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The map label for this gene is nuoL [H]

Identifier: 108563640

GI number: 108563640

Start: 1275553

End: 1277391

Strand: Direct

Name: nuoL [H]

Synonym: HPAG1_1215

Alternate gene names: 108563640

Gene position: 1275553-1277391 (Clockwise)

Preceding gene: 108563639

Following gene: 108563641

Centisome position: 79.9

GC content: 42.79

Gene sequence:

>1839_bases
ATGCAGTATTCTTCTTTGCTGTCAGTGGTGTTGTTTTTGCCTTTAATCGGCGCGATTTATGCTGGGTTGTTTGGGGCTAA
AGCTAAAGCGTTGCATGTGGGCGTTTTCAATTCTTTGTGCGTGCTGGTTTCTTTCATTGGCGCTGTGGTTCTTTTCGTTC
AAGCATGGCATCATCAAAGCTATGAAAAATACTTGTTTGACTGGATCGTGGTAGGGAATTTTAAAGTCGGCTTTTCTCTC
ATGCTGGACAATATCAATGCAGTCATGATTGTTGTGGTAACTTTAGTTTCTTTCTTAGTGCATGTGTATTCTATAGGCTA
TATGGAGCATGATAAAGGGTTTAACCGCTATTTTTCCTATCTCAGCGGCTTTGTGTTTTCCATGTTGGTGTTGGTGTTGA
GCGATAATTTTTTAGGGCTTTTCATTGGTTGGGAAGGGGTGGGGCTATGCTCTTACTTGCTCATTGGCTTTTGGTATCAT
AAAAAAAGTGCGAATGACGCTTCTATTGAAGCCTTTGTGATGAATCGGATCACGGATTTAGGCATGCTCATGGGGATTAT
TTTGATCTTTTGGAATTTTGGCACTCTTCAGTATAAAGAAGTCTTTAGCATGCTCAATAACGCCGATTATTCCATGCTCT
TTTTCATCAGCGTGTTTCTTTTCATTGGCGCTATGGGCAAGAGCGCGCAATTCCCTATGCACACATGGTTAGCCAACGCT
ATGGAGGGGCCTACGCCGGTGTCCGCACTCATCCATGCAGCGACGATGGTAACCGCTGGGGTGTATCTGGTCATTAGAGC
CAATCCCTTGTATAGCGCGGTGTTTGAAGTGGGCTATTTTATCGCATGCTTAGGGGCGTTTGTGGCTCTTTTTGGAGCGA
GCATGGCTTTAGTCAATAAGGATTTAAAACGCATTGTGGCTTATTCCACGCTTTCTCAATTGGGTTATATGTTTGTAGCG
GCCGGTCTTGGGGCTTATGCGATCGCGCTTTTCCACCTCTTCACGCATGCGTTTTTCAAATCCCTCCTTTTCTTAGGCTC
AGGCAATGTCATGCATGCGATGGAAGACAATCTGGATATTACTAAAATGGGCGCTTTATACAAGCCTATGAAAATCACAG
CGATCTTTATGATTATAGGTTCAGTGGCTTTGTGCGGGATCTACCCTTTCGCAGGATACTTTTCTAAAGACAAGATTTTA
GAAGTGGCTTTTGGGATGCACCACCACATTTTATGGTTTGTTCTTCTAATTGGGGCGATCTTTACCGCTTTTTATAGCTT
CAGGCTCATCATGCTAGTATTCTTTGCCCCCAAACAACACGAAATCAACCACCCCCATGAAGCTAAAAATTTCATGCTTT
TAAGCATGCTACCCTTAGGGGTTTTAGCGGTCATTGCCGGGTTTTTTGAAGAGCCGTTTTTTCATTTCATCTCTCAAGTG
ATCCCTAGCGTTGGAGAGTATCCCGTCCCGCTCGCTCTTTTAATCAGTATCACCACCATCGTGGTGTTGTTGAGTATCGC
TTATGCCATATTTAAATATAAAAATGGTATCACTTCCAAAAAAGAGGGGGGCTTTTTATACAAGCTCTTGCTCAACCAAT
ATTATATCCCCAAGCTCTATCAAGGGATTGCAAAAGTTTTTAGCACCATCGCTTCATTCTTGCACCAAGTCGTGGAATTA
AAAATCATTGATGCGATAGTGGATACTATAGGAAGAAGCGTTTTTGTTATAGGGCGTGTGTTTAGGATCAGTCAAGATGG
GAATTTAACTTCCATGCTGCGCTTCATGGTGGCTGGGGTTTTAATCTTGTTAGCGTTTGTAGCTTTTTTTGGGAGATAA

