BacMap

Definition	Helicobacter pylori HPAG1 chromosome, complete genome.
Accession	NC_008086
Length	1,596,366

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The map label for this gene is ppiA [H]

Identifier: 108563792

GI number: 108563792

Start: 1420827

End: 1421318

Strand: Direct

Name: ppiA [H]

Synonym: HPAG1_1367

Alternate gene names: 108563792

Gene position: 1420827-1421318 (Clockwise)

Preceding gene: 108563790

Following gene: 108563793

Centisome position: 89.0

GC content: 45.53

Gene sequence:

>492_bases
ATGATGGATCCAATTAAAACTTATGAAATTAAAGAAGAAGAGCTTGCAAAAACCGCTTACGCCACAATCAAAACCAATAA
AGGCAATATCGCTCTAGAGCTTTTTTACAAAGACGCGCCCCAAGCGGTGAGTAACTTTGTAACTTTGGCTAAAGAGGGTT
TTTATGACAGGCTTAACTTCCATCGTGTGATCGCTGGCTTTGTGGCTCAAGGAGGTTGCCCTTATGGCACAGGCACAGGC
GGGCCAGGACACCGCATTAAATGCGAAGTAGCCCACAACCCCAACAAGCACAAAAGAGGCTCTATTTCTATGGCGCATGC
TGGGAGAGACACAGGGGGGAGTCAGTTTTTCTTGTGTTTTGTGGATTTGCCCCATTTAGATGGCGAGCACACCGTGTTTG
GCAAGATCGCTAGTGCAGAAGGCCTTAGCGTTTTGGATAAAATCAAACAAGGCGATATTATAGAGAGCGTTGTGTTTAGC
CCTTCTCTATAA

Upstream 100 bases:

>100_bases
TTTCAAAAGTATCCTACAACACTATCGGCTAAAATACCATTTGTTTTAATTTATTGCTATAATAGAGCATTTGAATGACA
AAAGCTTATCGCAAAGGTTT

Downstream 100 bases:

>100_bases
AGGAACAAAAGATTAGACATGCTCATACTCAGCCGCAAAGTTAATGAAGGGATTGTCATTGATGATAACATCCATATTAA
AGTCATTTCTATAGATAGAG

Product: peptidyl-prolyl cis-trans isomerase B, cyclosporin-type rotamase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MMDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVTLAKEGFYDRLNFHRVIAGFVAQGGCPYGTGTG
GPGHRIKCEVAHNPNKHKRGSISMAHAGRDTGGSQFFLCFVDLPHLDGEHTVFGKIASAEGLSVLDKIKQGDIIESVVFS
PSL

Sequences:

