Click here to switch to the map view.

The map label for this gene is nuoI [H]

Identifier: 108563637

GI number: 108563637

Start: 1274048

End: 1274710

Strand: Direct

Name: nuoI [H]

Synonym: HPAG1_1212

Alternate gene names: 108563637

Gene position: 1274048-1274710 (Clockwise)

Preceding gene: 108563636

Following gene: 108563638

Centisome position: 79.81

GC content: 45.55

Gene sequence:

>663_bases
ATGGCCAAACAAGAATACAAGCAACTTCCTAAACGAGCCGAAGTCCATAGCGCGACCGAGCAATTTAAAGACACCATTAA
AACGAGCTTGGGTTTGGATCTATTCAAAGGGCTAGGGCTTACGATCAAGGAATTTTTTAGCCCAAGCGTAACCATCCATT
ACCCTATGGAGCAACTCCCTTTAAGCCCTCGTTATCGCGCGGTGCATCATTTGCAACGGCTTTTAGACTCAGGCTCTGAA
AGGTGTATTGGTTGCGGGCTGTGCGAAAAGATTTGCACGAGCAATTGCATAAGGATCATCACGCATAAGGGCGAAGACAA
CCGCAAAAAGATTGACTCTTACACGATCAATTTAGGGCGTTGCATTTATTGCGGGTTGTGCGCAGAAGTTTGCCCAGAAT
TAGCGATTGTTATGGGGAATCGGTTTGAAAACGCCAGCACCCAACGCTCCCAATACGGCTCTAAAAGCGAGTTTCTAACG
AACGAACAAGACGCTAAAAACTGCTCTCATGCCGAGTTTTTAGGCTTTGGTGCGGTAAGCCCTAATTACAACGAACGCAT
GCAAGCCACCCCTTTAGATTATGTCCAAGAGCCATCAAAGGAAGAATCAAAAGAAGAGACTCCAACAAACCCAGAAAGCA
ATAAGGGAGATGAAAATGTTTGA

Upstream 100 bases:

>100_bases
CCAGACCAACTGATGAATATGTGCTGGAAAATCATGCTGCCTTTAGCGTTATTGAACATTGTGCTAACGGGCATTATCAT
TTTAATTTAAAGGAGGTTTT

Downstream 100 bases:

>100_bases
AACCATTGCCTTTTATTTCTTTGCGATCCTTACTTTAAGCATGGCGTTAGTGGTGATCACCACCACGAATATCCTCTATG
CCATTACCGCTCTTGCCAGC

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHHLQRLLDSGSE
RCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLT
NEQDAKNCSHAEFLGFGAVSPNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV

Sequences:

>Translated_220_residues
MAKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHHLQRLLDSGSE
RCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLT
NEQDAKNCSHAEFLGFGAVSPNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV
>Mature_219_residues
AKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLPLSPRYRAVHHLQRLLDSGSER
CIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGRCIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTN
EQDAKNCSHAEFLGFGAVSPNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=138, Percent_Identity=42.7536231884058, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1788617, Length=124, Percent_Identity=36.2903225806452, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555194, Length=130, Percent_Identity=42.3076923076923, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17864306, Length=111, Percent_Identity=45.045045045045, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 24779; Mature: 24648

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLP
CCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCHHHCC
LSPRYRAVHHLQRLLDSGSERCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGR
CCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHEEEHCCCCCCHHHHHHHHEECHHH
CIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTNEQDAKNCSHAEFLGFGAVS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCCCHHHHCCCHHHHHCCCCCC
PNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV
CCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQEYKQLPKRAEVHSATEQFKDTIKTSLGLDLFKGLGLTIKEFFSPSVTIHYPMEQLP
CHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCHHHCC
LSPRYRAVHHLQRLLDSGSERCIGCGLCEKICTSNCIRIITHKGEDNRKKIDSYTINLGR
CCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHEEEHCCCCCCHHHHHHHHEECHHH
CIYCGLCAEVCPELAIVMGNRFENASTQRSQYGSKSEFLTNEQDAKNCSHAEFLGFGAVS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCCCHHHHCCCHHHHHCCCCCC
PNYNERMQATPLDYVQEPSKEESKEETPTNPESNKGDENV
CCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA