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The map label for this gene is serS [H]

Identifier: 108563858

GI number: 108563858

Start: 1489235

End: 1490482

Strand: Direct

Name: serS [H]

Synonym: HPAG1_1433

Alternate gene names: 108563858

Gene position: 1489235-1490482 (Clockwise)

Preceding gene: 108563857

Following gene: 108563859

Centisome position: 93.29

GC content: 41.67

Gene sequence:

>1248_bases
ATGATTGACAGAAAACTTTTATTGCAAGATTTTGACAAGGTGGCTCTTTCTTTAAAAAAGCGTAATCATGCGATGGGTGA
TGAGTTGGAGCGTTTGCGCGAAGTCATCACGCATTATAAAAAGCAGCTCATTGAATTGGAAGGCTTGCAAGCCTTTCAAA
ACAAGGTTTCTAAAGAATTTGGCATCAAAATGGCTCAAAAAGTGGATACAAGCGATCTCAAAAAAGAGCTAGAAAACAAT
AAAATCAAATTGAATGAGCTTTCCAAAAGCGTGGGCGAATTGGAGCAACAAATTGATTTGAAACTTTCCATAATCCCTAA
TCTGGTGGATGAAAAAACCCCTTTAGGTGCAAGCGAAGAAGATAATATAGAAATTAAAAAAATATTAACCCCAAGGGTCT
TCACTTTCAAACCCAAAGAGCATTTTGAACTCGCTCAACAAAATGGCTGGATTGATTTTGAAAGCGGCGTGAAACTCGCC
AAAAGCCGTTTTTCTGTCATCAGGGGTTTTGGGGCTAAAATTTATCGTGCGCTCATTCATTTAATGCTGGATTTTAATGA
AAAAAATGGCTTTGAAATCATCTACACGCCGGCGTTAGTGAATGAAAAAATGCTTTTTGGGACCGGGCAATTACCCAAAT
TCAAAGAAGATGTTTTCAAAATAGAAAATGAAAATTTGTATTTAATCCCCACCGCTGAAGTAACGCTCACTAATCTCTAC
AACGACACGATCATTGGCGTTGAAAATCTCCCCATTAAAATGACCGCACACACGCCTTGTTTTAGGAGCGAAGCAGGGAG
TGCGGGCAAGGACACAAGGGGGATGATAAGACAGCACCAGTTTGATAAAGTGGAGCTAGTGGCTATCACGCACTCTAAAG
AAAGCGATGCCATGCAAGAGCATATGCTAGAGAGCGCGAGCGAAATTTTAAAGGCTTTGGAATTACCGCACCGGTTTGTG
CAATTGTGCAGCGCGGATTTAGGCTTTAGCGCGAGCAACACCATAGATATTGAAGTGTGGCTGCCCGGGCAAAATTGCTA
CCGAGAAATCAGCTCGGTGTCTAACACGAGGGATTTTCAGGCTAGGCGAGCCAAAATCCGCTTCAAAGAAAATCAAAAAA
ACCAATTAGCGCACACCTTAAACGGCTCTTCTTTAGCGGTAGGCAGGACGATGGTCGCTTTAATGGAAAACCACCAGCAA
GAAGATGGGAGCATCCACATTCCTAAGGCGTTAGAAAAATACCTTTAA

Upstream 100 bases:

>100_bases
TTTAGAGGGTAAAATGGGGGCTTTGAACGCTCAAATAGATAAAAACGATATAGACGAATGGGCTAAATTGTGGCATTTTA
GAACGATTAAAGAGGGTTGA

Downstream 100 bases:

>100_bases
GGATAGTTTGTGCTGAATGAAGAGCAAAATTCATTAGAAGAAAAAGGGGGCGAAAACAAAAACGAAAAAGAAACCCCCCT
AAAGGGCATTCATTCTAAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MIDRKLLLQDFDKVALSLKKRNHAMGDELERLREVITHYKKQLIELEGLQAFQNKVSKEFGIKMAQKVDTSDLKKELENN
KIKLNELSKSVGELEQQIDLKLSIIPNLVDEKTPLGASEEDNIEIKKILTPRVFTFKPKEHFELAQQNGWIDFESGVKLA
KSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIIGVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHSKESDAMQEHMLESASEILKALELPHRFV
QLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQ
EDGSIHIPKALEKYL

Sequences:

>Translated_415_residues
MIDRKLLLQDFDKVALSLKKRNHAMGDELERLREVITHYKKQLIELEGLQAFQNKVSKEFGIKMAQKVDTSDLKKELENN
KIKLNELSKSVGELEQQIDLKLSIIPNLVDEKTPLGASEEDNIEIKKILTPRVFTFKPKEHFELAQQNGWIDFESGVKLA
KSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIIGVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHSKESDAMQEHMLESASEILKALELPHRFV
QLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQ
EDGSIHIPKALEKYL
>Mature_415_residues
MIDRKLLLQDFDKVALSLKKRNHAMGDELERLREVITHYKKQLIELEGLQAFQNKVSKEFGIKMAQKVDTSDLKKELENN
KIKLNELSKSVGELEQQIDLKLSIIPNLVDEKTPLGASEEDNIEIKKILTPRVFTFKPKEHFELAQQNGWIDFESGVKLA
KSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIIGVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHSKESDAMQEHMLESASEILKALELPHRFV
QLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQ
EDGSIHIPKALEKYL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=328, Percent_Identity=32.0121951219512, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI8923421, Length=330, Percent_Identity=31.5151515151515, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI225579074, Length=330, Percent_Identity=31.5151515151515, Blast_Score=179, Evalue=5e-45,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=46.0093896713615, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17539260, Length=421, Percent_Identity=27.790973871734, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17542084, Length=317, Percent_Identity=26.1829652996845, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=31.447963800905, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321799, Length=360, Percent_Identity=27.7777777777778, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581334, Length=353, Percent_Identity=30.8781869688385, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17737985, Length=247, Percent_Identity=32.7935222672065, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47328; Mature: 47328

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRKLLLQDFDKVALSLKKRNHAMGDELERLREVITHYKKQLIELEGLQAFQNKVSKEF
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKMAQKVDTSDLKKELENNKIKLNELSKSVGELEQQIDLKLSIIPNLVDEKTPLGASEE
CCHHHHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCEEEECCHHHCCCCCCCCCCC
DNIEIKKILTPRVFTFKPKEHFELAQQNGWIDFESGVKLAKSRFSVIRGFGAKIYRALIH
CCEEEEEECCCCEEEECCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
HHHHCCCCCCCEEEEECHHHCCEEEECCCCCCHHHHHHHEECCCCEEEEECCCEEEEECC
NDTIIGVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHSKESDAMQE
CCEEEEECCCCEEEEECCCCHHCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHH
HMLESASEILKALELPHRFVQLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHH
ARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQEDGSIHIPKALEKYL
HHHHHEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEECCHHHHHCC
>Mature Secondary Structure
MIDRKLLLQDFDKVALSLKKRNHAMGDELERLREVITHYKKQLIELEGLQAFQNKVSKEF
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKMAQKVDTSDLKKELENNKIKLNELSKSVGELEQQIDLKLSIIPNLVDEKTPLGASEE
CCHHHHHCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCCEEEECCHHHCCCCCCCCCCC
DNIEIKKILTPRVFTFKPKEHFELAQQNGWIDFESGVKLAKSRFSVIRGFGAKIYRALIH
CCEEEEEECCCCEEEECCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
HHHHCCCCCCCEEEEECHHHCCEEEECCCCCCHHHHHHHEECCCCEEEEECCCEEEEECC
NDTIIGVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHSKESDAMQE
CCEEEEECCCCEEEEECCCCHHCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHH
HMLESASEILKALELPHRFVQLCSADLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHH
ARRAKIRFKENQKNQLAHTLNGSSLAVGRTMVALMENHQQEDGSIHIPKALEKYL
HHHHHEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA