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The map label for this gene is thyX [H]

Identifier: 108563808

GI number: 108563808

Start: 1432271

End: 1432897

Strand: Reverse

Name: thyX [H]

Synonym: HPAG1_1383

Alternate gene names: 108563808

Gene position: 1432897-1432271 (Counterclockwise)

Preceding gene: 108563809

Following gene: 108563805

Centisome position: 89.76

GC content: 38.92

Gene sequence:

>627_bases
ATGGAAGTGATTTGTAAGCACTACACCCCTTTAGACATTGCAAGCCAAGCGATCCGCACTTGCTGGCAGAGCTTTGAATA
CAGCGATGATGGAGGCTGTAAGGATAAGGAGCTTATCCATAGGGTGGGGAATATTTTTAGGCATTCTTCCACTTTAGAGC
ATCTTTATTACAATTTTGAAATCAAGGGTTTGAGTAGGGGAGCGTTGCAAGAATTGAGCCGGCATAGAATGGCGAGCTTG
AGCGTGAAATCAAGCCGTTACACTTTAAGGGAATTGAAAGAAGTGGAGAGCTTTTTACCCCTTAATGAAACGAATTTAGA
AAGAGCCAAAGAGTTTTTAGTTTTTGTGGATAATGAAAAAGTGGATGCAATGAGCGTTTTAGCTTTAGAAAATCTCAGGG
TTTTATTGAGCGAGCATAACATTAAAAACGATTTAGCCAAATACGCCATGCCTGAAAGCTATAAAACGCATTTAGCCTAT
AGCATTAACGCTAGGAGCTTGCAAAATTTATTGACTTTAAGAAGCAGTAATAAAGCCTTAAAAGAAATGCAAGATTTAGC
CAAAGCCTTATTTGACGCTTTACCTGGCGAGCATCAATATTTGTTTGAAGATTGTTTGAAGCATTAG

Upstream 100 bases:

>100_bases
AGCCTTAGAAATCGCTATGCGTTTGAACCACGATGTGGATCACCCAAGAAACTTAGCTAAAAGCGTTACCGTGGAATAAA
AAGCGATTAGGAGTCAAATA

Downstream 100 bases:

>100_bases
TTTTAAACAATACCGCTTAATAACGCTCATTCTTTAATGTTTTAAAAACGCCTTGTTTTTGATTAGATGAGATTTTAAGG
GGGTTTGTTGTAGGATTTCA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRMASL
SVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEKVDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAY
SINARSLQNLLTLRSSNKALKEMQDLAKALFDALPGEHQYLFEDCLKH

Sequences:

>Translated_208_residues
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRMASL
SVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEKVDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAY
SINARSLQNLLTLRSSNKALKEMQDLAKALFDALPGEHQYLFEDCLKH
>Mature_208_residues
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRMASL
SVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEKVDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAY
SINARSLQNLLTLRSSNKALKEMQDLAKALFDALPGEHQYLFEDCLKH

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24043; Mature: 24043

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFE
CCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEE
IKGLSRGALQELSRHRMASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEK
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEEECCCC
VDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAYSINARSLQNLLTLRSSNKAL
CHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHEEEEECHHHHHHHHHHHCCHHHH
KEMQDLAKALFDALPGEHQYLFEDCLKH
HHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFE
CCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEE
IKGLSRGALQELSRHRMASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEK
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEEECCCC
VDAMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAYSINARSLQNLLTLRSSNKAL
CHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHEEEEECHHHHHHHHHHHCCHHHH
KEMQDLAKALFDALPGEHQYLFEDCLKH
HHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]