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The map label for this gene is phoR [H]

Identifier: 108756798

GI number: 108756798

Start: 292680

End: 294749

Strand: Direct

Name: phoR [H]

Synonym: MXAN_0245

Alternate gene names: 108756798

Gene position: 292680-294749 (Clockwise)

Preceding gene: 108759936

Following gene: 108763273

Centisome position: 3.2

GC content: 70.82

Gene sequence:

>2070_bases
ATGTGCGTGCCAGGGGGCCGCGGTGGGCAGGCGGCTGGACAACGGTGGACTGGGCAGCCCGGGGTGGCTCTGCTAGGCCC
TGGCCCCGTGGCGACGCGAACGGGTCAGCACTGGAGTCAGGACACGCGCAGCAGGCCCGCGGTGACGGAGCCCCGCTCCT
TGCGCGAACAGCTCGCCGAGGTGCCGGATTCGCTCGCGCTGCTCGAAGGGCTGTTCACCCATTCACCGGTGCCCTACGCC
GTCTTCACCTCGGACGGCCACTGTCTGCTCACCAACCCCGCCTTCCTGGCGATGTTCGGCGCGGCGCCGCCACCCGAGTA
CAGCCTCTTCAAGGACGAACTGCTCGCGCAGTTGGGCTACGCGAAGTTGCTCCAGCGGGTCGTGTCGGGCGAGCGCGTCC
AGACGCCGGTGTTCTGGTACGACGTGAAGGAGTTGGCGCACGTCCGCGCGCCCGCCGAGGCGCGGCGCATCGCCATCTCC
TGCACCGGCTTCCCCCTGGTTGCCTCCAGCGGCGGCGTCACGCACCTCGCCGTGGCCTACAAGGACATGACGGCGGAGCT
GGCGGCCCGTGAGGCGGCGCAGGTGGAGCGGCGCAACCTGCTCCAGGTCTTCACGCAGGCGCCGGTGGCCCTCAGCGTGC
TGCGCGGCTACGAGCTGCGCTACGAGTTCGCCAACCCGCTGCTCCAGAAGCTCATGGGCGGACGCGAGCTGAACGGGCGC
ACCCAGGAGGAGGCCATTCCGGATTTGTCGCCGGAGCTGCTGAGCCTCCACCGGGGCGTGCTGGAGACGGGCGAGCGCGC
CATCGCGCGGGAGTACCCCATCACCATCGACTACGAGGGCGCCGGCCGCGTCGAGACCCGGTTCTGGAACATCATCTTCG
AGCCCCTGCGCGACGAGCGCGGCCTCGTGGACGGCCTGGTGACGTTGGCCTTCGACGTCACCGAGCAGGTGTTCGCGCGC
CAGGCCGTGGAGAGCCAGCAGAAGTGGCTGGAGGCCGTGCTCGACCTGATGCCCATGCCGGTGGTGATGGCGGACCCGGC
CAGTGGCGACCTCAACTTCTCCAACGCCGCGGCGGACCGGCTCTACGGCCTGCACATCCCCAAGGACGTGCCCACCACCG
CGTATGGCGAGCACTTCCACGTCACGGACCTGGAGGGCCGCCGGCTGAGCGTGGATGACCTCCCCTCCAACCGCGCGGCC
CGGGGCGAGCGGCTGGACGGGCTGGAGGTCCACTGGCACACGCCCGCGGGCCGGTACGCCCTCAGCATCTCGTCGGAGAC
GCTGCCCGCCATGCATGGCCATCCGTCCGTGGTGGTGATTCCCTTCCTGGACATCACCCGCCTGAAGACGGTGGAGCAGC
ACCTCCAGGAGGCCGTGCGTGCCCGTGACGAGTTCCTGTCCGTGGCCAGCCACGAGCTGAAGACGCCGCTGACGTCACTG
GGGCTGCGGCTCCAGTCCTTCGTGCGCGCCATCCACGCGGACCCGGAGTCCGCGTTGGCCCAGCGTCACGGGCGCGAGGT
GGAGGCCATGCGCCGGCAGGTGACGCGTCTGGCCGAGCTCGTGGACGGGCTGCTCGACGTGTCGCGCATCAGCACCGGCC
GGTTGAAGCTCCAGTTCGAGCCGGTGGACCTGCCCTCGCTCGTGAGCGAGGTGGCCGCGCGTTTCGAGCTGGAGGCCGCG
CGCGCCGGCTGCGAGCTGCACGTCACGCAGGCGGAAGGGTTCGAAGGGGTGTGGGACCGGCTGCGGCTGGAGCAGGTGGT
CTCCAACCTGCTGTCCAACGCGCTCAAGTACGGCGCGGGCGCACCCGTGCACATCGACGTGGCGCCGGGGGGCATGGGCG
CCCGGCTGCGGGTGAAGGACCGGGGCATTGGCATCGACCCGGAAGCCCACGCGCGCATCTTCCAGAAGTTCGAGCGCGCC
GTGTCCGAGCGGAACTACGGCGGCATGGGCCTGGGGCTCTACGTGACGCGCACGCTGGTGGAGGCCCTGGGCGGCACCAT
CCAGGTGGACAGCCAGCCCGGCGAGGGCGCCACCTTCGTGGTGGAGCTGCCGCTCCAGCCCGCGAGATAG

