLPFMSYQVSNQEAVRNAGRLVAEGGAGSIKLEGGA
EEHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCHHHHHHCCCEEEECCCCEEEECCCC
EFADTVRAIVRASIPVMGHLGLTPQSVHKMGGYVVQGRGEDQARQILDDALALEQAGAYA
CHHHHHHHHHHHCCCCEECCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
LVLEGVPMDLARTVTQRLSIPTIGIGAGVDCDGQVLVCYDLLGMNPDFKPKFVKRYANLH
EEEECCCHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHCC
GSITEAAGAYFAEVRKGAFPDEEHSFKATKNIRLAPGAPAPAARVEPSAPAEAGEKLGPV
CCHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCC
YGRPA
CCCCC
>Mature Secondary Structure
MKDKVTIHTLKRFKQIGQKICMVTAYDATFAHILEEAGADVLLIGDSLGMVIQGHDSTLP
CCCCCHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCC
VTMDQMVYHTAAVARGARRAHVVADLPFMSYQVSNQEAVRNAGRLVAEGGAGSIKLEGGA
EEHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCHHHHHHCCCEEEECCCCEEEECCCC
EFADTVRAIVRASIPVMGHLGLTPQSVHKMGGYVVQGRGEDQARQILDDALALEQAGAYA
CHHHHHHHHHHHCCCCEECCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
LVLEGVPMDLARTVTQRLSIPTIGIGAGVDCDGQVLVCYDLLGMNPDFKPKFVKRYANLH
EEEECCCHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHCC
GSITEAAGAYFAEVRKGAFPDEEHSFKATKNIRLAPGAPAPAARVEPSAPAEAGEKLGPV
CCHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEECCCCCCCCCCCCCCCCHHHHHHCCCC
YGRPA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA