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The map label for this gene is nuoM [H]

Identifier: 108563641

GI number: 108563641

Start: 1277395

End: 1278933

Strand: Direct

Name: nuoM [H]

Synonym: HPAG1_1216

Alternate gene names: 108563641

Gene position: 1277395-1278933 (Clockwise)

Preceding gene: 108563640

Following gene: 108563642

Centisome position: 80.02

GC content: 41.2

Gene sequence:

>1539_bases
ATGCAGTTTTTACATGCGCATCTTTTAAGTGTGGTGATCTTTTTCCCCATGCTGAGCGCGCTATTAGCGTTCTTTATGAG
CGATCAAGCGAGTAGGGCGTATGCGATTGTCATCGCTTTGATTGAATTGTTATTAATCTTGTTGTTGTGGCATGGGTTTG
ATATTCAAAAAGCAGGCATGCAGTTTGAAGAAATGAAGGAATTAGTCTATCAAATTGGCGTGAATTACCATGTGGGCGTT
GATGGCATCGCGCTCTTTTTGTTGCTCTTAAACGCTATCGTGGTGTTATTGTCCGTGATTTATGTCAAAGAGCGTCGTAA
AGACTTCGCGATTTGTCTTTTATTGCTAGAAGGGATCTTAATGGGCGTATTTTCTTCTCTTAATGTGATCTTTTTCTACG
CTTTTTGGGAAATCTCGCTCTTGCCGGTTTTATACCTCATCGGTCGTTTTGGCCGTAATAACAAAATCTATTCTGGCATG
AAGTTTTTCCTCTACACCTTTTTAGCGTCATTGTGCATGCTCTTAGGCATTTTATATATTGGGTATTACTACGCTAGCAA
TTACGGCATGATGAGTTTTGATATTTTAGACTGGTATCAATTGAACTTTTCTGGCGGGGTTAAAACCTGGCTCTTTGTGG
CTTTCTTAATAGGGATTGCGGTTAAAATCCCGCTCTTTCCCTTACACACATGGCTGCCTTATGCGTATTCTAACGCCCCC
ACTTTAGGCTCTGTCATGCTTTCGGCCTTGCTTTCTAAAATGGGGACTTACGCCTTATTACGCTTCTTGCTCCCGCTTTT
TCCTGAGCTTTCAGAAATTTATTTAACCCCCATAGCCATTGCAGCGCTATGCATGATCATTTATGGAGGTTTTCTAGCCT
ACGCTCAAAAAGATTTAAAAACCCTCATCGCTTATAGCTCATTCTCGCACATGGGAGTTGTGGTGCTTGGGATTTTTTCT
TTCAATGTTGAGGGGATTTCAGGGGCGGTGTTTATGATGTTTGCGCATGGTATTATCGTCATGGGGTTATTTTTACTCGC
TGGTATCTTAGAAGAGCGCGCCAGCAGTTTAGAAATCGCTCGCTTTGGATCGATCGCTAAAAGCGCTCCTGTTTTTGCAG
CCTTTTTTATGATCGTTTTAATGGCGAATGTGGGCATGCCTTTAAGCATTGGCTTTGTGGGAGAGTTTTTAAGCTTATTA
GGATTTTTTGCCACTTACCCTCTTTTAGCTATCATTGCCGGGACAAGCATCATCCTGTCAGCGGTTTACATGCTCACTTC
ATATAAAGACGTGTTCTTTGGCAACTTAAAAACCGGGAACAATCAAATCAGCGTGTTTGAAGATTTGAACGCTCGTGAGG
TAGGGGTTTTGAGCGTGATTTTAGCTTTGATTTTAATTTTAGGGATTTATCCTAAAATACTTTTAAAACCGATTGAGCAA
GGCTCTAAGCAGCTTTTAGAGGTGATAGAAATCCGCTCGCTCCCTTTTTTAGGTTCATTGGATACTAAGATAAAAGAGGT
CTCTTATGCTAATAGATAG

Upstream 100 bases:

>100_bases
TAGGATCAGTCAAGATGGGAATTTAACTTCCATGCTGCGCTTCATGGTGGCTGGGGTTTTAATCTTGTTAGCGTTTGTAG
CTTTTTTTGGGAGATAAGAA

Downstream 100 bases:

>100_bases
TCTCCACATCTCTTTTGACAGCTTTAATTTTGAGAGCGTTTTACCCATGCTGGTGTTGGTGTGTGGGGGGATTTTCACGC
TCTTAATCAACGCTTTCACT

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLILLLWHGFDIQKAGMQFEEMKELVYQIGVNYHVGV
DGIALFLLLLNAIVVLLSVIYVKERRKDFAICLLLLEGILMGVFSSLNVIFFYAFWEISLLPVLYLIGRFGRNNKIYSGM
KFFLYTFLASLCMLLGILYIGYYYASNYGMMSFDILDWYQLNFSGGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIAALCMIIYGGFLAYAQKDLKTLIAYSSFSHMGVVVLGIFS
FNVEGISGAVFMMFAHGIIVMGLFLLAGILEERASSLEIARFGSIAKSAPVFAAFFMIVLMANVGMPLSIGFVGEFLSLL
GFFATYPLLAIIAGTSIILSAVYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKILLKPIEQ
GSKQLLEVIEIRSLPFLGSLDTKIKEVSYANR