>Translated_163_residues
MMDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVTLAKEGFYDRLNFHRVIAGFVAQGGCPYGTGTG
GPGHRIKCEVAHNPNKHKRGSISMAHAGRDTGGSQFFLCFVDLPHLDGEHTVFGKIASAEGLSVLDKIKQGDIIESVVFS
PSL
>Mature_163_residues
MMDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVTLAKEGFYDRLNFHRVIAGFVAQGGCPYGTGTG
GPGHRIKCEVAHNPNKHKRGSISMAHAGRDTGGSQFFLCFVDLPHLDGEHTVFGKIASAEGLSVLDKIKQGDIIESVVFS
PSL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=117, Percent_Identity=43.5897435897436, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI7706339, Length=129, Percent_Identity=39.5348837209302, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI24308049, Length=132, Percent_Identity=41.6666666666667, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=39.0977443609023, Blast_Score=97, Evalue=4e-21,
Organism=Homo sapiens, GI4758950, Length=130, Percent_Identity=43.8461538461538, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI22547212, Length=134, Percent_Identity=41.7910447761194, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI7657473, Length=134, Percent_Identity=41.7910447761194, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4826932, Length=131, Percent_Identity=38.9312977099237, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI22547215, Length=134, Percent_Identity=41.7910447761194, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=43.4108527131783, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=32.3741007194245, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=38.4615384615385, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI310127646, Length=143, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310114371, Length=143, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310119221, Length=143, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI6631100, Length=137, Percent_Identity=35.7664233576642, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI256017253, Length=119, Percent_Identity=41.1764705882353, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI221139811, Length=119, Percent_Identity=41.1764705882353, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI256017251, Length=119, Percent_Identity=41.1764705882353, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310129267, Length=130, Percent_Identity=36.9230769230769, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310120620, Length=130, Percent_Identity=36.9230769230769, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310110104, Length=130, Percent_Identity=36.9230769230769, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI42560244, Length=132, Percent_Identity=35.6060606060606, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI5031987, Length=131, Percent_Identity=40.4580152671756, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI178057341, Length=119, Percent_Identity=40.3361344537815, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI169164185, Length=130, Percent_Identity=34.6153846153846, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI169163623, Length=130, Percent_Identity=34.6153846153846, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI169163387, Length=130, Percent_Identity=34.6153846153846, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI209417936, Length=116, Percent_Identity=38.7931034482759, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI30102944, Length=116, Percent_Identity=38.7931034482759, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI219842199, Length=116, Percent_Identity=38.7931034482759, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1789763, Length=135, Percent_Identity=41.4814814814815, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1786736, Length=139, Percent_Identity=37.410071942446, Blast_Score=72, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=139, Percent_Identity=41.0071942446043, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71997782, Length=125, Percent_Identity=43.2, Blast_Score=106, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17532641, Length=144, Percent_Identity=36.8055555555556, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17506311, Length=139, Percent_Identity=39.568345323741, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506307, Length=132, Percent_Identity=48.4848484848485, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=36.3636363636364, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=36.3636363636364, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32563659, Length=139, Percent_Identity=33.0935251798561, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=130, Percent_Identity=43.0769230769231, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=138, Percent_Identity=39.1304347826087, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=136, Percent_Identity=36.0294117647059, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=141, Percent_Identity=36.8794326241135, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=141, Percent_Identity=36.8794326241135, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=137, Percent_Identity=35.7664233576642, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=129, Percent_Identity=37.2093023255814, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=136, Percent_Identity=37.5, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=135, Percent_Identity=38.5185185185185, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=132, Percent_Identity=38.6363636363636, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320359, Length=129, Percent_Identity=37.984496124031, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=131, Percent_Identity=37.4045801526718, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323246, Length=142, Percent_Identity=35.2112676056338, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=162, Percent_Identity=37.6543209876543, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357249, Length=127, Percent_Identity=40.9448818897638, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17986117, Length=132, Percent_Identity=39.3939393939394, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19922912, Length=117, Percent_Identity=45.2991452991453, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=33.0827067669173, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130249, Length=131, Percent_Identity=42.7480916030534, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355677, Length=150, Percent_Identity=35.3333333333333, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549139, Length=132, Percent_Identity=40.1515151515151, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650807, Length=129, Percent_Identity=37.984496124031, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136360, Length=147, Percent_Identity=36.734693877551, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=37.2093023255814, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=37.2093023255814, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17647301, Length=132, Percent_Identity=37.1212121212121, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17701; Mature: 17701

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVTLAKEGFYDRLNF
CCCCCCCEECCHHHHHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHH
HRVIAGFVAQGGCPYGTGTGGPGHRIKCEVAHNPNKHKRGSISMAHAGRDTGGSQFFLCF
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCEEEEEE
VDLPHLDGEHTVFGKIASAEGLSVLDKIKQGDIIESVVFSPSL
EECCCCCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure
MMDPIKTYEIKEEELAKTAYATIKTNKGNIALELFYKDAPQAVSNFVTLAKEGFYDRLNF
CCCCCCCEECCHHHHHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHH
HRVIAGFVAQGGCPYGTGTGGPGHRIKCEVAHNPNKHKRGSISMAHAGRDTGGSQFFLCF
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCEEEEEE
VDLPHLDGEHTVFGKIASAEGLSVLDKIKQGDIIESVVFSPSL
EECCCCCCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]