Upstream 100 bases:

>100_bases
CCGCTAGTGAGGTGGCTATTGGTTTGGGCTTGGTGATTTTGTGGTTTAAGAAATACAAGAGCTTAGACATTGATTCTTTA
AACGCTATGAAAGGTTGAGC

Downstream 100 bases:

>100_bases
GAAATGCAGTTTTTACATGCGCATCTTTTAAGTGTGGTGATCTTTTTCCCCATGCTGAGCGCGCTATTAGCGTTCTTTAT
GAGCGATCAAGCGAGTAGGG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MQYSSLLSVVLFLPLIGAIYAGLFGAKAKALHVGVFNSLCVLVSFIGAVVLFVQAWHHQSYEKYLFDWIVVGNFKVGFSL
MLDNINAVMIVVVTLVSFLVHVYSIGYMEHDKGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KKSANDASIEAFVMNRITDLGMLMGIILIFWNFGTLQYKEVFSMLNNADYSMLFFISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMKITAIFMIIGSVALCGIYPFAGYFSKDKIL
EVAFGMHHHILWFVLLIGAIFTAFYSFRLIMLVFFAPKQHEINHPHEAKNFMLLSMLPLGVLAVIAGFFEEPFFHFISQV
IPSVGEYPVPLALLISITTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPKLYQGIAKVFSTIASFLHQVVEL
KIIDAIVDTIGRSVFVIGRVFRISQDGNLTSMLRFMVAGVLILLAFVAFFGR

Sequences:

>Translated_612_residues
MQYSSLLSVVLFLPLIGAIYAGLFGAKAKALHVGVFNSLCVLVSFIGAVVLFVQAWHHQSYEKYLFDWIVVGNFKVGFSL
MLDNINAVMIVVVTLVSFLVHVYSIGYMEHDKGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KKSANDASIEAFVMNRITDLGMLMGIILIFWNFGTLQYKEVFSMLNNADYSMLFFISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMKITAIFMIIGSVALCGIYPFAGYFSKDKIL
EVAFGMHHHILWFVLLIGAIFTAFYSFRLIMLVFFAPKQHEINHPHEAKNFMLLSMLPLGVLAVIAGFFEEPFFHFISQV
IPSVGEYPVPLALLISITTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPKLYQGIAKVFSTIASFLHQVVEL
KIIDAIVDTIGRSVFVIGRVFRISQDGNLTSMLRFMVAGVLILLAFVAFFGR
>Mature_612_residues
MQYSSLLSVVLFLPLIGAIYAGLFGAKAKALHVGVFNSLCVLVSFIGAVVLFVQAWHHQSYEKYLFDWIVVGNFKVGFSL
MLDNINAVMIVVVTLVSFLVHVYSIGYMEHDKGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KKSANDASIEAFVMNRITDLGMLMGIILIFWNFGTLQYKEVFSMLNNADYSMLFFISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMKITAIFMIIGSVALCGIYPFAGYFSKDKIL
EVAFGMHHHILWFVLLIGAIFTAFYSFRLIMLVFFAPKQHEINHPHEAKNFMLLSMLPLGVLAVIAGFFEEPFFHFISQV
IPSVGEYPVPLALLISITTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPKLYQGIAKVFSTIASFLHQVVEL
KIIDAIVDTIGRSVFVIGRVFRISQDGNLTSMLRFMVAGVLILLAFVAFFGR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=406, Percent_Identity=38.6699507389163, Blast_Score=271, Evalue=1e-72,
Organism=Escherichia coli, GI1788614, Length=508, Percent_Identity=41.7322834645669, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI1788829, Length=418, Percent_Identity=30.1435406698565, Blast_Score=172, Evalue=7e-44,
Organism=Escherichia coli, GI1788831, Length=358, Percent_Identity=27.6536312849162, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788827, Length=425, Percent_Identity=26.8235294117647, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788613, Length=395, Percent_Identity=25.3164556962025, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI2367154, Length=442, Percent_Identity=23.3031674208145, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI145693160, Length=370, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68181; Mature: 68181

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]