Sequences:

>Translated_512_residues
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLILLLWHGFDIQKAGMQFEEMKELVYQIGVNYHVGV
DGIALFLLLLNAIVVLLSVIYVKERRKDFAICLLLLEGILMGVFSSLNVIFFYAFWEISLLPVLYLIGRFGRNNKIYSGM
KFFLYTFLASLCMLLGILYIGYYYASNYGMMSFDILDWYQLNFSGGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIAALCMIIYGGFLAYAQKDLKTLIAYSSFSHMGVVVLGIFS
FNVEGISGAVFMMFAHGIIVMGLFLLAGILEERASSLEIARFGSIAKSAPVFAAFFMIVLMANVGMPLSIGFVGEFLSLL
GFFATYPLLAIIAGTSIILSAVYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKILLKPIEQ
GSKQLLEVIEIRSLPFLGSLDTKIKEVSYANR
>Mature_512_residues
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLILLLWHGFDIQKAGMQFEEMKELVYQIGVNYHVGV
DGIALFLLLLNAIVVLLSVIYVKERRKDFAICLLLLEGILMGVFSSLNVIFFYAFWEISLLPVLYLIGRFGRNNKIYSGM
KFFLYTFLASLCMLLGILYIGYYYASNYGMMSFDILDWYQLNFSGGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIAALCMIIYGGFLAYAQKDLKTLIAYSSFSHMGVVVLGIFS
FNVEGISGAVFMMFAHGIIVMGLFLLAGILEERASSLEIARFGSIAKSAPVFAAFFMIVLMANVGMPLSIGFVGEFLSLL
GFFATYPLLAIIAGTSIILSAVYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKILLKPIEQ
GSKQLLEVIEIRSLPFLGSLDTKIKEVSYANR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=373, Percent_Identity=30.0268096514745, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1788613, Length=493, Percent_Identity=33.8742393509128, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI1788827, Length=334, Percent_Identity=26.9461077844311, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788831, Length=394, Percent_Identity=26.1421319796954, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693160, Length=391, Percent_Identity=24.8081841432225, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56983; Mature: 56983

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLILLLWHGFDIQKAGM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
QFEEMKELVYQIGVNYHVGVDGIALFLLLLNAIVVLLSVIYVKERRKDFAICLLLLEGIL
CHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGVFSSLNVIFFYAFWEISLLPVLYLIGRFGRNNKIYSGMKFFLYTFLASLCMLLGILYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GYYYASNYGMMSFDILDWYQLNFSGGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
HHHHHCCCCCEEEEHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHCCCCC
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIAALCMIIYGGFLAYAQKDLK
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIAYSSFSHMGVVVLGIFSFNVEGISGAVFMMFAHGIIVMGLFLLAGILEERASSLEIA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGSIAKSAPVFAAFFMIVLMANVGMPLSIGFVGEFLSLLGFFATYPLLAIIAGTSIILS
HHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKILLKPIEQ
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSKQLLEVIEIRSLPFLGSLDTKIKEVSYANR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQFLHAHLLSVVIFFPMLSALLAFFMSDQASRAYAIVIALIELLLILLLWHGFDIQKAGM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
QFEEMKELVYQIGVNYHVGVDGIALFLLLLNAIVVLLSVIYVKERRKDFAICLLLLEGIL
CHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGVFSSLNVIFFYAFWEISLLPVLYLIGRFGRNNKIYSGMKFFLYTFLASLCMLLGILYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GYYYASNYGMMSFDILDWYQLNFSGGVKTWLFVAFLIGIAVKIPLFPLHTWLPYAYSNAP
HHHHHCCCCCEEEEHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHCCCCC
TLGSVMLSALLSKMGTYALLRFLLPLFPELSEIYLTPIAIAALCMIIYGGFLAYAQKDLK
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLIAYSSFSHMGVVVLGIFSFNVEGISGAVFMMFAHGIIVMGLFLLAGILEERASSLEIA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGSIAKSAPVFAAFFMIVLMANVGMPLSIGFVGEFLSLLGFFATYPLLAIIAGTSIILS
HHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVYMLTSYKDVFFGNLKTGNNQISVFEDLNAREVGVLSVILALILILGIYPKILLKPIEQ
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSKQLLEVIEIRSLPFLGSLDTKIKEVSYANR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]