Upstream 100 bases:

>100_bases
ACGCGCCGAGGCGTTCGACAAGCCGCGCGTCGAAGAAGGTCTTGAGGTGGTCCGCCATGGGGCGCGCAATCTGGCATGGG
CTCGCCAGAGCACCAGCACC

Downstream 100 bases:

>100_bases
GTCCCCCGCCGGGGAGCGGAGAGGTTATACGGAGGGGGCCGTGCGCCTCCTCGCGCTTCACGTCCACGACTTCCGGAACC
TCCCCCAGGTCCAGCTCACG

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MCVPGGRGGQAAGQRWTGQPGVALLGPGPVATRTGQHWSQDTRSRPAVTEPRSLREQLAEVPDSLALLEGLFTHSPVPYA
VFTSDGHCLLTNPAFLAMFGAAPPPEYSLFKDELLAQLGYAKLLQRVVSGERVQTPVFWYDVKELAHVRAPAEARRIAIS
CTGFPLVASSGGVTHLAVAYKDMTAELAAREAAQVERRNLLQVFTQAPVALSVLRGYELRYEFANPLLQKLMGGRELNGR
TQEEAIPDLSPELLSLHRGVLETGERAIAREYPITIDYEGAGRVETRFWNIIFEPLRDERGLVDGLVTLAFDVTEQVFAR
QAVESQQKWLEAVLDLMPMPVVMADPASGDLNFSNAAADRLYGLHIPKDVPTTAYGEHFHVTDLEGRRLSVDDLPSNRAA
RGERLDGLEVHWHTPAGRYALSISSETLPAMHGHPSVVVIPFLDITRLKTVEQHLQEAVRARDEFLSVASHELKTPLTSL
GLRLQSFVRAIHADPESALAQRHGREVEAMRRQVTRLAELVDGLLDVSRISTGRLKLQFEPVDLPSLVSEVAARFELEAA
RAGCELHVTQAEGFEGVWDRLRLEQVVSNLLSNALKYGAGAPVHIDVAPGGMGARLRVKDRGIGIDPEAHARIFQKFERA
VSERNYGGMGLGLYVTRTLVEALGGTIQVDSQPGEGATFVVELPLQPAR

Sequences:

>Translated_689_residues
MCVPGGRGGQAAGQRWTGQPGVALLGPGPVATRTGQHWSQDTRSRPAVTEPRSLREQLAEVPDSLALLEGLFTHSPVPYA
VFTSDGHCLLTNPAFLAMFGAAPPPEYSLFKDELLAQLGYAKLLQRVVSGERVQTPVFWYDVKELAHVRAPAEARRIAIS
CTGFPLVASSGGVTHLAVAYKDMTAELAAREAAQVERRNLLQVFTQAPVALSVLRGYELRYEFANPLLQKLMGGRELNGR
TQEEAIPDLSPELLSLHRGVLETGERAIAREYPITIDYEGAGRVETRFWNIIFEPLRDERGLVDGLVTLAFDVTEQVFAR
QAVESQQKWLEAVLDLMPMPVVMADPASGDLNFSNAAADRLYGLHIPKDVPTTAYGEHFHVTDLEGRRLSVDDLPSNRAA
RGERLDGLEVHWHTPAGRYALSISSETLPAMHGHPSVVVIPFLDITRLKTVEQHLQEAVRARDEFLSVASHELKTPLTSL
GLRLQSFVRAIHADPESALAQRHGREVEAMRRQVTRLAELVDGLLDVSRISTGRLKLQFEPVDLPSLVSEVAARFELEAA
RAGCELHVTQAEGFEGVWDRLRLEQVVSNLLSNALKYGAGAPVHIDVAPGGMGARLRVKDRGIGIDPEAHARIFQKFERA
VSERNYGGMGLGLYVTRTLVEALGGTIQVDSQPGEGATFVVELPLQPAR
>Mature_689_residues
MCVPGGRGGQAAGQRWTGQPGVALLGPGPVATRTGQHWSQDTRSRPAVTEPRSLREQLAEVPDSLALLEGLFTHSPVPYA
VFTSDGHCLLTNPAFLAMFGAAPPPEYSLFKDELLAQLGYAKLLQRVVSGERVQTPVFWYDVKELAHVRAPAEARRIAIS
CTGFPLVASSGGVTHLAVAYKDMTAELAAREAAQVERRNLLQVFTQAPVALSVLRGYELRYEFANPLLQKLMGGRELNGR
TQEEAIPDLSPELLSLHRGVLETGERAIAREYPITIDYEGAGRVETRFWNIIFEPLRDERGLVDGLVTLAFDVTEQVFAR
QAVESQQKWLEAVLDLMPMPVVMADPASGDLNFSNAAADRLYGLHIPKDVPTTAYGEHFHVTDLEGRRLSVDDLPSNRAA
RGERLDGLEVHWHTPAGRYALSISSETLPAMHGHPSVVVIPFLDITRLKTVEQHLQEAVRARDEFLSVASHELKTPLTSL
GLRLQSFVRAIHADPESALAQRHGREVEAMRRQVTRLAELVDGLLDVSRISTGRLKLQFEPVDLPSLVSEVAARFELEAA
RAGCELHVTQAEGFEGVWDRLRLEQVVSNLLSNALKYGAGAPVHIDVAPGGMGARLRVKDRGIGIDPEAHARIFQKFERA
VSERNYGGMGLGLYVTRTLVEALGGTIQVDSQPGEGATFVVELPLQPAR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=31.4741035856574, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788713, Length=303, Percent_Identity=27.7227722772277, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=28.4132841328413, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=33.7719298245614, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=31.3559322033898, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=29.4354838709677, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1787894, Length=241, Percent_Identity=29.4605809128631, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=30.5439330543933, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790436, Length=260, Percent_Identity=28.8461538461538, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=267, Percent_Identity=28.4644194756554, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=29.535864978903, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788549, Length=272, Percent_Identity=25.7352941176471, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=27.9166666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=26.6094420600858, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 75489; Mature: 75489

