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The map label for this gene is lon [H]

Identifier: 108563750

GI number: 108563750

Start: 1371413

End: 1373917

Strand: Direct

Name: lon [H]

Synonym: HPAG1_1325

Alternate gene names: 108563750

Gene position: 1371413-1373917 (Clockwise)

Preceding gene: 108563749

Following gene: 108563751

Centisome position: 85.91

GC content: 41.08

Gene sequence:

>2505_bases
ATGACTGAAGATTTTCCTAAAATTCTGCCTTTATTGGTAGAAGAAGACACCTTTTTATACCCCTTTATGATAGCCCCTAT
TTTTTTGCAAAATAACGCCAGCATCAAGGCGGTGGCTTACGCTAAAAACAATAAATCATTAGTCTTTATTGCATGCCAAA
AAGACAAATTGAACGATAATGAAGCCCCTTATTATGATGTGGGGGTGATTGGATCGATTATGCGTGAAGCCAACATGCCT
AATGGGCGCGTGAAATTGCTCTTTAATGGCATCGCTAAGGGGCGTATTTTAGAGCCTGCTAAAGAAAACGAGCAAGGCTT
TTTAGAAGCTCAAATAAGCCCTATTGAATATTTAGAATACGATAAAGAAAACATTCAAGCTATCGTGGAAGTGCTAAAAG
AAAAAGTGATCACTCTAGCCAATGTCAGCTCACTCTTTCCTCCAGATTTGATCAAGGCTTTAGAAGACAATGACGATCCT
AACCGCATCGCTGATTTAATCGCAGCGGCCTTGCATTTGAAAAGAGATCAAGCGTATTCTCTTTTTGCAAACAACAACAC
CGAACAGCGCTTGTTGGATTTGATTGATATTGTGATAGAAGAGACTAAAACCCAAAAACTCCAAAAAGAAATCAAATCCA
AAGTCCATCAAAAAATGGAGCAAACCAATAAGGAATATTTCTTAAAAGAGCAACTCAAACAAATCCAAAAAGAGCTTGGC
ACAGACAAACAGCGAGATGAAGATTTAAACCAATACTACCAAAAACTAGAAAGCATCAAGCCTTTTTTAAAAGAAGAAGC
GTTTAAGGAGATTAAAAAGCAAATTGACCGGCTGAGCCGAACCCATGCGGACAGCTCTGATAGCGCGACTTTACAAAATT
ATATTGAAACCATGTTAGATGTGCCTTTTGGGCAATATGGGAAAAAAGCGCTTGACATCAAGCTAGTGAGAGAACAACTA
GACAAGGATCATTATTCCTTAAAAAGGCCTAAAGAGCGTATTGTAGAATACTTTGCCACCATGCAGCTTTTAGAAATGCG
CCGCAAGAAAAAGCCAGAAAAAAAAGACAAAGCTAAAGGCACGATTTTATGCTTTTATGGGCCTCCTGGCGTGGGTAAAA
CGAGTTTAGCCAATTCCATTGCTAAAGCGATAGAGCGCCCTTTAGTTCGGATCGCTTTAGGGGGATTAGAAGATGTGAAT
GAATTAAGAGGGCACAGACGCACTTATATAGGCTCAATGCCTGGGCGCATTGTCCAAGGGCTTATTGAAGCTAAAAAGAT
GAATCCGGTCATGGTTTTAGATGAAATTGATAAGGTGGATAGGAGCGTTAGGGGTGATCCAGCGAGCGCTTTATTAGAGA
TCTTAGACCCTGAGCAAAATACCGCTTTTAGGGATCATTATGCGAATTTTAGCATTGATTTATCGCAAGTGATTTTTATC
GCTACCGCTAACAATATTGACAGAATCCCGGCCCCTTTAAGAGACAGAATGGAATTTATCAGCGTGTCCAGCTACACGCC
TAATGAAAAAGAAGAAATCGCTAAAAACTACCTCATCCCCCAAGAATTAGAAAAGCACGCCTTAAAGCCTAGCGAAGTGG
AGATTAGCCATGAGTGTTTGAAACTCATTATTGAAAAATACACTAGAGAAGCGGGCGTTAGGGATTTACGGAGACAGATC
GCAACGATTATGCGTAAAGTAGCTTTAAAATACCTAGAAGATAACCCGCACCAAAAAGGGCGAACCAAAAAAGGCGAAAA
TGAAAAAAGCGAAGATAAAAAAAACGAAAATGAGGAAAACGAAAAAAGAGGTGGAAACAAAGATTTCTGCGTCTCTATCA
CGCCTAGCAACCTTAAAGAGTATTTAGAACGCATGGTGTTTGAAATTGACCCCATAGATGGAGAAAATAAAATCGGTATC
GTCAATGGTTTGGCATGGACTCCAGTGGGCGGCGATGTGCTTAAAATTGAAGCGCTTAAGATTAGAGGCAAGGGGGAATT
GAAACTCACAGGGAGTTTAGGCGATGTGATGAAAGAATCCGCTCTCATCGCTTTTTCTGTTGTCAAAGCCTTATTGGATA
ACGAAACCTTAAAAGCGCCTAAAATCCCTAGCGAAACCGATGCAGAGGGTAAGAAAAAGAAAAAAGCACTGAAAGTTTAT
AACGCTTATGATTTGCATTTGCATGTCCCTGAGGGGGCTACGCCTAAAGACGGTCCGAGCGCTGGGATCGCTATGGCGAG
CGTGATGGCGAGCATTTTGTGCGACAGGGCTACAAGAAGCGAGGTGGCAATGACGGGCGAATTGACTTTGAGCGGGGAAG
TTTTACCCATAGGAGGGTTGAAAGAAAAATTGATCGCCGCTTTTAAAGCCGGCATTAAAACCGCTCTTGTTCCTGTCAAA
AATTACGAAAGGGATTTAGATGAAATCCCTGCTGAAGTGCGAGAGAATTTAAACATCGTTGCGGTGAAAAACATCGCTGA
AGTGTTGGAAAAAACTTTGCTTTGA

