Click here to switch to the map view.

The map label for this gene is dnaA [H]

Identifier: 108563812

GI number: 108563812

Start: 1435690

End: 1437057

Strand: Direct

Name: dnaA [H]

Synonym: HPAG1_1387

Alternate gene names: 108563812

Gene position: 1435690-1437057 (Clockwise)

Preceding gene: 108563807

Following gene: 108563813

Centisome position: 89.93

GC content: 39.91

Gene sequence:

>1368_bases
ATGGATACCAACAACAATATTGAAAAAGAAATCTTGGCGCTAGCCAAACAAAAAGTCAGCCCCATAGAGTATGAAAATTG
CTTAAGCCAGCTCAAATACAACCCTAACGCGAGCAAGAGCGACATTGCCTTTTTTTATGCCCCTAACACGCTCTTATGCA
ATTGGATTACGGCTAAATACGGCACGTTGCTTAAAGAAATTTTAAGCCAGAATAAAGTCGGCATGCATTTAGCCCATAGC
GTGGATGTGCGTATTGAAGTAGCGCCTAAAATCCAAATTAGCACCCAATCTAATATCAATTACAAAGCCACAAAAATGAG
CGTCAAAGACTCTTACACTTTTGAAAATTTTGTCGTAGGCTCATGCAATAACACCGTTTATGAAATCGCTAAAAAAGTCG
CCCAAAGCGATACCCCCCCTTATAACCCGGTGCTTTTTTATGGCGGCACAGGGTTAGGCAAAACGCACATTTTAAACGCT
ATCGGTAACCATGCCCTAGAAAAGCATAAAAAAGTCGTGTTAGTCACTTCAGAAGACTTTTTGACAGACTTTTTAAAGCA
TTTAGACAACAAAACCATGGATTCTTTTAAAGCAAAATACCGCCATTGCGACTTTTTCTTGTTAGATGACGCTCAATTTT
TGCAAGGAAAACCCAAACTAGAAGAAGAATTTTTCCACACTTTCAACGAATTGCACGCCAACAGCAAACAAATCGTATTG
ATTTCAGACCGATCGCCTAAAAACATCGCCGGCTTAGAAGATCGCTTAAAATCGCGCTTTGAATGGGGGATAACCGCTAA
AGTCATGCCCCCTGATTTAGAAACCAAACTTTCCATTGTCAAACAAAAATGCCAGCTCAATCAAATCATTTTGCCTGAAG
AGGTGATGGAATACATCGCCCAACACATCAGCGACAATATCCGCCAAATGGAAGGCGCGATCATTAAAATCAGCGTGAAC
GCGAACTTAATGAACGCTTCCATTGATTTGAATCTCGCTAAAACCGTTTTAGAAGATTTGCAAAAAGATCATGCTGAAGG
CTCAAGCTTGGAAAATATCTTACTCGCTGTCGCGCAAAGCTTAAATCTCAAATCCAGCGAAATCAAAGTCTCTTCGCGCC
AAAAAAATGTCGCTCTAGCGAGAAAATTAGTCGTGTATTTCGCCAGGCTTTATACCCCTAACCCCACGCTCTCGCTCGCT
CAATTTTTGGATTTAAAGGATCATTCAAGCATTTCTAAAATGTATTCTAGCGTTAAAAAAATGCTTGAAGAAGAAAAAAG
CCCTTTTATCTTAAGCCTTAGAGAAGAAATCAAAAACCGCTTGAACGAATTGAACGACAAAAAAACCGCTTTCAATTCAA
GTGAATGA

Upstream 100 bases:

>100_bases
AAACCCTTAAAAGAAACACCTTAATTTTAAGGCTTCATTCACATTTCATTCACATGTTATTCCTTTTTCATTCACCACTT
ATTCACGCTATAATAACGCC

Downstream 100 bases:

>100_bases
AAAAAGGCTTATCAAAAAGCGTTCCATTCACTTTTTTTAAAATCCTACAACCCCCCTAAAAACGCGCACCTCTAAAGCTT
TTTAATTTTTCATTCCATCC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MDTNNNIEKEILALAKQKVSPIEYENCLSQLKYNPNASKSDIAFFYAPNTLLCNWITAKYGTLLKEILSQNKVGMHLAHS
VDVRIEVAPKIQISTQSNINYKATKMSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNA
IGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVL
ISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQIILPEEVMEYIAQHISDNIRQMEGAIIKISVN
ANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLA
QFLDLKDHSSISKMYSSVKKMLEEEKSPFILSLREEIKNRLNELNDKKTAFNSSE

Sequences:

>Translated_455_residues
MDTNNNIEKEILALAKQKVSPIEYENCLSQLKYNPNASKSDIAFFYAPNTLLCNWITAKYGTLLKEILSQNKVGMHLAHS
VDVRIEVAPKIQISTQSNINYKATKMSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNA
IGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVL
ISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQIILPEEVMEYIAQHISDNIRQMEGAIIKISVN
ANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLA
QFLDLKDHSSISKMYSSVKKMLEEEKSPFILSLREEIKNRLNELNDKKTAFNSSE
>Mature_455_residues
MDTNNNIEKEILALAKQKVSPIEYENCLSQLKYNPNASKSDIAFFYAPNTLLCNWITAKYGTLLKEILSQNKVGMHLAHS
VDVRIEVAPKIQISTQSNINYKATKMSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNA
IGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVL
ISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQIILPEEVMEYIAQHISDNIRQMEGAIIKISVN
ANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLA
QFLDLKDHSSISKMYSSVKKMLEEEKSPFILSLREEIKNRLNELNDKKTAFNSSE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=415, Percent_Identity=33.2530120481928, Blast_Score=246, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 51527; Mature: 51527

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTNNNIEKEILALAKQKVSPIEYENCLSQLKYNPNASKSDIAFFYAPNTLLCNWITAKY
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCHHEEHHHHHHH
GTLLKEILSQNKVGMHLAHSVDVRIEVAPKIQISTQSNINYKATKMSVKDSYTFENFVVG
HHHHHHHHCCCCCCEEEEEEEEEEEEECCEEEEECCCCCCEEEEEEECCCCCCCCCEEEE
SCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSEDF
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECHHH
LTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVL
HHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEE
ISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQIILPEEVMEYIA
EECCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQS
HHHHHHHHHHCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSSVKK
CCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
MLEEEKSPFILSLREEIKNRLNELNDKKTAFNSSE
HHHHCCCCEEEHHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure
MDTNNNIEKEILALAKQKVSPIEYENCLSQLKYNPNASKSDIAFFYAPNTLLCNWITAKY
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCHHEEHHHHHHH
GTLLKEILSQNKVGMHLAHSVDVRIEVAPKIQISTQSNINYKATKMSVKDSYTFENFVVG
HHHHHHHHCCCCCCEEEEEEEEEEEEECCEEEEECCCCCCEEEEEEECCCCCCCCCEEEE
SCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSEDF
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECHHH
LTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVL
HHHHHHHHCCCHHHHHHHHHHCCCEEEECCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEE
ISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQIILPEEVMEYIA
EECCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQS
HHHHHHHHHHCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSSVKK
CCCCCHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
MLEEEKSPFILSLREEIKNRLNELNDKKTAFNSSE
HHHHCCCCEEEHHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]