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50109 HIS_KIN ; PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVPGGRGGQAAGQRWTGQPGVALLGPGPVATRTGQHWSQDTRSRPAVTEPRSLREQLAE
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
VPDSLALLEGLFTHSPVPYAVFTSDGHCLLTNPAFLAMFGAAPPPEYSLFKDELLAQLGY
CCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AKLLQRVVSGERVQTPVFWYDVKELAHVRAPAEARRIAISCTGFPLVASSGGVTHLAVAY
HHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCHHCEEEEEECCCEEEECCCCCEEEEEHH
KDMTAELAAREAAQVERRNLLQVFTQAPVALSVLRGYELRYEFANPLLQKLMGGRELNGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
TQEEAIPDLSPELLSLHRGVLETGERAIAREYPITIDYEGAGRVETRFWNIIFEPLRDER
CHHHCCCCCCHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GLVDGLVTLAFDVTEQVFARQAVESQQKWLEAVLDLMPMPVVMADPASGDLNFSNAAADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHH
LYGLHIPKDVPTTAYGEHFHVTDLEGRRLSVDDLPSNRAARGERLDGLEVHWHTPAGRYA
HEEEECCCCCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
LSISSETLPAMHGHPSVVVIPFLDITRLKTVEQHLQEAVRARDEFLSVASHELKTPLTSL
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLRLQSFVRAIHADPESALAQRHGREVEAMRRQVTRLAELVDGLLDVSRISTGRLKLQFE
HHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
PVDLPSLVSEVAARFELEAARAGCELHVTQAEGFEGVWDRLRLEQVVSNLLSNALKYGAG
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
APVHIDVAPGGMGARLRVKDRGIGIDPEAHARIFQKFERAVSERNYGGMGLGLYVTRTLV
CCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EALGGTIQVDSQPGEGATFVVELPLQPAR
HHCCCEEEECCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MCVPGGRGGQAAGQRWTGQPGVALLGPGPVATRTGQHWSQDTRSRPAVTEPRSLREQLAE
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
VPDSLALLEGLFTHSPVPYAVFTSDGHCLLTNPAFLAMFGAAPPPEYSLFKDELLAQLGY
CCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHH
AKLLQRVVSGERVQTPVFWYDVKELAHVRAPAEARRIAISCTGFPLVASSGGVTHLAVAY
HHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCHHCEEEEEECCCEEEECCCCCEEEEEHH
KDMTAELAAREAAQVERRNLLQVFTQAPVALSVLRGYELRYEFANPLLQKLMGGRELNGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
TQEEAIPDLSPELLSLHRGVLETGERAIAREYPITIDYEGAGRVETRFWNIIFEPLRDER
CHHHCCCCCCHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GLVDGLVTLAFDVTEQVFARQAVESQQKWLEAVLDLMPMPVVMADPASGDLNFSNAAADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHH
LYGLHIPKDVPTTAYGEHFHVTDLEGRRLSVDDLPSNRAARGERLDGLEVHWHTPAGRYA
HEEEECCCCCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEE
LSISSETLPAMHGHPSVVVIPFLDITRLKTVEQHLQEAVRARDEFLSVASHELKTPLTSL
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLRLQSFVRAIHADPESALAQRHGREVEAMRRQVTRLAELVDGLLDVSRISTGRLKLQFE
HHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
PVDLPSLVSEVAARFELEAARAGCELHVTQAEGFEGVWDRLRLEQVVSNLLSNALKYGAG
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
APVHIDVAPGGMGARLRVKDRGIGIDPEAHARIFQKFERAVSERNYGGMGLGLYVTRTLV
CCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EALGGTIQVDSQPGEGATFVVELPLQPAR
HHCCCEEEECCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]