Upstream 100 bases:

>100_bases
AAGAGACCAAACCCAAACCATCGCACATGCCTTGGTATGTGTTAATCTTTGATTGGTAGGATATTTCAAAACCATACACA
TTATAACAGAGAGATGAAAA

Downstream 100 bases:

>100_bases
AATTTGGCATGAAAGCAGGCATTATTGGTTTAGGGCTTATGGGGGGGAGTTTAGGGTTGGCTTTGCAAGAATGGGGGCGT
TTTAAAAGCGTTACAGGCTA

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 834; Mature: 833

Protein sequence:

>834_residues
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDNEAPYYDVGVIGSIMREANMP
NGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDP
NRIADLIAAALHLKRDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELG
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKLVREQL
DKDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKAKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVN
ELRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFI
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQI
ATIMRKVALKYLEDNPHQKGRTKKGENEKSEDKKNENEENEKRGGNKDFCVSITPSNLKEYLERMVFEIDPIDGENKIGI
VNGLAWTPVGGDVLKIEALKIRGKGELKLTGSLGDVMKESALIAFSVVKALLDNETLKAPKIPSETDAEGKKKKKALKVY
NAYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALVPVK
NYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL

Sequences:

>Translated_834_residues
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDNEAPYYDVGVIGSIMREANMP
NGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDP
NRIADLIAAALHLKRDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELG
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKLVREQL
DKDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKAKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVN
ELRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFI
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQI
ATIMRKVALKYLEDNPHQKGRTKKGENEKSEDKKNENEENEKRGGNKDFCVSITPSNLKEYLERMVFEIDPIDGENKIGI
VNGLAWTPVGGDVLKIEALKIRGKGELKLTGSLGDVMKESALIAFSVVKALLDNETLKAPKIPSETDAEGKKKKKALKVY
NAYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALVPVK
NYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL
>Mature_833_residues
TEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDNEAPYYDVGVIGSIMREANMPN
GRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPN
RIADLIAAALHLKRDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELGT
DKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLDVPFGQYGKKALDIKLVREQLD
KDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKAKGTILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNE
LRGHRRTYIGSMPGRIVQGLIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFIA
TANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECLKLIIEKYTREAGVRDLRRQIA
TIMRKVALKYLEDNPHQKGRTKKGENEKSEDKKNENEENEKRGGNKDFCVSITPSNLKEYLERMVFEIDPIDGENKIGIV
NGLAWTPVGGDVLKIEALKIRGKGELKLTGSLGDVMKESALIAFSVVKALLDNETLKAPKIPSETDAEGKKKKKALKVYN
AYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALVPVKN
YERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=576, Percent_Identity=44.0972222222222, Blast_Score=471, Evalue=1e-132,
Organism=Homo sapiens, GI21396489, Length=683, Percent_Identity=37.1888726207906, Blast_Score=463, Evalue=1e-130,
Organism=Escherichia coli, GI1786643, Length=831, Percent_Identity=40.3128760529483, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17505831, Length=697, Percent_Identity=37.5896700143472, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17556486, Length=691, Percent_Identity=32.1273516642547, Blast_Score=366, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319449, Length=702, Percent_Identity=37.4643874643875, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI221513036, Length=714, Percent_Identity=36.2745098039216, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24666867, Length=714, Percent_Identity=36.2745098039216, Blast_Score=446, Evalue=1e-125,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 94051; Mature: 93919

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDN
CCCCHHHHHHHHCCCCCEEHHHHHHHHHEECCCCEEEEEEECCCCEEEEEEEECCCCCCC
EAPYYDVGVIGSIMREANMPNGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEY
CCCEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCHHHHHHC
DKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALHLKRDQAYS
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEE
LFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
VPFGQYGKKALDIKLVREQLDKDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKAKG
CCCCCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
TILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNELRGHRRTYIGSMPGRIVQG
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHH
LIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFI
HHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEHHHEEEE
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECL
EECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
KLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDNPHQKGRTKKGENEKSEDKKNENEEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCHH
EKRGGNKDFCVSITPSNLKEYLERMVFEIDPIDGENKIGIVNGLAWTPVGGDVLKIEALK
HHCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEECCCCCCEEEEEEEE
IRGKGELKLTGSLGDVMKESALIAFSVVKALLDNETLKAPKIPSETDAEGKKKKKALKVY
ECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHC
NAYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGL
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEECCCH
KEKLIAAFKAGIKTALVPVKNYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL
HHHHHHHHHHCHHHEEEEHHHHHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
TEDFPKILPLLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKNNKSLVFIACQKDKLNDN
CCCHHHHHHHHCCCCCEEHHHHHHHHHEECCCCEEEEEEECCCCEEEEEEEECCCCCCC
EAPYYDVGVIGSIMREANMPNGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEY
CCCEEHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEECCHHHHHHC
DKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALHLKRDQAYS
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEE
LFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQTNKEYFLKEQLKQIQKELG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHADSSDSATLQNYIETMLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
VPFGQYGKKALDIKLVREQLDKDHYSLKRPKERIVEYFATMQLLEMRRKKKPEKKDKAKG
CCCCCCCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
TILCFYGPPGVGKTSLANSIAKAIERPLVRIALGGLEDVNELRGHRRTYIGSMPGRIVQG
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHH
LIEAKKMNPVMVLDEIDKVDRSVRGDPASALLEILDPEQNTAFRDHYANFSIDLSQVIFI
HHHHHHCCCEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEHHHEEEE
ATANNIDRIPAPLRDRMEFISVSSYTPNEKEEIAKNYLIPQELEKHALKPSEVEISHECL
EECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
KLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDNPHQKGRTKKGENEKSEDKKNENEEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCHH
EKRGGNKDFCVSITPSNLKEYLERMVFEIDPIDGENKIGIVNGLAWTPVGGDVLKIEALK
HHCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEECCCCCCEEEEEEEE
IRGKGELKLTGSLGDVMKESALIAFSVVKALLDNETLKAPKIPSETDAEGKKKKKALKVY
ECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHC
NAYDLHLHVPEGATPKDGPSAGIAMASVMASILCDRATRSEVAMTGELTLSGEVLPIGGL
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEECCCH
KEKLIAAFKAGIKTALVPVKNYERDLDEIPAEVRENLNIVAVKNIAEVLEKTLL
HHHHHHHHHHCHHHEEEEHHHHHHHHHHCCHHHHCCCCEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]